JP2010501263A - 閉塞装置及び当該閉塞装置の使用法 - Google Patents
閉塞装置及び当該閉塞装置の使用法 Download PDFInfo
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
ム102は、変形でき、次に変形させる力が除去された後に変形前の形状を復元できる弾性材料から形成され得る。さらに、フレーム102は、フレーム102の実施形態が、バルーンカテーテルの使用を通じて径方向に拡張可能である形態を有し得る。
び混合物;ポリジオキサノン;ポリプロピレンフマル酸エステル;ポリデプシペプチド;ポリカプロラクトン;ポリ(D,L−ラクチド−コ−カプロラクトン)及びポリカプロラクトン−コ−アクリル酸ブチルのようなそれらの共重合体及び混合物;ポリヒドロキシブチレート;バレレート及びブレンド;チロシン誘導体ポリカーボネート及びアリレート;ポリイミノカーボネート(polyiminocaronates)及びポリジメチル−トリメチルカーボネートのようなカーボネート;シアノアクリレート;リン酸カルシウム;ポリグリコース−アミノグリカン;多糖類(ヒアルロン酸,セルロース及びヒドロキシプロピルメチルセルロース,ゼラチン,スターチ,デキストラン,アルギナート及びそれらの誘導体を含む);タンパク質及びポリペプチドのような巨大分子;また先のもののうちのいずれかの混合物及び共重合体を含んでいるが、これらに制限されない。
アンカー部材112がフレーム102の残りの部分の表面に対して起立位置に折り畳まれ、又は曲げられることを可能にするように、フレーム102から一体化して形成される。このような実施形態では、アンカー部材112は、レーザー切断、エッチング、又は打ち抜き加工等によって、一体的にフレーム102から形成され、次に、外向きに塑性変形され得る。さらに、第一の表面104又は第二の表面106上のいずれか一方のアンカー部材112は、フレームが第一の形態から第二の形態に拡張されるとき、アンカー部材がフレーム102の残りの部分の表面から遠ざかるように突出するように、フレーム102から一体化して形成できる。
材料は、ペプチド、ポリペプチドとタンパク質、オリゴヌクレオチド、(裸の相補的なDNA(naked and cDNA)を含む)二本又は一本鎖DNAのような核酸、RNA、アンチセンスのDNA及びRNAのようなアンチセンスの核酸、小さなインターフェアレンスRNA(siRNA)及びリボザイムス(riobozymes)、遺伝子、炭水化物、生長因子を含む脈管形成ファクター、細胞周期阻害剤、また反再狭窄因子を含んでいるが、これらに制限されない。
区分222から延びる。
ーム302を拡張するためにフレーム302の管腔内に充填可能なバルーン内に注入できる。充填可能なバルーンは、化学的接着、粘着剤、縫合、ステープル等を使用して、フレーム302に取り付けできる。
図4は、本願による送達装置438の例示である。ここに論じられるように、装置400は、フレーム402の材料に依存するいくつかの異なる方法で移植できる。この実施形態では、フレーム402は、ここに論じられるように、第二の形態に形成できるとともに、送達のために第一の形態に弾性変形できる、弾性変形可能な材料から作られる。装置400を移植するために、送達装置438は、装置400を第一の形態と第一の内側チューブ状本体442と第二の内側チューブ状本体444との中に保持するような外側チューブ状本体440を含むカテーテルである。送達装置438は、外側チューブ状本体440が引き抜かれる一方、第一の内側チューブ状本体442が人体経路の内部の適当な位置にフレーム402を保持できる場合、人体経路の内部へ押し進めることができる。外側チューブ状本体440が除去され、圧縮力がもはやフレーム402上に生じないときに、フレーム402は、第一の形態から第二の形態に拡張でき、且つアンカー部材412は、フレーム402を人体経路の内部へ固定できる。
02を人体経路の内部へ固定できる。
の材料から構築できる。
ることを含む。次に、装置500のフレーム502は、プラグ部分514を形成するためにフレーム502の一部を軸線方向に崩壊させるように圧縮できる。その後、装置500の第二の拡張可能なリング548は、装置500のプラグ部分514で人体経路を通る血液の流れを閉塞するために、第二の拡張可能なリング548を人体経路内へ固定するように拡張できる。ここに論じられるように、送達カテーテルは、別々に除去することができる複数の個別のシースを備えることができ、又は、第一の拡張可能なリング546及び第二の拡張可能なリング548を別々に拡張できるように別々に膨張できる複数のバルーンを備えることができる。
