JP2010514409A - ヒトの癌における鑑別式サイトカイン発現 - Google Patents
ヒトの癌における鑑別式サイトカイン発現 Download PDFInfo
- Publication number
- JP2010514409A JP2010514409A JP2009515770A JP2009515770A JP2010514409A JP 2010514409 A JP2010514409 A JP 2010514409A JP 2009515770 A JP2009515770 A JP 2009515770A JP 2009515770 A JP2009515770 A JP 2009515770A JP 2010514409 A JP2010514409 A JP 2010514409A
- Authority
- JP
- Japan
- Prior art keywords
- cytokine
- tumor
- agent
- apoptotic
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06012754 | 2006-06-21 | ||
| PCT/EP2007/005480 WO2007147600A2 (en) | 2006-06-21 | 2007-06-21 | Differential il-4 and/or il-10 cytokine expression in human cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010514409A true JP2010514409A (ja) | 2010-05-06 |
| JP2010514409A5 JP2010514409A5 (https=) | 2010-06-17 |
Family
ID=38359749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515770A Pending JP2010514409A (ja) | 2006-06-21 | 2007-06-21 | ヒトの癌における鑑別式サイトカイン発現 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090324616A1 (https=) |
| EP (1) | EP2041576B1 (https=) |
| JP (1) | JP2010514409A (https=) |
| CN (1) | CN101529253A (https=) |
| AT (1) | ATE520032T1 (https=) |
| AU (1) | AU2007263265A1 (https=) |
| BR (1) | BRPI0713484A2 (https=) |
| CA (1) | CA2656379A1 (https=) |
| DK (1) | DK2041576T3 (https=) |
| ES (1) | ES2371287T3 (https=) |
| RU (1) | RU2009101783A (https=) |
| WO (1) | WO2007147600A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020513574A (ja) * | 2016-11-24 | 2020-05-14 | ヒュベット バイオ, インコーポレイテッドHuvet Bio, Inc. | 疾患の診断用組成物 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2646626A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treatment of cancer |
| US20100086515A1 (en) * | 2006-07-06 | 2010-04-08 | Apogenix Gmbh | Human il-4 muteins in cancer therapy |
| EP3409686B1 (en) * | 2012-07-18 | 2022-04-13 | Apogenix AG | Composition comprising a mixture of cd95-fc isoforms |
| WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
| AU2015335607B2 (en) * | 2014-10-24 | 2020-04-23 | Calidi Biotherapeutics (Nevada), Inc. | Combination immunotherapy approach for treatment of cancer |
| CN108135996B (zh) | 2015-08-11 | 2022-06-21 | 卡利迪生物治疗有限公司 | 用以癌症治疗的天花疫苗 |
| US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| EA201892260A1 (ru) | 2016-04-07 | 2019-03-29 | Дзе Джонс Хопкинс Юниверсити | Композиции и способы для лечения панкреатита и боли с применением агонистов рецептора смерти |
| CN111051349A (zh) * | 2017-09-06 | 2020-04-21 | 弗雷德哈钦森癌症研究中心 | Strep-tag特异性嵌合受体及其用途 |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643427B2 (en) * | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| DE4137333A1 (de) * | 1991-11-13 | 1993-05-19 | W Prof Dr Sebald | Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung |
| US6534051B1 (en) * | 1992-11-20 | 2003-03-18 | University Of Medicine And Dentistry Of New Jersey | Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins |
| WO1995007301A1 (en) | 1993-09-07 | 1995-03-16 | Smithkline Beecham Corporation | Recombinant il4 antibodies useful in treatment of il4 mediated disorders |
| DE4423131A1 (de) * | 1994-07-01 | 1996-01-04 | Bayer Ag | Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4 |
| AU686816B2 (en) * | 1994-07-05 | 1998-02-12 | Steeno Research Group A/S | Immunomodulators |
| HUT76369A (en) * | 1994-07-29 | 1997-08-28 | Smithkline Beecham Corp | Novel soluble protein compounds |
