JP2010246904A - Ophthalmic observation program and ophthalmic observation apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To efficiently and suitably observe the progress of an examined eye. <P>SOLUTION: This ophthalmic observation apparatus includes a storage means for storing an examined eye image at the predetermined part of the examined eye acquired by an ophthalmic imaging apparatus; a monitor for displaying the examined eye image stored by the storage means; an operation input part operated to input by an examiner. A first examined eye image and a second examined eye image acquired at different examination dates and times respectively and stored in the storage means are displayed in parallel within a predetermined display range on the monitor, and in this state, a display control means synchronizes the first examined eye image and the second examined eye image to change the display region of both examined eye images based on an operation signal from the operation input part. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an ophthalmologic observation program and an ophthalmologic observation apparatus used for observing an image of a predetermined part of an eye to be examined, which is photographed by an ophthalmologic photographing apparatus.

  In an ophthalmologic imaging apparatus such as an optical coherence tomography (OCT), fundus camera, and laser scanning ophthalmoscope (SLO), images of the same part of the eye to be examined are acquired at different examination dates and times. , Follow-up may be performed. For example, in the case of OCT for ophthalmology, a tomographic image of the fundus is acquired a plurality of times, and the progress of the lesion is observed from the change in the tomographic image.

  In such a case, it is conceivable that the corresponding image data is selected from the eye images stored in the ophthalmic image filing system and the follow-up observation is performed based on the eye images displayed on the screen of the display monitor.

JP 2008-29467 A

  However, in the case of the conventional configuration, the selected eye image is merely displayed on the screen of the monitor, and it cannot be said to be sufficient for comparing images at the same site of the eye to be examined.

  In view of the above-described problems, the present invention relates to an ophthalmic observation program and an ophthalmic observation apparatus that can efficiently and suitably perform follow-up observation of an eye to be examined.

  In order to solve the above problems, the present invention is characterized by having the following configuration.

(1) Storage means for storing an eye image to be examined at a predetermined part of the eye to be examined acquired by the ophthalmologic imaging apparatus, a monitor for displaying the eye image to be examined stored in the storage means, and an operation input to be operated by the examiner An ophthalmologic observation device comprising:
In a state where the first eye image and the second eye image acquired at different examination dates and stored in the storage means are displayed in parallel in a predetermined display range on the monitor, the operation input And a display control unit configured to synchronize the first eye image and the second eye image based on an operation signal from the unit to change a display area of both eye images.
(2) In the ophthalmologic observation apparatus according to (1),
When the display control unit changes the display magnification of the eye image displayed on the monitor based on the operation signal from the operation input unit, the display control unit changes the display magnification for the first eye image and the second It is characterized in that the display magnification change for the eye image to be examined is synchronized.
(3) In the ophthalmologic observation apparatus according to (2),
When the display control unit outputs a signal instructing to change the display area or display magnification for one of the first and second eye images on the monitor, the display control unit The display area or the display magnification for the other eye image is changed in synchronization with the change of the display area or the display magnification.
(4) In the ophthalmic observation device according to (3),
A synchronous mode for synchronizing the change of the display area or display magnification for the first and second eye images; an asynchronous mode for not synchronizing the change of the display area or display magnification for the first and second eye images; Mode switching means for switching between
When the asynchronous mode is set, the display control unit outputs a signal instructing to change the display area or the display magnification for one of the first and second eye images on the monitor Only the change of the display area or the display magnification for the one eye image to be examined is performed.
(5) In the ophthalmic observation device according to (4),
The display control unit includes a first eye image, a second eye image, and a second eye image having different examination dates and times with respect to the first imaging position, with respect to the first imaging region and the second imaging region having different imaging positions. A third tomographic image and a fourth tomographic image having different examination dates and times with respect to the imaging position of the image, and a parallel display in a predetermined display range on the monitor,
In the synchronous mode, when the display area or the display magnification is changed with respect to any one of at least four eye images to be examined, if the eye image is related to the first imaging position, the first and second eye images are taken. The change of the display area or the display magnification of the optometry image is synchronized, and the change of the display area or the display magnification of the third and fourth eye images is synchronized if the eye image is related to the second imaging position. It is characterized by making it.
(6) In the ophthalmic observation device according to (5),
The eye image is a tomographic image or a front image of the eye fundus of the subject.
(7) In the ophthalmic observation device according to (6),
The display control unit further displays the eye image of the right eye and the eye image of the left eye acquired at the same date and time in parallel with a predetermined display range on the monitor,
When changing the display area displayed on the monitor in the eye image based on the operation signal from the operation input unit, the change of the display area with respect to the eye image in the right eye and the eye to be examined in the left eye The change of the display area with respect to the image is synchronized.
(8) Storage means for storing an eye image to be examined at a predetermined part of the eye to be examined acquired by the ophthalmologic imaging apparatus, display means for displaying the eye image to be examined stored in the storage means, and an operation input by the examiner A computer having input means,
In a state where the first eye image and the second eye image acquired at different examination dates and times and stored in the storage means are displayed side by side in a predetermined display range on the display means, the operation The first eye image and the second eye image are synchronized on the basis of an operation signal from the input means, and function as display control means for changing the display area of both eye images. .

