JP2010509744A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010509744A5 JP2010509744A5 JP2009536790A JP2009536790A JP2010509744A5 JP 2010509744 A5 JP2010509744 A5 JP 2010509744A5 JP 2009536790 A JP2009536790 A JP 2009536790A JP 2009536790 A JP2009536790 A JP 2009536790A JP 2010509744 A5 JP2010509744 A5 JP 2010509744A5
- Authority
- JP
- Japan
- Prior art keywords
- mass spectrometer
- ion
- mass
- mbar
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 description 191
- 238000013467 fragmentation Methods 0.000 description 59
- 238000006062 fragmentation reaction Methods 0.000 description 59
- 238000006243 chemical reaction Methods 0.000 description 47
- 230000001052 transient effect Effects 0.000 description 10
- 230000004323 axial length Effects 0.000 description 9
- 239000002243 precursor Substances 0.000 description 8
- 238000011144 upstream manufacturing Methods 0.000 description 7
- 238000010494 dissociation reaction Methods 0.000 description 6
- 230000005593 dissociations Effects 0.000 description 6
- 230000005405 multipole Effects 0.000 description 6
- 230000002238 attenuated effect Effects 0.000 description 5
- 238000005040 ion trap Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 238000001360 collision-induced dissociation Methods 0.000 description 3
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 2
- 238000000451 chemical ionisation Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000000688 desorption electrospray ionisation Methods 0.000 description 2
- 238000000132 electrospray ionisation Methods 0.000 description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000001698 laser desorption ionisation Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000001211 electron capture detection Methods 0.000 description 1
- 238000001077 electron transfer detection Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000010265 fast atom bombardment Methods 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 description 1
- 238000004150 penning trap Methods 0.000 description 1
- 238000005173 quadrupole mass spectroscopy Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0622780.5A GB0622780D0 (en) | 2006-11-15 | 2006-11-15 | Mass spectrometer |
| GB0622780.5 | 2006-11-15 | ||
| US86936606P | 2006-12-11 | 2006-12-11 | |
| US60/869,366 | 2006-12-11 | ||
| PCT/GB2007/004364 WO2008059255A2 (en) | 2006-11-15 | 2007-11-15 | Mass spectrometer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509744A JP2010509744A (ja) | 2010-03-25 |
| JP2010509744A5 true JP2010509744A5 (enExample) | 2012-04-26 |
| JP5178730B2 JP5178730B2 (ja) | 2013-04-10 |
Family
ID=37605336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536790A Expired - Fee Related JP5178730B2 (ja) | 2006-11-15 | 2007-11-15 | 質量分析計及び質量分析方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9685313B2 (enExample) |
| EP (3) | EP2208993B1 (enExample) |
| JP (1) | JP5178730B2 (enExample) |
| AT (1) | ATE542131T1 (enExample) |
| CA (1) | CA2667444A1 (enExample) |
| GB (3) | GB0622780D0 (enExample) |
| WO (1) | WO2008059255A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9859105B2 (en) * | 2006-02-14 | 2018-01-02 | Excellims Corporation | Multiple ion gate method and apparatus |
| GB0622780D0 (en) * | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
| US7932487B2 (en) * | 2008-01-11 | 2011-04-26 | Thermo Finnigan Llc | Mass spectrometer with looped ion path |
| GB0810125D0 (en) | 2008-06-03 | 2008-07-09 | Thermo Fisher Scient Bremen | Collosion cell |
| GB0900917D0 (en) * | 2009-01-20 | 2009-03-04 | Micromass Ltd | Mass spectrometer |
| JP5792155B2 (ja) * | 2009-03-17 | 2015-10-07 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | イオン移動度に対するイオン光学ドレイン |
| JP5671523B2 (ja) * | 2009-04-30 | 2015-02-18 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 濡れた多孔質材料を用いるイオン生成 |
| US9500572B2 (en) | 2009-04-30 | 2016-11-22 | Purdue Research Foundation | Sample dispenser including an internal standard and methods of use thereof |
