ES2825718T3 - Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia - Google Patents

Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia Download PDF

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Publication number
ES2825718T3
ES2825718T3 ES16166807T ES16166807T ES2825718T3 ES 2825718 T3 ES2825718 T3 ES 2825718T3 ES 16166807 T ES16166807 T ES 16166807T ES 16166807 T ES16166807 T ES 16166807T ES 2825718 T3 ES2825718 T3 ES 2825718T3
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seq
cell
cells
treg
substance
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Spanish (es)
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Franz-Josef Schneider
Christian Becker
Tobias Bopp
Helmut Jonuleit
Edgar Schmitt
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Johannes Gutenberg Universitaet Mainz
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
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Johannes Gutenberg Universitaet Mainz
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
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ES16166807T 2007-02-01 2008-01-30 Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia Active ES2825718T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101604 2007-02-01
EP07122424 2007-12-05

Publications (1)

Publication Number Publication Date
ES2825718T3 true ES2825718T3 (es) 2021-05-17

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ES16166807T Active ES2825718T3 (es) 2007-02-01 2008-01-30 Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia
ES08708459.6T Active ES2593789T3 (es) 2007-02-01 2008-01-30 Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia

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US (4) US8557533B2 (https=)
EP (2) EP3112866B1 (https=)
JP (2) JP5867795B2 (https=)
CA (1) CA2676170C (https=)
ES (2) ES2825718T3 (https=)
WO (1) WO2008092905A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007127787A2 (en) 2006-04-25 2007-11-08 Joslin Diabetes Center, Inc. Insulin autoantigen-specific regulatory cd4+ t cells
WO2008092905A2 (en) * 2007-02-01 2008-08-07 Boehringer Ingelheim International Gmbh Specific activation of a regulatory t cell and its use for treatment of asthma, allergic disease, autoimmune disease, graft rejection and for tolerance induction
EP2260057B1 (en) 2008-03-13 2016-11-23 Biotest AG Anti-CD4 antibody dosage regimen for treating autoimmune disease
EP2265643B1 (en) 2008-03-13 2016-10-19 Biotest AG Dosing regimen for treating psoriasis and rheumatoid arthritis
RU2540013C2 (ru) 2008-03-13 2015-01-27 Биотест Аг Средство для лечения заболевания
DK2318020T3 (en) * 2008-06-30 2015-11-30 Universitätsklinikum Heidelberg Immunosuppressive blood cells and methods of producing same
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
EP2471543A1 (en) * 2010-12-02 2012-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules
EP2691515A2 (en) * 2011-03-31 2014-02-05 President and Fellows of Harvard College A unique population of regulatory t cells that regulate tissue regeneration and wound healing
US20160271086A1 (en) * 2013-10-31 2016-09-22 Sloan-Kettering Institute For Cancer Research Methods and compositions for inducing regulatory t-cell generation
WO2019099788A1 (en) * 2017-11-16 2019-05-23 Benaroya Sesearch Institute At Virginia Mason Antigen-specific t regulatory cell assay
GB202401501D0 (en) 2024-02-05 2024-03-20 T Balance Therapeutics Gmbh Medical use of regulatory t cell activator

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695459A (en) * 1984-12-26 1987-09-22 The Board Of Trustees Of Leland Stanford Junior University Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells
IE872748L (en) * 1986-10-16 1988-04-16 Arjomari Europ Polypeptides derived from the evvelope gene of human¹immunodeficiency virus in recombinant baculovirus infected¹insect cells
JPH0768273B2 (ja) * 1988-12-02 1995-07-26 カルピス食品工業株式会社 抗hivペプチド
AU6523590A (en) * 1989-09-22 1991-04-18 Idec Pharmaceuticals Corporation Novel peptides associated with the cd4 binding region of gp120 and their methods of use
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP0789076A3 (en) 1996-02-07 1999-04-14 Takeda Chemical Industries, Ltd. G protein coupled receptor proteins, their production and use
US6585979B1 (en) * 1996-07-08 2003-07-01 Genentech, Inc. HIV envelope polypeptides and immunogenic composition
EP1066047A4 (en) * 1998-03-25 2004-10-13 Mayo Foundation For Medicaledu METHOD AND SUBSTANCES FOR TREATING FLAMMABLE DISEASES
US7608273B2 (en) * 1998-08-12 2009-10-27 University Of Western Ontario Recombinant lentivirus encoding modified GP 120 signal sequences
US6337181B1 (en) * 1998-12-21 2002-01-08 Jeffrey Joseph Stewart Method of specifying vaccine components for viral quasispecies
AU2487300A (en) * 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
SE9904660D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Inc Novel assays
EP1241249A1 (en) 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
WO2003065044A2 (en) 2002-02-01 2003-08-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with gpr72
WO2004072296A2 (en) * 2003-01-30 2004-08-26 The General Hospital Corporation Compositions for modulating immune cell activity and methods for detection thereof
EP1460088A1 (en) * 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
US20050048587A1 (en) * 2003-07-17 2005-03-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
WO2006085959A2 (en) * 2004-06-08 2006-08-17 Novartis Vaccines And Diagnostics Inc. Fusion proteins comprising cd4 minimal modules and methods of use thereof
JP2009509142A (ja) * 2005-09-19 2009-03-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 調節性T細胞機能をモジュレート(modulate)し得るGPR83アゴニストおよびGPR83アンタゴニストを同定するための方法
WO2008092905A2 (en) 2007-02-01 2008-08-07 Boehringer Ingelheim International Gmbh Specific activation of a regulatory t cell and its use for treatment of asthma, allergic disease, autoimmune disease, graft rejection and for tolerance induction

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