JP2009529041A5 - - Google Patents

Download PDF

Info

Publication number
JP2009529041A5
JP2009529041A5 JP2008558230A JP2008558230A JP2009529041A5 JP 2009529041 A5 JP2009529041 A5 JP 2009529041A5 JP 2008558230 A JP2008558230 A JP 2008558230A JP 2008558230 A JP2008558230 A JP 2008558230A JP 2009529041 A5 JP2009529041 A5 JP 2009529041A5
Authority
JP
Japan
Prior art keywords
carboxamide
pyridin
amino
methylpiperazin
pyrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008558230A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009529041A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/SE2007/000216 external-priority patent/WO2007102770A1/en
Publication of JP2009529041A publication Critical patent/JP2009529041A/ja
Publication of JP2009529041A5 publication Critical patent/JP2009529041A5/ja
Pending legal-status Critical Current

Links

JP2008558230A 2006-03-08 2007-03-06 骨粗鬆症治療のためのgsk−3阻害薬 Pending JP2009529041A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78025206P 2006-03-08 2006-03-08
PCT/SE2007/000216 WO2007102770A1 (en) 2006-03-08 2007-03-06 Gsk-3 inhibitors for the treatment of osteoporosis

Publications (2)

Publication Number Publication Date
JP2009529041A JP2009529041A (ja) 2009-08-13
JP2009529041A5 true JP2009529041A5 (cg-RX-API-DMAC7.html) 2010-04-22

Family

ID=38475142

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008558230A Pending JP2009529041A (ja) 2006-03-08 2007-03-06 骨粗鬆症治療のためのgsk−3阻害薬

Country Status (16)

Country Link
US (1) US7576093B2 (cg-RX-API-DMAC7.html)
EP (1) EP1993550A4 (cg-RX-API-DMAC7.html)
JP (1) JP2009529041A (cg-RX-API-DMAC7.html)
KR (1) KR20080114717A (cg-RX-API-DMAC7.html)
CN (1) CN101394851A (cg-RX-API-DMAC7.html)
AR (1) AR059754A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007222199A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0708619A2 (cg-RX-API-DMAC7.html)
CA (1) CA2644751A1 (cg-RX-API-DMAC7.html)
IL (1) IL193484A0 (cg-RX-API-DMAC7.html)
MX (1) MX2008011417A (cg-RX-API-DMAC7.html)
NO (1) NO20084182L (cg-RX-API-DMAC7.html)
TW (1) TW200800203A (cg-RX-API-DMAC7.html)
UY (1) UY30192A1 (cg-RX-API-DMAC7.html)
WO (1) WO2007102770A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200807234B (cg-RX-API-DMAC7.html)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100137330A1 (en) * 2007-03-08 2010-06-03 Ratan Bhat Use
EP2370424A1 (en) 2008-11-10 2011-10-05 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
SI3354650T1 (sl) 2008-12-19 2022-06-30 Vertex Pharmaceuticals Incorporated Spojine, uporabne kot zaviralci ATR kinaze
RU2012135093A (ru) * 2010-01-19 2014-03-10 Астразенека Аб Производные пиразина
EP2568984A1 (en) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP2013529200A (ja) 2010-05-12 2013-07-18 バーテックス ファーマシューティカルズ インコーポレイテッド Atrキナーゼ阻害剤として有用な化合物
EP2569287B1 (en) 2010-05-12 2014-07-09 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
AU2011253021A1 (en) 2010-05-12 2012-11-29 Vertex Pharmaceuticals Incorporated 2 -aminopyridine derivatives useful as inhibitors of ATR kinase
AU2011253025A1 (en) 2010-05-12 2012-11-29 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2011143419A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
AU2011270807A1 (en) 2010-06-23 2013-01-31 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of ATR kinase
MX2013011450A (es) 2011-04-05 2014-02-03 Vertex Pharma Compuestos de aminopirazina utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
BR112013029640A2 (pt) * 2011-05-23 2017-06-13 Merck Patent Gmbh derivados de piridina e pirazina
JP2014522818A (ja) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Atrキナーゼ阻害剤として有用な化合物
JP2014517079A (ja) 2011-06-22 2014-07-17 バーテックス ファーマシューティカルズ インコーポレイテッド Atrキナーゼ阻害剤として有用な化合物
EP2723745A1 (en) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
BR112014007690B1 (pt) 2011-09-30 2022-10-04 Vertex Pharmaceuticals Incorporated Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas
EP2751088B1 (en) 2011-09-30 2016-04-13 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013049720A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP6212045B2 (ja) 2011-09-30 2017-10-11 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼの阻害剤として有用な化合物を作製するためのプロセス
MX2014003796A (es) 2011-09-30 2015-01-16 Vertex Pharma Compuestos utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
US8846917B2 (en) 2011-11-09 2014-09-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US8841449B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US8841337B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2776420A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
DK2833973T3 (en) 2012-04-05 2018-01-02 Vertex Pharma Compounds useful as ATR kinase inhibitors and combination therapies thereof
US8999632B2 (en) 2012-10-04 2015-04-07 Vertex Pharmaceuticals Incorporated Method for measuring ATR inhibition mediated increases in DNA damage
EP2909202A1 (en) 2012-10-16 2015-08-26 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP3418281B1 (en) 2012-12-07 2020-09-30 Vertex Pharmaceuticals Inc. Pyrazolo[1,5-a]pyrimidines useful as inhibitors of atr kinase for the treatment of cancer diseases
BR112015023261A2 (pt) 2013-03-14 2017-07-18 Massachusetts Inst Technology composições e métodos para expansão e cultura de células-tronco epiteliais
EP2970286A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
EP3077397B1 (en) 2013-12-06 2019-09-18 Vertex Pharmaceuticals Inc. 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
CN103804312B (zh) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
ES2777608T3 (es) 2014-06-05 2020-08-05 Vertex Pharma Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
CA2950780C (en) 2014-06-17 2023-05-16 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of chk1 and atr inhibitors
JP6773645B2 (ja) 2014-09-03 2020-10-21 ザ ブリガム アンド ウィミンズ ホスピタル,インコーポレイテッド 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
WO2017120543A1 (en) 2016-01-08 2017-07-13 Massachusetts Institute Of Technology Production of differentiated enteroendocrine cells and insulin producing cells
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
AU2017386417B2 (en) 2016-12-30 2022-07-14 Frequency Therapeutics, Inc. 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
JP2021533788A (ja) 2018-08-17 2021-12-09 フリークエンシー セラピューティクス インコーポレイテッド Jag−1を上方制御することにより有毛細胞を生成するための組成物及び方法
WO2020163812A1 (en) 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders
TW202517268A (zh) * 2023-07-14 2025-05-01 美商塞萊托藥品股份有限公司 包含atr抑制劑之脂質體組合物之使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145757A (en) 2000-02-05 2007-12-03 Vertex Pharma History of pyrazole and pharmaceutical preparations containing them
SE0102438D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
SE0102439D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
ES2316756T3 (es) * 2002-01-10 2009-04-16 F. Hoffmann-La Roche Ag Uso de un inhibidor de gsk-3beta en la fabricacion de un medicamento para incrementar la formacion osea.
EP1483265B1 (en) 2002-03-05 2006-11-22 Eli Lilly And Company Purine derivatives as kinase inhibitors
SE0203752D0 (sv) * 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
MXPA05013115A (es) 2003-06-06 2006-05-25 Wyeth Corp Metodos y materiales para identificar agentes que modulan la remodelacion de hueso y agentes identificados por los mismos.
EP1653970A4 (en) 2003-08-13 2008-10-15 Novartis Vaccines & Diagnostic GSK-3 HEMMER AND ITS USES
US20050064044A1 (en) * 2003-09-19 2005-03-24 Georges Rawadi GSK-3beta inhibitors in the treatment of bone-related diseases

