JP2010512369A5 - - Google Patents
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- JP2010512369A5 JP2010512369A5 JP2009540744A JP2009540744A JP2010512369A5 JP 2010512369 A5 JP2010512369 A5 JP 2010512369A5 JP 2009540744 A JP2009540744 A JP 2009540744A JP 2009540744 A JP2009540744 A JP 2009540744A JP 2010512369 A5 JP2010512369 A5 JP 2010512369A5
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- Prior art keywords
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- compound
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 32
- 150000004697 chelate complex Chemical class 0.000 claims 11
- 102000009123 Fibrin Human genes 0.000 claims 9
- 108010073385 Fibrin Proteins 0.000 claims 9
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 9
- 229950003499 fibrin Drugs 0.000 claims 9
- 230000008021 deposition Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 230000005298 paramagnetic effect Effects 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- -1 dibenzyl DTPA Chemical compound 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 230000001394 metastastic effect Effects 0.000 claims 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims 3
- 239000011347 resin Substances 0.000 claims 3
- 229920005989 resin Polymers 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 230000003439 radiotherapeutic effect Effects 0.000 claims 2
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims 1
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 claims 1
- SQKUFYLUXROIFM-UHFFFAOYSA-N 2-[2-[carboxymethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]ethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]acetic acid Chemical compound CC1=NC=C(COP(O)(O)=O)C(CN(CCN(CC(O)=O)CC=2C(=C(C)N=CC=2COP(O)(O)=O)O)CC(O)=O)=C1O SQKUFYLUXROIFM-UHFFFAOYSA-N 0.000 claims 1
- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 claims 1
- JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 1
- AQOXEJNYXXLRQQ-KRWDZBQOSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid Chemical compound CCOC1=CC=C(C[C@@H](CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 AQOXEJNYXXLRQQ-KRWDZBQOSA-N 0.000 claims 1
- RZESKRXOCXWCFX-UHFFFAOYSA-N 2-[bis[2-[carboxymethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetic acid Chemical compound CNC(=O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(=O)NC RZESKRXOCXWCFX-UHFFFAOYSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 238000012879 PET imaging Methods 0.000 claims 1
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 claims 1
- 239000006096 absorbing agent Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- BJAJDJDODCWPNS-UHFFFAOYSA-N dotp Chemical compound O=C1N2CCOC2=NC2=C1SC=C2 BJAJDJDODCWPNS-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 229960000103 thrombolytic agent Drugs 0.000 claims 1
- 230000002476 tumorcidal effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86947206P | 2006-12-11 | 2006-12-11 | |
| US60/869,472 | 2006-12-11 | ||
| PCT/EP2007/063659 WO2008071679A1 (en) | 2006-12-11 | 2007-12-11 | Fibrin binding peptide conjugates for diagnostic and therapeutic applications. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512369A JP2010512369A (ja) | 2010-04-22 |
| JP2010512369A5 true JP2010512369A5 (enExample) | 2011-01-20 |
| JP5364589B2 JP5364589B2 (ja) | 2013-12-11 |
Family
ID=39232769
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540744A Expired - Fee Related JP5364589B2 (ja) | 2006-12-11 | 2007-12-11 | 診断および治療適用用フィブリン結合ペプチドコンジュゲート |
| JP2009541359A Expired - Fee Related JP5345945B2 (ja) | 2006-12-11 | 2007-12-11 | フィブリン結合ペプチドおよびそのコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541359A Expired - Fee Related JP5345945B2 (ja) | 2006-12-11 | 2007-12-11 | フィブリン結合ペプチドおよびそのコンジュゲート |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9333272B2 (enExample) |
| EP (2) | EP2097438B1 (enExample) |
| JP (2) | JP5364589B2 (enExample) |
| CN (2) | CN101558081B (enExample) |
| WO (2) | WO2008071679A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208727B2 (en) * | 2003-01-14 | 2007-04-24 | Georgia Tech Research Corporation | Electrospray systems and methods |
| US9333272B2 (en) * | 2006-12-11 | 2016-05-10 | Bracco Imaging Spa | Fibrin binding peptide conjugates for diagnostic and therapeutic applications |
| AU2009228163B2 (en) | 2008-03-28 | 2012-08-30 | Glaxosmithkline Llc | Methods of treatment |
| JP5491511B2 (ja) | 2008-10-07 | 2014-05-14 | ブラッコ・シュイス・ソシエテ・アノニム | 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物 |
| JP2012508231A (ja) * | 2008-11-11 | 2012-04-05 | ナンヤン テクノロジカル ユニヴァーシティー | 血管内造影剤 |
| US8293213B2 (en) * | 2009-03-12 | 2012-10-23 | Palo Alto Research Center Incorporated | Method and apparatus for thrombus removal using magnetic particles |
| WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| KR20110139274A (ko) | 2009-03-19 | 2011-12-28 | 와이어쓰 엘엘씨 | ［2-(8,9-다이옥소-2,6-다이아자바이사이클로［5.2.0］논-1(7)-엔-2-일)에틸］포스폰산 및 이의 전구체의 제조 방법 |
| GB0910013D0 (en) * | 2009-06-10 | 2009-07-22 | Ge Healthcare Ltd | PET imaging of fibogenesis |
