JP2010520181A5 - - Google Patents
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- Publication number
- JP2010520181A5 JP2010520181A5 JP2009551228A JP2009551228A JP2010520181A5 JP 2010520181 A5 JP2010520181 A5 JP 2010520181A5 JP 2009551228 A JP2009551228 A JP 2009551228A JP 2009551228 A JP2009551228 A JP 2009551228A JP 2010520181 A5 JP2010520181 A5 JP 2010520181A5
- Authority
- JP
- Japan
- Prior art keywords
- osteopontin
- diabetes
- disease
- endothelial progenitor
- activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004264 Osteopontin Human genes 0.000 claims description 76
- 108010081689 Osteopontin Proteins 0.000 claims description 76
- 206010012601 diabetes mellitus Diseases 0.000 claims description 40
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 39
- 230000002792 vascular Effects 0.000 claims description 35
- 230000003511 endothelial effect Effects 0.000 claims description 26
- 210000000130 stem cell Anatomy 0.000 claims description 26
- 230000014509 gene expression Effects 0.000 claims description 24
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 206010019280 Heart failures Diseases 0.000 claims description 8
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 8
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 8
- 208000028867 ischemia Diseases 0.000 claims description 8
- 208000010125 myocardial infarction Diseases 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 208000019553 vascular disease Diseases 0.000 claims description 5
- 238000001415 gene therapy Methods 0.000 claims description 4
- 208000029078 coronary artery disease Diseases 0.000 claims description 3
- 108091033319 polynucleotide Proteins 0.000 claims description 3
- 102000040430 polynucleotide Human genes 0.000 claims description 3
- 239000002157 polynucleotide Substances 0.000 claims description 3
- 239000002870 angiogenesis inducing agent Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 10
- 208000013600 Diabetic vascular disease Diseases 0.000 description 1
- 102100040557 Osteopontin Human genes 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000009101 diabetic angiopathy Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20070136 | 2007-03-02 | ||
| IE20070901 | 2007-12-10 | ||
| PCT/EP2008/052578 WO2008107422A1 (en) | 2007-03-02 | 2008-03-03 | Osteopontin for the prediction and treatment of cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520181A JP2010520181A (ja) | 2010-06-10 |
| JP2010520181A5 true JP2010520181A5 (https=) | 2012-04-19 |
Family
ID=39434086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551228A Pending JP2010520181A (ja) | 2007-03-02 | 2008-03-03 | 心血管疾患の予測および治療のためのオステオポンチン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8323968B2 (https=) |
| EP (1) | EP2114422A1 (https=) |
| JP (1) | JP2010520181A (https=) |
| AU (1) | AU2008223817A1 (https=) |
| CA (1) | CA2679545A1 (https=) |
| WO (1) | WO2008107422A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102073629B1 (ko) * | 2005-02-03 | 2020-02-05 | 코다 테라퓨틱스 (엔지) 리미티드 | 항-코넥신 화합물 및 그의 용도 |
| EP2140268A4 (en) * | 2007-04-17 | 2011-05-04 | Pfizer | METHOD FOR CONTROLLING GLUCOSE TREATMENT AND INSULIN SENSITIVITY |
| JP2011507859A (ja) * | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 外科的癒着の治療のための抗コネキシンポリヌクレオチドの使用 |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| CA2711635A1 (en) * | 2008-01-07 | 2009-08-06 | Coda Therapeutics, Inc. | Wound healing compositions and treatments |
| WO2011058182A1 (en) * | 2009-11-13 | 2011-05-19 | National University Of Ireland, Galway | Osteopontin-conditioned medium for the treatment of vascular diseases |
| CN107109410B (zh) | 2014-08-22 | 2021-11-02 | 奥克兰联合服务有限公司 | 通道调节剂 |
| CA3061738A1 (en) | 2017-04-28 | 2018-11-01 | Auckland Uniservices Limited | Methods of treatment and novel constructs |
| DK3618845T3 (da) * | 2017-05-04 | 2021-04-19 | Follicum Ab | Peptider til behandling af diabetes |
| KR20210088583A (ko) * | 2018-11-07 | 2021-07-14 | 폴리쿰 에이비 | 당뇨병 치료를 위한 펩타이드 단편 |
| WO2021024265A1 (en) * | 2019-08-08 | 2021-02-11 | Ramot At Tel-Aviv University Ltd. | Methods of treating non-infectious inflammatory disorders |
| US20230102414A1 (en) * | 2020-03-11 | 2023-03-30 | University Of Florida Research Foundation, Incorporated | Methods, devices, and compositions for lesion repair and prevention |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| WO1999015904A1 (en) * | 1997-09-26 | 1999-04-01 | University Of Washington | Methods and compositions for diagnosing renal pathologies |
| US6414219B1 (en) | 1998-06-30 | 2002-07-02 | Rutgers, The State University Of New Jersey | Osteopontin knock-out mouse and methods of use thereof |
| US6551990B2 (en) * | 1998-12-07 | 2003-04-22 | University Of Washington | Methods of inhibiting ectopic calcification |
| CA2412436C (en) * | 2000-06-05 | 2013-05-21 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
| AU2002357748A1 (en) | 2001-11-21 | 2003-06-10 | The Board Of Trustees Of The Leland Stanford Junior University | Osteopontin-related compositions and methods |
| JP2006217801A (ja) * | 2003-01-15 | 2006-08-24 | Kirin Brewery Co Ltd | ＴＧＦβ阻害活性を有する化合物の新規用途 |
| JP2004222836A (ja) | 2003-01-21 | 2004-08-12 | Tissue Engineering Initiative Co Ltd | 培養真皮シートの製造方法および培養真皮シート |
| ATE481477T1 (de) * | 2004-03-09 | 2010-10-15 | Absorber Ab | Endothelvorläuferzellen und verfahren zur verwendung davon |
| US8563511B2 (en) * | 2004-10-06 | 2013-10-22 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| WO2006060779A2 (en) | 2004-12-03 | 2006-06-08 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| US20100150885A1 (en) | 2005-06-01 | 2010-06-17 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
| FR2889200B1 (fr) * | 2005-07-27 | 2008-01-04 | Inst Vaisseaux Et Du Sang Ass | Systeme marqueur cellulaire/ligand, ou le marqueur est du type eph, materiau cellulaire comprenant ce systeme, procede de preparation et utilisation proangiogenique |
| WO2007024649A2 (en) | 2005-08-19 | 2007-03-01 | X-Cell Medical Incorporated | Methods of treating and preventing acute myocardial infarction |
-
2008
- 2008-03-03 AU AU2008223817A patent/AU2008223817A1/en not_active Abandoned
- 2008-03-03 WO PCT/EP2008/052578 patent/WO2008107422A1/en not_active Ceased
- 2008-03-03 CA CA002679545A patent/CA2679545A1/en not_active Abandoned
- 2008-03-03 EP EP08717341A patent/EP2114422A1/en not_active Withdrawn
- 2008-03-03 US US12/528,610 patent/US8323968B2/en not_active Expired - Fee Related
- 2008-03-03 JP JP2009551228A patent/JP2010520181A/ja active Pending
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