JP2010506871A5 - - Google Patents

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Publication number
JP2010506871A5
JP2010506871A5 JP2009532732A JP2009532732A JP2010506871A5 JP 2010506871 A5 JP2010506871 A5 JP 2010506871A5 JP 2009532732 A JP2009532732 A JP 2009532732A JP 2009532732 A JP2009532732 A JP 2009532732A JP 2010506871 A5 JP2010506871 A5 JP 2010506871A5
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JP
Japan
Prior art keywords
rspondin
polypeptide
agent
modulator
angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009532732A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010506871A (ja
JP5777281B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/009105 external-priority patent/WO2008046649A1/en
Publication of JP2010506871A publication Critical patent/JP2010506871A/ja
Publication of JP2010506871A5 publication Critical patent/JP2010506871A5/ja
Application granted granted Critical
Publication of JP5777281B2 publication Critical patent/JP5777281B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009532732A 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン Expired - Fee Related JP5777281B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06022070 2006-10-20
EP06022070.4 2006-10-20
PCT/EP2007/009105 WO2008046649A1 (en) 2006-10-20 2007-10-19 Rspondins as modulators of angiogenesis and vasculogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013247353A Division JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Publications (3)

Publication Number Publication Date
JP2010506871A JP2010506871A (ja) 2010-03-04
JP2010506871A5 true JP2010506871A5 (enExample) 2010-11-25
JP5777281B2 JP5777281B2 (ja) 2015-09-09

Family

ID=39149425

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009532732A Expired - Fee Related JP5777281B2 (ja) 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン
JP2013247353A Expired - Fee Related JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013247353A Expired - Fee Related JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Country Status (13)

Country Link
US (6) US8088374B2 (enExample)
EP (2) EP2081586B2 (enExample)
JP (2) JP5777281B2 (enExample)
AU (1) AU2007312538B2 (enExample)
CA (1) CA2664828A1 (enExample)
DK (1) DK2081586T4 (enExample)
ES (1) ES2564794T5 (enExample)
HK (1) HK1222799A1 (enExample)
HU (1) HUE027179T2 (enExample)
MX (1) MX2009003726A (enExample)
PL (1) PL2081586T5 (enExample)
SI (1) SI2081586T2 (enExample)
WO (1) WO2008046649A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2157192T3 (pl) 2003-10-10 2014-01-31 Deutsches Krebsforsch Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin)
WO2008046649A1 (en) * 2006-10-20 2008-04-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Rspondins as modulators of angiogenesis and vasculogenesis
EP2173379B2 (en) 2007-07-02 2023-07-05 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
EP2393917B1 (en) 2009-02-03 2016-04-06 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells.
US20120039912A1 (en) * 2009-04-15 2012-02-16 Galapagos Sasu Rspondin-3 inhibition in bone disorders
WO2011076932A1 (en) * 2009-12-23 2011-06-30 Deutsches Krebsforschungszentrum Receptors of rspo2 and rspo3
JP6185463B2 (ja) * 2011-07-15 2017-08-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｒｓｐｏ結合剤およびその使用法
AU2013204484B2 (en) * 2011-07-15 2016-05-12 Oncomed Pharmaceuticals, Inc. RSPO binding agents and uses thereof
JP6357419B2 (ja) * 2011-12-14 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 卵胞発育および卵成熟の刺激
KR102148303B1 (ko) * 2012-02-11 2020-08-26 제넨테크, 인크. R-스폰딘 전위 및 그의 사용 방법
US9181333B2 (en) * 2012-07-13 2015-11-10 Oncomed Pharmaceuticals, Inc. RSPO3 binding agents and uses thereof
BR112016008477A2 (pt) * 2013-10-18 2017-10-03 Genentech Inc Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo
CA2949171A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
CA2961374A1 (en) 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
EP3865511A1 (en) 2016-04-14 2021-08-18 F. Hoffmann-La Roche AG Anti-rspo3 antibodies and methods of use
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
KR102531265B1 (ko) * 2019-10-24 2023-05-12 가톨릭대학교 산학협력단 Rspo3 억제제를 포함하는 심장 판막 질환의 예방 또는 치료용 조성물
US20230241161A1 (en) * 2020-01-10 2023-08-03 Inserm (Institutnationaldelasanteetdelarecherchemedicale) Rspo1 proteins and their use
WO2022020544A1 (en) * 2020-07-23 2022-01-27 The Board Of Trustees Of The University Of Illinois Method of treating an inflammatory condition

