JP2009536193A - 予防若しくは治療の形態で投与されるα−ＭＳＨを用いた、改善の余地のある多様な病理学的過程に関する治療におけるニコチン、そのアナログ、その前駆体またはその誘導体の使用 - Google Patents

予防若しくは治療の形態で投与されるα−ＭＳＨを用いた、改善の余地のある多様な病理学的過程に関する治療におけるニコチン、そのアナログ、その前駆体またはその誘導体の使用 Download PDF

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JP2009536193A
JP2009536193A JP2009509455A JP2009509455A JP2009536193A JP 2009536193 A JP2009536193 A JP 2009536193A JP 2009509455 A JP2009509455 A JP 2009509455A JP 2009509455 A JP2009509455 A JP 2009509455A JP 2009536193 A JP2009536193 A JP 2009536193A
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msh
nicotine
derivatives
precursors
analogs
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JP2009536193A5 (https=
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ヘレラ，アルツロ ソリス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP2009509455A 2006-05-08 2006-05-08 予防若しくは治療の形態で投与されるα−ＭＳＨを用いた、改善の余地のある多様な病理学的過程に関する治療におけるニコチン、そのアナログ、その前駆体またはその誘導体の使用 Pending JP2009536193A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2006/000031 WO2007129879A1 (es) 2006-05-08 2006-05-08 EL USO DE LA NICOTINA, SUS ANÁLOGOS, SUS PRECURSORES O SUS DERIVADOS EN EL TRATAMIENTO DE DIVERSOS PROCESOS PATOLÓGICOS SUSCEPTIBLES DE MEJORAR CON α-MSH ADMINISTRADA EN FORMA PROFILÁCTICA O TERAPÉUTICA.

Publications (2)

Publication Number Publication Date
JP2009536193A true JP2009536193A (ja) 2009-10-08
JP2009536193A5 JP2009536193A5 (https=) 2011-03-24

Family

ID=38667940

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009509455A Pending JP2009536193A (ja) 2006-05-08 2006-05-08 予防若しくは治療の形態で投与されるα−ＭＳＨを用いた、改善の余地のある多様な病理学的過程に関する治療におけるニコチン、そのアナログ、その前駆体またはその誘導体の使用

Country Status (13)

Country Link
US (4) US20090197921A1 (https=)
EP (4) EP2801359A3 (https=)
JP (1) JP2009536193A (https=)
KR (1) KR20130116374A (https=)
CN (1) CN101437515B (https=)
AU (1) AU2006343439B2 (https=)
BR (1) BRPI0621650A2 (https=)
CA (1) CA2651580C (https=)
DK (1) DK2801360T3 (https=)
ES (1) ES2683323T3 (https=)
MX (1) MX2008011473A (https=)
NZ (1) NZ572366A (https=)
WO (1) WO2007129879A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8557804B2 (en) 2002-03-25 2013-10-15 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US8039459B2 (en) 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US20110206642A1 (en) * 2009-10-15 2011-08-25 Cohava Gelber Preventing obesity-related metabolic syndrome with melagonesis
US9668969B1 (en) 2012-02-22 2017-06-06 Arturo Solis Herrera Methods of using QIAPINE
MX369060B (es) 2014-09-09 2019-10-28 Solis Herrera Arturo Métodos para tratar y prevenir enfermedades, trastornos, y condiciones oculares con melanina y análogos de melanina, precursores y derivados.
EP3442583B1 (en) 2016-04-12 2024-04-10 Arturo Solis Herrera Composition comprising nicotine for treating bleeding of the nasal or paranasal mucosa
LU101520B1 (en) * 2019-12-02 2021-06-07 Herrera Arturo Solis (S)-3-[1-Methylpyrrolidin-2-yl]pyridine, analogues thereof, precursors thereof, or its derivatives, for the use as a pharmaceutical in form of a homogeneous, viscous, semi-solid topical medication and topical medication