  According to the present invention, the follow-up observation of the eye to be examined can be performed efficiently and suitably.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a block diagram illustrating the configuration of the ophthalmologic observation apparatus according to this embodiment.

  An ophthalmologic observation apparatus 1 for observing a fundus image photographed by the ophthalmologic photographing apparatus 10 on a monitor includes a CPU (calculation control unit) 70, a mouse (operation input unit) 76, a memory (storage unit) 72, A monitor 75, and each unit is electrically connected to the CPU 70 via a bus or the like.

  The CPU 70 controls the operation of each unit based on the ophthalmic observation program and various control programs stored in the memory 72. The ophthalmic observation apparatus 1 can be used by executing this ophthalmic observation program on a computer. Here, the CPU 70 controls the display screen of the monitor 75 according to the ophthalmic observation program.

  The mouse 76 in this embodiment includes a sensor for detecting a movement signal when the body of the mouse 76 is two-dimensionally moved by the examiner's hand, and a left and right for detecting that the mouse 76 is pressed by the examiner's hand. Two mouse buttons and a wheel mechanism that is rotatable in the front-rear direction are provided between the two left and right mouse buttons. As the CPU 70, mouse 76, memory 72, and monitor 75, an arithmetic processing section, an input section, a storage section, and a display section of a commercially available PC (personal computer) are used, and an ophthalmic observation program is installed on the commercially available PC. May be.

  The ophthalmic observation apparatus 1 is connected to an ophthalmologic imaging apparatus 10 for capturing an image at a predetermined part of the eye to be examined. In FIG. 1, an ophthalmologic photographing apparatus 10 includes an interference optical system (OCT optical system) 200 for obtaining a tomographic image of the fundus oculi to be examined, a front observation optical system 300 for obtaining a front image of the fundus oculi to be examined, and a control unit. 400, and the fundus region of the eye to be examined can be imaged. For the detailed configuration of the ophthalmologic photographing apparatus 10, refer to Japanese Patent Application Laid-Open No. 2008-29467.

  The interference optical system 200 is generated by a first scanning unit (optical scanner) that scans the eye fundus of the first measurement light emitted from the first light source and the light emitted from the first light source. A so-called ophthalmic optical tomography interferometer (OCT) device comprising: a first light receiving element that receives interference light obtained by combining reference light and reflected light of the first measurement light applied to the fundus of the eye to be examined. Has a configuration. The configuration of the interference optical system 200 includes Spectral-domain OCT (SD-OCT) using a spectrum meter, Swept-source OCT (SS-OCT) using a wavelength tunable light source, Time-domain OCT (TD-OCT), Etc. are considered.

  The front observation optical system 300 is arranged at a second scanning unit (optical scanner) that two-dimensionally scans the fundus of the eye to be examined with the second measurement light emitted from the second light source, and at a substantially conjugate position with the fundus. And a second light receiving element that receives fundus reflected light through the confocal aperture, and has a so-called ophthalmic scanning laser ophthalmoscope (SLO) device configuration. Note that the configuration of the observation optical system 300 may be a so-called fundus camera type configuration.

  The control unit 400 controls each member of the ophthalmologic photographing apparatus 10, acquires a tomographic image (OCT image) based on the light reception signal output from the first light receiving element of the interference optical system 200, and also uses front observation optics. A front image (SLO image) is acquired based on the light reception signal output from the second light receiving element of the system 300.

  The ophthalmic observation apparatus 1 and the ophthalmic imaging apparatus 10 are connected via a LAN or the like, and various data acquired by the ophthalmic imaging apparatus 10 (for example, tomographic image data, front image data, various imaging conditions at the time of image acquisition (for example, , Scanning position of measurement light, inspection date and time), etc.) are transferred to the memory 72 as a database.

  FIG. 2 is an example of a display screen (follow-up observation screen) displayed on the monitor 75. On the screen of the monitor 75, the cursor 100 that can move the entire screen on the monitor 75 by the movement operation of the mouse 76, the tomographic image display area 210, the front image display area 310, and the tomographic image display area 210 are displayed. A display condition setting area 410 for adjusting the display conditions of the tomographic images, and a synchronization button for selecting whether or not the tomographic images should be synchronized with changes in the display conditions / display areas for the tomographic images having different examination dates and times. 510 is provided.

