JP2010070468A5 - - Google Patents
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- Publication number
- JP2010070468A5 JP2010070468A5 JP2008237059A JP2008237059A JP2010070468A5 JP 2010070468 A5 JP2010070468 A5 JP 2010070468A5 JP 2008237059 A JP2008237059 A JP 2008237059A JP 2008237059 A JP2008237059 A JP 2008237059A JP 2010070468 A5 JP2010070468 A5 JP 2010070468A5
- Authority
- JP
- Japan
- Prior art keywords
- advanced glycation
- end product
- glycation end
- compound
- nmr spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 39
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 20
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 15
- 108010005094 Advanced Glycation End Products Proteins 0.000 claims description 12
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 230000015556 catabolic process Effects 0.000 claims description 7
- 238000000354 decomposition reaction Methods 0.000 claims description 7
- 238000006731 degradation reaction Methods 0.000 claims description 7
- 230000014759 maintenance of location Effects 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 6
- 238000001228 spectrum Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 235000003826 Artemisia Nutrition 0.000 claims description 5
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 5
- 235000009052 artemisia Nutrition 0.000 claims description 5
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims description 5
- 238000010898 silica gel chromatography Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 240000006891 Artemisia vulgaris Species 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002798 polar solvent Substances 0.000 claims description 3
- 241000208838 Asteraceae Species 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 238000000622 liquid--liquid extraction Methods 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 238000005194 fractionation Methods 0.000 claims 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 28
- 244000030166 artemisia Species 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012156 elution solvent Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- -1 s Species 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008237059A JP5424600B2 (ja) | 2008-09-16 | 2008-09-16 | アドバンスド・グリケーション・エンドプロダクツ分解剤及び該アドバンスド・グリケーション・エンドプロダクツ分解剤を含有してなる化粧料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008237059A JP5424600B2 (ja) | 2008-09-16 | 2008-09-16 | アドバンスド・グリケーション・エンドプロダクツ分解剤及び該アドバンスド・グリケーション・エンドプロダクツ分解剤を含有してなる化粧料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010070468A JP2010070468A (ja) | 2010-04-02 |
| JP2010070468A5 true JP2010070468A5 (enExample) | 2011-10-20 |
| JP5424600B2 JP5424600B2 (ja) | 2014-02-26 |
Family
ID=42202606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008237059A Active JP5424600B2 (ja) | 2008-09-16 | 2008-09-16 | アドバンスド・グリケーション・エンドプロダクツ分解剤及び該アドバンスド・グリケーション・エンドプロダクツ分解剤を含有してなる化粧料 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5424600B2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5969787B2 (ja) * | 2011-03-23 | 2016-08-17 | 第一三共ヘルスケア株式会社 | 生体内のメイラード反応抑制剤またはＡＧＥｓ生成抑制剤 |
| JP5926931B2 (ja) * | 2011-11-14 | 2016-05-25 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| KR20150119336A (ko) * | 2013-02-18 | 2015-10-23 | 아크레이 가부시키가이샤 | 산화 단백질 분해효소 활성 증강화제 |
| JP5766775B2 (ja) * | 2013-11-29 | 2015-08-19 | ポーラ化成工業株式会社 | くすみ改善に好適な皮膚外用剤の製造方法 |
| CN115015401B (zh) * | 2022-02-16 | 2023-04-07 | 广州医科大学附属第五医院 | 一种茵陈蒿汤复方制剂的指纹图谱检测方法 |
| CN115887518A (zh) * | 2022-12-26 | 2023-04-04 | 上海家化联合股份有限公司 | 青蒿提取物的抗糖化应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4979181B2 (ja) * | 2003-01-31 | 2012-07-18 | 株式会社ヤクルト本社 | グリケーション阻害剤及びその利用 |
| JP2007161663A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | ＡＧＥｓ分解化粧料 |
-
2008
- 2008-09-16 JP JP2008237059A patent/JP5424600B2/ja active Active
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