JP2010111679A5 - - Google Patents
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- Publication number
- JP2010111679A5 JP2010111679A5 JP2009288124A JP2009288124A JP2010111679A5 JP 2010111679 A5 JP2010111679 A5 JP 2010111679A5 JP 2009288124 A JP2009288124 A JP 2009288124A JP 2009288124 A JP2009288124 A JP 2009288124A JP 2010111679 A5 JP2010111679 A5 JP 2010111679A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- monoclonal antibody
- composition
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108700012439 CA9 Proteins 0.000 claims 17
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 4
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000003302 anti-idiotype Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 2
- 238000001415 gene therapy Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940122072 Carbonic anhydrase inhibitor Drugs 0.000 claims 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35882402P | 2002-02-21 | 2002-02-21 | |
| US60/358,824 | 2002-02-21 | ||
| US38306802P | 2002-05-23 | 2002-05-23 | |
| US60/383,068 | 2002-05-23 | ||
| US43149902P | 2002-12-05 | 2002-12-05 | |
| US60/431,499 | 2002-12-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Division JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248466A Division JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010111679A JP2010111679A (ja) | 2010-05-20 |
| JP2010111679A5 true JP2010111679A5 (cg-RX-API-DMAC7.html) | 2011-05-06 |
| JP5199228B2 JP5199228B2 (ja) | 2013-05-15 |
Family
ID=33425052
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Expired - Fee Related JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2008325146A Expired - Fee Related JP4514820B2 (ja) | 2002-02-21 | 2008-12-22 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡ ＩＸ）、ｓ−ＣＡ ＩＸを検出するためのアッセイ、ＣＡ ＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡ ＩＸ特異的モノクローナル抗体 |
| JP2009288124A Expired - Fee Related JP5199228B2 (ja) | 2002-02-21 | 2009-12-18 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2012248466A Expired - Fee Related JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Expired - Fee Related JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2008325146A Expired - Fee Related JP4514820B2 (ja) | 2002-02-21 | 2008-12-22 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡ ＩＸ）、ｓ−ＣＡ ＩＸを検出するためのアッセイ、ＣＡ ＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡ ＩＸ特異的モノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248466A Expired - Fee Related JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7846673B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1487972B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP4488351B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003217606C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2477163C (cg-RX-API-DMAC7.html) |
| DK (2) | DK1487972T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1226095B (cg-RX-API-DMAC7.html) |
| HU (3) | HUE026218T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004005348A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2704273C (en) * | 2002-02-21 | 2016-01-05 | Institute Of Virology | Mn/ca ix-antibody binding specifically to non-immunodominant epitope of mn/ca ix and uses thereof |
| DK1487972T3 (en) * | 2002-02-21 | 2015-10-19 | Inst Virology | MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use. |
| US20090162382A1 (en) * | 2002-03-01 | 2009-06-25 | Bernett Matthew J | Optimized ca9 antibodies and methods of using the same |
| DE60328477D1 (de) * | 2002-04-16 | 2009-09-03 | Univ California | Verfahren zur prognose von nierenzellkarzinom und behandlungsauswahl mit carboanhydrase ix |
| US20090239247A1 (en) * | 2002-12-13 | 2009-09-24 | Harris Adrian L | MN and Hypoxia |
| EP1896040B1 (en) | 2005-06-29 | 2012-08-01 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| EP2518163B1 (en) | 2006-10-10 | 2014-08-06 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Prostate cancer specific alterations in erg gene expression and detection methods based on those alterations |
| US7820159B2 (en) * | 2006-10-31 | 2010-10-26 | Instiute of Virology of the Slovak Academy of Sciences | MN/CA IX and EGFR pathway inhibition |
| EP2219668A1 (en) * | 2007-11-02 | 2010-08-25 | Wilex AG | Binding epitopes for g250 antibody |