  The CPU 70 moves the cursor 100 on the screen of the monitor 75 based on an operation signal output from the mouse 76 when the mouse 76 is operated by the examiner. When a click operation or a drag operation is performed with the cursor 100 positioned at a desired position on the monitor 75, various display conditions / display areas are set. The cursor 100 is used for designating an arbitrary position on the monitor 75.

  In the tomographic image display area 210, the first tomographic image 220 and the second tomographic image 230 acquired at different examination dates and stored in the memory 72 are respectively displayed in parallel in a predetermined display range. It has become. In this case, at least part of the tomographic image data stored in the memory 72 is displayed as the first tomographic image 220 and the second tomographic image 230. In FIG. 2, a tomographic image of the macula is displayed as a tomographic image of the same part.

  The CPU 70 displays, on the monitor 75, the image having the older examination date and time, and displays the image having the latest examination date below the monitor 75 based on the examination date information attached to each image data (not shown). To display.

  When displaying the tomographic image 220 and the tomographic image 230 on the monitor 75, the examiner displays the same part of the same subject stored in the memory 72 (for example, near the macular region of the fundus) on a predetermined image selection screen (not shown). Etc.), tomographic images with different examination dates and times are selected in advance, and two images with different examination dates and times selected are displayed on one screen by performing an operation to call an observation screen. Note that the tomographic imaging region can be identified from the scanning position information, fixation position information, and the like of the measurement light stored in the memory 72 simultaneously with the image acquisition.

  In the front image display area 310, the front image acquired almost simultaneously with the tomographic image displayed in the display area 210 and stored in the memory 72 is displayed in parallel in a predetermined display range, and the first front image 320 is the first front image 320. Corresponding to one tomographic image 220, the second front image 330 corresponds to the second tomographic image 230. These front images are output to the monitor 75 when a tomographic image is selected.

  The display condition setting area 410 includes a brightness adjustment unit 420 for adjusting the brightness of the tomographic image, a contrast adjustment unit 430 for adjusting the contrast of the tomographic image, and a zoom magnification (display magnification) of the tomographic image. A zoom magnification adjustment unit 440 for adjustment is displayed. As initial settings, brightness 50%, contrast 50%, and zoom magnification 100% are set. Here, when the display position of the slider provided in each adjustment unit is changed through the operation of the mouse 76, the CPU 70 changes various display conditions of each tomographic image.

  In addition to the setting area 410, when the wheel of the mouse 76 is rotated in a state where the cursor 100 is placed on the tomographic image 220 or the tomographic image 230, the CPU 70 zooms in on the tomographic image based on the operation signal. Change the magnification. Further, when a drag operation is performed with the mouse 76 in a state where the cursor 100 is placed on the tomographic image 220 or the tomographic image 230, the CPU 70 displays an area displayed on the monitor 75 in the tomographic image based on the operation signal. Change (Display Area).

  FIG. 3 is a schematic diagram for explaining the change in the display magnification and display area of the tomographic image displayed on the monitor 75. A rectangular area on the dotted line represents the tomographic image data A stored in the memory 72. The image data A is enlarged / reduced according to the zoom magnification. A rectangular area with a thick line (solid line) represents an area (display area) B that is actually displayed on the monitor 75 in the image data A of this size. The display area B corresponds to a predetermined display range set for each tomographic image in the tomographic image display area 210, and the area surrounded by the display area B in the image data A is the tomographic image 220 or the tomographic image 230. Will be displayed on the monitor 75.

  Here, when an operation signal instructing the change of the zoom magnification is output, the CPU 70 changes the magnification of the image data A with respect to the display area B (FIG. 3 shows the case where the zoom magnification is 200%). Thereby, the zoom magnification of the tomographic image displayed on the monitor 75 is changed.

  Further, when an operation signal instructing to change the display area is output, the CPU 70 moves the display area B in the vertical and horizontal directions with respect to the image data A set to a predetermined magnification. Thereby, the display area of the tomographic image displayed on the monitor 75 is changed. Specifically, the CPU 70 detects the vector amounts (ΔX, ΔY) starting from the point where the mouse 76 starts dragging and ending at the point where the drag ends, and displays it according to the detected vector amount. Move area B. Then, the CPU 70 outputs tomographic image data corresponding to the moved display area B to a predetermined range of the monitor 75. As a result, the tomographic image on the monitor 75 is scrolled vertically and horizontally. Thereby, the examiner can easily observe an arbitrary fundus site in the tomographic image.