図7は、本願による送達装置738の実施形態の例示である。送達装置738は、外部チューブ状本体740と第一の内部チューブ状本体742と内側のチューブ状本体766とを含んでいる。外部チューブ状本体740、第一の内部チューブ状本体742及び内側チューブ状本体766は、それらが互いに対して長手方向に移動でき及び/又は、互いに対して回転できるように形成できる。一実施形態では、ここに論じられるように、装置700は、弾力的に変形可能な材料から作られるフレーム702を有している。この実施形態では、第一の拡張可能なリング746は、外部チューブ状本体740の内部で圧縮され、第二の拡張可能なリング748は第一の内部チューブ状本体742の内部で圧縮される。第一の内部チューブ状本体742が第一の拡張可能なリング746に当接する一方、内側のチューブ状本体766が第二の拡張可能なリング748に当接する。送達装置738は、この送達装置738が人体経路の内部に存在するように押し進められる。外部チュー
ブ状本体740は、第一の拡張可能なリング746から取り除かれる一方、第一の内部チューブ状本体742が適切な位置に第一の拡張可能なリング746を保持している。一旦外部チューブ状本体740が除去されると、第一の拡張可能なリング746は第二の形態に拡張することができ、アンカー部材712は、第一の拡張可能なリング746を固定させるように人体経路の組織と係合できる。次に、第一の内部チューブ状本体742をねじることによりトルクが第二の拡張可能なリング748に付与できる。複数の繊維750が撚り合うとき、プラグ部分714は形成できる。一旦プラグ部分714が形成されると、第一の内部チューブ状本体742と外部チューブ状本体740とは、第二の拡張可能なリング748を解放するように収縮される一方、内側のチューブ状本体766が適切な位置に第二の拡張可能なリング748を保持する。一旦、外部チューブ状本体740と第一の内部チューブ状本体742とが取り除かれると、第二の拡張可能なリング748は第二の形態に拡張でき、アンカー部材712は、第二の拡張可能なリング746を固定させるように人体経路の組織と係合できる。
Claims (20)
- 第一の形態から該第一の形態より大きな第二の形態に拡張する、管腔を形成するフレームと、
前記第二の形態となっている間に前記フレームを固定するために該フレームから延びるアンカー部材と、
前記管腔の少なくとも一部を閉塞する前記フレームのプラグ部分と、
を備える装置。 - 前記フレームが、第一の拡張可能なリングと第二の拡張可能なリングとを含み、複数の繊維が前記両リングの間に延び、
前記複数の繊維は、前記管腔の少なくとも一部を閉塞するように前記プラグ部分を形成する、請求項1に記載の装置。 - 前記複数の繊維は織られている、請求項2に記載の装置。
- 前記複数の繊維は織られていない、請求項2に記載の装置。
- 前記複数の繊維が、前記プラグ部分を提供するように撚り合わせ可能である、請求項2に記載の装置。
- 前記複数の繊維が、前記プラグ部分を提供するために崩壊可能である、請求項2に記載の装置。
- 前記第一の拡張可能なリングと前記第二の拡張可能なリングとは、前記第一の拡張可能なリングと前記第二の拡張可能なリングとが自己拡張性を有することを可能にする材料から形成される、請求項2に記載の装置。
- 内部バルーンカテーテルと外部バルーンカテーテルとをさらに含み、
前記内部バルーンカテーテルは、同内部バルーンカテーテルの遠位端において内部バルーンカテーテルに隣接して配置された第一の拡張可能なバルーンに液密的に接続された膨張管腔を備え、
前記外部バルーンカテーテルは、同外部バルーンカテーテルの遠位端において外部バルーンカテーテルに隣接して配置された第二の拡張可能なバルーンに液密的に接続された膨張管腔を備え、該外部バルーンカテーテルは、前記内部バルーンカテーテルが配置可能な管腔を有し、前記外部バルーンカテーテルと前記内部バルーンカテーテルとは、互いに対して長手方向及び径方向に移動可能なように構成され、
前記フレームは、前記第一の拡張可能なバルーンが膨張するのに伴い同第一の拡張可能なバルーンが前記第一の拡張可能なリングを拡張することを可能とするように、前記第一の拡張可能なバルーンと前記第二の拡張可能なバルーンとの上に配置され、
前記第二の拡張可能なリングをねじるように前記外部バルーンカテーテルにトルクを付与することによって、前記複数の繊維をコイル状に撚って、前記プラグ部分を形成し、前記第二の拡張可能なバルーンが膨張するのに伴い前記第二の拡張可能なリングを前記第一の形態から前記第二の形態に拡張する、請求項2に記載の装置。 - 外部チューブ状本体と第一の内部チューブ状本体と内側チューブ状本体をさらに含み、
前記外部チューブ状本体と前記第一の内部チューブ状本体と前記内側チューブ状本体とは、互いに対して長手方向に移動する及び/又は互いに対して回転するように構成され、
前記フレームの前記第一の拡張可能なリングは、前記外部チューブ状本体の内部で圧縮され、前記第二の拡張可能なリングは、前記第一の内部チューブ状本体の内部で圧縮され
、
前記第一の内部チューブ状本体が前記第一の拡張可能なリングに当接する場合には、前記内側チューブ状本体が前記第二の拡張可能なリングに当接する一方、
