JP2010512413A5 - - Google Patents
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- Publication number
- JP2010512413A5 JP2010512413A5 JP2009541507A JP2009541507A JP2010512413A5 JP 2010512413 A5 JP2010512413 A5 JP 2010512413A5 JP 2009541507 A JP2009541507 A JP 2009541507A JP 2009541507 A JP2009541507 A JP 2009541507A JP 2010512413 A5 JP2010512413 A5 JP 2010512413A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- amphetamine
- disorder
- conjugate
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 25
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 12
- 229940025084 amphetamine Drugs 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 230000003880 negative regulation of appetite Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- -1 troche Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical group CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- UDHBXMXHYKXWEF-WCYXVCABSA-N NC(C)CC1=CC=CC=C1.N[C@@H](CCCN)C(=O)O[2H] Chemical group NC(C)CC1=CC=CC=C1.N[C@@H](CCCN)C(=O)O[2H] UDHBXMXHYKXWEF-WCYXVCABSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 229940001468 citrate Drugs 0.000 claims 1
- DRLPEFJOKVYESM-JSGCOSHPSA-N lomardexamfetamine Chemical group NC(N)=NCCCC[C@H](N)C(=O)N[C@@H](C)CC1=CC=CC=C1 DRLPEFJOKVYESM-JSGCOSHPSA-N 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229940042126 oral powder Drugs 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86937506P | 2006-12-11 | 2006-12-11 | |
| PCT/US2007/087028 WO2008073918A1 (en) | 2006-12-11 | 2007-12-10 | Non-standard amino acid conjugates of amphetamine and processes for making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512413A JP2010512413A (ja) | 2010-04-22 |
| JP2010512413A5 true JP2010512413A5 (enExample) | 2010-09-02 |
Family
ID=39512105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541507A Withdrawn JP2010512413A (ja) | 2006-12-11 | 2007-12-10 | アンフェタミンの非標準アミノ酸結合体およびそれらの製造方法および使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7776917B2 (enExample) |
| EP (1) | EP2101571B1 (enExample) |
| JP (1) | JP2010512413A (enExample) |
| CN (1) | CN101594778A (enExample) |
| AT (1) | ATE509622T1 (enExample) |
| AU (1) | AU2007333105A1 (enExample) |
| BR (1) | BRPI0720105A2 (enExample) |
| CA (1) | CA2672138A1 (enExample) |
| ES (1) | ES2364865T3 (enExample) |
| IL (1) | IL198930A0 (enExample) |
| WO (1) | WO2008073918A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| ATE536867T1 (de) | 2006-03-16 | 2011-12-15 | Tris Pharma Inc | Modifizierte freisetzungsformulierungen mit arznei-ion-austausch-harzkomplexen |
| ES2364865T3 (es) * | 2006-12-11 | 2011-09-15 | Kempharm, Inc. | Conjugados de ornitina de la anfetamina y procedimientos de fabricación y de utilización de los mismos. |
| EP2433655A3 (en) * | 2007-02-08 | 2013-05-15 | Kempharm, Inc. | Homoarginine-prodrugs of amphetamine |
| DE102007037478B3 (de) | 2007-08-08 | 2008-04-30 | Leifheit Ag | Wäschetrockenständer |
| US8614346B2 (en) | 2009-06-19 | 2013-12-24 | Cambrex Charles City, Inc. | Methods and compositions for preparation of amphetamine conjugates and salts thereof |
| WO2011133348A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| US8779191B2 (en) | 2010-12-20 | 2014-07-15 | Cambrex Charles City, Inc. | Methods and compositions for preparing lisdexamfetamine and salts thereof |
| JP5976111B2 (ja) * | 2011-07-28 | 2016-08-23 | ケムファーム・インコーポレーテッド | メチルフェニデート−プロドラッグ、その製造法及び使用法 |
| EP2739140A4 (en) * | 2011-07-29 | 2015-06-03 | Shire Llc | PRODRUGS OF HOMOARGININE AND / OR CONJUGATES OF AMPHETAMINES AND OTHER STIMULANTS AND METHODS OF MAKING AND USING SAME |
| SG10201805807PA (en) | 2012-06-26 | 2018-08-30 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| US20140073589A1 (en) * | 2012-06-27 | 2014-03-13 | Shire Ag | Amphetamine Prodrugs |
| WO2014058742A1 (en) | 2012-10-09 | 2014-04-17 | Sears Douglas | Therapeutic treatment |
| GB2545368B (en) | 2014-10-20 | 2021-04-21 | Elysium Therapeutics Inc | Diversion-resistant opioid formulations |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
| AU2016332071B2 (en) | 2015-10-01 | 2019-04-18 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| WO2018091473A1 (en) | 2016-11-15 | 2018-05-24 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| BR112019011640B1 (pt) | 2016-12-11 | 2021-08-17 | Kempharm, Inc | Compostos conjugados de d-metilfenidato, composições que compreendem os mesmos e kit farmacêutico que compreende as ditas composições |
