JP2010505827A5 - - Google Patents

Info

Publication number

JP2010505827A5

JP2010505827A5 JP2009531388A JP2009531388A JP2010505827A5 JP 2010505827 A5 JP2010505827 A5 JP 2010505827A5 JP 2009531388 A JP2009531388 A JP 2009531388A JP 2009531388 A JP2009531388 A JP 2009531388A JP 2010505827 A5 JP2010505827 A5 JP 2010505827A5

Authority

JP

Japan

Prior art keywords

azithromycin

acne

administered

medicament

agent

Prior art date

2007-09-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 206010000496 acne Diseases 0.000 claims description 24
• 208000002874 Acne Vulgaris Diseases 0.000 claims description 23
• 238000011282 treatment Methods 0.000 claims description 15
• 229960004099 azithromycin Drugs 0.000 claims description 13
• MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 13
• 239000003814 drug Substances 0.000 claims description 13
• 238000002560 therapeutic procedure Methods 0.000 claims description 3
• 239000003795 chemical substances by application Substances 0.000 claims 6
• HQUPLSLYZHKKQT-WVVFQGGUSA-N (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-o Chemical compound O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 HQUPLSLYZHKKQT-WVVFQGGUSA-N 0.000 claims 1
• VQEMDSRIOVZAOM-UHFFFAOYSA-N 4-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(N)=N1 VQEMDSRIOVZAOM-UHFFFAOYSA-N 0.000 claims 1
• 229960004924 azithromycin dihydrate Drugs 0.000 claims 1
• 229960003256 azithromycin monohydrate Drugs 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000002045 lasting effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000007910 systemic administration Methods 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 description 2
• 241001303601 Rosacea Species 0.000 description 2
• 230000003115 biocidal effect Effects 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 229960005280 isotretinoin Drugs 0.000 description 2
• 201000004700 rosacea Diseases 0.000 description 2
• 208000030507 AIDS Diseases 0.000 description 1
• 206010000503 Acne cystic Diseases 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 230000009897 systematic effect Effects 0.000 description 1
• 229940072172 tetracycline antibiotic Drugs 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1