  When the zoom magnification is larger than 100%, when the display area of the tomographic image is changed, the fundus portion displayed on the monitor 75 is changed in the depth direction and / or the left-right direction. When the zoom magnification is 100% or less, when the display area of the tomographic image is changed, the fundus region displayed on the monitor 75 is moved in the depth direction and / or the left-right direction.

  In addition, when changing a display area, it is not restricted to the said drag operation, If it is what controls the display of the monitor 75 based on the operation signal relevant to an up-down and left-right direction, it will not restrict to this. For example, the structure which moves the scroll bar displayed on the monitor 75 may be sufficient. Further, as a pointing device for outputting operation signals related to the up / down / left / right directions, a configuration using a track ball, a cross key of a keyboard, a touch panel, and the like in addition to the mouse 76 can be considered.

  The synchronization button 510 has a synchronous mode for synchronizing the change of the display condition / display area for one of the two tomographic images and the change of the display condition / display area for the other tomographic image, and an asynchronous mode for not synchronizing this. Used as a mode switching unit for selective switching. In the case of FIG. 2, the synchronous mode is set when the synchronous button 510 is checked, and the asynchronous mode is set when the synchronous button 510 is unchecked.

  A case will be described in which the examiner performs follow-up on the follow-up (follow-up) display screen as described above. When two tomographic images to be observed are selected and displayed on the monitor 75, the examiner can observe the tomographic images 220 and 230. In this embodiment, the synchronization mode is set as the initial setting.

  When the display mode / display area is changed for one of the two tomographic images in the synchronous mode, the CPU 70 performs the same operation for the other tomographic image in synchronization with the change. Change the display condition / display area.

  More specifically, when changing the display magnification in the synchronous mode, the CPU 70 determines the tomographic image 220, the tomographic image 230, and the like according to the zoom magnification set by the slider operation of the zoom magnification adjustment unit 440 or the wheel rotation operation. Are displayed at the same zoom magnification (see FIG. 4). Here, when the zoom magnification is changed, the zoom magnifications of both the tomographic image 220 and the tomographic image 230 are changed synchronously. When the zoom magnifications of the tomographic image 220 and the tomographic image 230 are different in the asynchronous mode, when the synchronous mode is set, the other zoom magnification is adjusted according to the zoom magnification of one of the tomographic images.

  Also in the adjustment of the tomographic image brightness and contrast, the CPU 70 makes the tomographic image 220 and the tomographic image 230 the same in accordance with the slider operation of the brightness adjustment unit 420 or the contrast adjustment unit 430, similarly to the adjustment of the zoom magnification. Display with brightness or the same contrast setting.

  In addition, the CPU 70 sequentially changes the display area of the tomographic image 220 and the display area of the tomographic image 230 according to the vector amount detected by the drag operation on one of the tomographic image 220 or the tomographic image 230. Then, the CPU 70 outputs each tomographic image corresponding to the changed display area to a predetermined range on the monitor 75. In this case, the moving direction and the moving amount of the display area of the tomographic image 220 and the tomographic image 230 with respect to the predetermined vector amount detected by the mouse 76 are set to be the same. For this reason, the tomographic images 220 and 230 are displayed so as to be moved substantially in parallel on the monitor 75 (FIG. 4 is before the drag operation and FIG. 5 is after the drag).

  In this way, when the display area displayed on the monitor 75 in one tomographic image is changed, the display area is similarly changed following the other tomographic image. Follow-up observation is easy.

  In the above description, when a signal indicating a display area for one of the first and second tomographic images on the monitor 75 is output, in synchronization with the change of the display area for one tomographic image. Although the display area for the other eye image to be examined is changed, the present invention is not limited to this. Any configuration may be used as long as the first tomographic image and the second tomographic image are synchronized with each other based on an operation signal from the operation input unit (for example, mouse 76) to change the display area of both tomographic images. For example, a scroll bar for synchronously changing the display area of both tomographic images may be provided on the monitor 75.

  On the other hand, when the asynchronous button 510 is set to the asynchronous mode, when the display condition / display area is changed for one of the two tomographic images, the CPU 70 displays the display condition / Change the display area.

  More specifically, when the zoom magnification is changed to a predetermined zoom magnification while the tomographic image 220 is designated by the cursor 100, the CPU 70 changes the tomographic image 220 to the set zoom magnification. Here, the zoom magnification of the tomographic image 230 is not changed. The same applies to the adjustment of image brightness and contrast.

