JP2010024141A - モルヒネの製造方法 - Google Patents

モルヒネの製造方法 Download PDF

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Publication number
JP2010024141A
JP2010024141A JP2008179499A JP2008179499A JP2010024141A JP 2010024141 A JP2010024141 A JP 2010024141A JP 2008179499 A JP2008179499 A JP 2008179499A JP 2008179499 A JP2008179499 A JP 2008179499A JP 2010024141 A JP2010024141 A JP 2010024141A
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JP
Japan
Prior art keywords
general formula
compound represented
group
morphine
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008179499A
Other languages
English (en)
Japanese (ja)
Inventor
Toru Fukuyama
透 福山
Satoshi Yokoshima
聡 横島
Hifumi Koizumi
一二三 小泉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
Original Assignee
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC filed Critical University of Tokyo NUC
Priority to JP2008179499A priority Critical patent/JP2010024141A/ja
Priority to PCT/JP2009/058040 priority patent/WO2009154041A1/fr
Publication of JP2010024141A publication Critical patent/JP2010024141A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008179499A 2008-06-20 2008-07-09 モルヒネの製造方法 Pending JP2010024141A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008179499A JP2010024141A (ja) 2008-06-20 2008-07-09 モルヒネの製造方法
PCT/JP2009/058040 WO2009154041A1 (fr) 2008-06-20 2009-04-23 Procédé de fabrication de la morphine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008161165 2008-06-20
JP2008179499A JP2010024141A (ja) 2008-06-20 2008-07-09 モルヒネの製造方法

Publications (1)

Publication Number Publication Date
JP2010024141A true JP2010024141A (ja) 2010-02-04

Family

ID=41433958

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008179499A Pending JP2010024141A (ja) 2008-06-20 2008-07-09 モルヒネの製造方法

Country Status (2)

Country Link
JP (1) JP2010024141A (fr)
WO (1) WO2009154041A1 (fr)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013022139; ＴＲＡＵＮＥＲ，Ｄ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　Ｅｎａｎｔｉｏｍｅｒｉｃａｌｌｙ　Ｐｕｒｅ　Ｍｏｒｐｈｉｎｅ　Ａｌｋａｌｏｉｄｓ：　Ｔｈｅ　Ｈｙｄｒｏｐｈｅｎａｎｔｈｒｅｎｅ　Ｒｏｕｔｅ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６３，　Ｎｏ．１７, 1998, ｐ．５９０８-５９１８ *
JPN6013022140; ＴＯＴＨ，Ｊ．Ｅ．　ｅｔ　ａｌ: 'Ｆｏｒｍａｔｉｏｎ　ｏｆ　ｔｈｅ　ｎｅｏｐｉｎｏｎｅ／ｃｏｄｅｉｎｏｎｅ　ｒｉｎｇ　ｓｙｓｔｅｍ　ｖｉａ　ｉｎｔｒａｍｏｌｅｃｕｌａｒ　１，６-ａｄｄｉｔｉｏｎ　ｏｆ　ａｎ　ａｍｉｎｏ　ｍｏｉｅｔｙ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５１，　Ｎｏ．１３, 1986, ｐ．２５９４-２５９６ *

Also Published As

Publication number Publication date
WO2009154041A1 (fr) 2009-12-23

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