JP2010160109A - Automatic analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To enable use of a reaction tube sufficiently cleaned by supplementarily cleaning the reaction tube even in a stand-by period of use thereof. <P>SOLUTION: A reaction section 113 measures the degree of reaction of a specimen with a reagent in a reaction tube. The reaction section 113 cleans the reaction tube that the measurement is completed. A sample section 111 or a reagent section 112 injects a detergent solution in the reaction tube after cleaned as an infusion fluid under the control of a system controller 160. The reaction section 113 re-cleans the reaction tube in response to a need to newly use the reaction tube with the infusion fluid injected therein, under the control of the system controller 160. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an automatic analyzer that analyzes a test sample based on the degree of reaction between the test sample and a reagent in a reaction tube.

In the conventional automatic analyzer, water is injected after the reaction tube after measurement is washed. The reaction tube is maintained in a state where water is injected until it is necessary to newly use the reaction tube. This is to prevent the reaction tube from drying.
JP-A-1-25423 Japanese Patent Laid-Open No. 5-70112 JP2000-102661

  When it becomes necessary to use a reaction tube, the test sample and the reagent are respectively dispensed after the water injected into the reaction tube is discharged.

  For this reason, when the washing before water injection is insufficient, the reaction tube in that state may be used as it is for a new measurement.

  The present invention has been made in consideration of such circumstances, and the object of the present invention is to sufficiently clean the reaction tube by auxiliary cleaning the reaction tube even during its use standby period. An object of the present invention is to provide an automatic analyzer that can be used in a state.

  An automatic analyzer according to one aspect of the present invention cleans a reaction tube, a measuring unit that measures the degree of reaction between a test sample and a reagent in the reaction tube, and the reaction tube that has been measured by the measuring unit. Cleaning means, injection means for injecting a detergent solution as an injection solution into the reaction tube after cleaning, and the reaction tube in which the injection solution is injected by the injection means need to be newly used. According to the circumstances, a rewashing means for rewashing the reaction tube was provided.

  According to the present invention, the reaction tube can be used in a sufficiently cleaned state by additionally cleaning the reaction tube even during the waiting period for use.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 is a block diagram showing a configuration of an automatic analyzer 100 according to the present embodiment.

  As shown in FIG. 1, the automatic analyzer 100 includes a measurement unit 110, an analysis control unit 120, an analysis data processing unit 130, an output unit 140, an operation unit 150, and a system control unit 160.

  The measurement unit 110 further includes a sample unit 111, a reagent unit 112, and a reaction unit 113. The sample unit 111 manages a calibrator for each measurement item and a test sample (sample) collected from the subject. The reagent unit 112 manages a reagent for causing a chemical reaction with a sample component corresponding to the measurement item. The reaction unit 113 performs measurement according to the measurement item regarding the reaction liquid of the sample and the reagent. The reaction unit 113 outputs a calibrator signal and an analysis signal representing measurement results for the calibrator and the test sample to the analysis data processing unit 130, respectively.

  Analysis control unit 120 further includes a mechanism unit 121 and a mechanism control unit 122. The mechanism unit 121 drives various movable elements described later included in the measurement unit 110. The mechanism control unit 122 controls the operation of the mechanism unit 121.

  The analysis data processing unit 130 further includes a calculation unit 131 and a storage unit 132. The calculation unit 131 creates a calibration table for each measurement item based on the calibrator signal output from the measurement unit 110. The calculation unit 131 calculates analysis data for each measurement item based on the analysis signal output from the measurement unit 110 and the calibration table. The storage unit 132 includes a hard disk and stores a calibration table, analysis data, and the like. The computing unit 131 outputs the calibration table and analysis data to the output unit 140 as necessary.

  The output unit 140 further includes a printing unit 141, a display unit 142, and an online unit 143. The printing unit 141 includes a printer or the like, and prints the calibration table and analysis data output from the calculation unit 131 on printer paper or the like in a preset format. The display unit 142 includes a CRT (cathode-ray tube), an LCD (liquid crystal display), and the like, and displays the calibration table and analysis data output from the calculation unit 131. The display unit 142 selects and sets a subject information input screen for inputting the ID and name of the subject, an analysis condition setting screen for setting analysis conditions for each measurement item, and a measurement item for each test sample. A measurement item setting screen for the purpose is displayed under the control of the system control unit 160. The online unit 143 transmits the calibration table and analysis data output from the calculation unit 131 to other devices via the network.

