CN101605533B - 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法 - Google Patents

制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法 Download PDF

Info

Publication number
CN101605533B
CN101605533B CN2008800044661A CN200880004466A CN101605533B CN 101605533 B CN101605533 B CN 101605533B CN 2008800044661 A CN2008800044661 A CN 2008800044661A CN 200880004466 A CN200880004466 A CN 200880004466A CN 101605533 B CN101605533 B CN 101605533B
Authority
CN
China
Prior art keywords
particles
inhibitor
water
substantially water
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800044661A
Other languages
English (en)
Chinese (zh)
Other versions
CN101605533A (zh
Inventor
L·林德福斯
U·斯坎特泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101605533A publication Critical patent/CN101605533A/zh
Application granted granted Critical
Publication of CN101605533B publication Critical patent/CN101605533B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
CN2008800044661A 2007-02-09 2008-02-08 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法 Expired - Fee Related CN101605533B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88895407P 2007-02-09 2007-02-09
US60/888,954 2007-02-09
PCT/SE2008/000107 WO2008097165A1 (en) 2007-02-09 2008-02-08 Process for preparation of a stable dispersion of solid amorphous submicron particles in an aqueous medium

Publications (2)

Publication Number Publication Date
CN101605533A CN101605533A (zh) 2009-12-16
CN101605533B true CN101605533B (zh) 2012-04-18

Family

ID=39681953

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800044661A Expired - Fee Related CN101605533B (zh) 2007-02-09 2008-02-08 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法

Country Status (5)

Country Link
US (1) US20100068287A1 (https=)
EP (1) EP2109443A4 (https=)
JP (1) JP2010517759A (https=)
CN (1) CN101605533B (https=)
WO (1) WO2008097165A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267989B1 (en) * 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
CN1564677A (zh) * 2001-08-06 2005-01-12 阿斯特拉曾尼卡有限公司 含有水不溶性的稳定纳米颗粒和赋形剂如中链甘油三酯(mct)的水性分散体
CN1668280A (zh) * 2002-07-18 2005-09-14 阿斯特拉曾尼卡有限公司 制备结晶纳米颗粒分散体的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
US5110717A (en) * 1990-12-17 1992-05-05 Eastman Kodak Company Stability improvement of amorphous particle dispersions
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
DE4329446A1 (de) * 1993-09-01 1995-03-02 Basf Ag Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen
GB9319129D0 (en) * 1993-09-15 1993-11-03 Dowelanco Ltd Storage and dilution of stable aqueous dispersions
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
AU5860798A (en) * 1997-12-29 1999-07-19 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
US6375986B1 (en) * 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
WO2001002087A1 (en) * 1999-07-06 2001-01-11 Universite De Geneve Laboratoire De Pharmacie Galenique Method for producing aqueous colloidal dispersions of nanoparticles
CA2407027C (en) * 2000-04-20 2011-02-15 Rtp Pharma Inc. Improved water-insoluble drug particle process
CA2470533A1 (en) * 2002-01-14 2003-07-24 Dow Global Technologies Inc. Drug nanoparticles from template emulsions
ATE395044T1 (de) * 2002-02-01 2008-05-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
US7390505B2 (en) * 2003-01-31 2008-06-24 Elan Pharma International, Ltd. Nanoparticulate topiramate formulations
US20060198856A1 (en) * 2005-03-01 2006-09-07 Keith Whitehead Ibuprofen suspension stabilized with docusate sodium
US20080193534A1 (en) * 2005-08-12 2008-08-14 Astrazeneca Ab Process
WO2008135855A2 (en) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267989B1 (en) * 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
CN1564677A (zh) * 2001-08-06 2005-01-12 阿斯特拉曾尼卡有限公司 含有水不溶性的稳定纳米颗粒和赋形剂如中链甘油三酯(mct)的水性分散体
CN1668280A (zh) * 2002-07-18 2005-09-14 阿斯特拉曾尼卡有限公司 制备结晶纳米颗粒分散体的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lennart Lindfors et al.Amorphous Drug Nanosuspensions. 2. Experimental Determination of Bulk Monomer Concentrations.《langmuir》.2006,第22卷(第3期),911-916. *

Also Published As

Publication number Publication date
EP2109443A4 (en) 2012-08-22
JP2010517759A (ja) 2010-05-27
US20100068287A1 (en) 2010-03-18
CN101605533A (zh) 2009-12-16
WO2008097165A1 (en) 2008-08-14
EP2109443A1 (en) 2009-10-21

Similar Documents

Publication Publication Date Title
JP4714412B2 (ja) 水不溶性の活性でかつ賦形剤様の中鎖トリグリセリド（ｍｃｔ）の安定なナノ粒子を含む水性分散液
AU2002317409A1 (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT)
Scholz et al. Nanocrystals: from raw material to the final formulated oral dosage form-a review
JP7716600B2 (ja) 医薬品有効成分の結晶化のための方法
EP1658052B1 (en) Particle size reduction of bioactive compounds
EP3613415B1 (en) Method for preparing active material nanoparticles using lipid as lubricant for milling
JP2005515224A (ja) テンプレート乳剤からの薬剤ナノ粒子
CN101605533B (zh) 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法
US20080193534A1 (en) Process
ZA200400847B (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like Middle Chain Triglycerides (MCT).
HK1064048B (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)
VERMA et al. Indian Journal of Novel Drug Delivery An Official Publication of
Rao et al. Evaporative nanocrystallization for enhanced solubility and bioavailability of sulfasalazine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120418

Termination date: 20160208