JP2010508530A5 - - Google Patents
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- JP2010508530A5 JP2010508530A5 JP2009535125A JP2009535125A JP2010508530A5 JP 2010508530 A5 JP2010508530 A5 JP 2010508530A5 JP 2009535125 A JP2009535125 A JP 2009535125A JP 2009535125 A JP2009535125 A JP 2009535125A JP 2010508530 A5 JP2010508530 A5 JP 2010508530A5
- Authority
- JP
- Japan
- Prior art keywords
- label
- substance
- analyte
- binding
- magnetizable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000126 substance Substances 0.000 claims 35
- 239000012491 analyte Substances 0.000 claims 20
- 239000002184 metal Substances 0.000 claims 16
- 229910052751 metal Inorganic materials 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 102000014914 Carrier Proteins Human genes 0.000 claims 6
- 108091008324 binding proteins Proteins 0.000 claims 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 239000012678 infectious agent Substances 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- 102000008857 Ferritin Human genes 0.000 claims 3
- 108050000784 Ferritin Proteins 0.000 claims 3
- 238000008416 Ferritin Methods 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 210000003850 cellular structure Anatomy 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000000696 magnetic material Substances 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 229910052804 chromium Inorganic materials 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000003925 fat Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 235000014413 iron hydroxide Nutrition 0.000 claims 2
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229910052748 manganese Inorganic materials 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- 210000000605 viral structure Anatomy 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 102000000546 Apoferritins Human genes 0.000 claims 1
- 108010002084 Apoferritins Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 108050006416 Ferric binding proteins Proteins 0.000 claims 1
- 102000003869 Frataxin Human genes 0.000 claims 1
- 108090000217 Frataxin Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010063045 Lactoferrin Proteins 0.000 claims 1
- 102000010445 Lactoferrin Human genes 0.000 claims 1
- 239000000589 Siderophore Substances 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 229910052793 cadmium Inorganic materials 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 1
- 229940078795 lactoferrin Drugs 0.000 claims 1
- 235000021242 lactoferrin Nutrition 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0621894.5 | 2006-11-02 | ||
| GBGB0621894.5A GB0621894D0 (en) | 2006-11-02 | 2006-11-02 | Magnetic recognition system |
| PCT/GB2007/004188 WO2008053229A1 (en) | 2006-11-02 | 2007-11-02 | Magnetic recognition system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508530A JP2010508530A (ja) | 2010-03-18 |
| JP2010508530A5 true JP2010508530A5 (enExample) | 2010-12-16 |
| JP5453095B2 JP5453095B2 (ja) | 2014-03-26 |
Family
ID=37547250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535125A Expired - Fee Related JP5453095B2 (ja) | 2006-11-02 | 2007-11-02 | 磁気認識システム |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100159442A1 (enExample) |
| EP (2) | EP2089714B1 (enExample) |
| JP (1) | JP5453095B2 (enExample) |
| CN (1) | CN101542287B (enExample) |
| AU (1) | AU2007315904A1 (enExample) |
| CA (1) | CA2668011A1 (enExample) |
| GB (1) | GB0621894D0 (enExample) |
| RU (1) | RU2442169C2 (enExample) |
| WO (1) | WO2008053229A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808086D0 (en) * | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | Magnetic proteins for in vivo imaging |
| GB0808089D0 (en) * | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | magnetic recognition system |
| JP5408905B2 (ja) * | 2008-05-27 | 2014-02-05 | 義弘 石川 | 抗体又は抗原の定量方法 |
| CN103308373A (zh) * | 2013-06-05 | 2013-09-18 | 南昌大学 | 磁珠分离大肠杆菌o157的方法 |
| PT3186192T (pt) * | 2014-09-30 | 2018-04-09 | Thena Biotech S R L | Uma proteína de fusão, uma nanopartícula composta por uma pluralidade de monómeros da dita proteína de fusão e utilizações das mesmas |
| CN105842456A (zh) * | 2015-01-14 | 2016-08-10 | 北京康诺生物科技有限公司 | 一种乳铁蛋白定向免疫磁珠及其制备方法和用途 |
| KR20160094550A (ko) * | 2015-01-30 | 2016-08-10 | 동국대학교 산학협력단 | 단일사슬항체조각과 페리틴을 포함하는 융합단백질 및 그의 용도 |
