JP2010105932A - Hair-nourishing cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair-nourishing cosmetic providing no uncomfortable feeling at use, imparting good condition to the scalp and the hair, and exhibiting excellent hair-nourishing effects although greasy feeling caused by formulated components, squeaky feeling caused by an alcohol formulated so as to dissolve various kinds of active ingredients, dry feeling after use, etc., are cited as problems, because hair-nourishing effects are taken seriously in a hair-nourishing cosmetic, and sometimes the condition at the use is not sufficiently considered. <P>SOLUTION: The hair-nourishing cosmetic ameliorating the greasy feeling, squeaky feeling and dry feeling, and containing a component selected from an isostearoyl hydrolyzed collagen or a salt thereof, n-pentadecyl nicotinate, cepharanthine and benzyl nicotinate is obtained by formulating an extract of leaves of loquat, and further formulating an extract of white birch and/or an extract of Japanese pepper. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

 In hair nourishing cosmetics, since the hair growth effect is regarded as important, there are many cases where sufficient consideration is not given to the condition during use. Examples of problems include “sticky feeling due to blended components”, “feel of squeaking due to alcohol blended to dissolve various active ingredients”, and “feeling sticky after use”.

 The present invention relates to a hair nourishing cosmetic that exhibits an excellent hair-growth effect and does not have the above-mentioned unpleasant feelings (stickiness, tingling, rustiness), and gives a good condition to the scalp and hair. It is.

  Along with changes in the social environment and an increase in the number of elderly people, an increasing number of people suffer from thinning and hair loss. Thinning and hair loss are generally said to have a large genetic factor. Causes include "imbalance of male and female hormone balance", "insufficient daily scalp care", "excessive stress", "rapid diet", "biased diet" Yes. In addition, regardless of gender, an increasing number of people are worried about the decrease in the firmness and glossiness of hair due to aging.

  Hair grows as hair matrix cells repeat division and keratinize. In order for hair matrix cells to divide normally, it is necessary to absorb nutrients from the surrounding capillaries. However, due to aging and changes in the social environment as described above, when the capillaries of the scalp become thinner and the blood flow decreases, sufficient nutrients do not reach the hair matrix cells, resulting in `` thin hair '' , Phenomena such as a decrease in the “harshness” and “shininess” of hair occur. Therefore, in general, hair growth agents, hair nourishing agents, hair growth agents (hereinafter sometimes collectively referred to as “hair restoration cosmetics”) are components having a “cell activation effect” or “blood circulation promotion effect”. It contains a certain component and has a function of promoting hair matrix cell division.

  In addition, in order for hair to grow healthy, it is necessary to keep the scalp (pores) environment clean. For hair nourishing cosmetics, ingredients with “bactericidal and bacteriostatic effects” and “anti-inflammatory effects” Certain ingredients are also blended. Thus, hair nourishing cosmetics generally contain active ingredients such as “cell activation”, “blood circulation promotion”, “bactericidal and bacteriostatic”, “anti-inflammatory” as active ingredients. .

  People who are suffering from a decrease in “hairiness”, “hair loss”, “harshness” and “shininess” of hair strongly desire to increase the amount of hair and impart “harshness” and “shininess”. In order to meet these demands, various hair growth agents, hair nourishing agents, and hair growth agents have been developed so far (for example, Non-Patent Documents 1 to 4).

  So far, isostearoyl hydrolyzed collagen or its salt with excellent hair growth effect has been used for hair growth agents, hair nourishing agents, hair growth agents, etc., and selected from this component, n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate A hair restorer containing an active ingredient as an active ingredient has been proposed (for example, Patent Document 1). However, the above-mentioned isostearoyl hydrolyzed collagen or a salt thereof has been cited as an improvement subject due to the sticky feeling during use.

Further, hair nourishing cosmetics generally contain an alcohol in order to dissolve various active ingredients, and the squeaky feeling and softness generated by the alcohol can be cited as problems.
In this way, hair restoration cosmetics place importance on the hair-growth effect, so there are many cases where sufficient consideration is not given to the condition at the time of use, and uncomfortable feeling at the time of use (stickiness, creaking, rustiness, crispness) Sense) is often cited as an improvement problem, and realizing a good feeling of use is also an important requirement for hair nourishing cosmetics.

