JP2010500406A - ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 - Google Patents

５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 Download PDF

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JP2010500406A
JP2010500406A JP2009524638A JP2009524638A JP2010500406A JP 2010500406 A JP2010500406 A JP 2010500406A JP 2009524638 A JP2009524638 A JP 2009524638A JP 2009524638 A JP2009524638 A JP 2009524638A JP 2010500406 A JP2010500406 A JP 2010500406A
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Japan
Prior art keywords
formula
crystalline
compound
salt
salt form
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JP2009524638A
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English (en)
Japanese (ja)
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JP2010500406A5 (cg-RX-API-DMAC10.html
Inventor
シャオミン チェン，
シャオ チェン，
チャンオー イン，
シャオヨン フー，
デイビッド ジェイ． ブライスン，
ロンツェ クアン，
ホ−ジェーン シュー，
スコット トルザスカ，
チー−ワ タン，
ビンセンツォ リオッタ，
ザハール シャバニ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
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Schering Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38895795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010500406(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2010500406A publication Critical patent/JP2010500406A/ja
Publication of JP2010500406A5 publication Critical patent/JP2010500406A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009524638A 2006-08-14 2007-08-10 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 Withdrawn JP2010500406A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83766106P 2006-08-14 2006-08-14
PCT/US2007/017848 WO2008021271A1 (en) 2006-08-14 2007-08-10 Salts of 5 - ( l ( s ) -amino - 2 - hydroxyethyl ) -n- [ ( 2, 4 -difluorophenyl) -methyl] - 2 - [ 8 -methoxy - 2 - (trifluoromethyl) - 5 - quinoline] - 4 - oxazolecarboxamide

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012137788A Division JP2012176989A (ja) 2006-08-14 2012-06-19 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩
JP2012247215A Division JP2013032394A (ja) 2006-08-14 2012-11-09 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩

Publications (2)

Publication Number Publication Date
JP2010500406A true JP2010500406A (ja) 2010-01-07
JP2010500406A5 JP2010500406A5 (cg-RX-API-DMAC10.html) 2012-08-09

Family

ID=38895795

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009524638A Withdrawn JP2010500406A (ja) 2006-08-14 2007-08-10 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩
JP2012137788A Withdrawn JP2012176989A (ja) 2006-08-14 2012-06-19 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩
JP2012247215A Pending JP2013032394A (ja) 2006-08-14 2012-11-09 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012137788A Withdrawn JP2012176989A (ja) 2006-08-14 2012-06-19 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩
JP2012247215A Pending JP2013032394A (ja) 2006-08-14 2012-11-09 ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩

Country Status (11)

Country Link
US (1) US7956189B2 (cg-RX-API-DMAC10.html)
EP (1) EP2069337A1 (cg-RX-API-DMAC10.html)
JP (3) JP2010500406A (cg-RX-API-DMAC10.html)
CN (1) CN101522671A (cg-RX-API-DMAC10.html)
AR (1) AR062373A1 (cg-RX-API-DMAC10.html)
CA (1) CA2660703A1 (cg-RX-API-DMAC10.html)
CL (1) CL2007002366A1 (cg-RX-API-DMAC10.html)
MX (1) MX2009001770A (cg-RX-API-DMAC10.html)
PE (1) PE20080424A1 (cg-RX-API-DMAC10.html)
TW (1) TW200819446A (cg-RX-API-DMAC10.html)
WO (1) WO2008021271A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015524400A (ja) * 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006249866B2 (en) 2005-05-26 2011-10-13 Aldeyra Therapeutics, Inc. Compositions and methods of treating retinal disease
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
CN111135171B (zh) 2013-01-23 2023-09-08 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
CN118724806A (zh) 2015-08-21 2024-10-01 奥尔德拉医疗公司 氘化化合物和其用途
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
CN112714762A (zh) * 2018-08-06 2021-04-27 奥尔德拉医疗公司 多晶型化合物及其用途
CN113784954A (zh) 2019-05-02 2021-12-10 奥尔德拉医疗公司 多晶型化合物和其用途
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116009A1 (en) * 2004-05-18 2005-12-08 Schering Corporation Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116009A1 (en) * 2004-05-18 2005-12-08 Schering Corporation Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6012020270; Ｃ．Ｇ．ＷＥＲＭＵＴＨ編、「最新　創薬化学　下巻」、株式会社テクノミック、平成１１年９月２５日、３４７-３４９，３５９-３６２，４５３ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015524400A (ja) * 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製

Also Published As

Publication number Publication date
CA2660703A1 (en) 2008-02-21
US7956189B2 (en) 2011-06-07
TW200819446A (en) 2008-05-01
EP2069337A1 (en) 2009-06-17
WO2008021271A1 (en) 2008-02-21
MX2009001770A (es) 2009-02-25
JP2012176989A (ja) 2012-09-13
JP2013032394A (ja) 2013-02-14
PE20080424A1 (es) 2008-04-28
US20080108818A1 (en) 2008-05-08
CL2007002366A1 (es) 2008-03-14
AR062373A1 (es) 2008-11-05
CN101522671A (zh) 2009-09-02

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