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO2003094843A2 (en) 2002-05-10 2003-11-20 Incyte Corporation Cell adhesion and extracellular matrix proteins
EP0971954A2 (en) 1997-03-19 2000-01-19 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU7159898A (en) 1997-04-25 1998-11-24 Genetics Institute Inc. Secreted proteins and polynucleotides encoding them
US20020065394A1 (en) 1998-03-18 2002-05-30 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
GB9828419D0 (en) 1998-12-23 1999-02-17 Smithkline Beecham Plc Novel compounds
JP2003505082A (ja) 1999-07-26 2003-02-12 ジェネンテック・インコーポレーテッド 新規なポリヌクレオチドとその使用法
AU6181000A (en) 1999-07-29 2001-02-19 Chugai Research Institute For Molecular Medicine, Inc. Novel genes encoding protein kinase/protein phosphatase
US6824973B2 (en) 2000-02-03 2004-11-30 Kirin Beer Kabushiki Kaisha Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide
US6653448B1 (en) 2000-03-29 2003-11-25 Curagen Corporation Wnt-7B-like polypeptides and nucleic acids encoding same
CA2405104A1 (en) 2000-04-05 2001-10-18 Kirin Beer Kabushiki Kaisha Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
US20030022255A1 (en) 2000-12-22 2003-01-30 Morris David W. Novel compositions and methods for breast cancer
US20040077048A1 (en) 2002-01-30 2004-04-22 Warren Bridget A. Protein modification and maintenance molecules
JP2005503108A (ja) 2001-01-31 2005-02-03 インサイト・ゲノミックス・インコーポレイテッド タンパク質修飾およびメンテナンス分子
US7411052B2 (en) 2001-03-05 2008-08-12 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
US20030032034A1 (en) * 2001-03-05 2003-02-13 Tang Y. Tom Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
WO2002097032A2 (en) 2001-04-06 2002-12-05 Incyte Genomics, Inc. Proteins associated with cell growth, differentiation, and death
EP1395610A2 (en) 2001-06-11 2004-03-10 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same
US20030022217A1 (en) 2001-07-02 2003-01-30 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
AU2002332454A1 (en) 2001-08-03 2003-04-07 Incyte Genomics, Inc. Cell adhesion and extracellular matrix proteins
CA2458818A1 (en) 2001-08-30 2003-04-10 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
WO2003025142A2 (en) 2001-09-16 2003-03-27 Nuvelo, Inc. Novel nucleic acids and secreted polypeptides
EP1499637A1 (en) 2002-04-26 2005-01-26 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
CA2500521A1 (en) 2002-10-02 2004-09-23 Nuvelo, Inc. Novel nucleic acids and polypeptides
WO2004099408A1 (ja) 2003-05-09 2004-11-18 Research Association For Biotechnology 新規蛋白質およびそれをコードするｄｎａ
WO2005110009A2 (en) † 2003-07-22 2005-11-24 Immunex Corporation COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d
PL2157192T3 (pl) 2003-10-10 2014-01-31 Deutsches Krebsforsch Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin)
EP1713900A4 (en) 2004-01-27 2009-06-17 Compugen Ltd METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES
US7439327B2 (en) 2005-01-18 2008-10-21 Nuvelo, Inc. Stem cell factor-like proteins and uses thereof
EP1917022A2 (en) 2005-07-26 2008-05-07 Kirin Pharma Kabushiki Kaisha Anti-tumor agents comprising r-spondins
US7541431B2 (en) 2005-09-07 2009-06-02 Maine Medical Center Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
WO2007100357A2 (en) 2005-10-07 2007-09-07 Nuvelo, Inc. Stem cell factor-like protein scfa1 and uses thereof
JP2008044926A (ja) * 2006-08-14 2008-02-28 Trustees Of Columbia Univ In The City Of New York Ｗｎｔ信号伝達に関係した分泌タンパク質
WO2008046649A1 (en) † 2006-10-20 2008-04-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Rspondins as modulators of angiogenesis and vasculogenesis
EP2173379B2 (en) 2007-07-02 2023-07-05 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
JP6185463B2 (ja) 2011-07-15 2017-08-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｒｓｐｏ結合剤およびその使用法

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