| GB0907619D0 (en) | 2009-05-01 | 2009-06-10 | Shimadzu Res Lab Europe Ltd | Ion analysis apparatus and method of use |
| WO2010141763A1 (en) * | 2009-06-03 | 2010-12-09 | Wayne State University | Mass spectrometry using laserspray ionization |
| US8440962B2 (en) * | 2009-09-08 | 2013-05-14 | Dh Technologies Development Pte. Ltd. | Targeted ion parking for quantitation |
| US8440963B2 (en) * | 2010-04-09 | 2013-05-14 | Battelle Memorial Institute | System and process for pulsed multiple reaction monitoring |
| US20130181125A1 (en) * | 2010-08-19 | 2013-07-18 | Dh Technologies Development Pte. Ltd. | Method and system for increasing the dynamic range of ion detectors |
| JP5454416B2 (ja) * | 2010-08-20 | 2014-03-26 | 株式会社島津製作所 | 質量分析装置 |
| GB201104292D0 (en) | 2011-03-15 | 2011-04-27 | Micromass Ltd | M/z targets attenuation on time of flight instruments |
| US9269548B2 (en) * | 2011-04-13 | 2016-02-23 | Battelle Memorial Institute | Method and apparatus for coupling fast separations and slow detection systems |
| CN103718270B (zh) | 2011-05-05 | 2017-10-03 | 岛津研究实验室（欧洲）有限公司 | 操纵带电粒子的装置 |
| WO2013059724A1 (en) | 2011-10-21 | 2013-04-25 | California Institute Of Technology | System and method for determining the isotopic anatomy of organic and volatile molecules |
| GB201118579D0 (en) * | 2011-10-27 | 2011-12-07 | Micromass Ltd | Control of ion populations |
| JP5923175B2 (ja) * | 2011-11-02 | 2016-05-24 | レコ コーポレイションＬｅｃｏ Ｃｏｒｐｏｒａｔｉｏｎ | イオン移動度分光計 |
| GB201205009D0 (en) * | 2012-03-22 | 2012-05-09 | Micromass Ltd | Multi-dimensional survey scans for improved data dependent acquisitions (DDA) |
| GB2561998A (en) * | 2012-10-10 | 2018-10-31 | California Inst Of Techn | Mass spectrometer, system comprising the same, and methods for determining isotopic anatomy of compounds |
| US8809769B2 (en) | 2012-11-29 | 2014-08-19 | Bruker Daltonics, Inc. | Apparatus and method for cross-flow ion mobility spectrometry |
| EP2951852B1 (en) | 2013-01-31 | 2020-07-22 | Purdue Research Foundation | Systems for analyzing an extracted sample |
| WO2014120552A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Research Foundation | Methods of analyzing crude oil |
| US8987664B2 (en) * | 2013-02-07 | 2015-03-24 | Shimadzu Corporation | Mass spectrometry device |
| US9523658B2 (en) * | 2013-03-06 | 2016-12-20 | Micromass Uk Limited | Optimised ion mobility separation timescales for targeted ions |
| JP2016513796A (ja) | 2013-03-13 | 2016-05-16 | マイクロマス ユーケー リミテッド | 削減されたデータ処理によるｄｄａ実験 |
| CA2905316C (en) * | 2013-03-14 | 2021-10-19 | Micromass Uk Limited | Data dependent control of the intensity of ions separated in multiple dimensions |
| EP3486937B1 (en) | 2013-06-25 | 2022-07-27 | Purdue Research Foundation | Mass spectrometry analysis of microorganisms in samples |
| GB201315145D0 (en) | 2013-08-23 | 2013-10-09 | Smiths Detection Watford Ltd | Ion Modification |
| US10551347B2 (en) | 2013-11-12 | 2020-02-04 | Micromass Uk Limited | Method of isolating ions |
| EP3069371B1 (en) | 2013-11-12 | 2023-01-04 | Micromass UK Limited | Ion trap mass spectrometers |
| US10586691B2 (en) * | 2013-11-12 | 2020-03-10 | Micromass Uk Limited | Method of correlating precursor and fragment ions using ion mobility and mass to charge ratio |
| GB201319952D0 (en) * | 2013-11-12 | 2013-12-25 | Micromass Ltd | Methods of isolating ions |
| GB201322515D0 (en) * | 2013-12-19 | 2014-02-05 | Micromass Ltd | High pressure mass resolving ion guide with axial field |
| WO2015092399A1 (en) | 2013-12-19 | 2015-06-25 | Micromass Uk Limited | High pressure mass resolving ion guide with axial field |
| CN105917220B (zh) * | 2014-01-16 | 2019-05-28 | 株式会社岛津制作所 | 质谱分析装置 |
| US10352900B2 (en) | 2014-02-14 | 2019-07-16 | Micromass Uk Limited | Flushing ion mobility separation cell between ion mobility separation cycles |
| GB201402584D0 (en) * | 2014-02-14 | 2014-04-02 | Micromass Ltd | Flushing IMS cell between IMS cycles |
| US10153147B2 (en) | 2014-06-10 | 2018-12-11 | Micromass Uk Limited | Method of compressing an ion beam |
