CA2680134A1 - Restrictive agonist of toll-like receptor 3 (tlr3) - Google Patents
Restrictive agonist of toll-like receptor 3 (tlr3) Download PDFInfo
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- CA2680134A1 CA2680134A1 CA002680134A CA2680134A CA2680134A1 CA 2680134 A1 CA2680134 A1 CA 2680134A1 CA 002680134 A CA002680134 A CA 002680134A CA 2680134 A CA2680134 A CA 2680134A CA 2680134 A1 CA2680134 A1 CA 2680134A1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/12011—Bunyaviridae
- C12N2760/12211—Phlebovirus, e.g. Rift Valley fever virus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US90479207P | 2007-03-05 | 2007-03-05 | |
| US60/904,792 | 2007-03-05 | ||
| PCT/US2008/002874 WO2008109083A2 (en) | 2007-03-05 | 2008-03-05 | Restrictive agonist of toll-like receptor 3 (tlr3) |
Publications (1)
| Publication Number | Publication Date |
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| CA2680134A1 true CA2680134A1 (en) | 2008-09-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002680134A Abandoned CA2680134A1 (en) | 2007-03-05 | 2008-03-05 | Restrictive agonist of toll-like receptor 3 (tlr3) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100183638A1 (https=) |
| EP (1) | EP2134172A4 (https=) |
| JP (1) | JP2010520284A (https=) |
| KR (1) | KR20090130019A (https=) |
| CN (1) | CN101652062A (https=) |
| AU (1) | AU2008223446B2 (https=) |
| BR (1) | BRPI0808637A2 (https=) |
| CA (1) | CA2680134A1 (https=) |
| NZ (1) | NZ579433A (https=) |
| WO (1) | WO2008109083A2 (https=) |
| ZA (1) | ZA200905954B (https=) |
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| WO2007067517A2 (en) | 2005-12-07 | 2007-06-14 | Hemispherx Biopharma | Dsrnas as influenza virus vaccine adjuvants or immuno-stimulants |
| WO2009102496A2 (en) * | 2008-02-15 | 2009-08-20 | Hemispherx Biopharma, Inc. | Selective agonist of toll-like receptor 3 |
| US8722874B2 (en) | 2008-10-23 | 2014-05-13 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| AU2009308105B2 (en) * | 2008-10-23 | 2016-07-07 | Aim Immunotech Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20100160413A1 (en) * | 2008-10-23 | 2010-06-24 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| RS55861B1 (sr) * | 2008-10-31 | 2017-08-31 | Janssen Biotech Inc | Antagonisti toll-like receptora 3 |
| US9090897B2 (en) * | 2009-12-18 | 2015-07-28 | Bavarian Nordic A/S | Production of IFN-lambda by conventional dendritic cells |
| CN101780279B (zh) * | 2009-12-22 | 2012-07-11 | 中山大学中山眼科中心 | Toll-like receptor-3激动剂在制备促进伤口愈合的药物中的应用 |
| EP2558069A1 (en) | 2010-04-13 | 2013-02-20 | Novartis AG | Benzonapthyridine compositions and uses thereof |
| CA2802721C (en) * | 2010-06-25 | 2015-08-18 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
| US10105305B2 (en) | 2014-02-19 | 2018-10-23 | The Johns Hopkins University | Compositions and methods for promoting skin regeneration and hair growth |
| EP3321362A1 (en) | 2016-11-10 | 2018-05-16 | Centre Leon Berard | Tlr3 agonist for use for inducing apoptosis in senescent cancer cells |
| EP3558350A1 (en) | 2016-12-22 | 2019-10-30 | Intervet International B.V. | Eimeria vaccine with improved efficacy |
| CN112703011A (zh) | 2018-08-06 | 2021-04-23 | 国家医疗保健研究所 | 用于治疗癌症的方法和组合物 |
| WO2020232226A1 (en) | 2019-05-16 | 2020-11-19 | The Johns Hopkins University | Compositions and methods for skin rejuvenation |
| CN117320722A (zh) | 2021-04-28 | 2023-12-29 | 埃尼奥制药公司 | 使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6080726A (en) * | 1985-08-12 | 2000-06-27 | University Of Maryland | Anti-viral and immuno stimulator polynucleotide duplex and use thereof |
| US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
| IE72103B1 (en) * | 1987-08-12 | 1997-03-12 | Hem Res Inc | Promotion of host defense by systemic dsRNA treatment |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| US5976800A (en) * | 1996-06-28 | 1999-11-02 | The Regents Of The University Of California | Enhancement of cancer cell death |
| GB0119346D0 (en) * | 2001-08-08 | 2001-10-03 | Bioclones Proprietary Ltd | Process for the maturation of dendritic cells |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| CA2587676A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
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2008
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- 2008-03-05 CA CA002680134A patent/CA2680134A1/en not_active Abandoned
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- 2008-03-05 US US12/530,148 patent/US20100183638A1/en not_active Abandoned
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- 2008-03-05 KR KR1020097020751A patent/KR20090130019A/ko not_active Ceased
- 2008-03-05 WO PCT/US2008/002874 patent/WO2008109083A2/en not_active Ceased
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2009
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Also Published As
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| EP2134172A2 (en) | 2009-12-23 |
| ZA200905954B (en) | 2011-10-26 |
| EP2134172A4 (en) | 2011-06-01 |
| BRPI0808637A2 (pt) | 2014-08-05 |
| KR20090130019A (ko) | 2009-12-17 |
| US20100183638A1 (en) | 2010-07-22 |
| WO2008109083A2 (en) | 2008-09-12 |
| NZ579433A (en) | 2012-05-25 |
| AU2008223446B2 (en) | 2012-02-02 |
| CN101652062A (zh) | 2010-02-17 |
| JP2010520284A (ja) | 2010-06-10 |
| WO2008109083A3 (en) | 2008-11-27 |
| AU2008223446A1 (en) | 2008-09-12 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20130219 |
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| FZDE | Discontinued |
Effective date: 20151112 |