JP2010510254A - アルツハイマー病および関連の神経変性疾患のための併用処置 - Google Patents
アルツハイマー病および関連の神経変性疾患のための併用処置 Download PDFInfo
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- JP2010510254A JP2010510254A JP2009537460A JP2009537460A JP2010510254A JP 2010510254 A JP2010510254 A JP 2010510254A JP 2009537460 A JP2009537460 A JP 2009537460A JP 2009537460 A JP2009537460 A JP 2009537460A JP 2010510254 A JP2010510254 A JP 2010510254A
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- cyclohexanehexol
- alkyl
- disease
- compound
- secretase inhibitor
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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| PCT/CA2007/002118 WO2008061373A1 (en) | 2006-11-24 | 2007-11-22 | Combination treatments for alzheimer's disease and similar diseases |
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| JP2010510254A true JP2010510254A (ja) | 2010-04-02 |
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| EP (1) | EP2091566A4 (enExample) |
| JP (1) | JP2010510254A (enExample) |
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| WO (1) | WO2008061373A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015535249A (ja) * | 2012-10-25 | 2015-12-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US10561612B2 (en) | 2017-07-20 | 2020-02-18 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ibuprofen |
| US12383528B2 (en) | 2018-12-10 | 2025-08-12 | The General Hospital Corporation | Cromolyn esters and uses thereof |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US20100144891A1 (en) * | 2007-04-12 | 2010-06-10 | Mclaurin Joanne | Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis |
| AT506535B1 (de) * | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| EP3060205A4 (en) | 2013-10-22 | 2017-06-28 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| GB201416832D0 (en) * | 2014-09-24 | 2014-11-05 | Glaxosmithkline Plc | Methods of treatment |
| EP3209655B1 (en) | 2014-10-24 | 2020-07-15 | Landos Biopharma, Inc. | Lanthionine synthetase c-like 2-based therapeutics |
| PT2017095250B (pt) * | 2015-11-30 | 2021-08-06 | Univ De Coimbra | Peptídeos inibidores da bace1 para o tratamento de doenças neurológicas |
| WO2018045217A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| EA202091325A1 (ru) | 2017-11-30 | 2020-08-28 | Лэндос Байофарма, Инк. | Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток |
| CN113038944A (zh) | 2018-07-02 | 2021-06-25 | 通用医疗公司 | 色甘酸钠和α-乳糖的粉末化制剂 |
| US11117881B2 (en) | 2019-12-20 | 2021-09-14 | Landos Biopharma, Inc. | Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same |
| EP4583851A1 (en) * | 2022-09-07 | 2025-07-16 | EirGen Pharma Ltd. | Scyllo-inositol in combination with immunotherapeutics for the treatment of alzheimer's disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006053428A1 (en) * | 2004-11-17 | 2006-05-26 | Joanne Mclaurin | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
| JP2006522740A (ja) * | 2003-02-27 | 2006-10-05 | ジョアン マクローリン, | タンパク質凝集性障害を予防、処置および診断をする方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| US4474806A (en) * | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
| US4952396A (en) * | 1986-11-19 | 1990-08-28 | Linus Pauling Institute Of Science & Medicine | Method of using phytic acid for inhibiting tumor growth |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
| US5217959A (en) * | 1990-09-06 | 1993-06-08 | Robert Sabin | Method of treating multiple sclerosis with phytic acid |
| US5112814A (en) * | 1990-10-24 | 1992-05-12 | Robert Sabin | Method of treatment of Parkinson's disease using phytic acid |
| KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
| SE469260B (sv) * | 1992-02-25 | 1993-06-14 | Perstorp Ab | En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat |
| NZ314112A (en) * | 1992-10-05 | 1997-08-22 | Virginia Tech Intell Prop | Preparation of allo-inositol by reduction of d-chiro-inosose |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| PT619369E (pt) * | 1993-04-05 | 2003-11-28 | Aveve Nv | Hidrolise de fitato e composicao enzimatica para a hidrolise de fitato |
| KR100332144B1 (ko) * | 1993-08-11 | 2002-11-13 | 자이단 호진 비세부츠 가가쿠 겐쿠 카이 | D-키로-이노시톨제조방법 |