| ES2685596T3 (es) | 2007-11-19 | 2018-10-10 | Asahi Kasei Kabushiki Kaisha | Derivados éster de ácido carbámico para la producción de isocianato y compuestos hidroxi aromáticos |
| US8673267B2 (en) | 2009-03-02 | 2014-03-18 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
| EP2674756B1 (en) * | 2009-09-10 | 2016-08-03 | Bruker Daltonik GmbH | Determining the expression status of human epidermal growth factor receptor 2 (HER2) in biological samples |
| ES2881535T3 (es) | 2011-03-15 | 2021-11-29 | Massachusetts Inst Technology | Detección multiplexada con indicadores codificados con isótopos |
| CA2784047C (en) | 2011-07-29 | 2015-08-11 | Milwaukee Electric Tool Corporation | Tape measure |
| US9080849B2 (en) | 2011-07-29 | 2015-07-14 | Milwaukee Electric Tool Corporation | Tape measure |
| US8863399B2 (en) | 2011-08-26 | 2014-10-21 | Milwaukee Electric Tool Corporation | Tape measure |
| EP2508890A1 (en) * | 2011-10-25 | 2012-10-10 | Roche Diagnostics GmbH | CAIX based diagnosis of heart failure |
| JP2015500885A (ja) | 2011-12-22 | 2015-01-08 | スレッショルド ファーマシューティカルズ，インコーポレイテッド | 癌を治療するためのｃｈｋ１阻害剤と組み合わせた低酸素活性化プロドラッグの投与 |
| US9267778B2 (en) | 2012-01-19 | 2016-02-23 | Milwaukee Electric Tool Corporation | Tape measure |
| US20150005264A1 (en) * | 2012-01-31 | 2015-01-01 | Threshold Pharmaceuticals, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| JP2015155795A (ja) * | 2012-05-21 | 2015-08-27 | 東レ株式会社 | 癌の検出方法 |
| USD733597S1 (en) | 2012-07-30 | 2015-07-07 | Milwaukee Electric Tool Corporation | Tape measure |
| EP2839860B1 (en) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びその結合体 |
| JP6847660B2 (ja) * | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| HUE054526T2 (hu) | 2014-10-29 | 2021-09-28 | Bicyclerd Ltd | MT1-MMP-ra specifikus biciklusos peptid ligandumok |
| EP3286337A4 (en) * | 2015-04-23 | 2018-12-12 | Cedars-Sinai Medical Center | Automated delineation of nuclei for three dimensional (3-d) high content screening |
| USD785475S1 (en) | 2015-12-10 | 2017-05-02 | Milwaukee Electric Tool Corporation | Tape measure |
| USD785476S1 (en) | 2015-12-10 | 2017-05-02 | Milwaukee Electric Tool Corporation | Tape measure |
| USD787347S1 (en) | 2016-01-07 | 2017-05-23 | Milwaukee Electric Tool Corporation | Tape measure |
| USD783429S1 (en) | 2016-01-07 | 2017-04-11 | Milwaukee Electric Tool Corporation | Tape measure |
| USD783430S1 (en) | 2016-01-07 | 2017-04-11 | Milwaukee Electric Tool Corporation | Tape measure |
| WO2017177115A1 (en) | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
| WO2017193070A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| USD788611S1 (en) | 2016-06-01 | 2017-06-06 | Milwaukee Electric Tool Corporation | Tape measure |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| US11519905B2 (en) | 2017-04-07 | 2022-12-06 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| EP3615550A1 (en) | 2017-04-27 | 2020-03-04 | BicycleTx Limited | Bicyclic peptide ligands and uses thereof |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| SG11202007678QA (en) | 2018-02-23 | 2020-09-29 | Bicycletx Ltd | Multimeric bicyclic peptide ligands |
| WO2019173332A1 (en) | 2018-03-05 | 2019-09-12 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| KR20210016562A (ko) | 2018-05-23 | 2021-02-16 | 에이디씨 테라퓨틱스 에스에이 | 분자 애쥬번트 |
| US11732009B2 (en) | 2018-06-08 | 2023-08-22 | Glympse Bio, Inc. | Activity sensor with tunable analyte |
| US11028425B2 (en) | 2018-06-08 | 2021-06-08 | Glympse Bio, Inc. | Diagnosis and monitoring of liver disease |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| US12173349B2 (en) | 2018-09-25 | 2024-12-24 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| JP2022514618A (ja) | 2018-12-21 | 2022-02-14 | バイスクルテクス・リミテッド | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
| US11835522B2 (en) | 2019-01-17 | 2023-12-05 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| WO2020191416A2 (en) | 2019-02-28 | 2020-09-24 | Georgia Tech Research Corporation | Compositions and methods for logic-gated profiling of biologic activity |
| AU2019444617B2 (en) * | 2019-05-06 | 2025-07-03 | Navi Bio-Therapeutics, Inc. | Anti-carbonic anhydrase IX antibody |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| AU2019472821A1 (en) * | 2019-11-05 | 2022-06-09 | Mabpro A.S. | Humanized anti-CA IX antibodies and methods of their use |