  Further, when a drag operation is performed on the tomographic image 220, the CPU 70 sequentially changes the display area of the tomographic image 220 according to the vector amount detected by the mouse 76. Then, the CPU 70 outputs the tomographic image 220 corresponding to the changed display area on a predetermined range on the monitor 75 (see FIG. 6). Here, the display area of the tomographic image 230 is not changed.

  As an application of the asynchronous mode as described above, the display part and the display position of the tomographic image 220 and the tomographic image 230 are shifted by the shift of the imaging position at the time of acquiring each tomographic image before the display area is changed by the synchronous mode. The case where it corrects is considered. In this case, the examiner may change the display area of each tomographic image by the above-described drag operation so that the same part of the fundus on the tomographic image 220 and the tomographic image 230 is displayed at substantially the same display position.

  In this way, when the display area of the tomographic image is changed in the above-described synchronization mode, even if there is a shift in the photographing position between the tomographic images, the examiner can easily view the images at the same site. Can be compared. This is particularly effective when the zoom magnification of the tomographic image is high (the effect of displacement of the imaging position is great).

  As other uses of the asynchronous mode, there are cases where the examiner wants to observe a tomographic image while paying attention to only one image, or where the examiner's attention position differs for each tomographic image.

  In the above description, the CPU 70 changes the display area of at least one of the tomographic image 220 and the tomographic image 230 based on the operation signal output from the mouse 76, and corrects the positional shift between the tomographic image 220 and the tomographic image 230. However, it is not limited to this. That is, any method may be used as long as the tomographic image 220 and the tomographic image 230 acquired by the ophthalmologic imaging apparatus 10 are processed and the positional deviation between the tomographic image 220 and the tomographic image 230 is corrected.

  For example, the CPU 70 detects positional deviation information between the tomographic image 220 and the tomographic image 230 by image processing, changes at least one display area of the tomographic image 220 and the tomographic image 230 based on the detected positional deviation information, and The positional deviation between the image 220 and the tomographic image 230 may be corrected.

  In this case, for example, a positional deviation between two images is detected, and processing is performed so that the deviation is corrected. Further, a deviation from the reference position may be detected for each image, and processing may be performed so that the same part of each image is corrected to a certain reference position. Further, the timing at which the positional deviation correction is performed is not particularly limited, and for example, it may be processed as needed when each image is acquired, or may be processed when both images are displayed in parallel.

  In addition, as a method for detecting positional deviation information between the tomographic image 220 and the tomographic image 230, various image processing methods (a method using various correlation functions, a method using Fourier transform, a method based on feature point matching, a depth, etc.) It is possible to use a method of detecting a shift in the peak position of the luminance distribution in the direction.

  In the above description, two tomographic images having different examination dates and times are displayed in parallel on the monitor 75. However, three or more tomographic images having different examination dates and times are displayed on the monitor 75 in parallel. It may be.

  In the above description, regarding a tomographic image at a predetermined imaging position (for example, a tomographic image obtained when the measurement light is scanned in the left-right direction with respect to the macular portion), tomographic images having different examination dates and times are displayed on the monitor 75. Although it was intended, it is not limited to this. That is, regarding two or more tomographic images having different imaging positions (for example, each tomographic image when the measurement light is scanned in the horizontal direction and the vertical direction with respect to the macular portion), the tomographic images having different examination dates and times are respectively displayed on the monitor 75. You may make it display.

  In this case, for example, at least a part of the first tomographic image and the second tomographic image having different examination dates and times with respect to the first imaging position, and a third tomography with different examination dates and times with respect to the second imaging position. At least a part of the image and at least a part of the fourth tomographic image are displayed in parallel in a predetermined display range on the monitor 75, respectively. In this case, the first and third tomographic images are images acquired at the same examination date and time, and the second and fourth tomographic images are images acquired at the same examination date and time.

  In the synchronous mode, when the display condition / display area is changed for any of the four tomographic images, if this is a tomographic image related to the first imaging position, the first tomographic image and the second tomographic image are displayed. Synchronize tomographic image display conditions / change of display area. If the tomographic image is related to the second imaging position, the display condition / display area change of the third tomographic image and the fourth tomographic image is synchronized.

  In the above description, the fundus tomographic image has been described as an example. However, the present invention is not limited to this, and two or more fundus front images (SLO or fundus cameras obtained by different examination dates and times for the same subject) are acquired. The present invention can also be applied to a configuration in which a fundus front image is displayed in parallel on a monitor.

  Further, the present invention is not limited to the fundus image, and any structure may be used as long as two or more eye images to be examined (images at predetermined portions of the eye to be examined) displayed in parallel on the monitor. For example, the present invention can be applied to a configuration in which a cross-sectional image or a front image of the anterior eye portion is displayed on a monitor.

