JP2010506871A5 - - Google Patents

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Publication number
JP2010506871A5
JP2010506871A5 JP2009532732A JP2009532732A JP2010506871A5 JP 2010506871 A5 JP2010506871 A5 JP 2010506871A5 JP 2009532732 A JP2009532732 A JP 2009532732A JP 2009532732 A JP2009532732 A JP 2009532732A JP 2010506871 A5 JP2010506871 A5 JP 2010506871A5
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JP
Japan
Prior art keywords
rspondin
polypeptide
agent
modulator
angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009532732A
Other languages
English (en)
Japanese (ja)
Other versions
JP5777281B2 (ja
JP2010506871A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/009105 external-priority patent/WO2008046649A1/en
Publication of JP2010506871A publication Critical patent/JP2010506871A/ja
Publication of JP2010506871A5 publication Critical patent/JP2010506871A5/ja
Application granted granted Critical
Publication of JP5777281B2 publication Critical patent/JP5777281B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009532732A 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン Expired - Fee Related JP5777281B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06022070.4 2006-10-20
EP06022070 2006-10-20
PCT/EP2007/009105 WO2008046649A1 (en) 2006-10-20 2007-10-19 Rspondins as modulators of angiogenesis and vasculogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013247353A Division JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Publications (3)

Publication Number Publication Date
JP2010506871A JP2010506871A (ja) 2010-03-04
JP2010506871A5 true JP2010506871A5 (enExample) 2010-11-25
JP5777281B2 JP5777281B2 (ja) 2015-09-09

Family

ID=39149425

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009532732A Expired - Fee Related JP5777281B2 (ja) 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン
JP2013247353A Expired - Fee Related JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013247353A Expired - Fee Related JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

Country Status (13)

Country Link
US (6) US8088374B2 (enExample)
EP (2) EP2997975A1 (enExample)
JP (2) JP5777281B2 (enExample)
AU (1) AU2007312538B2 (enExample)
CA (1) CA2664828A1 (enExample)
DK (1) DK2081586T4 (enExample)
ES (1) ES2564794T5 (enExample)
HK (1) HK1222799A1 (enExample)
HU (1) HUE027179T2 (enExample)
MX (1) MX2009003726A (enExample)
PL (1) PL2081586T5 (enExample)
SI (1) SI2081586T2 (enExample)
WO (1) WO2008046649A1 (enExample)

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EP2093298A3 (en) 2003-10-10 2009-09-23 Deutsches Krebsforschungszentrum Compositions for diagnosis and therapy of diseases associated with aberrant expression of Futrins (R-Spondins)
MX2009003726A (es) † 2006-10-20 2009-04-22 Deutsches Krebsforsch R-espondinas como moduladores de la angiogenesis y vasculogenesis.
HUE027154T2 (en) 2007-07-02 2016-08-29 Oncomed Pharm Inc Preparations and procedures for the treatment and diagnosis of cancer
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
HUE062459T2 (hu) 2009-02-03 2023-11-28 Koninklijke Nederlandse Akademie Van Wetenschappen Tenyésztõközeg epiteliális õssejtek és az epiteliális õssejteket tartalmazó organoidok részére
EP2419133A1 (en) * 2009-04-15 2012-02-22 Deutsches Krebsforschungszentrum Rspondin-3 inhibition in bone disorders
WO2011076932A1 (en) * 2009-12-23 2011-06-30 Deutsches Krebsforschungszentrum Receptors of rspo2 and rspo3
AU2013204484B2 (en) * 2011-07-15 2016-05-12 Oncomed Pharmaceuticals, Inc. RSPO binding agents and uses thereof
EP2731625B1 (en) * 2011-07-15 2018-04-18 OncoMed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
CA2894479A1 (en) * 2011-12-14 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Stimulation of ovarian follicle development and oocyte maturation
RU2014133069A (ru) * 2012-02-11 2016-04-10 Дженентек, Инк. Транслокации r-спондина и способы с их использованием
AU2013289990B2 (en) * 2012-07-13 2018-06-14 Oncomed Pharmaceuticals, Inc. RSPO3 binding agents and uses thereof
BR112016008477A2 (pt) 2013-10-18 2017-10-03 Genentech Inc Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo
WO2015173425A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
JP2017528523A (ja) 2014-09-16 2017-09-28 オンコメッド ファーマシューティカルズ インコーポレイテッド 線維性疾患の治療
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
EP3443004A1 (en) 2016-04-14 2019-02-20 H. Hoffnabb-La Roche Ag Anti-rspo3 antibodies and methods of use
WO2021080396A1 (ko) * 2019-10-24 2021-04-29 가톨릭대학교 산학협력단 Rspo3 억제제를 포함하는 심장 판막 질환의 예방 또는 치료용 조성물
IL294571A (en) * 2020-01-10 2022-09-01 Inst Nat Sante Rech Med rspo1 proteins and their uses
WO2022020544A1 (en) * 2020-07-23 2022-01-27 The Board Of Trustees Of The University Of Illinois Method of treating an inflammatory condition

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MX2009003726A (es) * 2006-10-20 2009-04-22 Deutsches Krebsforsch R-espondinas como moduladores de la angiogenesis y vasculogenesis.
HUE027154T2 (en) 2007-07-02 2016-08-29 Oncomed Pharm Inc Preparations and procedures for the treatment and diagnosis of cancer
EP2731625B1 (en) 2011-07-15 2018-04-18 OncoMed Pharmaceuticals, Inc. Rspo binding agents and uses thereof

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