JP2009538894A - インビボイメージング化合物としての四環式オキサゼピン類 - Google Patents
インビボイメージング化合物としての四環式オキサゼピン類 Download PDFInfo
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- JP2009538894A JP2009538894A JP2009512674A JP2009512674A JP2009538894A JP 2009538894 A JP2009538894 A JP 2009538894A JP 2009512674 A JP2009512674 A JP 2009512674A JP 2009512674 A JP2009512674 A JP 2009512674A JP 2009538894 A JP2009538894 A JP 2009538894A
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- 150000004905 tetrazines Chemical class 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 150000004654 triazenes Chemical class 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0610866.6A GB0610866D0 (en) | 2006-06-02 | 2006-06-02 | Novel in vivo imaging compounds |
| PCT/GB2007/002024 WO2007141491A1 (en) | 2006-06-02 | 2007-05-31 | Tricyclic oxazepines as in vivo imaging compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538894A true JP2009538894A (ja) | 2009-11-12 |
| JP2009538894A5 JP2009538894A5 (enExample) | 2010-06-17 |
Family
ID=36694794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512674A Pending JP2009538894A (ja) | 2006-06-02 | 2007-05-31 | インビボイメージング化合物としての四環式オキサゼピン類 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090317328A1 (enExample) |
| EP (1) | EP2024373A1 (enExample) |
| JP (1) | JP2009538894A (enExample) |
| CN (1) | CN101460504A (enExample) |
| GB (1) | GB0610866D0 (enExample) |
| WO (1) | WO2007141491A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5324122B2 (ja) * | 2008-04-08 | 2013-10-23 | 関東電化工業株式会社 | 含フッ素アシル化アミン及びその製造方法 |
| WO2010093001A1 (ja) * | 2009-02-13 | 2010-08-19 | 国立大学法人大阪大学 | アルツハイマー病の診断方法および診断薬 |
| GB0908711D0 (en) * | 2009-05-20 | 2009-07-01 | Isis Innovation | Preparation of labelled compounds |
| WO2011006922A1 (en) * | 2009-07-14 | 2011-01-20 | Sanofi-Aventis Deutschland Gmbh | Medicament container with a flexible inner layer and a rigid outer layer |
| ES2444779T3 (es) * | 2009-09-28 | 2014-02-26 | F. Hoffmann-La Roche Ag | Compuestos de benzoxazepina inhibidores de la PI3K y su utilización en el tratamiento de cáncer |
| US20150190534A1 (en) * | 2014-01-09 | 2015-07-09 | University Of Bern | Compounds for use as positron emission imaging agents |
| PE20211775A1 (es) | 2015-07-02 | 2021-09-08 | Hoffmann La Roche | Compuestos de benzoxacepina oxazolidinona y metodos de uso |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04211670A (ja) * | 1990-03-05 | 1992-08-03 | Merck & Co Inc | 膵イメージング用γ線放出ＣＣＫ−Ａ拮抗薬 |
| JPH0841036A (ja) * | 1995-03-03 | 1996-02-13 | Sumitomo Chem Co Ltd | 放射性ベンゾジアゼピン誘導体およびその製造法 |
| WO1998049900A1 (en) * | 1997-05-07 | 1998-11-12 | Emory University | Haloisoquinoline carboxamide |
| WO1999051594A1 (en) * | 1998-04-03 | 1999-10-14 | Australian Nuclear Science & Technology Organisation | IMIDAZO[1,2-a]PYRIDINES AS PERIPHERAL BENZODIAZEPINE RECEPTOR BINDING AGENTS |
| WO1999056736A2 (en) * | 1998-05-06 | 1999-11-11 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Apoptosis-inducing compounds |
| WO2001058904A1 (en) * | 2000-02-11 | 2001-08-16 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Apoptosis-inducing compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523506D0 (en) * | 2005-11-18 | 2005-12-28 | Hammersmith Imanet Ltd | Novel in vivo imaging compounds |
-
2006
- 2006-06-02 GB GBGB0610866.6A patent/GB0610866D0/en not_active Ceased
-
2007
- 2007-05-31 JP JP2009512674A patent/JP2009538894A/ja active Pending
- 2007-05-31 CN CNA2007800202961A patent/CN101460504A/zh active Pending
- 2007-05-31 WO PCT/GB2007/002024 patent/WO2007141491A1/en not_active Ceased
- 2007-05-31 EP EP07733040A patent/EP2024373A1/en not_active Withdrawn
- 2007-05-31 US US12/302,895 patent/US20090317328A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04211670A (ja) * | 1990-03-05 | 1992-08-03 | Merck & Co Inc | 膵イメージング用γ線放出ＣＣＫ−Ａ拮抗薬 |
| JPH0841036A (ja) * | 1995-03-03 | 1996-02-13 | Sumitomo Chem Co Ltd | 放射性ベンゾジアゼピン誘導体およびその製造法 |
| WO1998049900A1 (en) * | 1997-05-07 | 1998-11-12 | Emory University | Haloisoquinoline carboxamide |
| WO1999051594A1 (en) * | 1998-04-03 | 1999-10-14 | Australian Nuclear Science & Technology Organisation | IMIDAZO[1,2-a]PYRIDINES AS PERIPHERAL BENZODIAZEPINE RECEPTOR BINDING AGENTS |
| WO1999056736A2 (en) * | 1998-05-06 | 1999-11-11 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Apoptosis-inducing compounds |
| WO2001058904A1 (en) * | 2000-02-11 | 2001-08-16 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Apoptosis-inducing compounds |
Non-Patent Citations (7)
| Title |
|---|
| ANNALS OF NUCLEAR MEDICINE, vol. 3, no. 2, JPN6012054665, 1989, pages 63 - 71, ISSN: 0002359687 * |
| APPL. RADIAT. ISOT., vol. 41, no. 5, JPN6012054664, 1990, pages 477 - 482, ISSN: 0002359686 * |
| BIOCONJUGATE CHEM., vol. 17, no. 3, JPN6012054666, 2006, pages 735 - 740, ISSN: 0002359688 * |
| J. MED. CHEM., vol. 39, no. 18, JPN6012054660, 1996, pages 3435 - 3450, ISSN: 0002359684 * |
| J. MED. CHEM., vol. 45, no. 19, JPN6012054652, 2002, pages 4276 - 4281, ISSN: 0002359682 * |
| JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 14, no. 8, JPN6012054654, 2000, pages 753 - 768, ISSN: 0002359683 * |
| NUCLEAR MEDICINE AND BIOLOGY, vol. 30, no. 4, JPN6012054663, 2003, pages 435 - 439, ISSN: 0002359685 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101460504A (zh) | 2009-06-17 |
| GB0610866D0 (en) | 2006-07-12 |
| WO2007141491A1 (en) | 2007-12-13 |
| US20090317328A1 (en) | 2009-12-24 |
| EP2024373A1 (en) | 2009-02-18 |
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