JP2010273672A5

JP2010273672A5 -

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Publication number: JP2010273672A5
Authority: JP; Japan
Prior art keywords: cysteine; serine; amino acid; histidine; glutamine
Prior art date: 2010-04-14
Legal status : Pending

Application number

JP2010093307A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010273672A (ja

Filing date

2010-04-14

Publication date

2013-05-23

2010-04-14 Application filed filed Critical

2010-04-14 Priority to JP2010093307A priority Critical patent/JP2010273672A/ja

2010-04-14 Priority claimed from JP2010093307A external-priority patent/JP2010273672A/ja

2010-04-26 Priority to US13/266,525 priority patent/US8778650B2/en

2010-04-26 Priority to PCT/JP2010/057838 priority patent/WO2010126156A2/en

2010-04-26 Priority to EP16163320.1A priority patent/EP3061817B1/en

2010-04-26 Priority to EP10719131A priority patent/EP2424981A2/en

2010-04-26 Priority to CN201080019156.4A priority patent/CN102421893B/zh

2010-04-26 Priority to DK16163320.1T priority patent/DK3061817T3/en

2010-12-09 Publication of JP2010273672A publication Critical patent/JP2010273672A/ja

2013-05-23 Publication of JP2010273672A5 publication Critical patent/JP2010273672A5/ja

Status Pending legal-status Critical Current

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MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 18
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 15
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 15
235000018417 cysteine Nutrition 0.000 claims 15
229960002433 cysteine Drugs 0.000 claims 15
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 15
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ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 12
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 12
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KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 12
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 12
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ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 12
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235000006109 methionine Nutrition 0.000 claims 9
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235000008521 threonine Nutrition 0.000 claims 9
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235000014393 valine Nutrition 0.000 claims 9
229960004295 valine Drugs 0.000 claims 9
239000004474 valine Substances 0.000 claims 9
150000001413 amino acids Chemical group 0.000 claims 8
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
239000004471 Glycine Substances 0.000 claims 6
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 6
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 6
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 6
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 6
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 6
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 6
125000000539 amino acid group Chemical group 0.000 claims 6
235000013922 glutamic acid Nutrition 0.000 claims 6
229960002989 glutamic acid Drugs 0.000 claims 6
239000004220 glutamic acid Substances 0.000 claims 6
229960002449 glycine Drugs 0.000 claims 6
235000014705 isoleucine Nutrition 0.000 claims 6
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AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 6
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COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 6
229960004799 tryptophan Drugs 0.000 claims 6
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OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 6
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
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235000003704 aspartic acid Nutrition 0.000 claims 3
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OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
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239000003599 detergent Substances 0.000 claims 2
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108090000623 proteins and genes Proteins 0.000 claims 2
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238000000034 method Methods 0.000 claims 1
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JP2010093307A 2009-04-30 2010-04-14 アルカリプロテアーゼ変異体 Pending JP2010273672A (ja)