  The operation unit 150 includes an input device such as a keyboard, a mouse, a button, or a touch key panel. The operation unit 150 sets analysis conditions for each measurement item, inputs subject information such as the subject ID and subject name of the subject, selects and inputs measurement items for each subject sample, calibrates each measurement item, It is operated by an operator for measuring a test sample. The operation unit 150 outputs a command signal representing the content of the operation by the operator to the system control unit 160.

  The system control unit 160 includes a CPU and a storage circuit, and controls each unit of the automatic analyzer 100 in an integrated manner. Specifically, the system control unit 160 determines the analysis conditions of the measurement items, the subject information, the measurement items for each test sample, and the like based on the command signal supplied from the operation unit 150, and stores the information. Keep it. Based on these pieces of information, the system control unit 160 controls the operation of the measurement unit 110 so as to perform measurement in a predetermined sequence in a certain cycle. The system control unit 160 controls the analysis data processing unit 130 so as to create a required calibration table and calculate required analysis data. Furthermore, the system control unit 160 controls the output unit 140 so as to output the calibration table and analysis data in a required form.

  FIG. 2 is a perspective view showing the configuration of the sample unit 111, the reagent unit 112, and the reaction unit 113.

  The sample unit 111 includes sample containers 11a and 11b, samplers 12a and 12b, a rack 13, an arm 14, a sample probe 15, a pump 16, a cleaning unit 17, a flow path forming unit 18, and a pump 19.

  The sample containers 11a and 11b accommodate samples such as a calibrator, a quality control sample, or a test sample. The sample container 11b accommodates a small amount of test sample collected from a child or the like so that it can be aspirated. That is, the sample container 11b has a smaller horizontal cross section than the sample container 11a, and can make the water surface of a small amount of the sample to be tested higher than the sample container 11a.

  The sampler 12a can be set by arranging a large number of sample containers 11a in two circumferential rows. The sampler 12a rotates to move the set sample container 11a along the circumference. Each position where the sample container 11a is set in the sampler 12a is assigned in advance to a set position for a calibrator or a set position for a quality control sample. The sample container 11a containing the calibrator is set at the former setting position, and the sample container 11a containing the quality control sample is set at the latter setting position.

  The sampler 12b can set a large number of racks 13. The rack 13 can be set by arranging a plurality of sample containers 11a and 11b in a straight line. The rack 13 is arranged along a direction orthogonal to the arrangement direction of the sample containers 11a and 11b. The sampler 12b moves the rack 13 in the arrangement direction. The sampler 12b also moves the rack 13 in the direction orthogonal to the arrangement direction at the sample suction position. Each position where the sample containers 11a and 11b are set in the rack 13 is assigned in advance to the set position of the test sample, and the sample containers 11a and 11b containing the test sample are set at the set position.

  The arm 14 is supported at one end so that it can rotate. A sample probe 15 is attached to the other end of the arm 14. The arm 14 is movable in the vertical direction in order to move the sample probe 15 in the vertical direction. Thus, the arm 14 moves or moves the sample probe 15 along an arcuate trajectory.

  The sample probe 15 has a thin cavity inside, and a pump 16 is connected to the cavity via the internal space of the arm 14 and a tube. The sample probe 15 sucks the sample by making the inside of the cavity have a negative pressure by the pump 16. The sample probe 15 discharges the sample held in the cavity when the negative pressure in the cavity is eliminated by the pump 16. A sensor for detecting the liquid level of the sample is provided at the tip of the sample probe 15 so that the liquid level is detected when the tip of the sample probe 15 enters a predetermined depth from the liquid level of the sample. It has become.

  The pump 16 draws a pressure transmission medium such as water to make a negative pressure in the cavity of the sample probe 15 and discharges the pressure transmission medium to release the negative pressure in the cavity of the sample probe 15.

  The reagent part 112 includes c, reagent racks 22a and 22b, arms 23a, 23b, 24a and 24b, legs 25a, 25b, 26a and 26b, and reagent probes 27a, 27b, 28a and 28b.

  The reagent bottle 21 contains a reagent that selectively reacts with the sample.

