IL193306A - Use of Enhanced Forms of Factor V in the Preparation of Medicines to Treat Hemostasis-Related Disorders and Isolated Nucleic Acid Molecules Encoded into These Enhanced Forms - Google Patents

Use of Enhanced Forms of Factor V in the Preparation of Medicines to Treat Hemostasis-Related Disorders and Isolated Nucleic Acid Molecules Encoded into These Enhanced Forms

Info

Publication number
IL193306A
IL193306A IL193306A IL19330608A IL193306A IL 193306 A IL193306 A IL 193306A IL 193306 A IL193306 A IL 193306A IL 19330608 A IL19330608 A IL 19330608A IL 193306 A IL193306 A IL 193306A
Authority
IL
Israel
Prior art keywords
activated forms
medicaments
factor
preparation
nucleic acid
Prior art date
Application number
IL193306A
Other languages
English (en)
Hebrew (he)
Other versions
IL193306A0 (en
Original Assignee
Philadelphia Children Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philadelphia Children Hospital filed Critical Philadelphia Children Hospital
Publication of IL193306A0 publication Critical patent/IL193306A0/en
Publication of IL193306A publication Critical patent/IL193306A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL193306A 2006-02-23 2008-08-07 Use of Enhanced Forms of Factor V in the Preparation of Medicines to Treat Hemostasis-Related Disorders and Isolated Nucleic Acid Molecules Encoded into These Enhanced Forms IL193306A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77612406P 2006-02-23 2006-02-23
PCT/US2007/062720 WO2007101106A2 (en) 2006-02-23 2007-02-23 Compositions and methods for modulating hemostasis using variant forms of activated factor v

Publications (2)

Publication Number Publication Date
IL193306A0 IL193306A0 (en) 2011-08-01
IL193306A true IL193306A (en) 2013-04-30

Family

ID=38459752

Family Applications (1)

Application Number Title Priority Date Filing Date
IL193306A IL193306A (en) 2006-02-23 2008-08-07 Use of Enhanced Forms of Factor V in the Preparation of Medicines to Treat Hemostasis-Related Disorders and Isolated Nucleic Acid Molecules Encoded into These Enhanced Forms

Country Status (7)

Country Link
US (2) US8236764B2 (enExample)
EP (2) EP1986681A4 (enExample)
JP (1) JP2009528293A (enExample)
AU (1) AU2007220825B2 (enExample)
CA (1) CA2641519A1 (enExample)
IL (1) IL193306A (enExample)
WO (1) WO2007101106A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2365822B1 (en) * 2008-11-21 2015-07-01 The Children's Hospital Of Philadelphia Snake factor v and methods of use as a procoagulant
WO2012031240A2 (en) * 2010-09-03 2012-03-08 Richard Jenny Therapeutics for trauma induced factor v consumptive coagulopathy
US8637448B2 (en) 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface
WO2013056221A1 (en) * 2011-10-13 2013-04-18 The Children's Hospital Of Philadelphia Compositions and methods for modulating thrombin generation
AR101185A1 (es) * 2014-07-11 2016-11-30 Novo Nordiks As Anticuerpos anti-factor v o factor v activado
JP7274472B2 (ja) 2017-10-05 2023-05-16 エピバックス、インコーポレイテッド 制御性ｔ細胞エピトープ
US20210093735A1 (en) * 2018-04-26 2021-04-01 The University Of North Carolina At Chapel Hill Methods and compositions for treatment of hemophilia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093699A (en) 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
WO1994023744A1 (en) 1993-04-16 1994-10-27 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
WO1995005864A1 (en) 1993-08-27 1995-03-02 Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Convection-enhanced drug delivery
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
US6100242A (en) 1995-02-28 2000-08-08 The Regents Of The University Of California Gene therapies for enhancing cardiac function
US6228646B1 (en) 1996-03-07 2001-05-08 The Regents Of The University Of California Helper-free, totally defective adenovirus for gene therapy
US7211558B2 (en) * 2002-05-22 2007-05-01 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hemophilia A

Also Published As

Publication number Publication date
US20090318344A1 (en) 2009-12-24
AU2007220825B2 (en) 2013-02-21
EP1986681A4 (en) 2010-08-04
WO2007101106A3 (en) 2008-11-27
US20120288895A1 (en) 2012-11-15
JP2009528293A (ja) 2009-08-06
CA2641519A1 (en) 2007-09-07
EP2384764A3 (en) 2012-02-08
IL193306A0 (en) 2011-08-01
US8236764B2 (en) 2012-08-07
US8470557B2 (en) 2013-06-25
AU2007220825A1 (en) 2007-09-07
EP2384764A2 (en) 2011-11-09
EP1986681A2 (en) 2008-11-05
WO2007101106A2 (en) 2007-09-07

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