JP2009536021A5 - - Google Patents

Info

Publication number

JP2009536021A5

JP2009536021A5 JP2009504310A JP2009504310A JP2009536021A5 JP 2009536021 A5 JP2009536021 A5 JP 2009536021A5 JP 2009504310 A JP2009504310 A JP 2009504310A JP 2009504310 A JP2009504310 A JP 2009504310A JP 2009536021 A5 JP2009536021 A5 JP 2009536021A5

Authority

JP

Japan

Prior art keywords

sample

ratio

leukocytes

mrna

amount

Prior art date

2007-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 210000000265 leukocyte Anatomy 0.000 claims description 60
• 108020004999 messenger RNA Proteins 0.000 claims description 49
• 238000000034 method Methods 0.000 claims description 38
• 230000004936 stimulating effect Effects 0.000 claims description 36
• 238000000338 in vitro Methods 0.000 claims description 29
• 230000000638 stimulation Effects 0.000 claims description 18
• 238000002560 therapeutic procedure Methods 0.000 claims description 16
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 13
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 8
• 238000004587 chromatography analysis Methods 0.000 claims description 8
• 102000003390 tumor necrosis factor Human genes 0.000 claims description 8
• 241000282412 Homo Species 0.000 claims description 7
• 201000010099 disease Diseases 0.000 claims description 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
• 238000013518 transcription Methods 0.000 claims description 2
• 230000035897 transcription Effects 0.000 claims description 2
• 230000002776 aggregation Effects 0.000 claims 12
• 238000004220 aggregation Methods 0.000 claims 12
• 239000003795 chemical substances by application Substances 0.000 claims 10
• 108010062580 Concanavalin A Proteins 0.000 claims 8
• 108010047620 Phytohemagglutinins Proteins 0.000 claims 8
• 108010046516 Wheat Germ Agglutinins Proteins 0.000 claims 8
• 239000002158 endotoxin Substances 0.000 claims 8
• 229920006008 lipopolysaccharide Polymers 0.000 claims 8
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical group C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 claims 8
• 230000001885 phytohemagglutinin Effects 0.000 claims 8
• 229920000855 Fucoidan Polymers 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 4
• 239000002953 phosphate buffered saline Substances 0.000 claims 4
• 229930105110 Cyclosporin A Natural products 0.000 claims 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
• 108010036949 Cyclosporine Proteins 0.000 claims 2
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
• 229960001265 ciclosporin Drugs 0.000 claims 2
• 108010084553 jacalin Proteins 0.000 claims 2
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
• 229960001967 tacrolimus Drugs 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 description 1