| US6664227B1 (en) * | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| US5710023A (en) * | 1996-03-01 | 1998-01-20 | Genetics Institute, Inc. | IL-13 cytokine receptor chain |
| US20030124125A1 (en) * | 1996-04-05 | 2003-07-03 | South Alabama Medical Science Foundation | Oncofetal antigen specific T-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 |
| US6028176A (en) * | 1996-07-19 | 2000-02-22 | Bayer Corporation | High-affinity interleukin-4 muteins |
| CA2309598A1 (en) * | 1997-11-10 | 1999-05-20 | Mochida Pharmaceutical Co., Ltd. | Preventives and remedies for diffuse lung disease |
| JPH11312463A (ja) * | 1998-04-28 | 1999-11-09 | Hitachi Ltd | 配線基板およびそれを用いたガス放電型表示装置 |
| WO2001074388A1 (en) * | 2000-03-31 | 2001-10-11 | Idec Pharmaceuticals Corporation | Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma |
| AU2001273413A1 (en) * | 2000-07-12 | 2002-01-21 | Immunex Corporation | Method for treating cancer using an interleukin- 4 antagonist |
| US20040023338A1 (en) * | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-4 mutein proteins, antibodies, compositions, methods and uses |
| CA2464695A1 (en) * | 2001-10-26 | 2003-05-01 | Centocor, Inc. | Il-13 mutein proteins, antibodies, compositions, methods and uses |
| EP1444989A1 (en) * | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| EP1824886B1 (en) * | 2004-11-17 | 2010-12-22 | Amgen Inc. | Fully human monoclonal antibodies to il-13 |
| US20070122855A1 (en) * | 2005-11-28 | 2007-05-31 | Targetgen Inc. | Methods for diagnosing hepatocellular carcinoma |
| CA2646626A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treatment of cancer |
| US20100086515A1 (en) * | 2006-07-06 | 2010-04-08 | Apogenix Gmbh | Human il-4 muteins in cancer therapy |
-
2007
- 2007-06-21 WO PCT/EP2007/005480 patent/WO2007147600A2/en not_active Ceased
- 2007-06-21 CA CA002656379A patent/CA2656379A1/en not_active Abandoned
- 2007-06-21 CN CNA2007800295788A patent/CN101529253A/zh active Pending
- 2007-06-21 JP JP2009515770A patent/JP2010514409A/ja active Pending
- 2007-06-21 ES ES07764767T patent/ES2371287T3/es active Active
- 2007-06-21 AT AT07764767T patent/ATE520032T1/de not_active IP Right Cessation
- 2007-06-21 US US12/306,070 patent/US20090324616A1/en not_active Abandoned
- 2007-06-21 EP EP07764767A patent/EP2041576B1/en active Active
- 2007-06-21 DK DK07764767.5T patent/DK2041576T3/da active
- 2007-06-21 BR BRPI0713484-3A patent/BRPI0713484A2/pt not_active IP Right Cessation
- 2007-06-21 RU RU2009101783/15A patent/RU2009101783A/ru not_active Application Discontinuation
- 2007-06-21 AU AU2007263265A patent/AU2007263265A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| JPN6012032476; Cancer Res Vol.66, No.3, 20060201, p.1491-1419 * |
| JPN6012032478; The Journal of Immunology Vol.172, 2004, p.5467-5477 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020513574A (ja) * | 2016-11-24 | 2020-05-14 | ヒュベット バイオ, インコーポレイテッドHuvet Bio, Inc. | 疾患の診断用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007147600A2 (en) | 2007-12-27 |
| EP2041576A2 (en) | 2009-04-01 |
| BRPI0713484A2 (pt) | 2012-11-06 |
| EP2041576B1 (en) | 2011-08-10 |
| RU2009101783A (ru) | 2010-07-27 |
| ATE520032T1 (de) | 2011-08-15 |
| DK2041576T3 (da) | 2011-12-05 |
| CN101529253A (zh) | 2009-09-09 |
| US20090324616A1 (en) | 2009-12-31 |
| CA2656379A1 (en) | 2007-12-27 |
| AU2007263265A1 (en) | 2007-12-27 |
| ES2371287T3 (es) | 2011-12-29 |
| WO2007147600A3 (en) | 2008-04-10 |
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