JP2010508530A5 - - Google Patents
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- JP2010508530A5 JP2010508530A5 JP2009535125A JP2009535125A JP2010508530A5 JP 2010508530 A5 JP2010508530 A5 JP 2010508530A5 JP 2009535125 A JP2009535125 A JP 2009535125A JP 2009535125 A JP2009535125 A JP 2009535125A JP 2010508530 A5 JP2010508530 A5 JP 2010508530A5
- Authority
- JP
- Japan
- Prior art keywords
- label
- substance
- analyte
- binding
- magnetizable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000126 substance Substances 0.000 claims 35
- 239000012491 analyte Substances 0.000 claims 20
- 239000002184 metal Substances 0.000 claims 16
- 229910052751 metal Inorganic materials 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 102000014914 Carrier Proteins Human genes 0.000 claims 6
- 108091008324 binding proteins Proteins 0.000 claims 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 239000012678 infectious agent Substances 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- 102000008857 Ferritin Human genes 0.000 claims 3
- 108050000784 Ferritin Proteins 0.000 claims 3
- 238000008416 Ferritin Methods 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 210000003850 cellular structure Anatomy 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000000696 magnetic material Substances 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 229910052804 chromium Inorganic materials 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000003925 fat Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 235000014413 iron hydroxide Nutrition 0.000 claims 2
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229910052748 manganese Inorganic materials 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- 210000000605 viral structure Anatomy 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 102000000546 Apoferritins Human genes 0.000 claims 1
- 108010002084 Apoferritins Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 108050006416 Ferric binding proteins Proteins 0.000 claims 1
- 102000003869 Frataxin Human genes 0.000 claims 1
- 108090000217 Frataxin Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010063045 Lactoferrin Proteins 0.000 claims 1
- 102000010445 Lactoferrin Human genes 0.000 claims 1
- 239000000589 Siderophore Substances 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 229910052793 cadmium Inorganic materials 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 1
- 229940078795 lactoferrin Drugs 0.000 claims 1
- 235000021242 lactoferrin Nutrition 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0621894.5A GB0621894D0 (en) | 2006-11-02 | 2006-11-02 | Magnetic recognition system |
| GB0621894.5 | 2006-11-02 | ||
| PCT/GB2007/004188 WO2008053229A1 (en) | 2006-11-02 | 2007-11-02 | Magnetic recognition system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508530A JP2010508530A (ja) | 2010-03-18 |
| JP2010508530A5 true JP2010508530A5 (https=) | 2010-12-16 |
| JP5453095B2 JP5453095B2 (ja) | 2014-03-26 |
Family
ID=37547250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535125A Expired - Fee Related JP5453095B2 (ja) | 2006-11-02 | 2007-11-02 | 磁気認識システム |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100159442A1 (https=) |
| EP (2) | EP2428799A1 (https=) |
| JP (1) | JP5453095B2 (https=) |
| CN (1) | CN101542287B (https=) |
| AU (1) | AU2007315904A1 (https=) |
| CA (1) | CA2668011A1 (https=) |
| GB (1) | GB0621894D0 (https=) |
| RU (1) | RU2442169C2 (https=) |
| WO (1) | WO2008053229A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808086D0 (en) * | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | Magnetic proteins for in vivo imaging |
| GB0808089D0 (en) * | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | magnetic recognition system |
| JP5408905B2 (ja) * | 2008-05-27 | 2014-02-05 | 義弘 石川 | 抗体又は抗原の定量方法 |
| CN103308373A (zh) * | 2013-06-05 | 2013-09-18 | 南昌大学 | 磁珠分离大肠杆菌o157的方法 |
| JP6745795B2 (ja) * | 2014-09-30 | 2020-08-26 | テナ バイオテック エッセ．エッレ．エッレ． | 融合タンパク質、前記融合タンパク質の複数のモノマーにより構成されるナノ粒子、およびその使用 |
| CN105842456A (zh) * | 2015-01-14 | 2016-08-10 | 北京康诺生物科技有限公司 | 一种乳铁蛋白定向免疫磁珠及其制备方法和用途 |
| KR20160094550A (ko) * | 2015-01-30 | 2016-08-10 | 동국대학교 산학협력단 | 단일사슬항체조각과 페리틴을 포함하는 융합단백질 및 그의 용도 |