| SE502574C2 (sv) * | 1994-01-25 | 1995-11-13 | Perstorp Ab | En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US6232486B1 (en) * | 1996-06-11 | 2001-05-15 | Nutrimed Biotech | Molecular probes and modulators for PI-PLC and PI 3-kinase |
| US5880099A (en) * | 1996-09-20 | 1999-03-09 | The Regents Of The University Of California | Inositol polyphosphates and methods of using same |
| US5977078A (en) * | 1996-09-20 | 1999-11-02 | The Regents Of The Univesity Of California | Inositol polyphosphate derivatives and methods of using same |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US6153603A (en) * | 1997-06-27 | 2000-11-28 | Perstorp Ab | Method of treating angiogenesis in tumor tissue |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| US6818430B1 (en) * | 1999-06-07 | 2004-11-16 | Hokko Chemical Industry Co., Ltd. | Process for producing L-epi-2-inosose and novel process for producing epi-inositol |
| US6329256B1 (en) * | 1999-09-24 | 2001-12-11 | Advanced Micro Devices, Inc. | Self-aligned damascene gate formation with low gate resistance |
| AU784752B2 (en) * | 1999-10-18 | 2006-06-08 | Northern Innovations Holding Corp. | Food supplement for increasing lean mass and strength |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| DE10031955A1 (de) * | 2000-06-30 | 2002-01-17 | Deutsches Krebsforsch | Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel |
| CA2437561A1 (en) * | 2001-02-06 | 2002-08-15 | Qlt Inc. | Use of additional photodynamic therapy in the treatment of choroidal neovasculature |
| AU2002236988A1 (en) * | 2001-02-06 | 2002-08-19 | Novartis Ag | Photodynamic therapy of occult choroidal neovascularization linked to age-related macular degeneration |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| WO2003007944A1 (en) * | 2001-07-20 | 2003-01-30 | Qlt, Inc. | Treatment of macular edema with photodynamic therapy |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| CA2774930C (en) * | 2003-10-14 | 2014-08-05 | Hokko Chemical Industry Co., Ltd. | Method for producing purified scyllo-inositol utilizing boric acid |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US8193250B2 (en) * | 2004-10-22 | 2012-06-05 | Mount Sinai School Of Medicine | Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system |
| CA2626005A1 (en) * | 2005-10-13 | 2007-10-25 | Waratah Pharmaceuticals Inc. | Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| CA2579188A1 (en) * | 2006-02-17 | 2007-08-17 | Joanne Mclaurin | Treatment of amyloid-related diseases |
| CN103054837A (zh) * | 2006-03-09 | 2013-04-24 | 瓦拉塔药品公司 | 用于治疗蛋白积聚病症的环己烷多元醇制剂 |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
-
2007
- 2007-11-22 EP EP07845583A patent/EP2091566A4/en not_active Withdrawn
- 2007-11-22 JP JP2009537460A patent/JP2010510254A/ja active Pending
- 2007-11-22 WO PCT/CA2007/002118 patent/WO2008061373A1/en not_active Ceased
- 2007-11-22 US US12/445,164 patent/US20100292157A1/en not_active Abandoned
- 2007-11-22 CA CA002670405A patent/CA2670405A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006522740A (ja) * | 2003-02-27 | 2006-10-05 | ジョアン マクローリン, | タンパク質凝集性障害を予防、処置および診断をする方法 |
| WO2006053428A1 (en) * | 2004-11-17 | 2006-05-26 | Joanne Mclaurin | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
Non-Patent Citations (3)
| Title |
|---|
| CSNC200900876039; 医学のあゆみ Vol.208, 2004, pp.443-8 * |
| JPN6012067186; 医学のあゆみ Vol.208, 2004, pp.443-8 * |
| JPN6012067187; J Biol Chem Vol.275, 2000, pp.18495-502 * |
Cited By (6)
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|---|---|---|---|---|
| JP2015535249A (ja) * | 2012-10-25 | 2015-12-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US11013686B2 (en) | 2013-05-23 | 2021-05-25 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US10561612B2 (en) | 2017-07-20 | 2020-02-18 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ibuprofen |
| US12383528B2 (en) | 2018-12-10 | 2025-08-12 | The General Hospital Corporation | Cromolyn esters and uses thereof |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2091566A1 (en) | 2009-08-26 |
| WO2008061373A1 (en) | 2008-05-29 |
| CA2670405A1 (en) | 2008-05-29 |
| EP2091566A4 (en) | 2011-07-06 |
| US20100292157A1 (en) | 2010-11-18 |
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