JP2009545756A5 - - Google Patents
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- Publication number
- JP2009545756A5 JP2009545756A5 JP2009523338A JP2009523338A JP2009545756A5 JP 2009545756 A5 JP2009545756 A5 JP 2009545756A5 JP 2009523338 A JP2009523338 A JP 2009523338A JP 2009523338 A JP2009523338 A JP 2009523338A JP 2009545756 A5 JP2009545756 A5 JP 2009545756A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide sequence
- peptide
- identifying
- aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 238000000034 method Methods 0.000 claims 20
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 230000004845 protein aggregation Effects 0.000 claims 7
- 230000002776 aggregation Effects 0.000 claims 6
- 238000004220 aggregation Methods 0.000 claims 6
- 238000012360 testing method Methods 0.000 claims 6
- 108010067902 Peptide Library Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 230000002194 synthesizing effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000033077 cellular process Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000006384 oligomerization reaction Methods 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82155306P | 2006-08-04 | 2006-08-04 | |
| PCT/GB2007/002789 WO2008015384A1 (en) | 2006-08-04 | 2007-07-24 | Method for predicting protein aggregation and designing aggregation inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009545756A JP2009545756A (ja) | 2009-12-24 |
| JP2009545756A5 true JP2009545756A5 (enExample) | 2010-09-09 |
Family
ID=38573441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523338A Pending JP2009545756A (ja) | 2006-08-04 | 2007-07-24 | タンパク質凝集を予測し凝集阻害物質を設計する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8290713B2 (enExample) |
| EP (1) | EP2047393A1 (enExample) |
| JP (1) | JP2009545756A (enExample) |
| KR (1) | KR20090047470A (enExample) |
| CN (1) | CN101501694B (enExample) |
| AU (1) | AU2007280282B2 (enExample) |
| CA (1) | CA2657847A1 (enExample) |
| EA (1) | EA016884B1 (enExample) |
| IL (1) | IL196551A (enExample) |
| SG (1) | SG173405A1 (enExample) |
| WO (1) | WO2008015384A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| GB2455102A (en) * | 2007-11-28 | 2009-06-03 | Cambridge Entpr Ltd | Protein Aggregation Prediction Systems |
| EP2278998A1 (en) | 2008-04-17 | 2011-02-02 | Declion Pharmaceuticals, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| CN110187119B (zh) * | 2008-10-31 | 2022-07-29 | 耶鲁大学 | 子痫前期检测和治疗的方法和组合物 |
| WO2011047442A1 (en) * | 2009-10-23 | 2011-04-28 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using same |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| FI20105629A0 (fi) * | 2010-06-03 | 2010-06-03 | Estaja Oy | Menetelmä lipidiaktivoituvien entsyymien peptidi-inhibiittoreiden valmistamiseksi ja menetelmällä valmistettuja peptidejä |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US20120108904A1 (en) * | 2010-10-20 | 2012-05-03 | Yong Ma | Cleaner for endoscope |
| CN103772487B (zh) * | 2012-10-24 | 2015-11-25 | 国家纳米科学中心 | 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用 |
| US9618524B2 (en) * | 2014-03-26 | 2017-04-11 | Plaxgen Inc. | Method, composition, isolation and identification of a plaque particle and related biomarker |
| CN104502219B (zh) * | 2014-12-18 | 2017-09-29 | 江苏大学 | 一种淀粉样多肽聚集抑制剂及其抑制效果评估和验证方法 |
| SG11201705275VA (en) * | 2015-01-06 | 2017-07-28 | Univ North Carolina State | Modeling ribosome dynamics to optimize heterologous protein production |
| GB201600176D0 (en) * | 2016-01-06 | 2016-02-17 | Cambridge Entpr Ltd | Method of identifying novel protein aggregation inhibitors based on chemical kinetics |
| BR112018014870A2 (pt) * | 2016-01-21 | 2018-12-11 | Protein Dynamic Solutions Llc | método e sistema para análise de dados espectrais |
| US10815271B2 (en) * | 2016-06-29 | 2020-10-27 | The Regents Of The University Of California | Structure-based peptide inhibitors of alpha-synuclein aggregation |
| CN106501550A (zh) * | 2016-12-09 | 2017-03-15 | 江苏大学 | 基于原子力显微镜氨基酸影响鱼蛋白聚集行为的评价方法 |
| CN111653310B (zh) * | 2020-06-29 | 2023-06-20 | 北京大学深圳研究生院 | 含二硫键多肽的结构预测方法及装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA004739B1 (ru) * | 1999-11-05 | 2004-08-26 | Эксоникс, Инк. | ПЕПТИДНЫЕ АНАЛОГИ И МИМЕТИКИ, ПОДХОДЯЩИЕ ДЛЯ ПРИМЕНЕНИЯ IN VIVO ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АНОМАЛЬНОЙ УКЛАДКОЙ БЕЛКОВ В АМИЛОИДНЫЕ ИЛИ АМИЛОИДПОДОБНЫЕ ОТЛОЖЕНИЯ, ИЛИ ИХ ПАТОЛОГИЧЕСКИЕ ПРЕДШЕСТВЕННИКИ, ОБОГАЩЕННЫЕ b-СКЛАДКАМИ |
| EP1646375A2 (en) * | 2003-06-23 | 2006-04-19 | Neurochem (International) Limited | Treatment of protein aggregation disorders |
| GB0325817D0 (en) | 2003-11-05 | 2003-12-10 | Univ Cambridge Tech | Method and apparatus for assessing polypeptide aggregation |
-
2007
- 2007-07-24 KR KR1020097002794A patent/KR20090047470A/ko not_active Ceased
- 2007-07-24 CN CN2007800290322A patent/CN101501694B/zh not_active Expired - Fee Related
- 2007-07-24 EA EA200970180A patent/EA016884B1/ru not_active IP Right Cessation
- 2007-07-24 US US12/376,233 patent/US8290713B2/en not_active Expired - Fee Related
- 2007-07-24 SG SG2011052834A patent/SG173405A1/en unknown
- 2007-07-24 AU AU2007280282A patent/AU2007280282B2/en not_active Ceased
- 2007-07-24 JP JP2009523338A patent/JP2009545756A/ja active Pending
- 2007-07-24 WO PCT/GB2007/002789 patent/WO2008015384A1/en not_active Ceased
- 2007-07-24 EP EP07789035A patent/EP2047393A1/en not_active Withdrawn
- 2007-07-24 CA CA002657847A patent/CA2657847A1/en not_active Abandoned
-
2009
- 2009-01-15 IL IL196551A patent/IL196551A/en not_active IP Right Cessation
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