| CN111273036B (zh) * | 2020-03-06 | 2021-06-15 | 中国农业科学院兰州兽医研究所 | 检测口蹄疫非结构蛋白抗体的单抗竞争化学发光试剂盒 |
| JP2023542867A (ja) | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 抗体の特異的共役 |
| CN116167592B (zh) * | 2023-04-20 | 2023-06-23 | 交通运输部天津水运工程科学研究所 | 一种河流溢油风险防控和决策支持系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| US6093548A (en) | 1992-03-11 | 2000-07-25 | Institute Of Virology, Slovak Academy Of Sciences | Detection and quantitation of MN-specific antibodies. |
| US5981711A (en) | 1992-03-11 | 1999-11-09 | Institute Of Virology, Slovak Academy Of Sciences | MN-specific antibodies and hybridomas |
| US5972353A (en) | 1992-03-11 | 1999-10-26 | Institute Of Virology, Slovak Academy Of Sciences | MN proteins, polypeptides, fusion proteins and fusion polypeptides |
| US6069242A (en) | 1992-03-11 | 2000-05-30 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US5955075A (en) | 1992-03-11 | 1999-09-21 | Institute Of Virology, Slovak Academy Of Sciences | Method of inhibiting tumor growth using antibodies to MN protein |
| US5989838A (en) | 1992-03-11 | 1999-11-23 | Institute Of Virology, Slovak Academy Of Sciences | Immunological methods of detecting MN proteins and MN polypeptides |
| US5387676A (en) | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
| US6297051B1 (en) | 1997-01-24 | 2001-10-02 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6774117B1 (en) | 1992-03-11 | 2004-08-10 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6027887A (en) | 1992-03-11 | 2000-02-22 | Institute Of Virology, Solvak Academy Of Sciences | MN gene and protein |
| US6204370B1 (en) | 1992-03-11 | 2001-03-20 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6297041B1 (en) * | 1992-03-11 | 2001-10-02 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| CA2192678C (en) * | 1994-06-15 | 2010-12-14 | Jan Zavada | Mn gene and protein |
| US6451977B1 (en) * | 1998-02-26 | 2002-09-17 | Genentech, Inc. | Fused polypeptides |
| AU758957C (en) | 1998-10-23 | 2004-08-12 | Institute Of Virology Of The Slovak Academy Of Sciences | MN gene and protein |
| WO2003048328A2 (en) * | 2001-12-03 | 2003-06-12 | Abgenix, Inc. | Antibodies against carboxic anhydrase ix (ca ix) tumor antigen |
| DK1487972T3 (en) * | 2002-02-21 | 2015-10-19 | Inst Virology | MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use. |
| WO2004017923A2 (en) | 2002-08-23 | 2004-03-04 | Chiron Corporation | Compositions and methods of therapy for cancers characterized by expression of the tumor-associated antigen mn/ca ix |
| WO2008103327A2 (en) | 2007-02-20 | 2008-08-28 | Bayer Pharmaceuticals Corporation | Mn/ca ix and bladder cancer |
| EP2219668A1 (en) * | 2007-11-02 | 2010-08-25 | Wilex AG | Binding epitopes for g250 antibody |
-
2003
- 2003-02-21 DK DK03713562.1T patent/DK1487972T3/en active
- 2003-02-21 DK DK15180634.6T patent/DK3031910T3/en active
- 2003-02-21 JP JP2004508271A patent/JP4488351B2/ja not_active Expired - Fee Related
- 2003-02-21 AU AU2003217606A patent/AU2003217606C1/en not_active Ceased
- 2003-02-21 HU HUE12157145A patent/HUE026218T2/en unknown
- 2003-02-21 HU HUE15180634A patent/HUE036891T2/hu unknown
- 2003-02-21 HU HUE03713562A patent/HUE026277T2/en unknown
- 2003-02-21 CA CA2477163A patent/CA2477163C/en not_active Expired - Fee Related
- 2003-02-21 EP EP03713562.1A patent/EP1487972B1/en not_active Expired - Lifetime
- 2003-02-22 WO PCT/US2003/005137 patent/WO2004005348A1/en not_active Ceased
-
2004
- 2004-08-19 US US10/921,590 patent/US7846673B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/933,101 patent/US7833728B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/932,777 patent/US20080177046A1/en not_active Abandoned
- 2007-10-31 US US11/933,065 patent/US7816493B2/en not_active Expired - Fee Related
-
2008
- 2008-12-22 JP JP2008325146A patent/JP4514820B2/ja not_active Expired - Fee Related
-
2009
- 2009-12-18 JP JP2009288124A patent/JP5199228B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-12 JP JP2012248466A patent/JP5271443B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-30 US US14/529,138 patent/US20150266971A1/en not_active Abandoned
-
2016
- 2016-12-15 HK HK16114292.8A patent/HK1226095B/en not_active IP Right Cessation
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