In addition, various types of hair nourishing cosmetics that have an effect of suppressing the feeling of tingling and rustling have been proposed so far. For example, Patent Document 2 discloses that a mixed solution of tea leaf extract and gentian extract reduces hair tingling.
"Hair Doctor" by Irwin I Lubowe, published by Hakuyosha, "Proper hair care and bald eradication method", 1962, pages 185-218 "Baldness is healed" by Masashi Inaba, published by Mainichi Shimbun, "The fact and treatment of baldness", published in 1977, pages 97-123 "What works for hair growth and hair growth", published by Katsuyuki Takeda, published by Seishun Publishing Co., Ltd. “TOMOTOMO October issue” written by Shingo Hiira, published by Shin Beauty Publishing Co., “Customers suffering from hair loss ... What advice should I give? ”Published 2005, pp. 75-77 Japanese Patent No. 3247774 Patent Claim etc. JP 09-077639 A Claims etc.

 In hair nourishing cosmetics, since the hair growth effect is regarded as important, there are many cases where sufficient consideration is not given to the condition during use. Examples of problems include “sticky feeling due to blended components”, “feel of squeaking due to alcohol blended to dissolve various active ingredients”, and “feeling sticky after use”. Therefore, there is a need for a hair nourishing cosmetic that does not have the above-mentioned unpleasant feeling (stickiness, tingling, rustling feeling) as described above, gives a good condition to the scalp and hair, and exhibits an excellent hair-growth effect. It had been.

  The present invention has been made paying attention to the above-mentioned actual situation, and its purpose is to exhibit an excellent hair-growth effect, and there is no discomfort during use (a sticky feeling, a squeaky feeling, a soft feeling), An object of the present invention is to provide a hair nourishing cosmetic that gives good conditions to the scalp and hair.

  The hair nourishing cosmetic of the present invention that has been able to achieve the above object comprises 0.00001 to 0.2% by mass of an extract of loquat leaf, and further an extract of birch and / or an extract of salamander Is formulated from 0.000009 to 0.08% by mass to improve stickiness, tingling, and crispness, and is derived from isostearoyl hydrolyzed collagen or a salt thereof, n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate. It has the characteristic of exhibiting an excellent hair-growth effect by containing selected components.

  According to the present invention, a loquat leaf extract and a birch extract and / or a salamander extract are added to improve the stickiness, creaking, and crispness, and the By containing a degraded collagen or a salt thereof and a component selected from n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate, a hair nourishing cosmetic having an excellent hair growth effect could be realized.

  The inventor studied from various angles in order to solve the above problems. As a result, extract of loquat leaves, if necessary, extract of birch and / or salamander extract, isostearoyl hydrolyzed collagen or its salt, n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate The present inventors have found that by adding a component selected from the above, it is possible to improve the feeling of stickiness, tingling, and softness while maintaining an excellent hair-growth effect.

  In addition, the extract of loquat leaves is defined as one obtained by extracting from loquat leaves with water, ethanol, 1,3-butylene glycol or a mixture thereof or absolute ethanol, and the birch extract is It is defined as being obtained by extracting water, ethanol, propylene glycol, 1,3-butylene glycol or a mixture thereof from the leaves, bark or xylem of European birch or other congeneric plants. It is defined as being obtained by extracting with an ethanol solution from the peel of a salamander or other related plant.

 The extract of loquat leaf used in the present invention is 1.0% by weight in terms of evaporation residue of loquat leaf extract, and the extract of birch is 0.8% by weight in terms of evaporation residue of birch extract, extraction of salamander The product is a 0.18% by weight sample in terms of the evaporation residue of the salamander extract.

 In order to effectively exhibit the above effects, it is preferable to blend 0.00001% by mass or more of loquat leaf extract. By blending loquat leaf extract in an amount of 0.00001% by mass or more, it is possible to suppress a feeling of squeakiness or a soft feeling. However, when the blending amount of the extract of loquat leaves becomes excessive, the crispness peculiar to the extract is generated, and therefore it is preferably 0.2% by mass or less.

 Furthermore, it is also useful that the hair nourishing cosmetic of the present invention contains a birch extract and / or a salamander extract as necessary. By blending a birch extract and / or a salamander extract, it is possible to enhance the sticky feeling suppression effect. In order for the birch extract and / or the salamander extract to act effectively, it is preferably blended in the range of 0.000009 to 0.08 mass%. Further, by containing a component selected from isostearoyl hydrolyzed collagen or a salt thereof and n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate, an excellent hair growth effect can be maintained.