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004510695A (ja) * 2000-05-23 2004-04-08 ノース・ショア−ロング・アイランド・ジューイッシュ・リサーチ・インスティテュート コリン作動薬および迷走神経刺激による炎症性サイトカイン産生の阻害
JP2004523588A (ja) * 2001-03-23 2004-08-05 ユニヴェルシテ ラヴァル 炎症性疾患治療用のニコチン性受容体アゴニスト

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
SE0104388D0 (sv) * 2001-12-27 2001-12-27 Pharmacia Ab New formulation and use and manufacture thereof
JP2007530586A (ja) * 2004-03-25 2007-11-01 ザ ファインスタイン インスティテュート フォー メディカル リサーチ 神経性止血法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004510695A (ja) * 2000-05-23 2004-04-08 ノース・ショア−ロング・アイランド・ジューイッシュ・リサーチ・インスティテュート コリン作動薬および迷走神経刺激による炎症性サイトカイン産生の阻害
JP2004523588A (ja) * 2001-03-23 2004-08-05 ユニヴェルシテ ラヴァル 炎症性疾患治療用のニコチン性受容体アゴニスト

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6012016677; ＬＡＭＡＣＺ，　Ｍ．　ｅｔ　ａｌ．: Ａｎｎａｌｓ　ｏｆ　ｔｈｅ　Ｎｅｗ　Ｙｏｒｋ　Ａｃａｄｅｍｙ　ｏｆ　Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６８０, 1993, ｐｐ．５２０-５２３ *
JPN6012016681; Ｍａｒｔｙ，　Ｍ．Ａ．　ｅｔ　ａｌ．: Ｐｈａｒｍａｃｏｌｏｇｙ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　＆　Ｂｅｈａｖｉｏｒ Ｖｏｌ．２２, 1985, ｐｐ．３１７-３２５ *
JPN6012016684; Ｇａｒｎｉｅｒ，　Ｍ．　ｅｔ　ａｌ．: ＰＮＡＳ Ｖｏｌ．９１, 1994, ｐｐ．１１７４３-１１７４７ *
JPN6012016686; Ｈａｎ，　Ｋ-Ｊ．　ｅｔ　ａｌ．: Ａｒｃｈ．　Ｐｈａｒｍ．　Ｒｅｓ． Ｖｏｌ．２８，　Ｎｏ．２, 2005, ｐｐ．２０９-２１５ *
JPN6012016688; Ｇｌｅｎｎｏｎ，　Ｒ．Ａ．　ｅｔ　ａｌ．: Ｍｅｄ．　Ｃｈｅｍ．　Ｒｅｓ． Ｖｏｌ．１３, 2004, ｐｐ．７４-７７ *
JPN6012016690; Ｗａｎｇ，　Ｈ．　ｅｔ　ａｌ．: Ｎａｔｕｒｅ　Ｍｅｄｉｃｉｎｅ Ｖｏｌ．１０，　Ｎｏ．１１, 2004, ｐｐ．１２１６-１２２１ *

Also Published As

Publication number Publication date
DK2801360T3 (en) 2018-07-23
US20090197921A1 (en) 2009-08-06
CN101437515A (zh) 2009-05-20
EP2801358A2 (en) 2014-11-12
US20120270907A1 (en) 2012-10-25
CN101437515B (zh) 2016-04-20
MX2008011473A (es) 2008-09-24
EP2027860A1 (en) 2009-02-25
CA2651580A1 (en) 2007-11-15
AU2006343439A1 (en) 2007-11-15
EP2801360A3 (en) 2015-03-04
EP2801360B1 (en) 2018-04-25
EP2801359A3 (en) 2015-05-06
CA2651580C (en) 2016-01-19
BRPI0621650A2 (pt) 2011-12-20
EP2801359A2 (en) 2014-11-12
NZ572366A (en) 2012-02-24
US20160279116A1 (en) 2016-09-29
WO2007129879A1 (es) 2007-11-15
EP2801358A3 (en) 2015-03-04
EP2801360A2 (en) 2014-11-12
US20160008347A1 (en) 2016-01-14
AU2006343439B2 (en) 2013-05-16
KR20130116374A (ko) 2013-10-23
ES2683323T3 (es) 2018-09-26

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