JP2009534033A5 - - Google Patents

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Publication number
JP2009534033A5
JP2009534033A5 JP2009506619A JP2009506619A JP2009534033A5 JP 2009534033 A5 JP2009534033 A5 JP 2009534033A5 JP 2009506619 A JP2009506619 A JP 2009506619A JP 2009506619 A JP2009506619 A JP 2009506619A JP 2009534033 A5 JP2009534033 A5 JP 2009534033A5
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JP
Japan
Prior art keywords
target enzyme
substrate
mechanical properties
nucleic acid
polymerase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009506619A
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English (en)
Japanese (ja)
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JP2009534033A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/009747 external-priority patent/WO2007124105A2/en
Publication of JP2009534033A publication Critical patent/JP2009534033A/ja
Publication of JP2009534033A5 publication Critical patent/JP2009534033A5/ja
Pending legal-status Critical Current

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JP2009506619A 2006-04-21 2007-04-23 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置 Pending JP2009534033A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79372006P 2006-04-21 2006-04-21
PCT/US2007/009747 WO2007124105A2 (en) 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

Publications (2)

Publication Number Publication Date
JP2009534033A JP2009534033A (ja) 2009-09-24
JP2009534033A5 true JP2009534033A5 (enExample) 2011-06-30

Family

ID=38625640

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506619A Pending JP2009534033A (ja) 2006-04-21 2007-04-23 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置

Country Status (6)

Country Link
US (5) US9862984B2 (enExample)
EP (1) EP2016415B1 (enExample)
JP (1) JP2009534033A (enExample)
CN (1) CN101479605A (enExample)
CA (1) CA2646309C (enExample)
WO (1) WO2007124105A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005324505B2 (en) * 2004-05-13 2009-09-10 Nanobiosym, Inc. Nano-PCR: methods and devices for nucleic acid amplification and detection
JP2009534033A (ja) 2006-04-21 2009-09-24 ナノバイオシン，インコーポレイテッド 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置
EP2056849A4 (en) * 2006-08-04 2010-09-08 Univ Pennsylvania METHOD AND COMPOSITIONS FOR TREATING IGE-MEDIATED ILLNESSES
ES2387368B1 (es) * 2009-05-15 2013-08-08 Universidad De Barcelona Metodo y aparato de medida de las fuerzas opticas que actuan sobre una particula
WO2011028296A2 (en) * 2009-09-07 2011-03-10 Caerus Molecular Diagnostics Incorporated Sequence determination by use of opposing forces
CN102565057B (zh) * 2011-12-15 2014-07-23 大连理工大学 一种基于左手材料的光镊
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CN111505291B (zh) * 2020-04-14 2023-04-25 山东省千佛山医院 一种排除巨酶分子对血清酶浓度检测带来干扰的方法