  An ingredient selected from loquat leaf extract, birch extract and / or salamander extract, isostearoyl hydrolyzed collagen or salt thereof, and n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate is an essential component However, it may contain normal active ingredients and additives contained in hair nourishing cosmetics. Examples of such active ingredients include cell activators, blood circulation promoters, anti-inflammatory agents, bactericides, and bacteriostatic agents.

  Examples of the cell activator as the active ingredient include pantothenic acid and its derivatives (pantothenyl ethyl ether), N-acetyl-L-methionine, cephalanthin (Tamazaki tsumugi dialkaloid), adenosine triphosphate disodium, potassium aspartate, Photosensitive element No. 301, carrot extract, biotin, mononitroguaiacol, allantoin, pentadecane glyceride, yeast extract, garlic component, pearl protein extract, tiso extract, placenta extract, royal jelly and the like.

  Blood circulation promoters include carpronium chloride, assembly extract, capsicum tincture, cephalanthin, benzyl nicotinate, garlic extract, toki extract, γ-oryzanol, licorice, minoxidil, nematode, chixetsuninjin, ginseng, ginger, jiou, aloe, spironolactone , D-camphor, DL-camphor, DL-α-tocopherol, garlic iodide extract, DL-α-tocopherol linolenate, inositol hexanicotinate, nicotinic acid, DL-α-tocopherol nicotinate, butoxy nicotinate Examples include ethyl, methyl nicotinate, nonanoic acid vanillylamide, DL-α-tocopherol succinate, DL-α-tocopherol acetate, cantharis tincture and ginger tincture. .

  Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, fat-soluble glycyrrhetinic acids, licorice extract, azulene, guaiazulene, diphenhydramine and other antihistamines, sicon extract, age extract, oxon extract, chamomile extract, kumaza extract, birch extract Examples include extract, mallow extract, peach leaf extract, yarrow extract, fennel extract, body sage extract, hydrocortisone acetate, prednisolone, and the like.

  Bactericides and bacteriostatic agents include isopropylmethylphenol, resorcin, triclosan, trichlorocarbanilide, sulfur, photosensitizer 201, benzalkonium chloride, benzethonium chloride, zinc pyrithione, alkyldiaminoethylglycine hydrochloride, salicylic acid, piroctone ora Min, hinokitiol, potassium sorbate, vitamin B6 hydrochloride (pyridoxine hydrochloride), phenol and the like.

  As additives for hair nourishing cosmetics, humectants, pigments, fragrances, preservatives, keratolytic agents, antioxidants, pH adjusting agents, acid / alkali agents, and the like can be appropriately blended.

  Examples of the humectant include polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, and glycerin, collagen, collagen degrading peptide, elastin degrading peptide, keratin degrading peptide, silk proteolytic peptide, soybean proteolytic peptide, Proteins and peptides such as wheat proteolytic peptides and casein degrading peptides and their derivatives, amino acids such as arginine, serine, glycine, glutamic acid and trimethylglycine, aloe extract, hammamel water, loofah water, chamomile extract, licorice extract, etc. Plant extract components, sodium hyaluronate, citrate, chondroitin sulfate, sodium lactate, sodium 2-pyrrolidone-5-carboxylate and the like can be mentioned.

  Examples of the preservative include p-hydroxybenzoic acid esters, benzoates, phenoxyethanol, quaternary ammonium salts and the like.

  pH adjusters / acids / alkali agents include phosphoric acid, malic acid, tartaric acid, carbonic acid, fumaric acid, citric acid, lactic acid, glycolic acid, succinic acid, hydrochloric acid, sulfuric acid, nitric acid or salts thereof, sodium hydroxide, water Examples thereof include potassium oxide, disodium hydrogen phosphate, monoethanolamine, diethanolamine, triethanolamine, arginine, aqueous ammonia, aminomethylpropanol, and salts thereof.

  As the solvents for dissolving the hair nourishing cosmetic of the present invention, water, ethanol and decamethylcyclopentasiloxane are generally used. In addition to these, lower alcohols such as 2-propanol should be used. Can do. The dosage form of the hair nourishing cosmetic of the present invention is useful in liquid form.

  Next, the present invention will be specifically described by way of examples. However, the following examples are not intended to limit the present invention, and all modifications may be made without departing from the gist of the present invention. Included in the range.

