JP2010514834A5 - - Google Patents
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- Publication number
- JP2010514834A5 JP2010514834A5 JP2009544475A JP2009544475A JP2010514834A5 JP 2010514834 A5 JP2010514834 A5 JP 2010514834A5 JP 2009544475 A JP2009544475 A JP 2009544475A JP 2009544475 A JP2009544475 A JP 2009544475A JP 2010514834 A5 JP2010514834 A5 JP 2010514834A5
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- cyclosporin
- formula
- immunosuppressive
- immunosuppressive cyclosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 20
- 230000001506 immunosuppresive effect Effects 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- OLROWHGDTNFZBH-XEMWPYQTSA-N Alisporivir Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(CC)C(=O)[C@@H](C)N(C)C1=O OLROWHGDTNFZBH-XEMWPYQTSA-N 0.000 claims 4
- 108010036949 Cyclosporine Proteins 0.000 claims 4
- 102100022745 Laminin subunit alpha-2 Human genes 0.000 claims 4
- 229960001265 ciclosporin Drugs 0.000 claims 4
- 201000006815 congenital muscular dystrophy Diseases 0.000 claims 4
- 229930182912 cyclosporin Natural products 0.000 claims 4
- 229930105110 Cyclosporin A Natural products 0.000 claims 3
- 208000021642 Muscular disease Diseases 0.000 claims 3
- 201000009623 Myopathy Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000006304 Bethlem myopathy Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004065 mitochondrial dysfunction Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87841407P | 2007-01-04 | 2007-01-04 | |
| US60/878,414 | 2007-01-04 | ||
| PCT/IB2008/000003 WO2008084368A2 (en) | 2007-01-04 | 2008-01-03 | Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514834A JP2010514834A (ja) | 2010-05-06 |
| JP2010514834A5 true JP2010514834A5 (OSRAM) | 2011-02-17 |
| JP5801534B2 JP5801534B2 (ja) | 2015-10-28 |
Family
ID=39514754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544475A Expired - Fee Related JP5801534B2 (ja) | 2007-01-04 | 2008-01-03 | ウールリッヒ型先天筋ジストロフィーの処置のための、非免疫抑制性シクロスポリン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8450281B2 (OSRAM) |
| EP (1) | EP2124992A2 (OSRAM) |
| JP (1) | JP5801534B2 (OSRAM) |
| CN (2) | CN105056207A (OSRAM) |
| AU (1) | AU2008204344B2 (OSRAM) |
| BR (1) | BRPI0806265A2 (OSRAM) |
| CA (1) | CA2674296C (OSRAM) |
| HK (1) | HK1210951A1 (OSRAM) |
| IL (1) | IL199674A (OSRAM) |
| MX (1) | MX2009007045A (OSRAM) |
| RU (1) | RU2462262C2 (OSRAM) |
| WO (1) | WO2008084368A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009098533A1 (en) * | 2008-02-08 | 2009-08-13 | Debiopharm Sa | Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy |
| BR112012019866A8 (pt) | 2010-02-09 | 2017-12-26 | Biotica Tech Limited | Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto |
| WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| GB201008123D0 (en) | 2010-05-17 | 2010-06-30 | Biotica Tech Ltd | Novel compounds |
| EP2654753B1 (en) | 2010-12-20 | 2018-10-31 | Neurovive Pharmaceutical AB | Sanglifehrin derivatives and methods for their production |
| JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
| WO2013169616A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmacokinetic modulation with alisporivir |
| AR090964A1 (es) | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3884470T2 (de) * | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
| KR0148748B1 (ko) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| EP1071414A1 (en) * | 1998-04-24 | 2001-01-31 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
| AU759480B2 (en) * | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
| US6323039B1 (en) * | 1999-06-22 | 2001-11-27 | Mitokor | Compositions and methods for assaying subcellular conditions and processes using energy transfer |
| US7368423B1 (en) | 2001-12-05 | 2008-05-06 | The Scripps Research Institute | Composition and method for treating chronic allograft rejection |
| GB0320638D0 (en) * | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2009098533A1 (en) * | 2008-02-08 | 2009-08-13 | Debiopharm Sa | Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy |
-
2008
- 2008-01-03 EP EP08702176A patent/EP2124992A2/en not_active Withdrawn
- 2008-01-03 US US12/522,118 patent/US8450281B2/en not_active Expired - Fee Related
- 2008-01-03 CN CN201510378165.7A patent/CN105056207A/zh active Pending
- 2008-01-03 BR BRPI0806265-0A patent/BRPI0806265A2/pt not_active Application Discontinuation
- 2008-01-03 AU AU2008204344A patent/AU2008204344B2/en not_active Ceased
- 2008-01-03 CN CN200880001665A patent/CN101616683A/zh active Pending
- 2008-01-03 CA CA2674296A patent/CA2674296C/en not_active Expired - Fee Related
- 2008-01-03 RU RU2009129212/15A patent/RU2462262C2/ru not_active IP Right Cessation
- 2008-01-03 MX MX2009007045A patent/MX2009007045A/es active IP Right Grant
- 2008-01-03 WO PCT/IB2008/000003 patent/WO2008084368A2/en not_active Ceased
- 2008-01-03 JP JP2009544475A patent/JP5801534B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-02 IL IL199674A patent/IL199674A/en active IP Right Grant
-
2010
- 2010-05-20 HK HK15111764.4A patent/HK1210951A1/xx unknown
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