  In the above description, the display conditions / display areas for at least two eye images to be examined having different examination dates / times are changed. However, at least two eye images to be examined acquired at the same photographing position are used. It is not limited to this as long as the comparison is possible. For example, the fundus image in the right eye and the fundus image in the left eye acquired at the same date and time by the ophthalmologic imaging apparatus are acquired in advance, and at least a part of the fundus image in the right eye and the left eye acquired at the same date and time The present invention is also applicable when at least a part of the fundus image is displayed in parallel with a predetermined display range on the monitor 75. In this case, when changing the display area displayed on the monitor 75 in the fundus image based on the operation signal from the mouse 76, the CPU 70 changes the display area for the fundus image in the right eye and displays the fundus image in the left eye. Synchronize with region changes.

  In addition, as described above, two tomographic images are provided so that follow-up observation can be performed more efficiently when the fundus images (tomographic images) of the same subject having different examination dates and times are arranged and compared on the same observation screen. It is also possible to display each layer thickness in a graph. Such a layer thickness graph is displayed in parallel on the same screen together with two previously selected tomographic images in the above-described operation for calling the follow-up observation screen.

  Hereinafter, display control when displaying a layer thickness graph for comparing two tomographic images having different inspection dates and times will be described with reference to FIG. In addition, about what attached | subjected the same number as FIG. 2, unless there is particular description, it shall have the same function and structure.

  In FIG. 7, in the graph display area 610, a layer thickness graph 610a indicating the distribution of the layer thickness at a predetermined portion of the fundus regarding the first tomographic image and the second tomographic image is displayed. The layer thickness graph 610a is a graph in which the layer thickness in each depth direction is calculated, and the distribution of the layer thickness at each measurement position is plotted in the transverse direction. The layer thickness graph of FIG. 7 shows the layer thickness distribution for each tomographic image with the ILM (inner boundary membrane) as the start layer and the boundary position between the NFL (optic nerve fiber layer) and GCL (ganglion cell layer) as the end layer. The dotted line graph 220a corresponds to the first tomographic image, and the solid line graph 230a corresponds to the second tomographic image.

  When acquiring the layer thickness distribution information of each tomographic image, the CPU 70 first determines the boundary position of each layer on the fundus by predetermined image processing (for example, edge detection) for the tomographic image stored in the memory 72. To detect. Then, the CPU 70 detects the thickness of a predetermined part of the fundus based on each boundary position information detected as described above. In this case, the CPU 70 acquires boundary position information corresponding to a preset start layer and boundary position information corresponding to a preset end layer, and obtains a distance between the boundary positions to obtain a predetermined portion. The layer thickness distribution information at can be acquired.

  Note that the fundus layer thickness information to be graphed may be any information regarding the thickness of the fundus layer in the depth direction (Z direction), for example, the thickness of each layer, as well as the thickness of each layer. It may be the thickness of the layer when added together. For example, the thickness of the nerve fiber layer and the thickness from the retina surface to the choroid can be considered. In addition to the layer thickness information for each tomographic image, the difference information obtained by taking the difference in the layer thickness distribution between the first and second tomographic images may be graphed.

  In addition, on the layer thickness graph 610a, a line Lm extending in the depth direction (layer thickness direction) is synthesized and displayed. The CPU 70 displays the line Lm as a first index (marker) indicating a predetermined measurement position on the layer thickness graph 610a.

  Then, the CPU 70 changes the display position of the line Lm based on the operation signal from the mouse 76. More specifically, when the display position of the slider 630 below the layer thickness graph 610a is changed through the operation of the mouse 76, the line Lm changes the display position on the layer thickness graph 610a with respect to the transverse direction. It is like that.

  On the other hand, the CPU 70 displays the line L1 and the line L2 on the first tomographic image and the second tomographic image as the second index (marker) indicating the measurement position corresponding to the first index (line Lm). More specifically, the line L1 is synthesized and displayed on the tomographic image 220, and the line L2 is synthesized and displayed on the tomographic image 230. When the display position of the line Lm is changed, the CPU 70 displays the line L1 and the line L2 at the measurement position corresponding to the line Lm whose display position has been changed.

  The front image of the front image display area 310 includes a third index (marker) 320M indicating a measurement position corresponding to the line Lm (line L1 and line L2 of the tomographic image) of the layer thickness graph 610a on each front image. , 330M is displayed.

  FIG. 8 is a diagram for explaining the correspondence between the line Lm of the layer thickness graph 610a and the line L2 of the tomographic image 230. The layer thickness graph 610 a is a layer thickness graph corresponding to the image data A, and shows the overall layer thickness distribution of the first tomographic image (including the second tomographic image) stored in the memory 72. The image data A and the layer thickness graph 610a have a correspondence relationship with respect to the coordinate position in the transverse direction.