[Example 1]
(Sensory evaluation method of stickiness feeling suppression effect: confirmation test 1 of stickiness feeling suppression effect)
Each sample (formulation examples 1 to 27) shown in Tables 1 to 5 below was applied to a hair bundle not subjected to chemical treatment (for example, permanent treatment or hair color treatment) at a bath ratio of 1: 1. After the hair bundles were naturally dried, the sticky feeling of the hair bundles was subjected to sensory evaluation in the following three stages (evaluation points: 1 to 3 points) with 10 professional panelists, and the total was obtained and evaluated according to the following evaluation criteria. . At that time, with respect to the hair bundle treated in Formulation Example 1, the hair bundle treated in Formulation Example 1 was evaluated with respect to the sticky feeling suppression effect of the hair bundle treated in other Formulation Examples. The results are shown in Tables 1-5.

  3 points: Compared with Formulation Example 1, the sticky feeling was clearly suppressed.

  2 points: Compared with Formulation Example 1, the sticky feeling was suppressed.

1 point: Compared to Formulation Example 1, there was no change in the stickiness.
[Evaluation Criteria 1 for Stickiness Reduction Effect]
◎: 26 to 30 points ○: 21 to 25 points Δ: 16 to 20 points ×: 10 to 15 points (Measuring method in variation value of friction coefficient: Confirmation test 2 for effect of suppressing stickiness)
(A) Target hair A fixed hair piece for friction measurement (hereinafter referred to as “measurement hair bundle”) was prepared using hair that had not undergone chemical treatment.

(B) Measurement and evaluation (1) Treatment of hair: Formulation examples 1 to 27 were applied to the measurement hair bundle at a bath ratio of 1: 1.

  (2) Humidity adjustment of hair: The hair bundle for measurement was conditioned at (20 ° C., humidity 60%) for 24 hours or more.

  (3) Measuring equipment and conditions: A friction tester “KES-SE” (manufactured by Kato Tech Co., Ltd.) was used for the measurement.

  (4) Fluctuation coefficient fluctuation value (MMD: μ) was calculated by “KES-SE”.

 The obtained variation value of the friction coefficient was evaluated according to the following evaluation criteria. The results are also shown in Tables 1-5.

[Evaluation Criteria 2 for Stickiness (Friction Coefficient Variation μ)]
◎: Fluctuation coefficient variation value μ is 76 × 10 ⁻⁴ or more and less than 80 × 10 ⁻⁴ ○: Friction coefficient variation value μ is 70 × 10 ⁻⁴ or more and less than 76 × 10 ⁻⁴ , 80 × 10 ⁻⁴ or more and less than 86 × 10 ⁻⁴ △: Friction coefficient variation value μ is 64X10 ^-4 least 70x10 less than ^{-4, 86x10 -4} least 92X10 below ^-4 ×: variation coefficient of friction μ is 64X10 less than ^-4, 92x10 ^-4 above example 2
(Squeezing effect suppression effect)
Each sample (formulation examples 1 to 27) shown in Tables 1 to 5 below was applied to a hair bundle not subjected to chemical treatment so as to have a bath ratio of 1: 1. The sensory evaluation of the feeling of squeezing of the hair bundle when it was applied to the hair bundle was performed by the 10 panelists in the following three stages (evaluation points: 1 to 3 points), and the total was obtained and evaluated according to the following evaluation criteria. . The results are shown in Tables 1-5. At that time, the hair bundle treated in Formulation Example 1 was used as a reference, and the hair bundle treated in Formulation Example 1 was evaluated for the effect of suppressing the squeaky feeling of the hair bundle treated in other Formulation Examples. The results are shown in Tables 1-5.

  3 points: Compared with Formulation Example 1, the feeling of tingling was clearly suppressed.

  2 points: Compared with Formulation Example 1, the sensation of creaking was suppressed.

  1 point: Compared to Formulation Example 1, there was no change in the sensation of feeling.