| WO2018160178A1 (en) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
| CA3056239C (en) | 2017-03-17 | 2023-09-12 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| CA3059781A1 (en) * | 2017-04-10 | 2018-10-18 | Shire Pharmaceuticals Inc. | Methods of treatment using an amphetamine prodrug |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US12458592B1 (en) | 2017-09-24 | 2025-11-04 | Tris Pharma, Inc. | Extended release amphetamine tablets |
| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
| CA3078418A1 (en) * | 2017-10-06 | 2019-04-25 | Instituto De Medicina Molecular Joao Lobo Antunes | Treatment of obesity-related conditions |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| WO2019199731A1 (en) * | 2018-04-10 | 2019-10-17 | Shire Pharmaceuticals Inc. | Amphetamine prodrug and crystalline froms thereof |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| WO2020181000A1 (en) * | 2019-03-06 | 2020-09-10 | Ensysce Biosciences, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| KR20220009955A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈에 의한 우울증 및 기타 다양한 장애의 치료 |
| WO2021119316A1 (en) | 2019-12-11 | 2021-06-17 | Rgenix, Inc. | Methods of treating cancer |
| TW202309004A (zh) * | 2021-08-24 | 2023-03-01 | 美商精神醫學公司 | 藉由使用受控和非受控中間體獲取ｍｄｍａ前驅藥之合成途徑 |
| MX2024003466A (es) | 2021-09-29 | 2024-06-04 | Ensysce Biosciences Inc | Profarmacos de metadona escindibles por enzimas y metodos de uso de los mismos. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE539185A (enExample) * | 1954-06-28 | |||
| US2881113A (en) * | 1957-01-29 | 1959-04-07 | Ortho Pharma Corp | Therapeutically active compositions containing amphetamines |
| US2892753A (en) * | 1957-02-26 | 1959-06-30 | Boehringer Sohn Ingelheim | Central nervous system stimulant |
| DE1493824A1 (de) | 1964-01-27 | 1969-05-22 | Hoffmann La Roche | Verfahren zur Herstellung von Aminocarbonsaeureamiden |
| SI1041987T1 (sl) * | 1997-12-22 | 2006-10-31 | Euro Celtique Sa | Farmacevtska oralna dozirna oblika, ki obsega kombinacijo opioidnega agonista in naltreksona |
| WO2001013921A1 (en) * | 1999-08-23 | 2001-03-01 | Ockert David M | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| CA2411564A1 (en) * | 2000-06-09 | 2001-12-13 | The Regents Of The University Of California | Method of treating pain using nalbuphine and opioid antagonists |
| US6417184B1 (en) * | 2000-09-19 | 2002-07-09 | David M. Ockert | Triple drug therapy for the treatment and prevention of acute or chronic pain |
| US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
| EP1531844B1 (en) * | 2002-02-22 | 2014-08-20 | Shire LLC | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
| WO2004091499A2 (en) * | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
| EP1644019B2 (en) | 2003-05-29 | 2018-02-21 | Shire LLC | Abuse resistant amphetamine compounds |
| US20080234206A1 (en) | 2005-09-13 | 2008-09-25 | Shire Llc | Prodrugs of Phentermine |
| ES2364865T3 (es) * | 2006-12-11 | 2011-09-15 | Kempharm, Inc. | Conjugados de ornitina de la anfetamina y procedimientos de fabricación y de utilización de los mismos. |
| EP2433655A3 (en) * | 2007-02-08 | 2013-05-15 | Kempharm, Inc. | Homoarginine-prodrugs of amphetamine |
-
2007
- 2007-12-10 ES ES07869098T patent/ES2364865T3/es active Active
- 2007-12-10 CN CNA2007800458802A patent/CN101594778A/zh active Pending
- 2007-12-10 JP JP2009541507A patent/JP2010512413A/ja not_active Withdrawn
- 2007-12-10 US US11/953,668 patent/US7776917B2/en active Active
- 2007-12-10 EP EP07869098A patent/EP2101571B1/en not_active Not-in-force
- 2007-12-10 CA CA002672138A patent/CA2672138A1/en not_active Abandoned
- 2007-12-10 BR BRPI0720105-2A2A patent/BRPI0720105A2/pt not_active IP Right Cessation
- 2007-12-10 WO PCT/US2007/087028 patent/WO2008073918A1/en not_active Ceased
- 2007-12-10 AT AT07869098T patent/ATE509622T1/de not_active IP Right Cessation
- 2007-12-10 AU AU2007333105A patent/AU2007333105A1/en not_active Abandoned
-
2009
- 2009-05-25 IL IL198930A patent/IL198930A0/en unknown
- 2009-05-28 US US12/473,903 patent/US20090234018A1/en not_active Abandoned
-
2010
- 2010-07-26 US US12/843,169 patent/US8101661B2/en active Active
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