| GB201410247D0 (en) * | 2014-06-10 | 2014-07-23 | Micromass Ltd | Separation for space charge reduction |
| GB201410395D0 (en) * | 2014-06-11 | 2014-07-23 | Micromass Ltd | Improved quadrupole robustness |
| DE112015002725B4 (de) | 2014-06-11 | 2025-03-20 | Micromass Uk Limited | Verbesserte Quadrupolwiderstandsfähigkeit |
| EP3155633A4 (en) * | 2014-06-13 | 2018-01-31 | PerkinElmer Health Sciences, Inc. | Rf ion guide with axial fields |
| GB2531292B (en) * | 2014-10-14 | 2019-06-12 | Smiths Detection Watford Ltd | Method and apparatus |
| GB2531336B (en) | 2014-10-17 | 2019-04-10 | Thermo Fisher Scient Bremen Gmbh | Method and apparatus for the analysis of molecules using mass spectrometry and optical spectroscopy |
| US9786478B2 (en) | 2014-12-05 | 2017-10-10 | Purdue Research Foundation | Zero voltage mass spectrometry probes and systems |
| CN113725063B (zh) | 2015-02-06 | 2024-09-20 | 普度研究基金会 | 探针、盒、系统和样本分析的方法 |
| WO2016196181A1 (en) * | 2015-05-29 | 2016-12-08 | Waters Technologies Corporation | Mass spectrometry with quadrupole and ion mobility separation capabilities |
| GB201509402D0 (en) * | 2015-06-01 | 2015-07-15 | Micromass Ltd | Lock mass library for internal correction |
| US10317366B2 (en) * | 2015-09-09 | 2019-06-11 | Shimadzu Corporation | Ion mobility spectrometer |
| GB2544484B (en) * | 2015-11-17 | 2019-01-30 | Thermo Fisher Scient Bremen Gmbh | Addition of reactive species to ICP source in a mass spectrometer |
| CN105513937B (zh) * | 2015-12-28 | 2017-10-24 | 中国计量科学研究院 | 高效隔离离子阱内离子的操作方法 |
| US10049868B2 (en) * | 2016-12-06 | 2018-08-14 | Rapiscan Systems, Inc. | Apparatus for detecting constituents in a sample and method of using the same |
| GB201621927D0 (en) * | 2016-12-22 | 2017-02-08 | Micromass Ltd | Mass spectrometric analysis of lipids |
| GB2559145B (en) | 2017-01-26 | 2022-07-13 | Micromass Ltd | Method of separating different ions having similar mass to charge ratios |
| GB201808892D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| US11373849B2 (en) | 2018-05-31 | 2022-06-28 | Micromass Uk Limited | Mass spectrometer having fragmentation region |
| GB201808949D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808936D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808912D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808932D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808942D0 (en) * | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808894D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| US11367607B2 (en) | 2018-05-31 | 2022-06-21 | Micromass Uk Limited | Mass spectrometer |
| GB201808893D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808890D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| US11011362B2 (en) * | 2019-09-19 | 2021-05-18 | Thermo Finnigan Llc | Fast continuous SRM acquisitions with or without ion trapping |
| GB2592591B (en) * | 2020-03-02 | 2024-07-24 | Thermo Fisher Scient Bremen Gmbh | Time of flight mass spectrometer and method of mass spectrometry |
| EP3916755A1 (en) * | 2020-05-26 | 2021-12-01 | Thermo Finnigan LLC | Methods and apparatus for high speed mass spectrometry |
| US20250251363A1 (en) * | 2022-04-14 | 2025-08-07 | Dh Technologies Development Pte. Ltd. | System and Methods for High Throughput Mass Spectrometry |
| WO2024229273A1 (en) * | 2023-05-04 | 2024-11-07 | Peninsula Technologies, Llc | Systems and methods for field asymmetric ion mobility separation in reduced pressure |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234791A (en) * | 1978-11-13 | 1980-11-18 | Research Corporation | Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor |
| US4221964A (en) * | 1979-02-12 | 1980-09-09 | Inficon Leybold-Heraeus Inc. | Control system for mass spectrometer |
| DE19523859C2 (de) * | 1995-06-30 | 2000-04-27 | Bruker Daltonik Gmbh | Vorrichtung für die Reflektion geladener Teilchen |
| US6177668B1 (en) * | 1996-06-06 | 2001-01-23 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| US6960761B2 (en) * | 1997-06-02 | 2005-11-01 | Advanced Research & Technology Institute | Instrument for separating ions in time as functions of preselected ion mobility and ion mass |
