JP2009537140A - ジヒドロ葉酸還元酵素の不活性化のための方法及び組成物 - Google Patents

ジヒドロ葉酸還元酵素の不活性化のための方法及び組成物 Download PDF

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JP2009537140A
JP2009537140A JP2009511062A JP2009511062A JP2009537140A JP 2009537140 A JP2009537140 A JP 2009537140A JP 2009511062 A JP2009511062 A JP 2009511062A JP 2009511062 A JP2009511062 A JP 2009511062A JP 2009537140 A JP2009537140 A JP 2009537140A
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protein
cell
cells
dhfr
cleavage
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コリングウッド,トレバー
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サンガモ バイオサイエンシーズ, インコーポレイテッド
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases RNAses, DNAses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009511062A 2006-05-19 2007-05-17 ジヒドロ葉酸還元酵素の不活性化のための方法及び組成物 Pending JP2009537140A (ja)

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US80186706P 2006-05-19 2006-05-19
PCT/US2007/011799 WO2007136685A2 (fr) 2006-05-19 2007-05-17 Procédés et compositions pour inactivation de la dihydrofolate réductase

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JP2009537140A true JP2009537140A (ja) 2009-10-29

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JP2009511062A Pending JP2009537140A (ja) 2006-05-19 2007-05-17 ジヒドロ葉酸還元酵素の不活性化のための方法及び組成物

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US (1) US20080015164A1 (fr)
EP (1) EP2018424A2 (fr)
JP (1) JP2009537140A (fr)
AU (1) AU2007254251A1 (fr)
CA (1) CA2650414A1 (fr)
WO (1) WO2007136685A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019509748A (ja) * 2016-03-30 2019-04-11 スパーク セラピューティクス インコーポレイテッドSpark Therapeutics, Inc. 組換えタンパク質及び/又はウイルスベクター製造のための細胞株

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019509748A (ja) * 2016-03-30 2019-04-11 スパーク セラピューティクス インコーポレイテッドSpark Therapeutics, Inc. 組換えタンパク質及び/又はウイルスベクター製造のための細胞株

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Publication number Publication date
EP2018424A2 (fr) 2009-01-28
US20080015164A1 (en) 2008-01-17
WO2007136685A2 (fr) 2007-11-29
WO2007136685A3 (fr) 2008-05-22
CA2650414A1 (fr) 2007-11-29
AU2007254251A1 (en) 2007-11-29

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