| US20250075003A1 (en) * | 2021-05-07 | 2025-03-06 | Uif (University Industry Foundation), Yonsei University | Nanoparticles comprising fusion protein of single-chain variable fragment and ferritin, and use thereof |
| CN118556885B (zh) * | 2024-05-22 | 2025-10-03 | 江苏大学 | 一种低通量电磁吸附乳铁蛋白的高压静电喷雾干燥装置及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2656317C2 (de) * | 1976-12-11 | 1986-06-19 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur Herstellung einer Suspension von beladenen Erythrocyten |
| US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
| US5612019A (en) * | 1988-12-19 | 1997-03-18 | Gordon, Deceased; David | Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles |
| US5248589A (en) * | 1991-02-21 | 1993-09-28 | Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Separation of cells and biological macromolecules by ferritin conjugates |
| JPH05209884A (ja) * | 1991-10-11 | 1993-08-20 | Tdk Corp | 抗原、抗体検出方法 |
| US5491219A (en) * | 1993-06-11 | 1996-02-13 | Protein Magnetics | Ferritin with ferrimagnetically ordered ferrite core and method technical field |
| WO1995004753A1 (en) * | 1993-08-11 | 1995-02-16 | University Of New Mexico | Compositions of fusion proteins containing metallothionein and targeting-protein structural components |
| US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| WO1997035964A1 (en) | 1996-03-27 | 1997-10-02 | Tdk Corporation | Fine magnetic particles containing useful proteins bound thereto, process for producing the same, and use thereof |
| US6337215B1 (en) * | 1997-12-01 | 2002-01-08 | International Business Machines Corporation | Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules |
| US6251130B1 (en) * | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Device for applications of selective organ cooling |
| US7232691B2 (en) * | 2001-11-27 | 2007-06-19 | Los Alamos National Security, Llc | Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres |
| US7998704B2 (en) * | 2002-03-07 | 2011-08-16 | Carnegie Mellon University | Methods for magnetic resonance imaging |
| CN1659187A (zh) * | 2002-05-10 | 2005-08-24 | 新世纪药品有限公司 | 融合铁蛋白在疫苗和其他方面的应用 |
| WO2004083902A2 (en) | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
| WO2004088313A1 (en) * | 2003-04-02 | 2004-10-14 | Tero Soukka | Nanoparticle for bioaffinity assays |
| US6972095B1 (en) | 2003-05-07 | 2005-12-06 | Electric Power Research Institute | Magnetic molecules: a process utilizing functionalized magnetic ferritins for the selective removal of contaminants from solution by magnetic filtration |
| US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
| JP2006010529A (ja) * | 2004-06-25 | 2006-01-12 | Canon Inc | 磁性粒子分離装置および分離方法 |
| WO2006017428A2 (en) | 2004-08-03 | 2006-02-16 | Becton, Dickinson And Company | Use of magnetic material to direct isolation of compounds and fractionation of multipart samples |
| US20080093219A1 (en) * | 2005-03-15 | 2008-04-24 | Tufts University | Magnetic Protein Nanosensors and Methods of Use |
| WO2006104700A1 (en) | 2005-03-15 | 2006-10-05 | Tufts University | Magnetic protein nanosensors and methods of use |
| US20060240456A1 (en) | 2005-03-22 | 2006-10-26 | Liaohai Chen | Nanosized biological container and manufacture thereof |
| US7164010B1 (en) * | 2005-09-28 | 2007-01-16 | Academia Sinica | Molecular magnetic protein |
| WO2008048288A2 (en) * | 2005-11-09 | 2008-04-24 | Montana State University | Novel nanoparticles and use thereof |
| WO2007058454A1 (en) * | 2005-11-15 | 2007-05-24 | Cgk Co., Ltd. | System for detecting molecular interactions |
-
2006
- 2006-11-02 GB GBGB0621894.5A patent/GB0621894D0/en not_active Ceased
-
2007
- 2007-11-02 US US12/513,348 patent/US20100159442A1/en not_active Abandoned
- 2007-11-02 AU AU2007315904A patent/AU2007315904A1/en not_active Abandoned
- 2007-11-02 CA CA002668011A patent/CA2668011A1/en not_active Abandoned
- 2007-11-02 EP EP07824427A patent/EP2089714B1/en not_active Not-in-force
- 2007-11-02 CN CN200780041074.8A patent/CN101542287B/zh not_active Expired - Fee Related
- 2007-11-02 JP JP2009535125A patent/JP5453095B2/ja not_active Expired - Fee Related
- 2007-11-02 WO PCT/GB2007/004188 patent/WO2008053229A1/en not_active Ceased
- 2007-11-02 EP EP11182249A patent/EP2428799A1/en not_active Withdrawn
- 2007-11-02 RU RU2009120688/15A patent/RU2442169C2/ru not_active IP Right Cessation
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