CN101652062A - Toll样受体3(TLR3)的限制性激动剂 - Google Patents

Toll样受体3(TLR3)的限制性激动剂 Download PDF

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Publication number
CN101652062A
CN101652062A CN200880007263A CN200880007263A CN101652062A CN 101652062 A CN101652062 A CN 101652062A CN 200880007263 A CN200880007263 A CN 200880007263A CN 200880007263 A CN200880007263 A CN 200880007263A CN 101652062 A CN101652062 A CN 101652062A
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tlr3
virus
poly
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mice
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布赖恩·B·高恩
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Utah State University
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Utah State University
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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    • C12N2760/00011—Details
    • C12N2760/12011—Bunyaviridae
    • C12N2760/12211—Phlebovirus, e.g. Rift Valley fever virus
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN200880007263A 2007-03-05 2008-03-05 Toll样受体3(TLR3)的限制性激动剂 Pending CN101652062A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90479207P 2007-03-05 2007-03-05
US60/904,792 2007-03-05

Publications (1)

Publication Number Publication Date
CN101652062A true CN101652062A (zh) 2010-02-17

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CN200880007263A Pending CN101652062A (zh) 2007-03-05 2008-03-05 Toll样受体3(TLR3)的限制性激动剂

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US (1) US20100183638A1 (https=)
EP (1) EP2134172A4 (https=)
JP (1) JP2010520284A (https=)
KR (1) KR20090130019A (https=)
CN (1) CN101652062A (https=)
AU (1) AU2008223446B2 (https=)
BR (1) BRPI0808637A2 (https=)
CA (1) CA2680134A1 (https=)
NZ (1) NZ579433A (https=)
WO (1) WO2008109083A2 (https=)
ZA (1) ZA200905954B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300997A (zh) * 2008-10-31 2011-12-28 森托科尔奥索生物科技公司 Toll样受体3拮抗剂

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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AU2006322073A1 (en) 2005-12-07 2007-06-14 Hemispherx Biopharma, Inc. dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants
JP2011525169A (ja) * 2008-02-15 2011-09-15 へミスフェリックス・バイオファーマ，インコーポレーテッド Ｔｏｌｌ様受容体３の選択的アゴニスト
US8722874B2 (en) 2008-10-23 2014-05-13 Hemispherx Biopharma, Inc. Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
HUE026718T2 (en) * 2008-10-23 2016-07-28 Hemispherx Biopharma Inc Double-stranded ribonucleic acid with robust physico-chemical properties and very specific biological activity
US20100160413A1 (en) * 2008-10-23 2010-06-24 Hemispherx Biopharma, Inc. Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
NZ599677A (en) * 2009-12-18 2014-10-31 Bavarian Nordic As Production of ifn-lambda by conventional dendritic cells and uses thereof
CN101780279B (zh) * 2009-12-22 2012-07-11 中山大学中山眼科中心 Toll-like receptor-3激动剂在制备促进伤口愈合的药物中的应用
WO2011130379A1 (en) * 2010-04-13 2011-10-20 Novartis Ag Benzonapthyridine compositions and uses thereof
CA2802721C (en) 2010-06-25 2015-08-18 Idera Pharmaceuticals, Inc. Novel agonists of toll-like receptor 3 and methods of their use
US10105305B2 (en) 2014-02-19 2018-10-23 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
EP3321362A1 (en) 2016-11-10 2018-05-16 Centre Leon Berard Tlr3 agonist for use for inducing apoptosis in senescent cancer cells
US10758601B2 (en) 2016-12-22 2020-09-01 Intervet Inc. Eimeria vaccine with improved efficacy
WO2020030634A1 (en) 2018-08-06 2020-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
WO2020232226A1 (en) 2019-05-16 2020-11-19 The Johns Hopkins University Compositions and methods for skin rejuvenation
JP2024517181A (ja) 2021-04-28 2024-04-19 ウエヌイグレックオ・ファーマ 組合せ治療としてｆｘｒアゴニストを使用するｔｌｒ３アゴニストの効果の強い増強

Citations (1)

* Cited by examiner, † Cited by third party
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WO2006054177A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer using tlr3 agonists

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US6080726A (en) * 1985-08-12 2000-06-27 University Of Maryland Anti-viral and immuno stimulator polynucleotide duplex and use thereof
US5063209A (en) * 1985-08-26 1991-11-05 Hem Research, Inc. Modulation of aids virus-related events by double-stranded RNAs
IE72103B1 (en) * 1987-08-12 1997-03-12 Hem Res Inc Promotion of host defense by systemic dsRNA treatment
US5683986A (en) * 1987-08-12 1997-11-04 Hemispherx Biopharma Inc. Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment
AU3583797A (en) * 1996-06-28 1998-01-21 Regents Of The University Of California, The Enhancement of cancer cell death
GB0119346D0 (en) * 2001-08-08 2001-10-03 Bioclones Proprietary Ltd Process for the maturation of dendritic cells
US20060211752A1 (en) * 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054177A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer using tlr3 agonists

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300997A (zh) * 2008-10-31 2011-12-28 森托科尔奥索生物科技公司 Toll样受体3拮抗剂
CN102300997B (zh) * 2008-10-31 2016-01-20 森托科尔奥索生物科技公司 Toll样受体3拮抗剂

Also Published As

Publication number Publication date
EP2134172A4 (en) 2011-06-01
AU2008223446B2 (en) 2012-02-02
AU2008223446A1 (en) 2008-09-12
ZA200905954B (en) 2011-10-26
CA2680134A1 (en) 2008-09-12
BRPI0808637A2 (pt) 2014-08-05
NZ579433A (en) 2012-05-25
KR20090130019A (ko) 2009-12-17
EP2134172A2 (en) 2009-12-23
JP2010520284A (ja) 2010-06-10
WO2008109083A3 (en) 2008-11-27
US20100183638A1 (en) 2010-07-22
WO2008109083A2 (en) 2008-09-12

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