JP2009533338A5 - - Google Patents

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Publication number
JP2009533338A5
JP2009533338A5 JP2009504144A JP2009504144A JP2009533338A5 JP 2009533338 A5 JP2009533338 A5 JP 2009533338A5 JP 2009504144 A JP2009504144 A JP 2009504144A JP 2009504144 A JP2009504144 A JP 2009504144A JP 2009533338 A5 JP2009533338 A5 JP 2009533338A5
Authority
JP
Japan
Prior art keywords
styrylquinazoline
patent document
compounds
rastinejad
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009504144A
Other languages
English (en)
Other versions
JP2009533338A (ja
Filing date
Publication date
Priority claimed from NZ546477A external-priority patent/NZ546477A/en
Application filed filed Critical
Publication of JP2009533338A publication Critical patent/JP2009533338A/ja
Publication of JP2009533338A5 publication Critical patent/JP2009533338A5/ja
Pending legal-status Critical Current

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Description

大掛かりなランダムスクリーニング計画は、多くの小さい疎水性化合物であって、突然変異ｐ５３タンパク質を安定にすることができたものを識別した（Rastinejadらの２００２年４月２４日に公開された特許文献１）。これらは、種々の線状の三環化合物および２−スチリルキナゾリンを含んでいた。構造活性相関は極めて低かったが、研究によって、特に、非特許文献５に報告された２−スチリルキナゾリン（i）が識別された。
JP2009504144A 2006-04-07 2007-04-04 置換環縮合アジンおよび癌治療におけるそれらの使用 Pending JP2009533338A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ546477A NZ546477A (en) 2006-04-07 2006-04-07 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy
PCT/NZ2007/000077 WO2007117161A1 (en) 2006-04-07 2007-04-04 Substituted ring fused azines and their use in cancer therapy

Publications (2)

Publication Number Publication Date
JP2009533338A JP2009533338A (ja) 2009-09-17
JP2009533338A5 true JP2009533338A5 (ja) 2010-05-06

Family

ID=38581368

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009504144A Pending JP2009533338A (ja) 2006-04-07 2007-04-04 置換環縮合アジンおよび癌治療におけるそれらの使用

Country Status (8)

Country Link
US (1) US20090318479A1 (ja)
EP (1) EP2004637A4 (ja)
JP (1) JP2009533338A (ja)
CN (1) CN101460490A (ja)
AU (1) AU2007235751A1 (ja)
CA (1) CA2648323A1 (ja)
NZ (1) NZ546477A (ja)
WO (1) WO2007117161A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012046207A1 (en) * 2010-10-08 2012-04-12 Paraco Technology Limited Anti-parasitic substituted ring fused azine compounds
US8710064B2 (en) * 2011-10-20 2014-04-29 China Medical University 2-aryl-4-quinazolinones and their pharmaceutical compositions
JP2015518870A (ja) 2012-06-07 2015-07-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾロピリミドン及びタンキラーゼのピラゾロピリドン阻害剤
EP2858995A1 (en) 2012-06-07 2015-04-15 F. Hoffmann-La Roche AG Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
WO2014143609A1 (en) 2013-03-11 2014-09-18 Bristol-Myers Squibb Company Isoquinolines as potassium ion channel inhibitors
WO2015077375A1 (en) 2013-11-20 2015-05-28 Signalchem Lifesciences Corp. Quinazoline derivatives as tam family kinase inhibitors
AU2015340215B2 (en) * 2014-10-29 2018-11-15 Dong-A St Co., Ltd Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs)
US20170057955A1 (en) * 2015-08-26 2017-03-02 Dong-A Socio Holdings Co., Ltd. Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs)
CN107721982B (zh) * 2017-10-16 2019-12-03 中山大学 一种抗肥胖症化合物及其制备方法和应用
CN110483394A (zh) * 2019-09-02 2019-11-22 广东工业大学 一种化合物的应用
CN113072543B (zh) * 2020-01-03 2022-07-22 南方医科大学 一种2-芳杂环基喹唑啉酮类化合物及其制备方法和用途
WO2021155426A1 (en) * 2020-02-04 2021-08-12 TroBio Therapeutics Pty Ltd Quinazoline compounds and the use thereof in the treatment of cancer
IL301346A (en) 2020-09-21 2023-05-01 Landos Biopharma Inc Ligands of NLRX1
CN114044769B (zh) * 2021-11-25 2023-12-12 中山大学 一种β-吲哚喹唑啉酮衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897432A (en) * 1971-04-21 1975-07-29 Merck & Co Inc Substituted benzimidazole derivatives
CN1329493A (zh) * 1998-12-02 2002-01-02 辉瑞产品公司 恢复p53家族蛋白质的构象稳定性的方法和组合物
EP1088818B1 (en) * 1999-10-01 2004-11-03 F. Hoffmann-La Roche Ag Quinolin-4-yl derivatives
ES2360933T3 (es) * 2000-04-27 2011-06-10 Astellas Pharma Inc. Derivados de heteroarilo condensados.
WO2002062767A1 (fr) * 2001-02-07 2002-08-15 Sumitomo Pharmaceuticals Company, Limited Nouveaux derives de quinazoline

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