CA2646309C - Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents - Google Patents

Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents Download PDF

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Publication number
CA2646309C
CA2646309C CA2646309A CA2646309A CA2646309C CA 2646309 C CA2646309 C CA 2646309C CA 2646309 A CA2646309 A CA 2646309A CA 2646309 A CA2646309 A CA 2646309A CA 2646309 C CA2646309 C CA 2646309C
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polymerase
target enzyme
dna
drug
substrate
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CA2646309A
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English (en)
French (fr)
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CA2646309A1 (en
Inventor
Anita Goel
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Nanobiosym Inc
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Nanobiosym Inc
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Publication of CA2646309A1 publication Critical patent/CA2646309A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2646309A 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents Active CA2646309C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79372006P 2006-04-21 2006-04-21
US60/793,720 2006-04-21
PCT/US2007/009747 WO2007124105A2 (en) 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

Publications (2)

Publication Number Publication Date
CA2646309A1 CA2646309A1 (en) 2007-11-01
CA2646309C true CA2646309C (en) 2016-07-26

Family

ID=38625640

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2646309A Active CA2646309C (en) 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

Country Status (6)

Country Link
US (5) US9862984B2 (enExample)
EP (1) EP2016415B1 (enExample)
JP (1) JP2009534033A (enExample)
CN (1) CN101479605A (enExample)
CA (1) CA2646309C (enExample)
WO (1) WO2007124105A2 (enExample)

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Also Published As

Publication number Publication date
US9862984B2 (en) 2018-01-09
WO2007124105A4 (en) 2009-02-19
US11807892B2 (en) 2023-11-07
US20200308618A1 (en) 2020-10-01
EP2016415A4 (en) 2009-12-16
EP2016415A2 (en) 2009-01-21
US20180195104A1 (en) 2018-07-12
WO2007124105A2 (en) 2007-11-01
CA2646309A1 (en) 2007-11-01
EP2016415B1 (en) 2013-08-14
US20250382654A1 (en) 2025-12-18
JP2009534033A (ja) 2009-09-24
US20240309420A1 (en) 2024-09-19
US20070254279A1 (en) 2007-11-01
CN101479605A (zh) 2009-07-08
US12435351B2 (en) 2025-10-07
WO2007124105A3 (en) 2008-11-27

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Effective date: 20130410