[Evaluation Criteria for Suppressing Effect of Hair's Kishimi]
◎: 26 to 30 points ○: 21 to 25 points Δ: 16 to 20 points ×: 10 to 15 points [Example 3]
(Suppressing effect of rustling)
Each sample (formulation examples 1 to 27) shown in Tables 1 to 5 below was applied to a hair bundle not subjected to chemical treatment so as to have a bath ratio of 1: 1. After the hair bundle was naturally dried, the sense of roughness of the hair bundle was subjected to sensory evaluation in the following three stages (evaluation points: 1 to 3) by 10 professional panelists, and the total was obtained and evaluated according to the following evaluation criteria. . The results are shown in Tables 1-5. At that time, with respect to the hair bundles processed in Formulation Example 1, the hair bundles processed in Formulation Example 1 were evaluated for the effect of suppressing the loose feeling of the hair bundles processed in other Formulation Examples. The results are shown in Tables 1-5.

  3 points: Compared with Formulation Example 1, the crispness was clearly suppressed.

  2 points: Compared with Formulation Example 1, the feeling of rustling was suppressed.

  1 point: Compared to Formulation Example 1, there was no change in the crispness.

[Evaluation Criteria for Suppression Effect of Pasaki]
◎: 26-30 points ○: 21-25 points △: 16-20 points ×: 10-15 points

 As is apparent from these results, the extract of loquat leaves is contained in an amount of 0.00001 to 0.2% by mass (Formulation Examples 2, 8 to 11), and further, birch extract and / or salamander extract is added. It was recognized that if 0.000009 to 0.08% by mass (Prescription Examples 13 to 15, 17 to 18, 21 to 22, 25 to 26) was mixed, the sticky feeling, the squeaking feeling, and the soft feeling could be suppressed. If all of the three kinds of extracts are incorporated in an excessive amount, the effect cannot be obtained. If the amount is excessive, a new problem that the hair after application is variably caused occurs. Therefore, in order to suppress the sticky feeling, the squeaking feeling, and the soft feeling, it is preferably within the above range.

[Example 4]
(Evaluation method for hair growth effect)
As test animals, 6 week-old C3H / He male mice (10-15 mice per group) were preliminarily kept for 1 week, and the day before the test, the skin surface of the animal's back about 8 cm ² under ether anesthesia was used for animals. The hair was shaved with an electric clipper (manufactured by Natsume Seisakusho Co., Ltd.) so as not to damage the skin. Samples (Prescription Examples 28 to 30) shown in the following Table 6 were applied to each back skin of the hair-removed animal once a day every day except for soil and Sunday. The application amount at one time was 150 μL / time, and after dropping with a micropipette, the whole part was spread with a fluororesin rod. The evaluation of hair regeneration was performed based on the daily change in the area ratio of the hair regeneration part to the hair removal part (hair growth area (%)).

  The hair growth area (%) was determined by the following procedure. From the time when hair growth was confirmed, a photograph of the application site was taken using a digital camera every day. Thereafter, the image was read by image processing software “Image J”, the entire application site and the hair growth site were selected using a pen tablet, and the area of each site was measured by the number of pixels. The hair growth area (%) was calculated from the number of pixels (s) of the hair growth site and the number of pixels (S) of the entire application site using the following formula (1). The results are shown in Table 6.

Hair growth area (%) = s / S × 100 (1)
[Evaluation criteria for hair growth effect]
○: Hair growth area on 27th day after application is 30% or more ×: Hair growth area on 27th day after application is less than 30%

  As can be judged from the results shown in Table 6, the present three extracts and isostearoyl hydrolyzed collagen or a salt thereof and a component selected from n-pentadecyl nicotinate, cephalanthin and benzyl nicotinate It was found that the blended formulation example 28 showed a hair restoration effect as high as the formulation example 29 which is a known patent formulation example. In addition, it was found that the hair growth effect cannot be exhibited in Formulation Example 30 in which only three kinds of extracts are blended.

Claims (5)

 A hair nourishing cosmetic comprising a loquat leaf extract.  The hair nourishing cosmetic according to claim 1, wherein the extract of loquat leaves is blended at a ratio of 0.00001 to 0.2% by mass.   The hair nourishing cosmetic according to claim 1 or 2, wherein a birch extract and / or a salamander extract is blended.   The hair nourishing cosmetic according to any one of claims 1 to 3, wherein a birch extract and / or a salamander extract is blended in a proportion of 0.000009 to 0.08 mass%.  The hair nourishing cosmetic according to any one of claims 1 to 4, comprising a component selected from isostearoyl hydrolyzed collagen or a salt thereof and n-pentadecylnicotinate, cephalanthin and benzyl nicotinate.