JP2010518810A5 - - Google Patents
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- JP2010518810A5 JP2010518810A5 JP2009547686A JP2009547686A JP2010518810A5 JP 2010518810 A5 JP2010518810 A5 JP 2010518810A5 JP 2009547686 A JP2009547686 A JP 2009547686A JP 2009547686 A JP2009547686 A JP 2009547686A JP 2010518810 A5 JP2010518810 A5 JP 2010518810A5
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- Prior art keywords
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- treg cells
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- 210000003289 regulatory T cell Anatomy 0.000 claims description 47
- 239000000126 substance Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 13
- 239000012190 activator Substances 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 5
- 230000004913 activation Effects 0.000 claims description 3
- 230000002452 interceptive effect Effects 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000001363 autoimmune Effects 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- 201000011152 Pemphigus Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000026872 Addison Disease Diseases 0.000 claims 2
- 206010001889 Alveolitis Diseases 0.000 claims 2
- 208000004300 Atrophic Gastritis Diseases 0.000 claims 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 2
- 206010016946 Food allergy Diseases 0.000 claims 2
- 208000007882 Gastritis Diseases 0.000 claims 2
- 208000036495 Gastritis atrophic Diseases 0.000 claims 2
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 2
- 201000009053 Neurodermatitis Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 208000010265 Sweet syndrome Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 201000009961 allergic asthma Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000028004 allergic respiratory disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 2
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims 2
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 2
- 235000020932 food allergy Nutrition 0.000 claims 2
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 201000002364 leukopenia Diseases 0.000 claims 2
- 231100001022 leukopenia Toxicity 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 201000004335 respiratory allergy Diseases 0.000 claims 2
- 201000003068 rheumatic fever Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010043778 thyroiditis Diseases 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 206010039580 Scar Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07101604 | 2007-02-01 | ||
| EP07101604.2 | 2007-02-01 | ||
| EP07122424.0 | 2007-12-05 | ||
| EP07122424 | 2007-12-05 | ||
| PCT/EP2008/051144 WO2008092905A2 (en) | 2007-02-01 | 2008-01-30 | Specific activation of a regulatory t cell and its use for treatment of asthma, allergic disease, autoimmune disease, graft rejection and for tolerance induction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097086A Division JP6038070B2 (ja) | 2007-02-01 | 2014-05-08 | 調節性ｔ細胞の特異的活性化ならびに喘息、アレルギー疾患、自己免疫疾患、移植片拒絶の治療および免疫寛容の誘導のためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518810A JP2010518810A (ja) | 2010-06-03 |
| JP2010518810A5 true JP2010518810A5 (https=) | 2013-10-24 |
| JP5867795B2 JP5867795B2 (ja) | 2016-02-24 |
Family
ID=39363828
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547686A Expired - Fee Related JP5867795B2 (ja) | 2007-02-01 | 2008-01-30 | 調節性ｔ細胞の特異的活性化ならびに喘息、アレルギー疾患、自己免疫疾患、移植片拒絶の治療および免疫寛容の誘導のためのその使用 |
| JP2014097086A Active JP6038070B2 (ja) | 2007-02-01 | 2014-05-08 | 調節性ｔ細胞の特異的活性化ならびに喘息、アレルギー疾患、自己免疫疾患、移植片拒絶の治療および免疫寛容の誘導のためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097086A Active JP6038070B2 (ja) | 2007-02-01 | 2014-05-08 | 調節性ｔ細胞の特異的活性化ならびに喘息、アレルギー疾患、自己免疫疾患、移植片拒絶の治療および免疫寛容の誘導のためのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8557533B2 (https=) |
| EP (2) | EP3112866B1 (https=) |
| JP (2) | JP5867795B2 (https=) |
| CA (1) | CA2676170C (https=) |
| ES (2) | ES2593789T3 (https=) |
| WO (1) | WO2008092905A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007127787A2 (en) | 2006-04-25 | 2007-11-08 | Joslin Diabetes Center, Inc. | Insulin autoantigen-specific regulatory cd4+ t cells |
| ES2593789T3 (es) * | 2007-02-01 | 2016-12-13 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
| BRPI0909048A2 (pt) | 2008-03-13 | 2015-11-24 | Biotest Ag | composição farmacêutica, e, método de tratamento de uma doença autoimune |
| ES2610327T3 (es) | 2008-03-13 | 2017-04-27 | Biotest Ag | Régimen de dosificación de anticuerpos anti-CD4 para el tratamiento de enfermedades autoinmunitarias |
