JP2010520223A

JP2010520223A - 発作関連障害のための組成物および方法

発作関連障害のための組成物および方法 Download PDF

Info

Publication number: JP2010520223A
Authority: JP; Japan
Prior art keywords: substituted; alkyl; compound; hydrogen; group
Prior art date: 2007-03-02
Legal status : Pending

Application number

JP2009551873A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010520223A5 (https=

Inventor

ディー．マーティンワッターソン，

エルディク，リンダジェイ．バン

マークエス．ウェインライト，

Original Assignee

ノースウェスタンユニバーシティ

Priority date

2007-03-02

Filing date

2008-02-29

Publication date

2010-06-10

2008-02-29 Application filed by ノースウェスタンユニバーシティ filed Critical ノースウェスタンユニバーシティ

2010-06-10 Publication of JP2010520223A publication Critical patent/JP2010520223A/ja

2012-03-29 Publication of JP2010520223A5 publication Critical patent/JP2010520223A5/ja

Status Pending legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 91
238000000034 method Methods 0.000 title claims description 60
-1 pyridazine compound Chemical class 0.000 claims abstract description 295
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206010010904 Convulsion Diseases 0.000 claims abstract description 161
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 90
206010015037 epilepsy Diseases 0.000 claims abstract description 37
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
230000036461 convulsion Effects 0.000 claims abstract description 13
208000014526 Conduction disease Diseases 0.000 claims abstract description 7
239000001257 hydrogen Substances 0.000 claims description 183
229910052739 hydrogen Inorganic materials 0.000 claims description 183
125000000217 alkyl group Chemical group 0.000 claims description 151
125000003118 aryl group Chemical group 0.000 claims description 96
125000000623 heterocyclic group Chemical group 0.000 claims description 63
125000003545 alkoxy group Chemical group 0.000 claims description 57
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238000011282 treatment Methods 0.000 claims description 53
125000001072 heteroaryl group Chemical group 0.000 claims description 51
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125000000753 cycloalkyl group Chemical group 0.000 claims description 48
125000004193 piperazinyl group Chemical group 0.000 claims description 43
125000004076 pyridyl group Chemical group 0.000 claims description 42
150000003839 salts Chemical class 0.000 claims description 42
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 40
125000003342 alkenyl group Chemical group 0.000 claims description 38
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 37
125000000304 alkynyl group Chemical group 0.000 claims description 35
125000004093 cyano group Chemical group *C#N 0.000 claims description 35
125000000714 pyrimidinyl group Chemical group 0.000 claims description 30
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 29
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 28
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125000004104 aryloxy group Chemical group 0.000 claims description 20
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CTQJAETYIVEEFX-UHFFFAOYSA-N [N-]=[N+]=NN(N)N=[N+]=[N-] Chemical compound [N-]=[N+]=NN(N)N=[N+]=[N-] CTQJAETYIVEEFX-UHFFFAOYSA-N 0.000 claims description 14
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OSDBJMYIUDLIRI-UHFFFAOYSA-N oxo-[[1-[[4-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]cyclohexyl]oxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COC1CCC(OCN2C=CC(=C[NH+]=O)C=C2)CC1 OSDBJMYIUDLIRI-UHFFFAOYSA-N 0.000 claims description 6
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 22
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LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 21
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