| US20250075003A1 (en) * | 2021-05-07 | 2025-03-06 | Uif (University Industry Foundation), Yonsei University | Nanoparticles comprising fusion protein of single-chain variable fragment and ferritin, and use thereof |
| CN118556885B (zh) * | 2024-05-22 | 2025-10-03 | 江苏大学 | 一种低通量电磁吸附乳铁蛋白的高压静电喷雾干燥装置及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2656317C2 (de) * | 1976-12-11 | 1986-06-19 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur Herstellung einer Suspension von beladenen Erythrocyten |
| US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
| US5612019A (en) * | 1988-12-19 | 1997-03-18 | Gordon, Deceased; David | Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles |
| US5248589A (en) * | 1991-02-21 | 1993-09-28 | Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Separation of cells and biological macromolecules by ferritin conjugates |
| JPH05209884A (ja) * | 1991-10-11 | 1993-08-20 | Tdk Corp | 抗原、抗体検出方法 |
| US5491219A (en) * | 1993-06-11 | 1996-02-13 | Protein Magnetics | Ferritin with ferrimagnetically ordered ferrite core and method technical field |
| WO1995004753A1 (en) * | 1993-08-11 | 1995-02-16 | University Of New Mexico | Compositions of fusion proteins containing metallothionein and targeting-protein structural components |
| US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| DE69729154T2 (de) | 1996-03-27 | 2005-06-02 | Tdk Corp. | Feine magnetische partikel zur bindung nützlicher proteine, verfahren zu deren herstellung und anwendung |
| US6337215B1 (en) * | 1997-12-01 | 2002-01-08 | International Business Machines Corporation | Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules |
| US6251130B1 (en) * | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Device for applications of selective organ cooling |
| US7232691B2 (en) * | 2001-11-27 | 2007-06-19 | Los Alamos National Security, Llc | Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres |
| US7998704B2 (en) * | 2002-03-07 | 2011-08-16 | Carnegie Mellon University | Methods for magnetic resonance imaging |
| CN1659187A (zh) | 2002-05-10 | 2005-08-24 | 新世纪药品有限公司 | 融合铁蛋白在疫苗和其他方面的应用 |
| WO2004083902A2 (en) | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
| EP1608977B1 (en) * | 2003-04-02 | 2007-08-15 | Turun Yliopisto | Nanoparticle for bioaffinity assays |
| US6972095B1 (en) | 2003-05-07 | 2005-12-06 | Electric Power Research Institute | Magnetic molecules: a process utilizing functionalized magnetic ferritins for the selective removal of contaminants from solution by magnetic filtration |
| US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
| JP2006010529A (ja) * | 2004-06-25 | 2006-01-12 | Canon Inc | 磁性粒子分離装置および分離方法 |
| JP5053089B2 (ja) * | 2004-08-03 | 2012-10-17 | ベクトン・ディキンソン・アンド・カンパニー | 化合物の直接単離および多成分サンプルの分別のための磁性材料の使用 |
| WO2006104700A1 (en) | 2005-03-15 | 2006-10-05 | Tufts University | Magnetic protein nanosensors and methods of use |
| US20080093219A1 (en) * | 2005-03-15 | 2008-04-24 | Tufts University | Magnetic Protein Nanosensors and Methods of Use |
| US20060240456A1 (en) | 2005-03-22 | 2006-10-26 | Liaohai Chen | Nanosized biological container and manufacture thereof |
| US7164010B1 (en) * | 2005-09-28 | 2007-01-16 | Academia Sinica | Molecular magnetic protein |
| US20070258889A1 (en) * | 2005-11-09 | 2007-11-08 | Montana State University | Novel nanoparticles and use thereof |
| WO2007058454A1 (en) * | 2005-11-15 | 2007-05-24 | Cgk Co., Ltd. | System for detecting molecular interactions |
-
2006
- 2006-11-02 GB GBGB0621894.5A patent/GB0621894D0/en not_active Ceased
-
2007
- 2007-11-02 WO PCT/GB2007/004188 patent/WO2008053229A1/en not_active Ceased
- 2007-11-02 EP EP11182249A patent/EP2428799A1/en not_active Withdrawn
- 2007-11-02 CN CN200780041074.8A patent/CN101542287B/zh not_active Expired - Fee Related
- 2007-11-02 JP JP2009535125A patent/JP5453095B2/ja not_active Expired - Fee Related
- 2007-11-02 CA CA002668011A patent/CA2668011A1/en not_active Abandoned
- 2007-11-02 EP EP07824427A patent/EP2089714B1/en not_active Not-in-force
- 2007-11-02 US US12/513,348 patent/US20100159442A1/en not_active Abandoned
- 2007-11-02 RU RU2009120688/15A patent/RU2442169C2/ru not_active IP Right Cessation
- 2007-11-02 AU AU2007315904A patent/AU2007315904A1/en not_active Abandoned
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