JP2009528293A - 様々な形態の活性型第v因子を用いた止血を調節する組成物及び方法 - Google Patents

様々な形態の活性型第v因子を用いた止血を調節する組成物及び方法 Download PDF

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JP2009528293A
JP2009528293A JP2008556560A JP2008556560A JP2009528293A JP 2009528293 A JP2009528293 A JP 2009528293A JP 2008556560 A JP2008556560 A JP 2008556560A JP 2008556560 A JP2008556560 A JP 2008556560A JP 2009528293 A JP2009528293 A JP 2009528293A
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factor
active form
hemophilia
amino acids
nucleic acid
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JP2008556560A
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Japanese (ja)
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JP2009528293A5 (enExample
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カミレ、ロッドニー、エム.
アルダ、バルダー、アール.
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Childrens Hospital of Philadelphia CHOP
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Childrens Hospital of Philadelphia CHOP
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2008556560A 2006-02-23 2007-02-23 様々な形態の活性型第v因子を用いた止血を調節する組成物及び方法 Pending JP2009528293A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77612406P 2006-02-23 2006-02-23
PCT/US2007/062720 WO2007101106A2 (en) 2006-02-23 2007-02-23 Compositions and methods for modulating hemostasis using variant forms of activated factor v

Publications (2)

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JP2009528293A true JP2009528293A (ja) 2009-08-06
JP2009528293A5 JP2009528293A5 (enExample) 2010-04-15

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JP2008556560A Pending JP2009528293A (ja) 2006-02-23 2007-02-23 様々な形態の活性型第v因子を用いた止血を調節する組成物及び方法

Country Status (7)

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US (2) US8236764B2 (enExample)
EP (2) EP1986681A4 (enExample)
JP (1) JP2009528293A (enExample)
AU (1) AU2007220825B2 (enExample)
CA (1) CA2641519A1 (enExample)
IL (1) IL193306A (enExample)
WO (1) WO2007101106A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012509670A (ja) * 2008-11-21 2012-04-26 ザ チルドレンズ ホスピタル オブ フィラデルフィア 血液凝固促進剤としてのヘビ第五因子及び使用方法
US20120065137A1 (en) * 2010-09-03 2012-03-15 Richard Jenny Therapeutics for trauma induced factor v consumptive coagulopathy
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface
AU2012323928B2 (en) 2011-10-13 2017-09-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating thrombin generation
WO2016005564A2 (en) * 2014-07-11 2016-01-14 Novo Nordisk A/S Antibodies against activated factor v
US11441122B2 (en) 2017-10-05 2022-09-13 Epivax Inc. Regulatory T cell epitopes
US20210093735A1 (en) * 2018-04-26 2021-04-01 The University Of North Carolina At Chapel Hill Methods and compositions for treatment of hemophilia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093699A (en) 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
CA2160583A1 (en) 1993-04-16 1994-10-27 Stanley A. Plotkin Recombinant cytomegalovirus vaccine
AU7676894A (en) 1993-08-27 1995-03-21 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Convection-enhanced drug delivery
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
CN100569297C (zh) 1995-02-28 2009-12-16 加利福尼亚大学董事会 基因转移介导的血管形成疗法
AU2319497A (en) 1996-03-07 1997-09-22 Regents Of The University Of California, The Helper-free, totally defective adenovirus for gene therapy
US7211558B2 (en) * 2002-05-22 2007-05-01 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hemophilia A

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012019503; SCHLACHTERMAN, et al.: Journal of Thrombosis and Haemostasis Vol.3, 2005, pp.2730-2737 *
JPN6012019504; TOSO, R. et al.: The Journal of Biological Chemistry Vol.279, No.20, 2004, pp.21643-21650 *

Also Published As

Publication number Publication date
IL193306A (en) 2013-04-30
EP1986681A2 (en) 2008-11-05
US20120288895A1 (en) 2012-11-15
IL193306A0 (en) 2011-08-01
EP2384764A3 (en) 2012-02-08
WO2007101106A2 (en) 2007-09-07
CA2641519A1 (en) 2007-09-07
EP1986681A4 (en) 2010-08-04
WO2007101106A3 (en) 2008-11-27
EP2384764A2 (en) 2011-11-09
AU2007220825B2 (en) 2013-02-21
US8236764B2 (en) 2012-08-07
US20090318344A1 (en) 2009-12-24
AU2007220825A1 (en) 2007-09-07
US8470557B2 (en) 2013-06-25

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