JP2009530624A5 - - Google Patents
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- Publication number
- JP2009530624A5 JP2009530624A5 JP2009500679A JP2009500679A JP2009530624A5 JP 2009530624 A5 JP2009530624 A5 JP 2009530624A5 JP 2009500679 A JP2009500679 A JP 2009500679A JP 2009500679 A JP2009500679 A JP 2009500679A JP 2009530624 A5 JP2009530624 A5 JP 2009530624A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- sample
- prostate cancer
- molecular formula
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 30
- 239000002207 metabolite Substances 0.000 claims 22
- 206010060862 Prostate cancer Diseases 0.000 claims 14
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 14
- 230000007704 transition Effects 0.000 claims 14
- 230000003862 health status Effects 0.000 claims 9
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 claims 4
- 108010003541 Platelet Activating Factor Proteins 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- ZPDQFUYPBVXUKS-YADHBBJMSA-N 1-stearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(O)(=O)OC[C@H](N)C(O)=O ZPDQFUYPBVXUKS-YADHBBJMSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- CWRILEGKIAOYKP-SSDOTTSWSA-M [(2r)-3-acetyloxy-2-hydroxypropyl] 2-aminoethyl phosphate Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCCN CWRILEGKIAOYKP-SSDOTTSWSA-M 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000004896 high resolution mass spectrometry Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- UOXRPRZMAROFPH-IESLQMLBSA-N lysophosphatidylinositol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(O)(=O)OC1[C@H](O)[C@@H](O)C(O)[C@@H](O)[C@H]1O UOXRPRZMAROFPH-IESLQMLBSA-N 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000005040 ion trap Methods 0.000 claims 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000004885 tandem mass spectrometry Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78548006P | 2006-03-24 | 2006-03-24 | |
| US60/785,480 | 2006-03-24 | ||
| PCT/CA2007/000469 WO2007109881A1 (en) | 2006-03-24 | 2007-03-23 | Biomarkers useful for diagnosing prostate cancer, and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012259409A Division JP5502972B2 (ja) | 2006-03-24 | 2012-11-28 | 前立腺癌を診断するために有用なバイオマーカー及びその方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009530624A JP2009530624A (ja) | 2009-08-27 |
| JP2009530624A5 true JP2009530624A5 (enExample) | 2010-05-06 |
| JP5612303B2 JP5612303B2 (ja) | 2014-10-22 |
Family
ID=38540744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500679A Expired - Fee Related JP5612303B2 (ja) | 2006-03-24 | 2007-03-23 | 患者における前立腺癌の健康状態等を判定するためにデータを得る方法 |
| JP2012259409A Expired - Fee Related JP5502972B2 (ja) | 2006-03-24 | 2012-11-28 | 前立腺癌を診断するために有用なバイオマーカー及びその方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012259409A Expired - Fee Related JP5502972B2 (ja) | 2006-03-24 | 2012-11-28 | 前立腺癌を診断するために有用なバイオマーカー及びその方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8409794B2 (enExample) |
| EP (2) | EP2674435A3 (enExample) |
| JP (2) | JP5612303B2 (enExample) |
| KR (1) | KR20090006837A (enExample) |
| CN (1) | CN101454331A (enExample) |
| AU (1) | AU2007231487B2 (enExample) |
| BR (1) | BRPI0709176A2 (enExample) |
| CA (1) | CA2644330C (enExample) |
| SG (1) | SG170061A1 (enExample) |
| WO (1) | WO2007109881A1 (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3003765B2 (ja) | 1994-09-20 | 2000-01-31 | 株式会社デンソー | チューブジョイント |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
| US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
| US20090075284A1 (en) * | 2006-09-19 | 2009-03-19 | The Regents Of The University Of Michigan | Metabolomic profiling of prostate cancer |
| AU2007299846B2 (en) * | 2006-09-19 | 2014-11-20 | Metabolon, Inc. | Biomarkers for prostate cancer and methods using the same |
| KR101542037B1 (ko) * | 2006-12-21 | 2015-08-05 | 아지노모토 가부시키가이샤 | 암 상태의 평가 방법, 및 암 평가 장치, 암 평가 방법, 암 평가 시스템, 암 평가 프로그램 및 기록 매체 |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US20100291690A1 (en) * | 2007-11-07 | 2010-11-18 | Lian Shan | Methods for detecting or monitoring cancer using lpc as a marker |
| WO2009061404A1 (en) * | 2007-11-07 | 2009-05-14 | Frantz Biomarkers, Llc | Methods for detecting or monitoring cancer using lpc as a marker |
| WO2009086297A2 (en) * | 2007-12-21 | 2009-07-09 | The Board Of Regents Of The University Of Oklahoma | Identification of biomarkers in biological samples and methods of unsing same |
| KR101361601B1 (ko) * | 2008-03-04 | 2014-02-12 | 아지노모토 가부시키가이샤 | 암종의 평가 방법 |
| WO2009154297A1 (ja) * | 2008-06-20 | 2009-12-23 | 味の素株式会社 | 前立腺疾患の評価方法 |
| CA2730614A1 (en) * | 2008-07-16 | 2010-01-21 | Dana-Farber Cancer Institute | Signatures and pcdeterminants associated with prostate cancer and methods of use thereof |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| KR101018665B1 (ko) | 2008-08-18 | 2011-03-04 | 재단법인서울대학교산학협력재단 | 전립선암 진단 방법 및 장치 |
| US8399829B2 (en) * | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US9500572B2 (en) | 2009-04-30 | 2016-11-22 | Purdue Research Foundation | Sample dispenser including an internal standard and methods of use thereof |
| US20120122243A1 (en) * | 2009-06-04 | 2012-05-17 | Charite Universitatsmedizin Berlin | Means and method and means for diagnosing prostate carcinomas |
| SG10201405975VA (en) * | 2009-10-01 | 2014-11-27 | Phenomenome Discoveries Inc | Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| JP2013515270A (ja) * | 2009-12-22 | 2013-05-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌の代謝学的プロファイリング |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| EP2354794A1 (en) * | 2010-01-29 | 2011-08-10 | IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. | Diagnosing prostate cancer relapse |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| EP4435111A1 (en) | 2010-02-12 | 2024-09-25 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| WO2011140492A2 (en) * | 2010-05-07 | 2011-11-10 | Ut-Battelle, Llc | System and method for extracting a sample from a surface |
| AU2011270968C1 (en) * | 2010-06-23 | 2017-01-19 | University Of Louisville Research Foundation, Inc. | Methods for detecting cancer |
| WO2012015904A2 (en) * | 2010-07-28 | 2012-02-02 | Metabolon, Inc. | Biomarkers for prostate cancer and methods using the same |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| EP2714970B1 (en) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US20130210659A1 (en) | 2012-02-10 | 2013-08-15 | Andrew Watson | Molecular diagnostic screening assay |
| JP6308954B2 (ja) | 2012-03-05 | 2018-04-11 | オサケユキテュア・アークティック・パートナーズ・アクチボラゲットＯｙ Ａｒｃｔｉｃ Ｐａｒｔｎｅｒｓ Ａｂ | 前立腺癌のリスク及び前立腺容積を予測する方法及び装置 |
| WO2013165748A1 (en) | 2012-04-30 | 2013-11-07 | Raindance Technologies, Inc | Digital analyte analysis |
| WO2014068144A1 (en) | 2012-11-05 | 2014-05-08 | Ospedale San Raffaele S.R.L. | Biomarkers of multiple myeloma development and progression |
| US9176154B2 (en) * | 2012-12-12 | 2015-11-03 | Bio-Rad Laboratories, Inc. | Calibration process and system |
| WO2014120411A1 (en) * | 2013-01-31 | 2014-08-07 | Purdue Research Foundation | Systems and methods for analyzing an extracted sample |
| BR112015018484A2 (pt) | 2013-01-31 | 2017-07-18 | Purdue Research Foundation | métodos de analisar o petróleo bruto |
| EP2986762B1 (en) | 2013-04-19 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| TR201906195T4 (tr) * | 2013-05-14 | 2019-05-21 | Centogene Ag | Niemann pıck hastalığının teşhisi için metot. |
| EP3486937B1 (en) | 2013-06-25 | 2022-07-27 | Purdue Research Foundation | Mass spectrometry analysis of microorganisms in samples |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| US12326453B2 (en) | 2014-03-28 | 2025-06-10 | Opko Diagnostics, Llc | Compositions and methods for active surveillance of prostate cancer |
| CN114740202A (zh) | 2014-03-28 | 2022-07-12 | 欧普科诊断有限责任公司 | 与前列腺癌的诊断有关的组合物和方法 |
| US10197551B2 (en) * | 2014-05-30 | 2019-02-05 | ASTA, Co. Ltd. | Integrated disease diagnostic system using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer |
| US10879056B2 (en) | 2014-05-30 | 2020-12-29 | ASTA, Co. Ltd | Integrated disease diagnostic system using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer |
| US9786478B2 (en) | 2014-12-05 | 2017-10-10 | Purdue Research Foundation | Zero voltage mass spectrometry probes and systems |
| EP4379770A3 (en) | 2015-02-06 | 2024-08-21 | Purdue Research Foundation | Probes, systems, and cartridges |
| EP3253800B1 (en) | 2015-03-27 | 2021-03-03 | Opko Diagnostics, LLC | Prostate antigen standards and uses thereof |
| CA2982262A1 (en) | 2015-04-29 | 2016-11-03 | Opko Diagnostics, Llc | Compositions and methods for active surveillance of prostate cancer |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| CN105424841B (zh) * | 2015-12-25 | 2017-11-03 | 齐炼文 | 用于诊断冠状动脉粥样硬化的代谢标志物 |
| JP2017203649A (ja) * | 2016-05-09 | 2017-11-16 | 国立大学法人大阪大学 | 前立腺がん判定方法 |
| US10006925B2 (en) | 2016-05-30 | 2018-06-26 | Universal Diagnostics, S. L. | Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps |
| WO2018016645A1 (ja) * | 2016-07-22 | 2018-01-25 | 国立大学法人秋田大学 | 新規リン脂質およびその利用ならびにリン脂質分離測定法の開発 |
| US10319574B2 (en) * | 2016-08-22 | 2019-06-11 | Highland Innovations Inc. | Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer |
| US11073522B2 (en) | 2016-10-03 | 2021-07-27 | Lincoln Memorial University | Structural validation of very long chain dicarboxylic acids |
| WO2018158801A1 (ja) * | 2017-02-28 | 2018-09-07 | 株式会社島津製作所 | スペクトルデータの特徴抽出装置および方法 |
| US10998178B2 (en) | 2017-08-28 | 2021-05-04 | Purdue Research Foundation | Systems and methods for sample analysis using swabs |
| CN118942699B (zh) * | 2024-07-23 | 2025-04-25 | 中日友好医院(中日友好临床医学研究所) | 一种肺动脉高压预测方法、系统 |
| CN120766944A (zh) * | 2025-06-09 | 2025-10-10 | 宁波大学附属第一医院 | 尿液小细胞外囊泡脂质标志物联合临床参数在前列腺癌风险分级诊断产品中的应用 |
| CN121096509B (zh) * | 2025-11-11 | 2026-02-10 | 山东第一医科大学附属省立医院(山东省立医院) | 磷脂酰肌醇和磷脂酰甘油作为颅内动脉粥样硬化进展预测的代谢标志物的应用 |
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| US4813171A (en) | 1987-11-24 | 1989-03-21 | Herbert Cooper | Power-operated lateral actuator for a fishing outrigger |
| US4953328A (en) | 1989-05-24 | 1990-09-04 | Sewell Scott R | Air conditioning compressor sectionalized cover |
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| JP2006509186A (ja) * | 2002-05-10 | 2006-03-16 | イースタン バージニア メディカル スクール | 前立腺癌バイオマーカー |
| AUPS282602A0 (en) * | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
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-
2007
- 2007-03-23 EP EP20130176367 patent/EP2674435A3/en not_active Withdrawn
- 2007-03-23 JP JP2009500679A patent/JP5612303B2/ja not_active Expired - Fee Related
- 2007-03-23 WO PCT/CA2007/000469 patent/WO2007109881A1/en not_active Ceased
- 2007-03-23 SG SG201101506-2A patent/SG170061A1/en unknown
- 2007-03-23 BR BRPI0709176-1A patent/BRPI0709176A2/pt not_active Application Discontinuation
- 2007-03-23 CN CNA2007800188377A patent/CN101454331A/zh active Pending
- 2007-03-23 AU AU2007231487A patent/AU2007231487B2/en not_active Ceased
- 2007-03-23 KR KR1020087026013A patent/KR20090006837A/ko not_active Withdrawn
- 2007-03-23 US US12/294,215 patent/US8409794B2/en not_active Expired - Fee Related
- 2007-03-23 CA CA2644330A patent/CA2644330C/en not_active Expired - Fee Related
- 2007-03-23 EP EP07710787A patent/EP1922326A4/en not_active Ceased
-
2012
- 2012-11-28 JP JP2012259409A patent/JP5502972B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-13 US US13/801,574 patent/US20130330746A1/en not_active Abandoned
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