  Each of the reagent racks 22a and 22b stores a plurality of reagent bottles 21. Each of the reagent racks 22a and 22b is a substantially cylindrical container having an upper surface opened. Each of the reagent racks 22a and 22b can accommodate a plurality of reagent bottles 21 arranged in two rows in a circumferential shape. The reagent racks 22a and 22b are rotated by a rotation mechanism (not shown in FIG. 1) described later.

  One end of each of the arms 23a, 23b, 24a, and 24b is supported by the leg portions 25a, 25b, 26a, and 26b. Reagent probes 27a, 27b, 28a, and 28b are attached to the other ends of the arms 23a, 23b, 24a, and 24b, respectively.

  The leg portions 25a, 25b, 26a, and 26b are respectively rotated by a rotation mechanism having a known structure that is not shown in FIG. 1, thereby rotating the arms 23a, 23b, 24a, and 24b, respectively. The legs 25a, 25b, 26a, 26b are only partially shown in FIG. 1, and are actually longer than shown. The legs 25a, 25b, 26a, and 26b are linearly moved in the vertical direction by a known linear movement mechanism that is not shown in FIG.

  The reagent probes 27a, 27b, 28a, and 28b are moved or moved up and down along an arc-shaped track by the arms 23a, 23b, 24a, and 24b and the leg portions 25a, 25b, 26a, and 26b, respectively. The reagent probes 27a, 27b, 28a, 28b have thin cavities inside, and pumps (not shown) are respectively inserted into the cavities via arms 23a, 23b, 24a, 24b and legs 25a, 25b, 26a, 26b. It is connected to the. The reagent probes 27a, 27b, 28a, and 28b suck and discharge the reagent by the same operation as that of the sample probe 15.

  The reaction unit 113 includes a reaction tube 31, a disk 32, stirring units 33 a and 33 b, a photometric unit 34, and a cleaning unit 35.

  A large number of reaction tubes 31 are arranged circumferentially. The reaction tube 31 accommodates a reaction solution of a sample and a reagent.

  The disk 32 holds the reaction tube 31 rotatably. The disk 32 rotates counterclockwise at a constant angle during 4 analysis cycles. One analysis cycle is, for example, 4.5 seconds. The disk 32 may be rotated clockwise.

  The stirring unit 33a includes two stirring bars. The stirring unit 33a can move two stirring bars between two stirring positions respectively corresponding to the upper side of the reaction tube 31 and two different cleaning positions. The stirring unit 33a can move the two stirring bars in the vertical direction. The stirring unit 33a has a function of cleaning two stirring bars at two cleaning positions. The stirring unit 33a is used for stirring the sample dispensed in the reaction tube 31 and the first reagent.

  The stirring unit 33b includes two stirring bars. The stirring unit 33b can move two stirring bars between two half days respectively corresponding to the upper side of the reaction tube 31 and two different cleaning positions. The stirring unit 33b can move the two stirring bars in the vertical direction. The stirring unit 33b has a function of cleaning two stirring bars at two cleaning positions. The stirring unit 33b is used for stirring the sample dispensed in the reaction tube 31, the first reagent, and the second reagent.

  The photometric unit 34 emits light when the reaction tube 31 passes through the photometric position, and measures the absorbance of the set wavelength from the transmitted light. Then, the photometry unit 34 generates an analysis signal as a signal representing the measured absorbance.

  The cleaning unit 35 includes a cleaning nozzle and a drying nozzle. The cleaning unit 35 sucks and cleans the reaction solution in the reaction tube 31 by the cleaning nozzle. The washing unit 35 dries the reaction tube 31 after washing with a drying nozzle. The reaction tube 31 washed and dried by the washing unit 35 is used again for measurement.

  Next, some embodiments of the operation of the automatic analyzer 100 configured as described above will be described. Note that the characteristic operation in the automatic analyzer 100 is the operation after the reaction tube 31 is cleaned by the cleaning unit 35, so this point will be described below. Other operations may be the same as those of other conventional automatic analyzers.

(First embodiment)
In the first embodiment, the system control unit 160 accepts user designation regarding whether or not a solution needs to be filled as one item of measurement conditions for each reaction tube 31. If solution filling is necessary, user designation regarding the type of detergent solution to be used is accepted. The measurement conditions are stored in a built-in memory of the system control unit 160 or an external storage medium (not shown) as a data table as shown in FIG. 3, for example.