| HUE028962T2 (en) | 2008-03-13 | 2017-01-30 | Biotest Ag | Active ingredient for treating disease |
| EP2318020B1 (en) * | 2008-06-30 | 2015-08-19 | Universitätsklinikum Heidelberg | Immunosuppressive blood cells and methods of producing same |
| GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
| EP2471543A1 (en) | 2010-12-02 | 2012-07-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules |
| WO2012135842A2 (en) * | 2011-03-31 | 2012-10-04 | President And Fellows Of Harvard College | A unique population of regulatory t cells that regulate tissue regeneration and wound healing |
| EP3063271A4 (en) * | 2013-10-31 | 2017-05-03 | Sloan-Kettering Institute for Cancer Research | Methods and compositions for inducing regulatory t-cell generation |
| WO2019099788A1 (en) * | 2017-11-16 | 2019-05-23 | Benaroya Sesearch Institute At Virginia Mason | Antigen-specific t regulatory cell assay |
| GB202401501D0 (en) | 2024-02-05 | 2024-03-20 | T Balance Therapeutics Gmbh | Medical use of regulatory t cell activator |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695459A (en) * | 1984-12-26 | 1987-09-22 | The Board Of Trustees Of Leland Stanford Junior University | Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells |
| IE872748L (en) * | 1986-10-16 | 1988-04-16 | Arjomari Europ | Polypeptides derived from the evvelope gene of human¹immunodeficiency virus in recombinant baculovirus infected¹insect cells |
| JPH0768273B2 (ja) | 1988-12-02 | 1995-07-26 | カルピス食品工業株式会社 | 抗ｈｉｖペプチド |
| AU6523590A (en) * | 1989-09-22 | 1991-04-18 | Idec Pharmaceuticals Corporation | Novel peptides associated with the cd4 binding region of gp120 and their methods of use |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| CN1165147A (zh) | 1996-02-07 | 1997-11-19 | 武田药品工业株式会社 | 鸟嘌呤核苷酸结合蛋白偶联受体蛋白质，其生产和应用 |
| US6585979B1 (en) * | 1996-07-08 | 2003-07-01 | Genentech, Inc. | HIV envelope polypeptides and immunogenic composition |
| US6455497B1 (en) * | 1998-03-25 | 2002-09-24 | Mayo Foundation For Medical Education And Research | Methods and materials for treating inflammatory diseases |
| US7608273B2 (en) * | 1998-08-12 | 2009-10-27 | University Of Western Ontario | Recombinant lentivirus encoding modified GP 120 signal sequences |
| US6337181B1 (en) * | 1998-12-21 | 2002-01-08 | Jeffrey Joseph Stewart | Method of specifying vaccine components for viral quasispecies |
| AU2487300A (en) * | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| SE9904660D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Inc | Novel assays |
| EP1241249A1 (en) | 2001-03-12 | 2002-09-18 | Gerold Schuler | CD4+CD25+regulatory T cells from human blood |
| WO2003065044A2 (en) | 2002-02-01 | 2003-08-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with gpr72 |
| JP2006517227A (ja) * | 2003-01-30 | 2006-07-20 | ザ・ジェネラル・ホスピタル・コーポレイション | 免疫細胞活性を調節する組成物およびその検出方法 |
| EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| US20050048587A1 (en) * | 2003-07-17 | 2005-03-03 | Tolerrx, Inc. | Methods for identifying tolerance modulatory compounds and uses therefor |
| US8206720B2 (en) * | 2004-06-08 | 2012-06-26 | Novartis Vaccines & Diagnostics, Inc | Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes |
| WO2007035551A1 (en) | 2005-09-19 | 2007-03-29 | Eisai R & D Management Co., Ltd. | Methods for identifying gpr83 agonists and antagonists capable of modulating regulatory t cell function |
| ES2593789T3 (es) | 2007-02-01 | 2016-12-13 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
-
2008
- 2008-01-30 ES ES08708459.6T patent/ES2593789T3/es active Active
- 2008-01-30 US US12/525,142 patent/US8557533B2/en not_active Expired - Fee Related
- 2008-01-30 CA CA2676170A patent/CA2676170C/en active Active
- 2008-01-30 JP JP2009547686A patent/JP5867795B2/ja not_active Expired - Fee Related
- 2008-01-30 EP EP16166807.4A patent/EP3112866B1/en active Active
- 2008-01-30 ES ES16166807T patent/ES2825718T3/es active Active
- 2008-01-30 WO PCT/EP2008/051144 patent/WO2008092905A2/en not_active Ceased
- 2008-01-30 EP EP08708459.6A patent/EP2109770B1/en not_active Not-in-force
-
2013
- 2013-09-19 US US14/031,919 patent/US20140093509A1/en not_active Abandoned
-
2014
- 2014-05-08 JP JP2014097086A patent/JP6038070B2/ja active Active
-
2016
- 2016-10-05 US US15/285,561 patent/US10729742B2/en active Active
-
2020
- 2020-06-25 US US16/912,199 patent/US20200316167A1/en not_active Abandoned
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