  The display area B in the second tomographic image is an area displayed on the monitor 75 as the tomographic image 230. The display position of the line Lm corresponds to the coordinate position X1 in the transverse direction in the image data A. The coordinate position X1 specified by the line Lm corresponds to the display position of the line L2. For this reason, the line L2 on the tomographic image 230 is displayed at the display position corresponding to the line Lm on the layer thickness graph 610a.

  More specifically, when the coordinate position X1 specified by the line Lm is within the range corresponding to the display area B, the CPU 70 displays the line L2 at the display position corresponding to the coordinate position X1 in the display area B. (FIG. 7 shows a case where the zoom magnification is 100%, and FIG. 9 shows a case where the zoom magnification is 200%). When the coordinate position X1 specified by the line Lm is outside the range corresponding to the display area B, the CPU 70 sets the line L2 at the right end or the left end of the tomographic image 230 according to the position of the coordinate position X1 with respect to the display area B. indicate.

  When displaying the line L1, the CPU 70 stores the first fundus front image (corresponding to the first tomographic image) and the second fundus front image (corresponding to the second tomographic image) stored in the memory 72. Based on this, a relative shift in the photographing position between the first and second tomographic images is detected. Then, the CPU 70 corrects the display position of the line L1 based on the detection result.

  More specifically, the CPU 70 compares the first front image stored in the memory 72 with the second front image, and the positional deviation direction and positional deviation of the first front image with respect to the second front image. The amount is detected (calculated) by image processing. Note that various image processing methods (a method using various correlation functions, a method using Fourier transform, and a method based on feature point matching) can be used as a method for detecting a positional deviation between two images. is there.

  Next, the CPU 70 calculates a positional shift direction and a positional shift amount with respect to the transverse direction of the tomographic image (measurement light scanning direction) based on the detected positional shift information between the front images. Then, the CPU 70 corrects the coordinate position X1 specified by the line Lm based on the position shift direction and the position shift amount Δdx with respect to the transverse direction (X1 + Δdx), and sets the line L1 at the display position corresponding to the corrected coordinate position. indicate.

  In this case, the line L1 displayed on the tomographic image 220 is in a state in which the shift amount of the photographing position between the tomographic image 220 and the tomographic image 230 is offset with respect to the display position corresponding to the line Lm on the layer thickness graph 610a. Is displayed. Therefore, when performing follow-up observation using two or more tomographic images having different examination dates and times, the lines L1 and L2 are displayed on substantially the same site on the fundus even if there is a shift in the photographing position between the tomographic images. Is done. This is particularly effective when the zoom magnification of the tomographic image is high (the effect of displacement of the imaging position is great).

  Thus, the examiner can easily grasp the correspondence relationship between the tomographic images displayed on the monitor 72 when comparing the layer thicknesses of the first and second tomographic images using the layer thickness graph 610a.

  Further, by displaying the line L1 and the line L2 as described above, it is possible to easily grasp the deviation of the photographing position between the tomographic images. For example, in the synchronous mode, the examiner refers to the shift of the display position between the line L1 and the line L2 when the line L2 is displayed on a predetermined part (for example, a blood vessel part) of the tomographic image 230. The deviation can be confirmed.

  Note that, contrary to the above description, a configuration may be used in which the position shift is detected and the display position of the line L2 is offset based on the line L1 corresponding to the first tomographic image 220.

  When displaying tomographic images with different examination dates and times on the monitor 75, three-dimensional OCT images with different examination dates and times may be acquired in advance, and arbitrary tomographic images may be obtained from the three-dimensional data. In addition, when detecting a shift in imaging position as described above, a fundus front image acquired by the front observation optical system 300 may be used substantially simultaneously with acquisition of a tomographic image, or in the depth direction of the three-dimensional OCT image. An accumulated image can also be used.

  In addition, when an index indicating the measurement position corresponding to the line Lm is displayed on each tomographic image, the index may be displayed at a display position corresponding to the part graphed in the layer thickness graph 610a. For example, when the nerve fiber layer thickness distribution is displayed on the graph 610a, an indicator (for example, a line display) may be displayed at a display position corresponding to the nerve fiber layer in the tomographic image on the monitor 72.

  In the above description, a line-shaped index extending in the layer thickness direction is used as a display pattern for associating the measurement position on the layer thickness graph with the measurement position on the tomographic image. Various modifications are possible. For example, the shape, size, color, etc. of the index can be arbitrarily changed.

