AU2007220825B2 - Compositions and methods for modulating hemostasis using variant forms of activated Factor V - Google Patents

Compositions and methods for modulating hemostasis using variant forms of activated Factor V Download PDF

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Publication number
AU2007220825B2
AU2007220825B2 AU2007220825A AU2007220825A AU2007220825B2 AU 2007220825 B2 AU2007220825 B2 AU 2007220825B2 AU 2007220825 A AU2007220825 A AU 2007220825A AU 2007220825 A AU2007220825 A AU 2007220825A AU 2007220825 B2 AU2007220825 B2 AU 2007220825B2
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AU
Australia
Prior art keywords
hemophilia
activated form
nucleic acid
fvl
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007220825A
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English (en)
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AU2007220825A1 (en
Inventor
Valder R. Arruda
Rodney M. Camire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
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Childrens Hospital of Philadelphia CHOP
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Publication date
Application filed by Childrens Hospital of Philadelphia CHOP filed Critical Childrens Hospital of Philadelphia CHOP
Publication of AU2007220825A1 publication Critical patent/AU2007220825A1/en
Application granted granted Critical
Publication of AU2007220825B2 publication Critical patent/AU2007220825B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2007220825A 2006-02-23 2007-02-23 Compositions and methods for modulating hemostasis using variant forms of activated Factor V Ceased AU2007220825B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77612406P 2006-02-23 2006-02-23
US60/776,124 2006-02-23
PCT/US2007/062720 WO2007101106A2 (en) 2006-02-23 2007-02-23 Compositions and methods for modulating hemostasis using variant forms of activated factor v

Publications (2)

Publication Number Publication Date
AU2007220825A1 AU2007220825A1 (en) 2007-09-07
AU2007220825B2 true AU2007220825B2 (en) 2013-02-21

Family

ID=38459752

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007220825A Ceased AU2007220825B2 (en) 2006-02-23 2007-02-23 Compositions and methods for modulating hemostasis using variant forms of activated Factor V

Country Status (7)

Country Link
US (2) US8236764B2 (enExample)
EP (2) EP1986681A4 (enExample)
JP (1) JP2009528293A (enExample)
AU (1) AU2007220825B2 (enExample)
CA (1) CA2641519A1 (enExample)
IL (1) IL193306A (enExample)
WO (1) WO2007101106A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012509670A (ja) * 2008-11-21 2012-04-26 ザ チルドレンズ ホスピタル オブ フィラデルフィア 血液凝固促進剤としてのヘビ第五因子及び使用方法
US20120065137A1 (en) * 2010-09-03 2012-03-15 Richard Jenny Therapeutics for trauma induced factor v consumptive coagulopathy
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface
AU2012323928B2 (en) 2011-10-13 2017-09-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating thrombin generation
WO2016005564A2 (en) * 2014-07-11 2016-01-14 Novo Nordisk A/S Antibodies against activated factor v
US11441122B2 (en) 2017-10-05 2022-09-13 Epivax Inc. Regulatory T cell epitopes
US20210093735A1 (en) * 2018-04-26 2021-04-01 The University Of North Carolina At Chapel Hill Methods and compositions for treatment of hemophilia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093699A (en) 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
CA2160583A1 (en) 1993-04-16 1994-10-27 Stanley A. Plotkin Recombinant cytomegalovirus vaccine
AU7676894A (en) 1993-08-27 1995-03-21 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Convection-enhanced drug delivery
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
CN100569297C (zh) 1995-02-28 2009-12-16 加利福尼亚大学董事会 基因转移介导的血管形成疗法
AU2319497A (en) 1996-03-07 1997-09-22 Regents Of The University Of California, The Helper-free, totally defective adenovirus for gene therapy
US7211558B2 (en) * 2002-05-22 2007-05-01 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hemophilia A

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SCHLACHTERMAN, A. et al 2005 JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 3, no. 12, pp. 2730-2737 *
TOSO, R. et al 2004 JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 20, pp. 21643-21650 *

Also Published As

Publication number Publication date
IL193306A (en) 2013-04-30
EP1986681A2 (en) 2008-11-05
US20120288895A1 (en) 2012-11-15
IL193306A0 (en) 2011-08-01
JP2009528293A (ja) 2009-08-06
EP2384764A3 (en) 2012-02-08
WO2007101106A2 (en) 2007-09-07
CA2641519A1 (en) 2007-09-07
EP1986681A4 (en) 2010-08-04
WO2007101106A3 (en) 2008-11-27
EP2384764A2 (en) 2011-11-09
US8236764B2 (en) 2012-08-07
US20090318344A1 (en) 2009-12-24
AU2007220825A1 (en) 2007-09-07
US8470557B2 (en) 2013-06-25

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired