JP2009531275A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009531275A5 JP2009531275A5 JP2008545843A JP2008545843A JP2009531275A5 JP 2009531275 A5 JP2009531275 A5 JP 2009531275A5 JP 2008545843 A JP2008545843 A JP 2008545843A JP 2008545843 A JP2008545843 A JP 2008545843A JP 2009531275 A5 JP2009531275 A5 JP 2009531275A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oral administration
- administration according
- oxalate
- degrading
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 81
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 30
- 241000894006 Bacteria Species 0.000 claims 22
- 230000000593 degrading effect Effects 0.000 claims 17
- 239000000546 pharmaceutical excipient Substances 0.000 claims 12
- 239000002577 cryoprotective agent Substances 0.000 claims 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 239000000463 material Substances 0.000 claims 6
- 229920002472 Starch Polymers 0.000 claims 5
- 235000010443 alginic acid Nutrition 0.000 claims 5
- 229920000615 alginic acid Polymers 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 5
- 239000001913 cellulose Substances 0.000 claims 5
- 235000010980 cellulose Nutrition 0.000 claims 5
- 229920002678 cellulose Polymers 0.000 claims 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 229940072056 alginate Drugs 0.000 claims 4
- 230000001332 colony forming effect Effects 0.000 claims 4
- 238000000354 decomposition reaction Methods 0.000 claims 4
- 239000002702 enteric coating Substances 0.000 claims 4
- 238000009505 enteric coating Methods 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000377 silicon dioxide Substances 0.000 claims 4
- 239000008107 starch Substances 0.000 claims 4
- 235000019698 starch Nutrition 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 208000008852 Hyperoxaluria Diseases 0.000 claims 3
- 229920002774 Maltodextrin Polymers 0.000 claims 3
- 239000005913 Maltodextrin Substances 0.000 claims 3
- 241000605936 Oxalobacter formigenes Species 0.000 claims 3
- -1 diglucose Chemical compound 0.000 claims 3
- 150000002016 disaccharides Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000000968 intestinal effect Effects 0.000 claims 3
- 229940035034 maltodextrin Drugs 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 239000008176 lyophilized powder Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- 241000186000 Bifidobacterium Species 0.000 claims 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 240000003183 Manihot esculenta Species 0.000 claims 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 206010049226 Oxalosis Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 208000004777 Primary Hyperoxaluria Diseases 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- 206010041969 Steatorrhoea Diseases 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 235000010410 calcium alginate Nutrition 0.000 claims 1
- 239000000648 calcium alginate Substances 0.000 claims 1
- 229960002681 calcium alginate Drugs 0.000 claims 1
- 208000003980 calcium oxalate nephrolithiasis Diseases 0.000 claims 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 230000011128 cardiac conduction Effects 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 230000000959 cryoprotective effect Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 125000000600 disaccharide group Chemical group 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 238000011049 filling Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 208000022437 nephrolithiasis susceptibility caused by SLC26A1 Diseases 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 235000010408 potassium alginate Nutrition 0.000 claims 1
- 239000000737 potassium alginate Substances 0.000 claims 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 229940100486 rice starch Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 235000020183 skimmed milk Nutrition 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 208000001162 steatorrhea Diseases 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 125000000647 trehalose group Chemical group 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 229940100445 wheat starch Drugs 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/045457 WO2007070052A2 (en) | 2005-12-14 | 2005-12-14 | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
| USPCT/US2005/045457 | 2005-12-14 | ||
| PCT/US2006/047909 WO2007070677A2 (en) | 2005-12-14 | 2006-12-14 | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531275A JP2009531275A (ja) | 2009-09-03 |
| JP2009531275A5 true JP2009531275A5 (https=) | 2010-01-14 |
| JP5203217B2 JP5203217B2 (ja) | 2013-06-05 |
Family
ID=36581703
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545553A Expired - Fee Related JP5047190B2 (ja) | 2005-12-14 | 2005-12-14 | シュウ酸塩関連疾患を治療または予防するための医薬組成物および方法 |
| JP2008545843A Expired - Fee Related JP5203217B2 (ja) | 2005-12-14 | 2006-12-14 | シュウ酸塩関連疾患を治療または予防するための医薬組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545553A Expired - Fee Related JP5047190B2 (ja) | 2005-12-14 | 2005-12-14 | シュウ酸塩関連疾患を治療または予防するための医薬組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100028422A1 (https=) |
| EP (2) | EP1962873B1 (https=) |
| JP (2) | JP5047190B2 (https=) |
| AU (2) | AU2005339139A1 (https=) |
| CA (2) | CA2645871A1 (https=) |
| CY (2) | CY1114397T1 (https=) |
| DK (1) | DK1962873T3 (https=) |
| ES (2) | ES2426258T3 (https=) |
| HU (1) | HUE034539T2 (https=) |
| LT (1) | LT1965816T (https=) |
| PL (2) | PL1962873T3 (https=) |
| PT (1) | PT1962873E (https=) |
| SI (1) | SI1962873T1 (https=) |
| WO (2) | WO2007070052A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| WO2007070052A2 (en) * | 2005-12-14 | 2007-06-21 | Oxthera, Inc. | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
| JP5558002B2 (ja) | 2005-12-16 | 2014-07-23 | オクセラ インコーポレイテッド | シュウ酸塩低減化のための組成物および方法 |
| WO2008105911A2 (en) | 2006-08-02 | 2008-09-04 | Altus Pharmaceuticals Inc. | Crystallized oxalate decarboxylase and methods of use |
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| US9283252B2 (en) | 2008-09-30 | 2016-03-15 | Meiji Co., Ltd. | Lactic acid bacterium having high oxalic acid decomposition ability |
| FR2936952A1 (fr) * | 2008-10-09 | 2010-04-16 | Monique Bellec | Administration par voie orale de medicaments et complements nutritionnels |
| PT2449098T (pt) * | 2009-07-02 | 2017-03-10 | Oxthera Intellectual Property Ab | Purificação e isolamento de enzimas de degradação de oxalato recombinantes e partículas secas por aspersão que contêm enzimas que degradam o oxalato |
| US8431122B2 (en) | 2009-07-02 | 2013-04-30 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
| EP2270138B1 (en) | 2009-07-02 | 2018-03-28 | OxThera Intellectual Property AB | Purification and isolation of recombinant oxalate degrading enzymes |
| US20110070334A1 (en) * | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
| CN108721612A (zh) * | 2009-11-25 | 2018-11-02 | 凯普托杰姆有限责任公司 | 草酸相关疾病治疗方法和组合物 |
| EP3424515A3 (en) * | 2010-08-04 | 2019-06-19 | Thomas Julius Borody | Stool collection devices and methods for using them |
| HK1253538A1 (en) * | 2010-08-04 | 2019-06-21 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them |
| US20140112985A1 (en) * | 2012-10-22 | 2014-04-24 | Polonez Therapeutics Llc | Method of prevention and treatment of clostridium difficile infection |
| US9714456B2 (en) | 2013-01-18 | 2017-07-25 | Allena Pharmaceuticals, Inc. | Crystallized oxalate decarboxylase and methods of use |
| WO2014197806A2 (en) | 2013-06-07 | 2014-12-11 | Allena Pharmaceuticals, Inc. | Compositions, methods, and devices for dialysis |
| WO2015002588A1 (en) | 2013-07-05 | 2015-01-08 | Oxthera Intellectual Property Ab | Secretagogues derived from oxalobacter formigenes |
| ES2694667T3 (es) | 2013-12-23 | 2018-12-26 | Nexttobe Ab | Método para producir oxalato oxidasas que tienen actividad óptica cerca de pH fisiológico y uso de tales oxalato oxidasas recombinantes en el tratamiento de enfermedades relacionadas con oxalato |
| MA40071A (fr) | 2014-07-01 | 2016-01-07 | Probi Usa Inc | Comprimés probiotiques bi-couche à double libération |
| CN107960105B (zh) | 2015-04-02 | 2025-05-16 | 武汉康复得生物科技股份有限公司 | 用于降解不溶性和可溶性草酸的高效草酸降解酶 |
| FR3045384B1 (fr) * | 2015-12-18 | 2020-02-07 | Institut National De La Recherche Agronomique | Composition lyophilisee pour la conservation de microbiote dans son ecosysteme |
| CN106974262B (zh) * | 2016-01-15 | 2021-05-25 | 深圳华大生命科学研究院 | 肠道益生杆菌在治疗和预防肥胖及其相关疾病中的应用 |
| CN109152796A (zh) * | 2016-03-09 | 2019-01-04 | 因库博实验室有限责任公司 | 用于将活细胞递送至实体组织的方法和制品 |
| EP3468572B1 (en) * | 2016-06-13 | 2022-03-02 | OxThera Intellectual Property AB | Compositions and methods for the treatment or prevention of oxalate-related disorders |
| JP2020521760A (ja) * | 2017-05-26 | 2020-07-27 | クレストヴォ・ホールディングス・エルエルシー | 糞便微生物ベースの治療剤を含む凍結乾燥組成物ならびにそれを製造および使用する方法 |
| ES3006512T3 (en) | 2017-11-17 | 2025-03-18 | Evonik Operations Gmbh | Process for preparing a coated hard shell capsule |
| CN110734861B (zh) * | 2018-07-20 | 2022-02-11 | 中国农业大学 | 一种猪肠道食糜微生物组的体外保藏方法 |
| JP2020055755A (ja) * | 2018-09-28 | 2020-04-09 | 日本ケミファ株式会社 | 腸溶性製剤 |
| US20210386793A1 (en) * | 2018-10-04 | 2021-12-16 | Oxthera Intellectual Property Ab | New medical use of oxalate-reducing bacteria |
| EP3646857A1 (en) * | 2018-11-01 | 2020-05-06 | Evonik Operations GmbH | Colonic delivery system for microorganisms |
| CN109402022A (zh) * | 2018-12-05 | 2019-03-01 | 上海上药信谊药厂有限公司 | 一种产甲酸草酸杆菌及其应用 |
| BR112022013867A2 (pt) * | 2020-01-14 | 2022-09-13 | Synlogic Operating Co Inc | Bactérias manipuladas para tratar distúrbios nos quais o oxalato é prejudicial |
| WO2021173895A1 (en) * | 2020-02-28 | 2021-09-02 | The Cleveland Clinic Foundation | Analysis of microbiome for diagnosis and treating of urinary stone disease |
| CA3175041A1 (en) * | 2020-03-10 | 2021-09-16 | Federation Bio Inc. | Microbial consortia for the treatment of disease |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| WO2022103639A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs |
| CA3216136A1 (en) * | 2021-04-30 | 2022-11-03 | Aaron Blake Cowley | Compositions for preserving anaerobic microorganisms and methods of making and using the same |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3030185A1 (de) | 1980-08-07 | 1982-04-08 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von oxalat mittels oxalat-oxidase |
| DE3204284A1 (de) | 1982-02-06 | 1983-08-18 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von sauerstoff |
| JPS5968344A (ja) * | 1982-10-12 | 1984-04-18 | Agency Of Ind Science & Technol | 非対称機能膜及びその製法 |
| US4539118A (en) * | 1984-03-23 | 1985-09-03 | Sigma Chemical Company | Rapid, accurate method of separation of oxalate from urine and other biological fluids |
| US5263992A (en) * | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
| US5427935A (en) * | 1987-07-24 | 1995-06-27 | The Regents Of The University Of Michigan | Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5286495A (en) * | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
| BR9307548A (pt) * | 1992-11-30 | 1999-06-01 | Zeneca Ltd | Fragmento de dna isolado molécula recombinante célula de planta transformada oxalato decarboxilase composição processo para proteger uma planta de ácido oxálico e planta |
| WO1994023593A1 (en) * | 1993-04-16 | 1994-10-27 | Mccormick & Company, Inc. | Encapsulation compositions |
| US5554147A (en) * | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
| US5788687A (en) * | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| US5505713A (en) * | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
| EP0764204B1 (en) | 1994-05-18 | 2001-08-22 | Human Genome Sciences, Inc. | HUMAN OXALYL-CoA DECARBOXYLASE |
| US6214980B1 (en) * | 1994-06-20 | 2001-04-10 | University Of Florida | Materials and methods for detection of Oxalobacte formigenes |
| US5912125A (en) * | 1994-06-20 | 1999-06-15 | University Of Florida | Materials and methods for detection of oxalobacter |
| US6090628A (en) | 1994-06-20 | 2000-07-18 | University Of Florida | Materials and methods for detection of Oxalobactor formigenes |
| US5604111A (en) * | 1994-06-20 | 1997-02-18 | University Of Florida Research Foundation | Method and kit for detection of oxalate |
| US6033719A (en) * | 1996-04-25 | 2000-03-07 | Medtronic, Inc. | Method for covalent attachment of biomolecules to surfaces of medical devices |
| SE9603029D0 (sv) | 1996-08-20 | 1996-08-20 | Svenska Traeforskningsinst | Method for lowering the level of oxalic acid |
| US6297425B1 (en) * | 1997-03-21 | 2001-10-02 | Pioneer Hi-Bred International, Inc. | Gene encoding oxalate decarboxylase from aspergillus phoenices |
| US8486389B2 (en) * | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| US6355242B1 (en) * | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
| JP4996780B2 (ja) * | 1997-05-23 | 2012-08-08 | オクセラ インコーポレイテッド | シュウ酸塩関連疾患を予防するためのシュウ酸塩分解微生物またはシュウ酸塩分解酵素 |
| US20040120941A1 (en) * | 1997-05-23 | 2004-06-24 | Allison Milton J. | Materials and methods for treating or preventing oxalate-related disease |
| US6161499A (en) * | 1997-07-07 | 2000-12-19 | Cvd Diamond Corporation | Apparatus and method for nucleation and deposition of diamond using hot-filament DC plasma |
| US6080404A (en) * | 1997-09-05 | 2000-06-27 | University Of Florida | Materials and methods for removal of substances from fluids |
| US6566407B2 (en) * | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US5985938A (en) * | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US6203797B1 (en) * | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| MXPA01003197A (es) * | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| IT1309427B1 (it) * | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
| MXPA01012658A (es) | 1999-06-07 | 2003-10-15 | Nanosphere Inc | Metodos para recubrir particulas, y particulas producidas mediante los mismos. |
| DE10026541A1 (de) * | 2000-05-27 | 2001-11-29 | Zeiss Carl | Vorrichtung zur präzisen Positionierung eines Bauteils, insbesondere eines optischen Bauteiles |
| AU2001284427A1 (en) | 2000-09-07 | 2002-03-22 | Shingo Tomoda | Analog electronic drum set, parts for drum stick, analog electronic drum set andfoot-pedal unit |
| KR20040018319A (ko) | 2000-12-18 | 2004-03-03 | 프로비오헬쓰 엘엘씨 | 락토바실러스 카제이 균주 κε01에서 유래된 정장제 화합물 |
| US7407668B2 (en) * | 2002-01-24 | 2008-08-05 | Boston Scimed, Inc. | Medical articles having enzymatic surfaces for localized therapy |
| US6929940B1 (en) * | 2002-08-20 | 2005-08-16 | University Of Florida Research Foundation, Inc. | Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| WO2007070052A2 (en) * | 2005-12-14 | 2007-06-21 | Oxthera, Inc. | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
-
2005
- 2005-12-14 WO PCT/US2005/045457 patent/WO2007070052A2/en not_active Ceased
- 2005-12-14 AU AU2005339139A patent/AU2005339139A1/en not_active Abandoned
- 2005-12-14 EP EP05854220.0A patent/EP1962873B1/en not_active Expired - Lifetime
- 2005-12-14 ES ES05854220T patent/ES2426258T3/es not_active Expired - Lifetime
- 2005-12-14 CA CA002645871A patent/CA2645871A1/en active Pending
- 2005-12-14 US US12/086,551 patent/US20100028422A1/en not_active Abandoned
- 2005-12-14 SI SI200531760T patent/SI1962873T1/sl unknown
- 2005-12-14 PT PT58542200T patent/PT1962873E/pt unknown
- 2005-12-14 JP JP2008545553A patent/JP5047190B2/ja not_active Expired - Fee Related
- 2005-12-14 DK DK05854220.0T patent/DK1962873T3/da active
- 2005-12-14 PL PL05854220T patent/PL1962873T3/pl unknown
-
2006
- 2006-12-14 EP EP06848618.2A patent/EP1965816B1/en not_active Not-in-force
- 2006-12-14 LT LTEP06848618.2T patent/LT1965816T/lt unknown
- 2006-12-14 ES ES06848618.2T patent/ES2628090T3/es active Active
- 2006-12-14 JP JP2008545843A patent/JP5203217B2/ja not_active Expired - Fee Related
- 2006-12-14 WO PCT/US2006/047909 patent/WO2007070677A2/en not_active Ceased
- 2006-12-14 AU AU2006326016A patent/AU2006326016B2/en not_active Ceased
- 2006-12-14 US US11/639,388 patent/US8545836B2/en not_active Expired - Fee Related
- 2006-12-14 CA CA2650122A patent/CA2650122C/en active Active
- 2006-12-14 HU HUE06848618A patent/HUE034539T2/en unknown
- 2006-12-14 PL PL06848618T patent/PL1965816T3/pl unknown
-
2013
- 2013-08-28 CY CY20131100733T patent/CY1114397T1/el unknown
-
2017
- 2017-06-07 CY CY20171100595T patent/CY1118936T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009531275A5 (https=) | ||
| ES2628090T3 (es) | Composiciones farmacéuticas y métodos para tratar o prevenir una enfermedad relacionada con el oxalato | |
| RU2403015C2 (ru) | Гастрорезистентные фармацевтические композиции, содержащие рифаксимин | |
| KR101228608B1 (ko) | 프로바이오틱 박테리아 기초 조성물 및 호흡기 병리 및/또는 감염의 예방 및/또는 치료 및 장 기능성 개선에 있어서 그들의 용도 | |
| EP2079445B1 (en) | Stable digestive enzyme compositions | |
| EP1553929B2 (en) | Controlled release preparation | |
| US20030175355A1 (en) | Fast melt multiparticulate formulations for oral delivery | |
| US10016467B2 (en) | Formulations of viable cells for oral delivery | |
| CN104968356A (zh) | 大肠输送胶囊及其制备方法 | |
| ES2386902T3 (es) | Composiciones que comprenden microorganismos deshidratados, sus procesos de preparación y sus utilizaciones | |
| Muvva et al. | Modified pectins for colon-specific drug delivery | |
| ES2969208T3 (es) | Composiciones de ácido gamma-poliglutámico y zinc | |
| CN101410127B (zh) | 口腔速崩片 | |
| JP2021527639A (ja) | 生物療法製品を含む剤形 | |
| DK1965816T3 (en) | PHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR TREATMENT OR PREVENTION OF OXALATE-RELATED DISEASE | |
| WO2020012243A2 (en) | Pharmaceutical composition containing a peptide | |
| HK1124538B (en) | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease | |
| HK1124538A (en) | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease | |
| CN1872056A (zh) | 适合儿童应用的阿莫西林与盐酸溴己新的复方制剂及其处方和制备方法 | |
| HK1220134B (zh) | 用於口服递送的活细胞制剂 |