JP2010510769A - 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 - Google Patents

食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 Download PDF

Info

Publication number
JP2010510769A
JP2010510769A JP2009537466A JP2009537466A JP2010510769A JP 2010510769 A JP2010510769 A JP 2010510769A JP 2009537466 A JP2009537466 A JP 2009537466A JP 2009537466 A JP2009537466 A JP 2009537466A JP 2010510769 A JP2010510769 A JP 2010510769A
Authority
JP
Japan
Prior art keywords
mirna
level
mir
hsa
esophageal cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009537466A
Other languages
English (en)
Japanese (ja)
Inventor
ヨン グオ,
ツァオリ チェン,
ジン チェン,
ジエ ヘ,
キース ミッチェルソン,
リァン ツァン,
シン メン,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CapitalBio Corp
Original Assignee
CapitalBio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CapitalBio Corp filed Critical CapitalBio Corp
Publication of JP2010510769A publication Critical patent/JP2010510769A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00Production
    • C12N2330/10Production naturally occurring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
JP2009537466A 2006-11-28 2006-11-28 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 Withdrawn JP2010510769A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/003195 WO2008064519A1 (en) 2006-11-28 2006-11-28 Methods and compositions for diagnosis of esophageal cancer and prognosis and improvement of patient survival

Publications (1)

Publication Number Publication Date
JP2010510769A true JP2010510769A (ja) 2010-04-08

Family

ID=39467406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009537466A Withdrawn JP2010510769A (ja) 2006-11-28 2006-11-28 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物

Country Status (3)

Country Link
JP (1) JP2010510769A (zh)
CN (1) CN101316935B (zh)
WO (1) WO2008064519A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015194627A1 (ja) * 2014-06-18 2015-12-23 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2487257B1 (en) 2006-01-05 2015-07-01 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
ES2446362T3 (es) 2006-03-20 2014-03-07 The Ohio State University Research Foundation Huellas de microARN durante megacariocipoyesis humana
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
CN103937876B (zh) * 2007-10-11 2016-08-17 俄亥俄州立大学研究基金会 用于诊断和治疗食管腺癌的方法和组合物
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CN101851682B (zh) * 2010-06-25 2013-08-28 中国人民解放军南京军区南京总医院 一种用于检测食管鳞状细胞癌的微小核糖核酸组合及其应用
GB201014049D0 (en) * 2010-08-23 2010-10-06 Sistemic Uk Cell characterisation
CA2816603A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
AU2011329066B2 (en) 2010-11-15 2017-03-09 The Ohio State University Research Foundation Controlled release mucoadhesive systems
WO2012135091A2 (en) * 2011-03-28 2012-10-04 The Johns Hopkins University Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac)
EP2766500A4 (en) 2011-10-14 2015-10-14 Univ Ohio State METHODS AND MATERIALS RELATED TO OVARIAN CANCER
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
CA2866052A1 (en) 2012-01-20 2013-07-25 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
CN103243161B (zh) * 2013-05-07 2015-02-25 中国医学科学院肿瘤医院 一种辅助预测食管鳞癌患者术后生存时间长短的产品
CN104034902B (zh) * 2014-05-09 2015-11-25 赤峰学院 利用4个蛋白联合预测食道癌患者预后的试剂盒
CN104774929B (zh) * 2015-03-18 2017-06-30 中山大学肿瘤防治中心 miR‑455‑3p在食管鳞状细胞癌中的诊断、治疗和预后的应用
CA3032827A1 (en) * 2016-08-04 2018-02-08 Baylor Research Institute Methods for diagnosing and treating esophageal cancer
CN109652545A (zh) * 2019-01-11 2019-04-19 山西医科大学 Znf750在筛选用于治疗食管鳞癌靶向药物中的用途
CN112826504B (zh) * 2021-01-07 2024-03-26 中新国际联合研究院 一种游戏化的帕金森症状等级评估方法及装置
CN113430123A (zh) * 2021-06-28 2021-09-24 福建医科大学 一种与食管鳞癌发病相关的真菌菌群及其筛选方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1150317C (zh) * 1999-08-10 2004-05-19 中国医学科学院肿瘤医院肿瘤研究所 一种食管癌相关新基因
CN1223677C (zh) * 1999-08-10 2005-10-19 中国医学科学院肿瘤医院肿瘤研究所 一种食管癌相关基因
EP1713938A2 (en) * 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015194627A1 (ja) * 2014-06-18 2015-12-23 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
JPWO2015194627A1 (ja) * 2014-06-18 2017-04-20 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
US10619212B2 (en) 2014-06-18 2020-04-14 Toray Industries, Inc. Esophageal cancer detection kit or device, and detection method
JP2021100411A (ja) * 2014-06-18 2021-07-08 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
JP7090851B2 (ja) 2014-06-18 2022-06-27 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
JP7153283B2 (ja) 2014-06-18 2022-10-14 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
US11542558B2 (en) 2014-06-18 2023-01-03 Toray Industries, Inc. Esophageal cancer detection kit or device, and detection method
JP7436995B2 (ja) 2014-06-18 2024-02-22 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法

Also Published As

Publication number Publication date
CN101316935A (zh) 2008-12-03
CN101316935B (zh) 2012-02-29
WO2008064519A1 (en) 2008-06-05

Similar Documents

Publication Publication Date Title
JP2010510769A (ja) 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物
US11220713B2 (en) MicroRNAs as biomarkers for endometriosis
US20180105888A1 (en) Methods and Kits for Detecting Subjects at Risk of Having Cancer
WO2008042231A9 (en) Compositions and methods for evaluating and treating heart failure
KR102029775B1 (ko) 비근침윤성 방광암 진단용 바이오마커 및 이의 용도
US8957039B2 (en) Methods and compositions for the diagnosis and prognosis of cervical intraepithelial neoplasia and cervical cancer
WO2016186987A1 (en) Biomarker micrornas and method for determining tumor burden
WO2010094155A1 (en) Methods and compositions diagnosing lung cancer, determining prognosis, and improving patient survival
WO2011012074A1 (zh) 肝癌检测标记物及其检测方法、试剂盒和生物芯片
EP3122905B1 (en) Circulating micrornas as biomarkers for endometriosis
US10030269B2 (en) Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
CN108220446B (zh) Linc01356作为分子标志物在胃癌中的应用
WO2020092672A2 (en) A quantitative algorithm for endometriosis
US20100234445A1 (en) Patterns of known and novel small RNAS in human cervical cancer
CN107267616B (zh) 一种非编码基因生物标记物在肝癌中的应用
US20190316207A1 (en) Mir-320e and colorectal cancer
CN107227362B (zh) 一种与肝癌相关的基因及其应用
CN111979315A (zh) 环状tp63作为肺鳞癌诊断或治疗靶点的应用
JP5757032B2 (ja) miRNAを利用した慢性肝疾患の線維化の検査方法
WO2016160882A1 (en) Methods for diagnosing and treating colorectal cancer using mirna549a
CN111424092A (zh) 一种检测基因及其应用
CN102510905A (zh) 用于宫颈上皮内瘤样病变和宫颈癌的诊断和预后的方法与组合物
US20150216893A1 (en) Methods and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
WO2013122918A1 (en) Methods and compositions for inhibiting a multi-cancer mesenchymal transition mechanism

Legal Events

Date Code Title Description
A300 Withdrawal of application because of no request for examination

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20100202