  And the system control part 160 performs the process as shown in FIG. 4 by making the reaction tube 31 which washing | cleaning was made into an object reaction tube.

  In step Sa1, the system control unit 160 confirms whether or not the target reaction tube is designated as requiring solution filling. If solution filling is requested by the user, the system control unit 160 proceeds from step Sa1 to step Sa2. In step Sa2, the system control unit 160 confirms whether or not the type of detergent solution used for filling the solution is designated. If the type of the detergent solution is designated, the system control unit 160 proceeds from step Sa2 to step Sa3, and dispenses a certain amount of the designated type of detergent solution into the target reaction tube.

  On the other hand, if filling of the solution is requested by the user but the type of the detergent solution to be used is not designated, the system control unit 160 proceeds from step Sa2 to step Sa4, and the detergent designated as the standard detergent solution. Dispense a certain amount of the solution into the target reaction tube.

  Specifically, when the measurement conditions are set as shown in FIG. 3, the alkaline detergent solution is used for the reaction tube 31 with the reaction tube number “1”, and the reaction tube number is “2”. An acidic detergent solution is dispensed to each reaction tube 31. Regarding the reaction tube 31 with the reaction tube number “3”, the solution designated as the standard detergent solution among the alkaline detergent and the acidic detergent is dispensed. Note that the standard detergent solution may be fixedly set or may be arbitrarily designated by the user.

  The detergent solution may be dispensed into the target reaction tube with any of the reagent probes 27a, 27b, 28a, 28b, or set in the sample containers 11a, 11b. The detergent solution may be dispensed into the target reaction tube by the sample probe 15. In this case, the reagent probes 27a, 27b, 28a, 28b and the sample probe 15 used for dispensing the detergent solution are simultaneously cleaned. Alternatively, a detergent solution dispensing probe may be provided separately from the sample probe 15 and the reagent probes 27a, 27b, 28a, and 28b, and the detergent solution may be dispensed into the target reaction tube by this probe.

  If solution filling is not requested by the user, the system control unit 160 proceeds from step Sa1 to step Sa5 and targets the internal water (pure water) of the sample probe 15 and the reagent probes 27a, 27b, 28a, and 28b. Inject into reaction tube.

  If it becomes necessary to newly use the reaction tube 31, for example, the detergent solution or water contained in the reaction tube 31 is discharged by the cleaning unit 35. Further, if necessary, the reaction tube 31 is rinsed with pure water and dried.

  Thus, according to the first embodiment, the detergent solution can be put in the reaction tube 31 in a standby state until the next use after washing. Therefore, even in the standby state, the reaction tube 31 can be supplementarily cleaned by the chemical action of the detergent, and the reaction tube 31 can be made to be in a cleaner state when newly used.

  Furthermore, according to the first embodiment, since the user can arbitrarily select the type of detergent solution to be put in the reaction tube 31 as described above, it is suitable for the sample or reagent dispensed to each reaction tube 31. Efficient cleaning can be performed using a detergent solution.

(Second Embodiment)
In the second embodiment, the system control unit 160 accepts a user designation as to whether priority is given to a cleaning agent solution, an alkaline detergent solution, or an acidic detergent solution that conforms to the last measurement item in the target reaction tube as an operation condition. . This designation is not accepted individually for each reaction tube 31, but is accepted as a common designation for each reaction tube 31.

  And the system control part 160 performs the process as shown in FIG. 5 by making the reaction tube 31 which washing | cleaning was made into an object reaction tube.

  In step Sb1, the system control unit 160 confirms whether the detergent solution set and usable in the automatic analyzer 100 is only an alkaline detergent solution, only an acidic detergent solution, or both of them. To do.

  If only the alkaline detergent solution is usable, the system control unit 160 proceeds from step Sb1 to step Sb2. In step Sb2, the system control unit 160 uses the target reaction tube before washing to check whether or not measurement has been performed on a measurement item to which the alkaline detergent is suitable. If such measurement has been performed, the system control unit 160 proceeds from step Sb2 to step Sb3, and dispenses the alkaline detergent solution into the target reaction tube.

  On the other hand, if only the acidic detergent solution is usable, the system control unit 160 proceeds from step Sb1 to step Sb4. In step Sb4, the system control unit 160 uses the target reaction tube before washing to check whether or not measurement has been performed on a measurement item to which the acidic detergent is suitable. If such measurement has been performed, the system control unit 160 proceeds from step Sb4 to step Sb5, and dispenses the acidic detergent solution into the target reaction tube.