| US6753523B1 (en) * | 1998-01-23 | 2004-06-22 | Analytica Of Branford, Inc. | Mass spectrometry with multipole ion guides |
| US6504148B1 (en) * | 1999-05-27 | 2003-01-07 | Mds Inc. | Quadrupole mass spectrometer with ION traps to enhance sensitivity |
| US7057168B2 (en) * | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
| ATE459976T1 (de) * | 2000-03-14 | 2010-03-15 | Ca Nat Research Council | Faims apparatur und verfahren unter verwendung eines trägergases von gemischter zusammensetzung |
| US7041967B2 (en) * | 2001-05-25 | 2006-05-09 | Mds Inc. | Method of mass spectrometry, to enhance separation of ions with different charges |
| CA2391060C (en) * | 2001-06-21 | 2011-08-09 | Micromass Limited | Mass spectrometer |
| US7586088B2 (en) * | 2001-06-21 | 2009-09-08 | Micromass Uk Limited | Mass spectrometer and method of mass spectrometry |
| JP3840417B2 (ja) * | 2002-02-20 | 2006-11-01 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| US6906319B2 (en) * | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| GB2389704B (en) * | 2002-05-17 | 2004-06-02 | * Micromass Limited | Mass Spectrometer |
| CA2495378C (en) * | 2002-08-22 | 2011-03-01 | Applera Corporation | Method for characterizing biomolecules utilizing a result driven strategy |
| US6992283B2 (en) * | 2003-06-06 | 2006-01-31 | Micromass Uk Limited | Mass spectrometer |
| US6953928B2 (en) * | 2003-10-31 | 2005-10-11 | Applera Corporation | Ion source and methods for MALDI mass spectrometry |
| GB2423867B (en) * | 2004-04-05 | 2007-01-17 | Micromass Ltd | Mass spectrometer |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| US20050253059A1 (en) * | 2004-05-13 | 2005-11-17 | Goeringer Douglas E | Tandem-in-time and-in-space mass spectrometer and associated method for tandem mass spectrometry |
| GB0425426D0 (en) * | 2004-11-18 | 2004-12-22 | Micromass Ltd | Mass spectrometer |
| WO2006061593A2 (en) | 2004-12-07 | 2006-06-15 | Micromass Uk Limited | Mass spectrometer |
| US7161146B2 (en) * | 2005-01-24 | 2007-01-09 | Science & Engineering Services, Inc. | Method and apparatus for producing an ion beam from an ion guide |
| US20070114382A1 (en) * | 2005-11-23 | 2007-05-24 | Clemmer David E | Ion mobility spectrometer |
| GB0608470D0 (en) * | 2006-04-28 | 2006-06-07 | Micromass Ltd | Mass spectrometer |
| WO2007125354A2 (en) * | 2006-04-28 | 2007-11-08 | Micromass Uk Limited | Mass spectrometer |
| GB0622780D0 (en) * | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
-
2006
- 2006-11-15 GB GBGB0622780.5A patent/GB0622780D0/en not_active Ceased
-
2007
- 2007-11-15 CA CA002667444A patent/CA2667444A1/en not_active Abandoned
- 2007-11-15 EP EP10003699.5A patent/EP2208993B1/en active Active
- 2007-11-15 GB GB0901074A patent/GB2456068B/en active Active
- 2007-11-15 EP EP09008338A patent/EP2112682B1/en active Active
- 2007-11-15 US US12/514,972 patent/US9685313B2/en active Active
- 2007-11-15 GB GB0722433A patent/GB2443952B/en active Active
- 2007-11-15 EP EP07824585.9A patent/EP2082415B1/en active Active
- 2007-11-15 JP JP2009536790A patent/JP5178730B2/ja not_active Expired - Fee Related
- 2007-11-15 WO PCT/GB2007/004364 patent/WO2008059255A2/en not_active Ceased
- 2007-11-15 AT AT09008338T patent/ATE542131T1/de active
-
2017
- 2017-06-19 US US15/626,447 patent/US10319577B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010509744A5 (enExample) | ||
| JP5178730B2 (ja) | 質量分析計及び質量分析方法 | |
| CA2663016C (en) | Mass spectrometer | |
| EP2033208B1 (en) | Mass spectrometer | |
| JP5198467B2 (ja) | 質量分析計 | |
| JP4911781B2 (ja) | 質量分析計 | |
| EP3640970B1 (en) | Ion guiding device | |
| US9620346B2 (en) | Mass spectrometer | |
| JP2010511985A5 (enExample) | ||
| JP5290960B2 (ja) | 質量分析計 | |
| GB2455593A (en) | A mass analyzer utilising a plurality of axial pseudo-potential barriers | |
| JP2009514179A5 (enExample) | ||
| EP2041560A1 (en) | Apparatus comprising an ion mobilility spectrometer |