Similar Documents

Publication Publication Date Title
JP2009529041A5 (cg-RX-API-DMAC7.html)
NO20084182L (no) GSK-3 inhibitorer for behandling av osteoporose
RU2012132692A (ru) Новые ингибиторы s-нитрозоглутатионредуктазы
RU2005135016A (ru) Производные хинолина в качестве ингибиторов фосфодиэстеразы
JP5527205B2 (ja) 脊柱管狭窄症治療剤
GB0324654D0 (en) Medicinal compounds
JP2016512825A5 (cg-RX-API-DMAC7.html)
JP2008110984A5 (cg-RX-API-DMAC7.html)
JP2013500986A5 (cg-RX-API-DMAC7.html)
EA200200551A1 (ru) Новые содержащие тиотропий порошки для ингаляции
JP2007502806A5 (cg-RX-API-DMAC7.html)
HRP20050432A2 (en) Novel medicaments for the treatment of chronic obstructive pulmonary diseases
RU2003114752A (ru) Лечение желудочно-кишечных стромальных опухолей
JP2004512328A5 (cg-RX-API-DMAC7.html)
NZ593593A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
DE602005026007D1 (de) Opioide zur behandlung von chronisch-obstruktiver lungenerkrankung (copd)
EA200400881A1 (ru) Азаарилпиперазины
CA2463102A1 (en) Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors
NO20065061L (no) Benzoksazin for behandling av sykdommer i luftveiene
JP2004504400A5 (cg-RX-API-DMAC7.html)
JP2010526801A5 (cg-RX-API-DMAC7.html)
JP2010521516A5 (cg-RX-API-DMAC7.html)
DE602004016850D1 (de) Pyrazoloä3,4-büpyridin-6-one als gsk-3 inhibitoren
JP2013508385A5 (cg-RX-API-DMAC7.html)
EA200600854A1 (ru) Новые соли тиотропия, способ их получения, а также содержащие их лекарственные композиции