JP2009536156A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009536156A5 JP2009536156A5 JP2009505499A JP2009505499A JP2009536156A5 JP 2009536156 A5 JP2009536156 A5 JP 2009536156A5 JP 2009505499 A JP2009505499 A JP 2009505499A JP 2009505499 A JP2009505499 A JP 2009505499A JP 2009536156 A5 JP2009536156 A5 JP 2009536156A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- formula
- hydrogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C*N(*)C(C)=O Chemical compound C*N(*)C(C)=O 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79216206P | 2006-04-14 | 2006-04-14 | |
| PCT/US2007/009138 WO2007120827A2 (en) | 2006-04-14 | 2007-04-12 | Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536156A JP2009536156A (ja) | 2009-10-08 |
| JP2009536156A5 true JP2009536156A5 (https=) | 2011-05-26 |
Family
ID=38474269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505499A Withdrawn JP2009536156A (ja) | 2006-04-14 | 2007-04-12 | ヘッジホッグ経路関連障害の処置におけるビアリールカルボキサミドの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090306149A1 (https=) |
| EP (1) | EP2010170A2 (https=) |
| JP (1) | JP2009536156A (https=) |
| KR (1) | KR20090006089A (https=) |
| CN (1) | CN101420949A (https=) |
| AU (1) | AU2007238676A1 (https=) |
| BR (1) | BRPI0710723A2 (https=) |
| CA (1) | CA2648196A1 (https=) |
| MX (1) | MX2008013204A (https=) |
| RU (1) | RU2008144805A (https=) |
| WO (1) | WO2007120827A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MY150379A (en) * | 2008-02-26 | 2013-12-31 | Takeda Pharmaceutical | Fused heterocyclic derivative and use thereof |
| AU2009286528B2 (en) * | 2008-08-29 | 2014-07-17 | Msd Italia S.R.L. | Saturated bicyclic heterocyclic derivatives as Smo antagonists |
| EP2617414A3 (en) * | 2008-10-01 | 2013-11-06 | Novartis AG | Smoothened antagonism for the treatment of hedgehog pathway-related disorders |
| JP6141015B2 (ja) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク． | シクロパミン類似体の酵素によるアミノ基転移 |
| CA2799579A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| FR2967498B1 (fr) * | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| WO2012148994A1 (en) | 2011-04-25 | 2012-11-01 | Usher Iii Initiative | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
| WO2013012915A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| KR20140075693A (ko) | 2011-08-29 | 2014-06-19 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
| WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| CA2893133A1 (en) | 2012-11-29 | 2014-06-05 | Strasspharma Llc | Methods of modulating follicle stimulating hormone activity |
| US20160024051A1 (en) | 2013-03-15 | 2016-01-28 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
| SG11201509842SA (en) | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
| MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| NZ724368A (en) | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CA2988289C (en) | 2015-06-04 | 2023-12-05 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| EP4585268A3 (en) | 2015-09-14 | 2025-10-15 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| US20170231968A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| IL299695A (en) | 2020-07-09 | 2023-03-01 | Usher Iii Initiative Inc | Treatment of cancer, inflammatory diseases and autoimmune diseases |
| US12605387B2 (en) | 2020-07-24 | 2026-04-21 | Secura Bio, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| GB9807903D0 (en) * | 1998-04-14 | 1998-06-10 | Smithkline Beecham Plc | Novel compounds |
| US6197798B1 (en) * | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| CO5090829A1 (es) * | 1998-07-21 | 2001-10-30 | Novartis Ag | Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b. |
| JP2002538167A (ja) * | 1999-03-03 | 2002-11-12 | バイオジェン インコーポレイテッド | 脂質の代謝および貯蔵を調節する方法 |
| AU6824700A (en) * | 1999-07-20 | 2001-02-05 | Novartis Ag | Organic compounds |
| WO2001053260A1 (en) * | 2000-01-18 | 2001-07-26 | Novartis Ag | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
-
2007
- 2007-04-12 EP EP07755420A patent/EP2010170A2/en not_active Withdrawn
- 2007-04-12 BR BRPI0710723-4A patent/BRPI0710723A2/pt not_active IP Right Cessation
- 2007-04-12 WO PCT/US2007/009138 patent/WO2007120827A2/en not_active Ceased
- 2007-04-12 KR KR1020087024972A patent/KR20090006089A/ko not_active Withdrawn
- 2007-04-12 CA CA002648196A patent/CA2648196A1/en not_active Abandoned
- 2007-04-12 JP JP2009505499A patent/JP2009536156A/ja not_active Withdrawn
- 2007-04-12 RU RU2008144805/14A patent/RU2008144805A/ru not_active Application Discontinuation
- 2007-04-12 AU AU2007238676A patent/AU2007238676A1/en not_active Abandoned
- 2007-04-12 US US12/297,158 patent/US20090306149A1/en not_active Abandoned
- 2007-04-12 MX MX2008013204A patent/MX2008013204A/es not_active Application Discontinuation
- 2007-04-12 CN CNA2007800134377A patent/CN101420949A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009536156A5 (https=) | ||
| Jia et al. | RETRACTED ARTICLE: The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/β-Catenin pathway | |
| Duxbury et al. | Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells | |
| Skowron et al. | Genetic and molecular alterations across medulloblastoma subgroups | |
| CN115215808B (zh) | 用于治疗癌症的组合物和方法 | |
| Komarova et al. | Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors | |
| Sun et al. | DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation | |
| Hackl et al. | Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition | |
| JP2015520753A5 (https=) | ||
| Ju et al. | Oncogenic KRAS promotes malignant brain tumors in zebrafish | |
| ES2743507T3 (es) | Inmunoterapia resistente a fármaco para el tratamiento de un cáncer | |
| RU2008144805A (ru) | Применение биарилкарбоксамидов в лечении заболеваний, связанных с hedgehog-путем | |
| JP2017514806A5 (https=) | ||
| JP2018062523A5 (https=) | ||
| Cruickshanks et al. | Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1 | |
| ES2978159T3 (es) | Inhibidores de factores de choque térmico (HSF) y usos de los mismos | |
| JP2020515582A5 (https=) | ||
| Dean | Cancer stem cells: Implications for cancer causation and therapy resistance. | |
| Ghassemifar et al. | MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells | |
| US20120238518A1 (en) | Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer | |
| Liu et al. | Notch pathway deactivation sensitizes breast cancer stem cells toward chemotherapy using NIR Light-Responsive nanoparticles | |
| Oliver et al. | Resistance to apoptosis is increased during metastatic dissemination of colon cancer | |
| JP2014523426A5 (https=) | ||
| US20210137898A1 (en) | Methods to treat gliomas using a stat3 inhibitor | |
| CN116715613A (zh) | 一种RORγ共价抑制化合物及其制备方法与应用 |