It is a block diagram explaining the structure of the ophthalmic observation apparatus which concerns on this embodiment. It is an example of the display screen (follow-up observation screen) displayed on a monitor. It is a schematic diagram for demonstrating the change of the display magnification of a tomographic image displayed on a monitor, and a display area. It is an example when synchronizing the change of the display magnification in two tomographic images acquired at different examination dates and times. It is an example in the case of synchronizing the change of the display area in two tomographic images acquired at different examination dates and times. It is an example in the case of changing the display area of a tomographic image in asynchronous mode. It is an example at the time of displaying the layer thickness graph for comparing two tomographic images from which the inspection date differs. It is a schematic diagram for demonstrating the correspondence of the line of a layer thickness graph, and the line of a tomographic image. It is a figure shown about the display of the line of a layer thickness graph, and the line of a tomographic image in case a zoom magnification is 200%.

1 Ophthalmic observation device 70 CPU
72 memory 75 monitor 76 mouse 100 cursor 220 first tomographic image 230 second tomographic image 440 zoom magnification adjustment unit 510 synchronization button 610a layer thickness graph Lm line (first index)
L1 and L2 lines (second indicator)

Claims (8)

Storage means for storing an eye image to be examined at a predetermined part of the eye to be examined acquired by the ophthalmologic imaging apparatus, a monitor for displaying the eye image to be examined stored in the storage means, an operation input unit for operation input by the examiner, An ophthalmic observation device comprising:
In a state where the first eye image and the second eye image acquired at different examination dates and stored in the storage means are displayed in parallel in a predetermined display range on the monitor, the operation input Ophthalmic observation characterized by comprising display control means for changing the display region of both eye images by synchronizing the first eye image and the second eye image based on an operation signal from the unit apparatus. The ophthalmic observation apparatus according to claim 1,
When the display control unit changes the display magnification of the eye image displayed on the monitor based on the operation signal from the operation input unit, the display control unit changes the display magnification for the first eye image and the second An ophthalmologic observation apparatus that synchronizes a change in display magnification for an eye image to be examined. The ophthalmic observation apparatus according to claim 2,
When the display control unit outputs a signal instructing to change the display area or display magnification for one of the first and second eye images on the monitor, the display control unit An ophthalmic observation apparatus that changes the display area or the display magnification for the other eye image in synchronization with the change of the display area or the display magnification. The ophthalmic observation device according to claim 3.
A synchronous mode that synchronizes changes in the display area or display magnification for the first and second eye images; an asynchronous mode that does not synchronize changes in the display area or display magnification for the first and second eye images; Mode switching means for switching between
When the asynchronous mode is set, the display control unit outputs a signal instructing to change the display area or the display magnification for one of the first and second eye images on the monitor An ophthalmic observation apparatus that performs only the change of the display area or the display magnification for the one eye image to be examined. The ophthalmic observation apparatus according to claim 4.
The display control unit includes a first eye image, a second eye image, and a second eye image having different examination dates and times with respect to the first imaging position, with respect to the first imaging region and the second imaging region having different imaging positions. A third tomographic image and a fourth tomographic image having different examination dates and times with respect to the imaging position of the image, and a parallel display in a predetermined display range on the monitor,
In the synchronous mode, when the display area or the display magnification is changed with respect to any one of at least four eye images to be examined, if the eye image is related to the first imaging position, the first and second eye images are taken. The change of the display area or the display magnification of the optometry image is synchronized, and the change of the display area or the display magnification of the third and fourth eye images is synchronized if the eye image is related to the second imaging position. An ophthalmologic observation device characterized in that The ophthalmic observation apparatus according to claim 5.
The ophthalmic observation apparatus, wherein the eye image is a tomographic image or a front image of the fundus of the subject's eye. The ophthalmic observation apparatus according to claim 6,
The display control unit further displays the eye image of the right eye and the eye image of the left eye acquired at the same date and time in parallel with a predetermined display range on the monitor,
When changing the display area displayed on the monitor in the eye image based on the operation signal from the operation input unit, the change of the display area with respect to the eye image in the right eye and the eye to be examined in the left eye An ophthalmic observation apparatus that synchronizes the change of the display area with respect to an image. Storage means for storing an eye image to be examined at a predetermined part of the eye to be examined acquired by the ophthalmologic photographing apparatus, display means for displaying the eye image stored in the storage means, and operation input means for operation input by the examiner A computer having
In a state where the first eye image and the second eye image acquired at different examination dates and times and stored in the storage means are displayed side by side in a predetermined display range on the display means, the operation The first eye image and the second eye image are synchronized on the basis of an operation signal from the input means, and function as display control means for changing the display area of both eye images. Ophthalmic observation program.

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