EA016884B1 - Способ предсказания агрегации белков и конструирования ингибиторов агрегации - Google Patents
Способ предсказания агрегации белков и конструирования ингибиторов агрегации Download PDFInfo
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- EA016884B1 EA016884B1 EA200970180A EA200970180A EA016884B1 EA 016884 B1 EA016884 B1 EA 016884B1 EA 200970180 A EA200970180 A EA 200970180A EA 200970180 A EA200970180 A EA 200970180A EA 016884 B1 EA016884 B1 EA 016884B1
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82155306P | 2006-08-04 | 2006-08-04 | |
| PCT/GB2007/002789 WO2008015384A1 (en) | 2006-08-04 | 2007-07-24 | Method for predicting protein aggregation and designing aggregation inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970180A1 EA200970180A1 (ru) | 2009-08-28 |
| EA016884B1 true EA016884B1 (ru) | 2012-08-30 |
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| EA200970180A EA016884B1 (ru) | 2006-08-04 | 2007-07-24 | Способ предсказания агрегации белков и конструирования ингибиторов агрегации |
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| EP (1) | EP2047393A1 (enExample) |
| JP (1) | JP2009545756A (enExample) |
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| IL (1) | IL196551A (enExample) |
| SG (1) | SG173405A1 (enExample) |
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Families Citing this family (22)
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| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| GB2455102A (en) * | 2007-11-28 | 2009-06-03 | Cambridge Entpr Ltd | Protein Aggregation Prediction Systems |
| EP2278998A1 (en) | 2008-04-17 | 2011-02-02 | Declion Pharmaceuticals, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| CN110187119B (zh) * | 2008-10-31 | 2022-07-29 | 耶鲁大学 | 子痫前期检测和治疗的方法和组合物 |
| WO2011047442A1 (en) * | 2009-10-23 | 2011-04-28 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using same |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| FI20105629A0 (fi) * | 2010-06-03 | 2010-06-03 | Estaja Oy | Menetelmä lipidiaktivoituvien entsyymien peptidi-inhibiittoreiden valmistamiseksi ja menetelmällä valmistettuja peptidejä |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US20120108904A1 (en) * | 2010-10-20 | 2012-05-03 | Yong Ma | Cleaner for endoscope |
| CN103772487B (zh) * | 2012-10-24 | 2015-11-25 | 国家纳米科学中心 | 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用 |
| US9618524B2 (en) * | 2014-03-26 | 2017-04-11 | Plaxgen Inc. | Method, composition, isolation and identification of a plaque particle and related biomarker |
| CN104502219B (zh) * | 2014-12-18 | 2017-09-29 | 江苏大学 | 一种淀粉样多肽聚集抑制剂及其抑制效果评估和验证方法 |
| SG11201705275VA (en) * | 2015-01-06 | 2017-07-28 | Univ North Carolina State | Modeling ribosome dynamics to optimize heterologous protein production |
| GB201600176D0 (en) * | 2016-01-06 | 2016-02-17 | Cambridge Entpr Ltd | Method of identifying novel protein aggregation inhibitors based on chemical kinetics |
| BR112018014870A2 (pt) * | 2016-01-21 | 2018-12-11 | Protein Dynamic Solutions Llc | método e sistema para análise de dados espectrais |
| US10815271B2 (en) * | 2016-06-29 | 2020-10-27 | The Regents Of The University Of California | Structure-based peptide inhibitors of alpha-synuclein aggregation |
| CN106501550A (zh) * | 2016-12-09 | 2017-03-15 | 江苏大学 | 基于原子力显微镜氨基酸影响鱼蛋白聚集行为的评价方法 |
| CN111653310B (zh) * | 2020-06-29 | 2023-06-20 | 北京大学深圳研究生院 | 含二硫键多肽的结构预测方法及装置 |
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| WO2005045442A1 (en) * | 2003-11-05 | 2005-05-19 | Cambridge University Technical Services Limited | Method and apparatus for assessing polypeptide aggregation |
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| EA004739B1 (ru) * | 1999-11-05 | 2004-08-26 | Эксоникс, Инк. | ПЕПТИДНЫЕ АНАЛОГИ И МИМЕТИКИ, ПОДХОДЯЩИЕ ДЛЯ ПРИМЕНЕНИЯ IN VIVO ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АНОМАЛЬНОЙ УКЛАДКОЙ БЕЛКОВ В АМИЛОИДНЫЕ ИЛИ АМИЛОИДПОДОБНЫЕ ОТЛОЖЕНИЯ, ИЛИ ИХ ПАТОЛОГИЧЕСКИЕ ПРЕДШЕСТВЕННИКИ, ОБОГАЩЕННЫЕ b-СКЛАДКАМИ |
| EP1646375A2 (en) * | 2003-06-23 | 2006-04-19 | Neurochem (International) Limited | Treatment of protein aggregation disorders |
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| WO2005045442A1 (en) * | 2003-11-05 | 2005-05-19 | Cambridge University Technical Services Limited | Method and apparatus for assessing polypeptide aggregation |
Non-Patent Citations (3)
| Title |
|---|
| ARAVINDA SUBRAYASHASTRY ET AL.: "Structure and Assembly of Designed beta - Hairpin Peptides in Crystals as Models for beta - Sheet Aggregation", BIOCHEMISTRY; BIOCHEMISTRY FEB 24 2004, vol. 43, no. 7, 24 February 2004 (2004-02-24), pages 1832-1846, XP002456617, the whole document * |
| DE GROOT NATALIA SÁNCHEZ ET AL.: "Prediction of hot spots of aggregation in disease-linked polypeptides" BMC STRUCTURAL BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 5, no. 1, 30 September 2005 (2005-09-30), page 18, XP021006180, ISSN: 1472-6807, whole document, in particular abstract, p.9, left. col. whole first paragraph, p.11., right col. second paragraph, p.12, left col. * |
| PAWAR A.R. ET AL.: "Prediction of ''Aggregation-prone'' and "Aggregation-susceptible" Regions in Proteins Associated with Neurodegenerative Diseases", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 350, no. 2, 8 July 2005 (2005-07-08), pages 379-392, XP004927302, ISSN: 0022-2836, whole document, in particular, abstract, p. 381, right col. - p. 382, left col., first paragraph, p. 382, left col. Third paragraph, p. 387, right col., last 2 paragraphs * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL196551A (en) | 2013-01-31 |
| SG173405A1 (en) | 2011-08-29 |
| KR20090047470A (ko) | 2009-05-12 |
| EP2047393A1 (en) | 2009-04-15 |
| CN101501694A (zh) | 2009-08-05 |
| US8290713B2 (en) | 2012-10-16 |
| JP2009545756A (ja) | 2009-12-24 |
| CA2657847A1 (en) | 2008-02-07 |
| WO2008015384A1 (en) | 2008-02-07 |
| HK1131239A1 (en) | 2010-01-15 |
| AU2007280282A1 (en) | 2008-02-07 |
| CN101501694B (zh) | 2011-11-30 |
| AU2007280282B2 (en) | 2012-02-02 |
| US20100160602A1 (en) | 2010-06-24 |
| IL196551A0 (en) | 2009-11-18 |
| WO2008015384A8 (en) | 2008-05-15 |
| EA200970180A1 (ru) | 2009-08-28 |
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