  However, the measurement items for which the alkaline detergent is compatible with the use of only the alkaline detergent solution have not been measured, or the measurement items for which the acidic detergent is compatible with the use of only the acidic detergent solution are available. If the measurement has not been performed, the system control unit 160 proceeds from step Sb2 or step Sb4 to step Sb6. In this case, the system control unit 160 injects pure water into the target reaction tube in step Sb6.

  If both the alkaline detergent solution and the acidic detergent solution are usable, the system control unit 160 proceeds from step Sb1 to step Sb7. In step Sb7, the system control unit 160 confirms whether or not it is specified that the cleaning solution suitable for the last measurement item in the target reaction tube is given priority as the above-described operation condition. If so, the system controller 160 proceeds from step Sb7 to step Sb8 and step Sb9, and the last measurement item in the target reaction tube is compatible with the alkaline detergent solution or the acidic detergent solution, or Check if it does not fit any of them.

  If the last measurement item in the target reaction tube is compatible with the alkaline detergent solution, the system control unit 160 proceeds from step Sb8 to step Sb3, and dispenses the alkaline detergent solution into the target reaction tube. If the last measurement item in the target reaction tube is compatible with the acidic detergent solution, the system control unit 160 proceeds from step Sb9 to step Sb5, and dispenses the acidic detergent solution into the target reaction tube. If the last measurement item in the target reaction tube is not compatible with either the alkaline detergent solution or the acidic detergent solution, the system control unit 160 proceeds from step Sb9 to step Sb6 and dispenses pure water into the target reaction tube. .

  If it is specified that the alkaline detergent solution or the acidic detergent solution is given priority as the operating condition, the system control unit 160 proceeds from step Sb7 to step Sb10. In step Sb10, the system control unit 160 performs the target reaction to measure the measurement item suitable for the detergent solution designated as the priority among the alkaline detergent solution and the acidic detergent solution (herein referred to as the preferred detergent solution). Check if it was done using a tube. If the corresponding measurement has been performed, the system control unit 160 proceeds from step Sb10 to step Sb11, and dispenses the priority detergent solution into the target reaction tube. However, if the corresponding measurement has not been performed, the system control unit 160 proceeds from step Sb10 to step Sb12, and is a detergent solution that is not a preferred detergent solution of the alkaline detergent solution and the acidic detergent solution (hereinafter, non-preferred detergent). It is confirmed whether the measurement item suitable for (referred to as a solution) was measured using the target reaction tube. If the corresponding measurement has been performed, the system control unit 160 proceeds from step Sb12 to step Sb13, and dispenses the non-priority detergent solution into the target reaction tube. If measurement is not performed for any of the measurement items suitable for the priority detergent solution and the measurement items suitable for the non-priority detergent solution, the system control unit 160 proceeds from step Sb12 to step Sb6, and targets pure water. Inject into the reaction tube.

  Thus, according to the second embodiment, the detergent solution can be put in the reaction tube 31 in a standby state until the next use after washing. Therefore, even in the standby state, the reaction tube 31 can be supplementarily cleaned by the chemical action of the detergent, and the reaction tube 31 can be made to be in a cleaner state when newly used.

  Furthermore, according to the second embodiment, an appropriate detergent solution corresponding to the measurement item for which the measurement has been performed is automatically selected. Therefore, it is not necessary for the user to make such a selection, and the burden on the user can be reduced.

  Furthermore, according to the second embodiment, the type of detergent solution used for filling the solution is changed as shown in FIG. 6 according to the operating conditions specified by the user. For this reason, the flexible operation according to a user's needs is possible.

  This embodiment can be variously modified as follows.

  (1) If the detergent solution is put in the reaction tube 31 for a long time, the cleaning agent component is concentrated, precipitated, solidified, etc., and the cleaning agent component is sufficiently rinsed when the reaction tube 31 is reused. May not be removed or the time required for rinsing must be increased. Therefore, the reaction tube 31 may be rewashed when the solution filling state continues for a long time. This can be realized, for example, when the system control unit 160 executes a process as shown in FIG. 7 as each of the reaction tubes 31 in a solution-filled state as a target reaction tube.

