JP2010517759A5 - - Google Patents
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- Publication number
- JP2010517759A5 JP2010517759A5 JP2009549040A JP2009549040A JP2010517759A5 JP 2010517759 A5 JP2010517759 A5 JP 2010517759A5 JP 2009549040 A JP2009549040 A JP 2009549040A JP 2009549040 A JP2009549040 A JP 2009549040A JP 2010517759 A5 JP2010517759 A5 JP 2010517759A5
- Authority
- JP
- Japan
- Prior art keywords
- substantially water
- inhibitor
- insoluble substance
- dispersion
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 10
- 239000006185 dispersion Substances 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 239000012736 aqueous medium Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000002198 insoluble material Substances 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88895407P | 2007-02-09 | 2007-02-09 | |
| PCT/SE2008/000107 WO2008097165A1 (en) | 2007-02-09 | 2008-02-08 | Process for preparation of a stable dispersion of solid amorphous submicron particles in an aqueous medium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010517759A JP2010517759A (ja) | 2010-05-27 |
| JP2010517759A5 true JP2010517759A5 (https=) | 2011-03-24 |
Family
ID=39681953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549040A Pending JP2010517759A (ja) | 2007-02-09 | 2008-02-08 | 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100068287A1 (https=) |
| EP (1) | EP2109443A4 (https=) |
| JP (1) | JP2010517759A (https=) |
| CN (1) | CN101605533B (https=) |
| WO (1) | WO2008097165A1 (https=) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
| US5110717A (en) * | 1990-12-17 | 1992-05-05 | Eastman Kodak Company | Stability improvement of amorphous particle dispersions |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| DE4327063A1 (de) * | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
| DE4329446A1 (de) * | 1993-09-01 | 1995-03-02 | Basf Ag | Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen |
| GB9319129D0 (en) * | 1993-09-15 | 1993-11-03 | Dowelanco Ltd | Storage and dilution of stable aqueous dispersions |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| AU5860798A (en) * | 1997-12-29 | 1999-07-19 | Universite De Geneve | Method for producing an aqueous colloidal dispersion of nanoparticles |
| US6375986B1 (en) * | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| US6267989B1 (en) * | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
| WO2001002087A1 (en) * | 1999-07-06 | 2001-01-11 | Universite De Geneve Laboratoire De Pharmacie Galenique | Method for producing aqueous colloidal dispersions of nanoparticles |
| CA2407027C (en) * | 2000-04-20 | 2011-02-15 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
| CN1254233C (zh) * | 2001-08-06 | 2006-05-03 | 阿斯特拉曾尼卡有限公司 | 含有水不溶性的稳定纳米颗粒和赋形剂如中链甘油三酯(mct)的水性分散体 |
| CA2470533A1 (en) * | 2002-01-14 | 2003-07-24 | Dow Global Technologies Inc. | Drug nanoparticles from template emulsions |
| ATE395044T1 (de) * | 2002-02-01 | 2008-05-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| WO2004006959A1 (en) * | 2002-07-16 | 2004-01-22 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
| GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| US7390505B2 (en) * | 2003-01-31 | 2008-06-24 | Elan Pharma International, Ltd. | Nanoparticulate topiramate formulations |
| US20060198856A1 (en) * | 2005-03-01 | 2006-09-07 | Keith Whitehead | Ibuprofen suspension stabilized with docusate sodium |
| US20080193534A1 (en) * | 2005-08-12 | 2008-08-14 | Astrazeneca Ab | Process |
| WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
-
2008
- 2008-02-08 WO PCT/SE2008/000107 patent/WO2008097165A1/en not_active Ceased
- 2008-02-08 JP JP2009549040A patent/JP2010517759A/ja active Pending
- 2008-02-08 US US12/524,882 patent/US20100068287A1/en not_active Abandoned
- 2008-02-08 EP EP08712705A patent/EP2109443A4/en not_active Withdrawn
- 2008-02-08 CN CN2008800044661A patent/CN101605533B/zh not_active Expired - Fee Related
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