JP2010248206A5 - - Google Patents
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- JP2010248206A5 JP2010248206A5 JP2010128713A JP2010128713A JP2010248206A5 JP 2010248206 A5 JP2010248206 A5 JP 2010248206A5 JP 2010128713 A JP2010128713 A JP 2010128713A JP 2010128713 A JP2010128713 A JP 2010128713A JP 2010248206 A5 JP2010248206 A5 JP 2010248206A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- formulation
- weight
- density
- aerosol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (5)
- 一種またはそれ以上の膜形成性リン脂質と少なくとも一種の界面活性剤で被覆され、1,1,1,2-テトラフルオロエタン(HFA 134a)または1,1,1,2,3,3,3-ヘプタフルオロプロパン(HFA 227)プロペラント中に分散されている平均粒度範囲0.1〜10ミクロンの薬物微結晶から本質的に構成され、
被覆した薬物微結晶の密度がプロペラントの密度と実質的に同じであり、
薬物微結晶上の被覆の量が薬物の重量を基準に0.1%を超え200%未満である、1.0〜1.5g/mlの密度を有する乾燥懸濁物エーロゾル製剤。 - プロペラントが製剤の少なくとも70重量%の割合を占める請求項1に記載のエーロゾル製剤。
- 薬物が製剤の5重量%未満の割合を占める請求項1又は2に記載のエーロゾル製剤。
- 界面活性剤に対するリン脂質の重量比が0.04〜25の範囲である請求項1〜3のいずれかに記載のエーロゾル製剤。
- リン脂質が製剤の20重量%未満の割合を占める請求項1に記載のエーロゾル。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/016,265 US6086376A (en) | 1998-01-30 | 1998-01-30 | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000529227A Division JP2002501885A (ja) | 1998-01-30 | 1998-12-30 | 微粒子吸入用製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010248206A JP2010248206A (ja) | 2010-11-04 |
JP2010248206A5 true JP2010248206A5 (ja) | 2012-11-15 |
Family
ID=21776235
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000529227A Withdrawn JP2002501885A (ja) | 1998-01-30 | 1998-12-30 | 微粒子吸入用製剤 |
JP2010128713A Pending JP2010248206A (ja) | 1998-01-30 | 2010-06-04 | 微粒子吸入用製剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000529227A Withdrawn JP2002501885A (ja) | 1998-01-30 | 1998-12-30 | 微粒子吸入用製剤 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6086376A (ja) |
EP (1) | EP1051154A1 (ja) |
JP (2) | JP2002501885A (ja) |
KR (1) | KR20010040402A (ja) |
CN (1) | CN1155367C (ja) |
AU (1) | AU756464B2 (ja) |
CA (1) | CA2319100C (ja) |
IL (1) | IL137472A (ja) |
SE (1) | SE0002643L (ja) |
WO (1) | WO1999038493A1 (ja) |
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PL2400950T3 (pl) | 2009-02-26 | 2019-12-31 | Glaxo Group Limited | Preparaty farmaceutyczne zawierające 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol |
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US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
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WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
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-
1998
- 1998-01-30 US US09/016,265 patent/US6086376A/en not_active Expired - Lifetime
- 1998-12-30 CA CA002319100A patent/CA2319100C/en not_active Expired - Fee Related
- 1998-12-30 AU AU20244/99A patent/AU756464B2/en not_active Ceased
- 1998-12-30 KR KR1020007008094A patent/KR20010040402A/ko not_active Application Discontinuation
- 1998-12-30 CN CNB988133849A patent/CN1155367C/zh not_active Expired - Fee Related
- 1998-12-30 EP EP98965051A patent/EP1051154A1/en not_active Ceased
- 1998-12-30 IL IL13747298A patent/IL137472A/xx not_active IP Right Cessation
- 1998-12-30 JP JP2000529227A patent/JP2002501885A/ja not_active Withdrawn
- 1998-12-30 WO PCT/US1998/027922 patent/WO1999038493A1/en not_active Application Discontinuation
-
2000
- 2000-07-13 SE SE0002643A patent/SE0002643L/xx not_active Application Discontinuation
-
2010
- 2010-06-04 JP JP2010128713A patent/JP2010248206A/ja active Pending
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