JP2010508024A5 - - Google Patents
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- JP2010508024A5 JP2010508024A5 JP2009534809A JP2009534809A JP2010508024A5 JP 2010508024 A5 JP2010508024 A5 JP 2010508024A5 JP 2009534809 A JP2009534809 A JP 2009534809A JP 2009534809 A JP2009534809 A JP 2009534809A JP 2010508024 A5 JP2010508024 A5 JP 2010508024A5
- Authority
- JP
- Japan
- Prior art keywords
- mass spectrum
- oligonucleotide
- subset
- mass
- peak
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 39
- 238000001819 mass spectrum Methods 0.000 claims 30
- 238000000034 method Methods 0.000 claims 22
- 239000000470 constituent Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- 239000000463 material Substances 0.000 claims 8
- 238000005259 measurement Methods 0.000 claims 6
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 claims 4
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 4
- 238000000132 electrospray ionisation Methods 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 2
- 239000004566 building material Substances 0.000 claims 2
- 238000005040 ion trap Methods 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 claims 2
- 238000005173 quadrupole mass spectroscopy Methods 0.000 claims 2
- 238000001269 time-of-flight mass spectrometry Methods 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86306306P | 2006-10-26 | 2006-10-26 | |
| PCT/US2007/082197 WO2008070314A2 (en) | 2006-10-26 | 2007-10-23 | Fingerprint analysis for a plurality of oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508024A JP2010508024A (ja) | 2010-03-18 |
| JP2010508024A5 true JP2010508024A5 (https=) | 2010-12-16 |
Family
ID=39492927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534809A Pending JP2010508024A (ja) | 2006-10-26 | 2007-10-23 | 複数のオリゴヌクレオチド用のフィンガープリント分析 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7604998B2 (https=) |
| EP (1) | EP2089706A4 (https=) |
| JP (1) | JP2010508024A (https=) |
| AU (1) | AU2007329729A1 (https=) |
| CA (1) | CA2667374A1 (https=) |
| WO (1) | WO2008070314A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010508024A (ja) * | 2006-10-26 | 2010-03-18 | インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド | 複数のオリゴヌクレオチド用のフィンガープリント分析 |
| WO2011137368A2 (en) | 2010-04-30 | 2011-11-03 | Life Technologies Corporation | Systems and methods for analyzing nucleic acid sequences |
| US9268903B2 (en) | 2010-07-06 | 2016-02-23 | Life Technologies Corporation | Systems and methods for sequence data alignment quality assessment |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6002127A (en) * | 1995-05-19 | 1999-12-14 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| IT1295226B1 (it) * | 1997-10-14 | 1999-05-04 | Magneti Marelli Spa | Impianto per la produzione di manufatti pressocolati o stampati ad iniezione impiegando anime in sale. |
| US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6306643B1 (en) * | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
| US6613509B1 (en) * | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| US20040126772A1 (en) * | 2001-12-06 | 2004-07-01 | Yoshihide Hayashizaki | Method for maldi-tof-ms analysis and/or sequencing of oligonucleotides |
| DE10305612B4 (de) * | 2003-02-11 | 2005-04-07 | Ashland-Südchemie-Kernfest GmbH | Beschichtungsmassen für Gusskerne |
| DE10359547B3 (de) * | 2003-12-17 | 2005-03-03 | Emil Müller GmbH | Wasserlösliche Salzkerne |
| US20070207555A1 (en) * | 2005-02-03 | 2007-09-06 | Cesar Guerra | Ultra-sensitive detection systems using multidimension signals |
| US7783429B2 (en) * | 2005-02-18 | 2010-08-24 | Charite'-Universitatsmedizin Berlin | Peptide sequencing from peptide fragmentation mass spectra |
| JP2010508024A (ja) * | 2006-10-26 | 2010-03-18 | インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド | 複数のオリゴヌクレオチド用のフィンガープリント分析 |
-
2007
- 2007-10-23 JP JP2009534809A patent/JP2010508024A/ja active Pending
- 2007-10-23 EP EP07871211A patent/EP2089706A4/en not_active Withdrawn
- 2007-10-23 CA CA002667374A patent/CA2667374A1/en not_active Abandoned
- 2007-10-23 WO PCT/US2007/082197 patent/WO2008070314A2/en not_active Ceased
- 2007-10-23 US US11/876,960 patent/US7604998B2/en active Active
- 2007-10-23 AU AU2007329729A patent/AU2007329729A1/en not_active Abandoned
-
2009
- 2009-09-10 US US12/557,095 patent/US7855080B2/en not_active Expired - Fee Related
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