前記第一の拡張可能なリングが前記第二の形態に拡張することを可能とするように前記外部チューブ状本体が前記第一の拡張可能なリングから取り除かれる場合、前記複数の繊維でプラグ部分を形成するように前記第一の内部チューブ状本体をねじることにより、トルクが前記第二の拡張可能なリングに付与可能であるとともに、前記第一の内部チューブ状本体と前記外部チューブ状本体とが、前記第二の拡張可能なリングを解放して前記第二の形態に拡張させるように収縮可能である、請求項2に記載の装置。 - 前記プラグ部分が、前記フレームの内側の周囲に連結されたフィルタである、請求項1に記載の装置。
- 前記フレームが第一端部と第二端部と中央部とを含み、
前記第二の形態における前記第一端部と前記第二端部とが、第二の形態における前記中央部より大きな周囲を有する、請求項1から10の何れか1項に記載の装置。 - 前記プラグ部分が、架橋可能なポリマーからなり、前記フレームの内部に配置される、請求項1に記載の装置。
- 送達システムを提供するための送達カテーテルをさらに含む、請求項1から12の何れか1項に記載の装置。
- 前記装置が、前記フレームから延びる前記アンカー部材を含む第一の要素と前記プラグ部分を含む第二の要素とから形成され、
前記第一の要素が第二の要素と連結されている、請求項1に記載の装置。 - 第一の形態から該第一の形態より大きな第二の形態に拡張可能な、管腔を形成するフレームを形成するステップと、
前記フレームから延びるアンカー部材を形成するステップと、
前記フレームの前記管腔内に、管腔の少なくとも一部を閉塞可能なプラグ部分を提供するステップと、
を備える方法。 - 前記フレームを形成するステップが、
第一の拡張可能なリングと、第二の拡張可能なリングと、両リングの間を延びる複数の繊維とを提供するステップを含む、請求項15に記載の方法。 - 前記プラグ部分を提供するステップが、前記プラグ部分を形成するために前記複数の繊維を撚り合わせるステップをさらに含む、請求項16に記載の方法。
- 前記プラグ部分を提供するステップが、前記プラグ部分を形成するために前記複数の繊維を崩壊させるステップをさらに含む、請求項17に記載の方法。
- 前記プラグ部分を提供するステップが、前記プラグ部分を形成するために前記フレームの内側の周囲にフィルタを連結するステップをさらに含む、請求項15に記載の方法。
- 前記プラグ部分を提供するステップが、前記プラグ部分を形成するために架橋可能なポリマーを前記フレーム内へ注入するステップを含む、請求項15に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US11/509,135 US20080051830A1 (en) | 2006-08-24 | 2006-08-24 | Occluding device and method |
US11/509,135 | 2006-08-24 | ||
PCT/US2007/018781 WO2008024491A1 (en) | 2006-08-24 | 2007-08-24 | Occluding device and method |
Publications (3)
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JP2010501263A true JP2010501263A (ja) | 2010-01-21 |
JP2010501263A5 JP2010501263A5 (ja) | 2010-07-29 |
JP5079808B2 JP5079808B2 (ja) | 2012-11-21 |
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JP2009525650A Expired - Fee Related JP5079808B2 (ja) | 2006-08-24 | 2007-08-24 | 閉塞装置及び当該閉塞装置の製造方法 |
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US (1) | US20080051830A1 (ja) |
EP (1) | EP2068721B1 (ja) |
JP (1) | JP5079808B2 (ja) |
AT (1) | ATE514380T1 (ja) |
CA (1) | CA2661159A1 (ja) |
WO (1) | WO2008024491A1 (ja) |
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US20080051830A1 (en) | 2008-02-28 |
EP2068721B1 (en) | 2011-06-29 |
JP5079808B2 (ja) | 2012-11-21 |
WO2008024491A1 (en) | 2008-02-28 |
CA2661159A1 (en) | 2008-02-28 |
EP2068721A1 (en) | 2009-06-17 |
ATE514380T1 (de) | 2011-07-15 |
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