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4962020A (en) 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
DE4027616A1 (de) * 1990-08-31 1992-03-05 Boehringer Mannheim Gmbh Verfahren zur bestimmung von polymerase-aktivitaet
US5527670A (en) 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
AU8517391A (en) 1990-09-12 1992-03-30 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5824477A (en) 1990-09-12 1998-10-20 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
KR960703174A (ko) 1993-06-09 1996-06-19 미안 알렉 자기장 순환식 반응방법(magnetic cycle reaction)
DE69507289T2 (de) 1994-03-15 1999-07-08 Scientific Generics Ltd., Cambridge Elektrochemische denatusierung von doppelsträngiger nukleinsäure
KR100230718B1 (ko) 1994-03-16 1999-11-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 등온 가닥 변위 핵산 증폭법
US6613560B1 (en) 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US5683875A (en) 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
WO1996041864A1 (en) 1995-06-13 1996-12-27 The Regents Of The University Of California Diode laser heated micro-reaction chamber with sample detection means
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1997008293A1 (en) 1995-08-25 1997-03-06 Scientific Generics Limited Release of intracellular material
PT1179600E (pt) 1996-06-04 2005-08-31 Univ Utah Res Found Monitorizacao da hibridacao durante a rcp
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
GB9613980D0 (en) 1996-07-02 1996-09-04 Scient Generics Ltd Denaturation of double-stranded nucleic acid
GB9614544D0 (en) 1996-07-11 1996-09-04 Scient Generics Ltd Denaturation of double-stranded nucleic acid
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
DE19710166C1 (de) 1997-03-12 1998-12-10 Bruker Franzen Analytik Gmbh Zwei-Schritt-Verfahren der DNA-Amplifikation für MALDI-TOF-Messungen
US7052650B2 (en) 1997-03-28 2006-05-30 Center National De La Recherche Scientifique (Cnrs) Apparatus and method for the manipulation and testing of molecules, and in particular of DNA
GB9706654D0 (en) 1997-04-02 1997-05-21 Scient Generics Ltd Disassociation of interacting molecules
EP0917590A1 (en) 1997-04-04 1999-05-26 Innogenetics N.V. Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions
AU7477398A (en) 1997-05-09 1998-11-27 Regents Of The University Of California, The Peltier-assisted microfabricated reaction chambers for thermal cycling
WO1999009042A2 (en) 1997-08-13 1999-02-25 Cepheid Microstructures for the manipulation of fluid samples
CA2312102C (en) 1997-12-24 2007-09-04 Cepheid Integrated fluid manipulation cartridge
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
GB9903906D0 (en) 1999-02-19 1999-04-14 Microbiological Res Authority Method and apparatus for nucleic acid strand separation
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
IL147302A0 (en) 1999-06-28 2002-08-14 California Inst Of Techn Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
WO2001013088A1 (en) 1999-08-13 2001-02-22 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6793752B2 (en) 2001-09-21 2004-09-21 The Goodyear Tire & Rubber Company Precision longitudinal registration of tire building drum to automated tire building system work station
US6783647B2 (en) 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
US7013717B1 (en) 2001-12-06 2006-03-21 Veeco Instruments Inc. Manual control with force-feedback for probe microscopy-based force spectroscopy
US6828786B2 (en) 2002-01-18 2004-12-07 California Institute Of Technology Method and apparatus for nanomagnetic manipulation and sensing
US7404945B2 (en) 2002-02-21 2008-07-29 Tokyo Gas Company Limited Method of evaluating pharmacological effects of medicine
US20040022764A1 (en) 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
GB2416030B (en) 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
AU2005324505B2 (en) 2004-05-13 2009-09-10 Nanobiosym, Inc. Nano-PCR: methods and devices for nucleic acid amplification and detection
JP2008512128A (ja) 2004-09-09 2008-04-24 マイクロフルイディク システムズ インコーポレイテッド 抽出装置及び試料準備方法
US7315376B2 (en) 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system
US7981696B2 (en) * 2005-02-18 2011-07-19 The United States of America, as represented by the Secretary of Commerce, The National Institute of Standards and Technology Microfluidic platform of arrayed switchable spin-valve elements for high-throughput sorting and manipulation of magnetic particles and biomolecules
WO2007038260A2 (en) * 2005-09-23 2007-04-05 Massachusetts Institute Of Technology Systems and methods for force-fluorescence microscopy
ES2393758T3 (es) 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
JP2009534033A (ja) 2006-04-21 2009-09-24 ナノバイオシン，インコーポレイテッド 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置
US7892816B2 (en) 2006-09-28 2011-02-22 Colorado State University Research Foundation Electrochemical detection of substrates
CN101558302B (zh) 2006-10-27 2013-11-06 蒙泰西托生物科学有限公司 用于改进的取样分析的便携设备
US8409877B2 (en) 2006-12-29 2013-04-02 Intel Corporation Enzymatic signal generation and detection of binding complexes in stationary fluidic chip
US20120082985A1 (en) 2007-08-09 2012-04-05 Frederic Zenhausern Sensing And Identifying Biological Samples On Microfluidic Devices
CL2008003007A1 (es) 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro chip con capas de ceramicas de coccion conjunta a baja temperatura (ltcc) formando una camara de reaccion, anillos conductores que rodean a la camara de reaccion y un calentador que suministra calor a los anillos, el metodo de fabricacion del micro chip y un micro dispositivo de reaccion en cadena de polimerasa (pcr).
GB0812681D0 (en) 2008-07-10 2008-08-20 Sec Dep For Innovation Universities Apparatus and methods for effecting chemical assays
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
EP2438016B1 (en) 2009-06-05 2021-06-02 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
WO2011028296A2 (en) * 2009-09-07 2011-03-10 Caerus Molecular Diagnostics Incorporated Sequence determination by use of opposing forces
WO2011156842A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device for pathogen detection and genetic analysis with dialysis and nucleic acid amplification
CN113604356A (zh) 2013-03-15 2021-11-05 纳诺拜希姆公司 用于移动设备分析核酸和蛋白质的系统和方法
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins

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