  In step Sc1, the system controller 160 is required to limit the solution filling period for the target reaction tube, and whether the elapsed time in the solution filling state is equal to or greater than a predetermined upper limit value. Confirm. Whether or not to limit the solution filling period for the target reaction tube and the upper limit value may be fixed regardless of the user's needs, or may be arbitrarily determined according to an instruction from the user. Also good. Whether or not to limit the solution filling period for the target reaction tube and the upper limit value may be determined in common for each of the reaction tubes 31 or may be determined individually.

  Only when the above condition is satisfied, the system control unit 160 re-cleans the target reaction tube in step Sc3. To the reaction tube 31 after the re-washing, pure water or a detergent solution is newly injected to prevent the reaction tube 31 from drying.

  (2) In the second embodiment, any two or only one of the three types of operations described above may be performed.

  (3) The detergent solution may be a neutral detergent solution, an alkaline detergent solution having components different from the alkaline detergent solution, or the acidic detergent solution instead of or in addition to the alkaline detergent solution or acidic detergent solution. It is also possible to use other types of detergent solutions such as acidic detergent solutions with different ingredients.

  Note that the present invention is not limited to the above-described embodiment as it is, and can be embodied by modifying the constituent elements without departing from the scope of the invention in the implementation stage. In addition, various inventions can be formed by appropriately combining a plurality of components disclosed in the embodiment. For example, some components may be deleted from all the components shown in the embodiment. Furthermore, constituent elements over different embodiments may be appropriately combined.

The block diagram which showed the structure of the automatic analyzer 100 which concerns on one Embodiment of this invention. The perspective view which shows the structure of the sample part 111, the reagent part 112, and the reaction part 113 in FIG. The figure which shows an example of the data table which described the measurement conditions. The flowchart which shows the process by the system control part 160 for the solution filling in 1st Embodiment. The flowchart which shows the process by the system control part 160 for the solution filling in 2nd Embodiment. The figure which showed the corresponding | compatible relationship between an operating condition and the kind of detergent solution used for solution filling. The flowchart which shows the process by the system control part 160 for the re-washing | cleaning of the reaction tube 31 when the state of solution filling continues for a long time.

  11a, 11b ... sample containers, 12a, 12b ... samplers, 13 ... rack, 14 ... arms, 15 ... sample probes, 16 ... pumps, 17 ... washing units, 18 ... flow path forming units, 19 ... pumps, 21 ... reagent bottles 22a, 22b ... reagent rack, 23a, 23b, 24a, 24b ... arm, 25a, 25b, 26a, 26b ... leg, 27a, 27b, 28a, 28b ... reagent probe, 31 ... reaction tube, 32 ... disk, 33a , 33b ... Stirring unit, 34 ... Photometric unit, 35 ... Cleaning unit, 100 ... Automatic analyzer, 110 ... Measuring part, 111 ... Sample part, 112 ... Reagent part, 113 ... Reaction part, 120 ... Analysis control part, 121 ... Mechanism unit, 122 ... Mechanism control unit, 130 ... Analysis data processing unit, 131 ... Calculation unit, 132 ... Storage unit, 140 ... Output unit, 41 ... printing section, 142 ... display unit, 143 ... line section, 150 ... operation unit, 160 ... system control unit.

Claims (5)

A reaction tube;
Measuring means for measuring the degree of reaction between the test sample and the reagent in the reaction tube;
Cleaning means for cleaning the reaction tube after measurement by the measuring means;
Injection means for injecting a detergent solution as an injection into the reaction tube after washing;
An automatic analyzer comprising: a re-cleaning means for re-cleaning the reaction tube in response to the necessity to newly use the reaction tube into which the injection solution has been injected by the injection means. .   The automatic analyzer according to claim 1, further comprising selection means for selecting one of a plurality of types of detergent solutions as the injection solution.   The automatic analyzer according to claim 1, further comprising selection means for selecting the injection liquid from a plurality of types of detergent solutions and the water.   The re-washing means re-washes the reaction tube even if it is not necessary to newly use the reaction tube when the detergent solution is injected as the injection solution and a certain time has passed. The automatic analyzer according to claim 2 or 3, wherein The measurement means can selectively perform measurement on a plurality of measurement items,
4. The automatic analysis according to claim 2, wherein the selection unit selects the infusion solution based on which of the plurality of measurement items is a measurement performed by the measurement unit. apparatus.

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