JP2009535410A - ピロロキノリンキノンおよびその使用 - Google Patents

ピロロキノリンキノンおよびその使用 Download PDF

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Publication number
JP2009535410A
JP2009535410A JP2009509708A JP2009509708A JP2009535410A JP 2009535410 A JP2009535410 A JP 2009535410A JP 2009509708 A JP2009509708 A JP 2009509708A JP 2009509708 A JP2009509708 A JP 2009509708A JP 2009535410 A JP2009535410 A JP 2009535410A
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Japan
Prior art keywords
pqq
ischemia
reperfusion
subject
pyrroloquinoline quinone
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JP2009509708A
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English (en)
Japanese (ja)
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JP2009535410A5 (enExample
Inventor
ジョエル エス． カーリナー，
シャカー エー． ムーサ，
ジョージ エル． ドルサノ，
ポール ジェイ． デービス，
Original Assignee
シーエルエフ メディカル テクノロジー アクセラレーション プログラム インコーポレイテッド
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Publication of JP2009535410A publication Critical patent/JP2009535410A/ja
Publication of JP2009535410A5 publication Critical patent/JP2009535410A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009509708A 2006-05-02 2007-05-02 ピロロキノリンキノンおよびその使用 Withdrawn JP2009535410A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79716906P 2006-05-02 2006-05-02
PCT/US2007/010721 WO2007130509A2 (en) 2006-05-02 2007-05-02 Pyrroloquinoline quinones and use thereof

Publications (2)

Publication Number Publication Date
JP2009535410A true JP2009535410A (ja) 2009-10-01
JP2009535410A5 JP2009535410A5 (enExample) 2011-06-30

Family

ID=38562815

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009509708A Withdrawn JP2009535410A (ja) 2006-05-02 2007-05-02 ピロロキノリンキノンおよびその使用

Country Status (3)

Country Link
EP (1) EP2068879A2 (enExample)
JP (1) JP2009535410A (enExample)
WO (1) WO2007130509A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015530374A (ja) * 2012-08-13 2015-10-15 ユニバーシティ・オブ・シンシナティ 心筋症、収縮期心機能不全及びうっ血性心不全症状の治療のためのプロベネシド
JP2016512564A (ja) * 2013-03-13 2016-04-28 ユニバーシティ・オブ・シンシナティ Ｔｒｐｖ２受容体アゴニストを用いる拡張期心機能不全の治療
JP2019194173A (ja) * 2018-04-27 2019-11-07 国立大学法人 新潟大学 腎障害の抑制におけるシラスタチンの利用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2666649A1 (en) * 2006-09-19 2008-03-27 Kyowa Hakko Bio Co., Ltd Insulin resistance improving agent
US9216185B2 (en) * 2008-07-11 2015-12-22 Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Maranon Use of cilastatin to reduce nephrotatoxicity of various compounds
KR101913326B1 (ko) * 2016-03-29 2018-10-30 순천향대학교 산학협력단 실라스타틴을 포함하는, 신장 허혈 재관류 손상의 예방 또는 치료용 약학적 조성물
CN110870866A (zh) * 2018-09-03 2020-03-10 浙江医药股份有限公司新昌制药厂 吡咯喹啉醌在制备用于防治急性高原反应和急性高原低氧损伤的药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997854A (en) * 1989-08-25 1991-03-05 Trustees Of Boston University Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates
JP4777489B2 (ja) * 1997-03-31 2011-09-21 ザ チルドレンズ メディカル センター コーポレーション アポトーシス性酵素を不活性化するためのニトロシル化
WO2005107871A2 (en) * 2004-05-05 2005-11-17 Clf Medical Technology Acceleration Program, Inc. Pyrroloquinoline quinone drugs for treatment of cardiac injury
US20060199241A1 (en) * 2005-03-02 2006-09-07 Hyoungsik Yim Electrochemically and optically monitoring cleaving enzyme activity

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10806711B2 (en) 2011-08-12 2020-10-20 University Of Cincinnati Method of treating acute decompensated heart failure with probenecid
JP2015530374A (ja) * 2012-08-13 2015-10-15 ユニバーシティ・オブ・シンシナティ 心筋症、収縮期心機能不全及びうっ血性心不全症状の治療のためのプロベネシド
JP2018131463A (ja) * 2012-08-13 2018-08-23 ユニバーシティ・オブ・シンシナティ 心筋症、収縮期心機能不全及びうっ血性心不全症状の治療のためのプロベネシド
JP2020111617A (ja) * 2012-08-13 2020-07-27 ユニバーシティ・オブ・シンシナティ 心筋症、収縮期心機能不全及びうっ血性心不全症状の治療のためのプロベネシド
JP7618391B2 (ja) 2012-08-13 2025-01-21 ユニバーシティ・オブ・シンシナティ 心筋症、収縮期心機能不全及びうっ血性心不全症状の治療のためのプロベネシド
JP2016512564A (ja) * 2013-03-13 2016-04-28 ユニバーシティ・オブ・シンシナティ Ｔｒｐｖ２受容体アゴニストを用いる拡張期心機能不全の治療
US10583103B2 (en) 2013-03-13 2020-03-10 University Of Cincinnati Method of treating heart failure with preserved ejection fraction with probenecid
JP2019194173A (ja) * 2018-04-27 2019-11-07 国立大学法人 新潟大学 腎障害の抑制におけるシラスタチンの利用
US11304919B2 (en) 2018-04-27 2022-04-19 Niigata University Utilization of cilastatin in inhibiting renal disorder

Also Published As

Publication number Publication date
EP2068879A2 (en) 2009-06-17
WO2007130509A3 (en) 2008-01-10
WO2007130509A9 (en) 2008-02-21
WO2007130509A2 (en) 2007-11-15

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