| CA2777841C (en) | 2009-11-02 | 2017-01-17 | Francis M. Creighton | Magnetomotive stator system and methods for wireless control of magnetic rotors |
| JP2012000072A (ja) * | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
| EP2672986B1 (en) * | 2011-02-09 | 2020-03-18 | GlaxoSmithKline LLC | Lyophilized formulations |
| WO2012150254A1 (en) * | 2011-05-02 | 2012-11-08 | Baxter International Inc. | Fgf based fibrin binding peptides |
| EP2771478B1 (en) * | 2011-10-25 | 2018-03-14 | The Scripps Research Institute | Synthesis of libraries of peptide tertiary amides |
| US20130195752A1 (en) | 2012-02-01 | 2013-08-01 | Regents Of The University Of Minnesota | Functionalized nanoparticles and methods of use thereof |
| WO2013131884A1 (en) | 2012-03-05 | 2013-09-12 | Bracco Imaging Spa | Dynamic contrast enhanced mri method and agents for the assessment of the macromolecular transport within pathologic tissues |
| US9883878B2 (en) | 2012-05-15 | 2018-02-06 | Pulse Therapeutics, Inc. | Magnetic-based systems and methods for manipulation of magnetic particles |
| KR101474063B1 (ko) * | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| US9849201B2 (en) | 2013-05-03 | 2017-12-26 | Washington University | Homing agents |
| US10231993B2 (en) * | 2013-06-27 | 2019-03-19 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
| KR20150010908A (ko) * | 2013-07-21 | 2015-01-29 | 더 스테이트 유니버시티 오브 뉴욕 버팔로 | 결합된 광음향 및 초음파 이미징용 조영제 |
| WO2015038968A1 (en) | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
| CN103664701A (zh) * | 2013-11-29 | 2014-03-26 | 成都普康生物科技有限公司 | [2-[2-(Fmoc-氨基)乙氧基]乙氧基]乙酸合成路线 |
| WO2015091948A1 (en) | 2013-12-20 | 2015-06-25 | Roche Diagnostics Gmbh | Method of immobilizing a cell on a support using compounds comprising a polyethylene glycol moiety |
| JP6461973B2 (ja) | 2013-12-20 | 2019-01-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用 |
| ES2708360T3 (es) | 2013-12-20 | 2019-04-09 | Hoffmann La Roche | Compuestos que comprenden uno o más dominios hidrófobos y un dominio hidrófilo que comprende restos de PEG, útiles para unir células |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| US10688199B2 (en) | 2015-06-10 | 2020-06-23 | Teikyo University | Theranostic bubble preparation (TB), and method for using same |
| CA2995210A1 (en) | 2015-08-13 | 2017-02-16 | The General Hospital Corporation | Manganese-based chelate conjugates for molecular mr imaging |
| CN108699130A (zh) | 2016-02-09 | 2018-10-23 | 博莱科瑞士股份有限公司 | 用于选择素靶向的重组嵌合蛋白 |
| KR102397783B1 (ko) | 2016-06-01 | 2022-05-12 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-l1 결합 폴리펩티드에 의한 pet 영상화 |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
| CN109316608B (zh) * | 2018-10-31 | 2021-09-28 | 重庆医科大学附属第二医院 | 一种低强度聚焦超声响应型相变溶栓纳米粒、应用及其制备方法 |
| WO2020099398A1 (en) | 2018-11-12 | 2020-05-22 | Bracco Imaging Spa | Chelating aazta conjugates and complexes thereof |
| ES2930177T3 (es) * | 2018-12-18 | 2022-12-07 | Bracco Suisse Sa | Procedimiento optimizado para el conjugado péptido-fosfolípido dimérico |
| WO2020247315A1 (en) * | 2019-06-05 | 2020-12-10 | Microvascular Therapeutics, Llc | Compositions and methods of detecting and treating thrombosis and vascular plaques |
| CN110237256A (zh) * | 2019-07-22 | 2019-09-17 | 重庆医科大学 | 一种载n2o微泡及其制备方法与应用 |
| KR102333606B1 (ko) * | 2019-10-15 | 2021-12-01 | 주식회사 엔지켐생명과학 | 1-팔미토일-2-리놀레오일-3-아세틸 글리세롤의 제조 방법 |
| WO2021081430A1 (en) * | 2019-10-23 | 2021-04-29 | Collagen Medical, LLC | Fibrin-binding compounds for imaging and treatment |
| CN111041025B (zh) * | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| US12171443B1 (en) | 2021-03-09 | 2024-12-24 | Pulse Therapeutics, Inc. | Magnetically controlled flow generation |
| EP4397671A4 (en) | 2021-08-31 | 2025-02-19 | FUJIFILM Corporation | COMPOUND AND MARKED BIOMATERIAL WITH IT |
| CN118725025A (zh) * | 2024-06-04 | 2024-10-01 | 厦门稀土材料研究所 | 用于177Lu标记的三齿类酰胺酸型双功能螯合剂及其制备方法和应用 |
| CN120668837B (zh) * | 2025-08-18 | 2025-10-31 | 复星安特金(成都)生物制药有限公司 | 一种检测消泡剂204的方法 |
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-
2007
- 2007-12-11 US US12/448,102 patent/US9333272B2/en not_active Expired - Fee Related
- 2007-12-11 EP EP07848047.2A patent/EP2097438B1/en active Active
- 2007-12-11 JP JP2009540744A patent/JP5364589B2/ja not_active Expired - Fee Related
- 2007-12-11 EP EP07862810.4A patent/EP2111237B1/en active Active
- 2007-12-11 CN CN200780045892.5A patent/CN101558081B/zh not_active Expired - Fee Related
- 2007-12-11 JP JP2009541359A patent/JP5345945B2/ja not_active Expired - Fee Related
- 2007-12-11 WO PCT/EP2007/063659 patent/WO2008071679A1/en not_active Ceased
- 2007-12-11 US US12/517,239 patent/US8278274B2/en not_active Expired - Fee Related
- 2007-12-11 WO PCT/US2007/025403 patent/WO2008073458A2/en not_active Ceased
- 2007-12-11 CN CN2007800458747A patent/CN101573143B/zh not_active Expired - Fee Related
-
2012
- 2012-08-30 US US13/598,811 patent/US8466107B2/en not_active Expired - Fee Related
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