JP2009527498A - 癌におけるcaPCNA相互作用のペプチドによる抑制 - Google Patents

癌におけるcaPCNA相互作用のペプチドによる抑制 Download PDF

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Publication number
JP2009527498A
JP2009527498A JP2008555524A JP2008555524A JP2009527498A JP 2009527498 A JP2009527498 A JP 2009527498A JP 2008555524 A JP2008555524 A JP 2008555524A JP 2008555524 A JP2008555524 A JP 2008555524A JP 2009527498 A JP2009527498 A JP 2009527498A
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Japan
Prior art keywords
capcna
cancer
peptide
pcna
protein
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Pending
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JP2008555524A
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English (en)
Japanese (ja)
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JP2009527498A5 (enExample
Inventor
ヒッキー,ロバート,ジェイ.
マルカス,リンダ,エイチ.
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of JP2009527498A publication Critical patent/JP2009527498A/ja
Publication of JP2009527498A5 publication Critical patent/JP2009527498A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2008555524A 2006-02-17 2007-02-16 癌におけるcaPCNA相互作用のペプチドによる抑制 Pending JP2009527498A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74331306P 2006-02-17 2006-02-17
PCT/US2007/062335 WO2007098415A2 (en) 2006-02-17 2007-02-16 Peptide based inhibition of capcna protein-protein interactions in cancer

Publications (2)

Publication Number Publication Date
JP2009527498A true JP2009527498A (ja) 2009-07-30
JP2009527498A5 JP2009527498A5 (enExample) 2009-10-22

Family

ID=38235155

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008555524A Pending JP2009527498A (ja) 2006-02-17 2007-02-16 癌におけるcaPCNA相互作用のペプチドによる抑制

Country Status (9)

Country Link
US (3) US8653039B2 (enExample)
EP (1) EP1989225A2 (enExample)
JP (1) JP2009527498A (enExample)
CN (1) CN101384618A (enExample)
AU (1) AU2007217037A1 (enExample)
BR (1) BRPI0707948A2 (enExample)
CA (1) CA2638866C (enExample)
EA (1) EA200801847A1 (enExample)
WO (1) WO2007098415A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522613A (ja) * 2010-03-18 2013-06-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 化学療法に対する応答性を予測するための方法
KR20150040314A (ko) * 2012-08-07 2015-04-14 스캔셀 리미티드 개질된 자가 항원결정기에 대한 항종양 반응
JP2018510917A (ja) * 2015-04-10 2018-04-19 アールエルエル・リミテッド・ライアビリティ・カンパニーRll, Llc 抗癌治療剤
US12458688B2 (en) 2018-09-14 2025-11-04 Scancell Limited Epitopes

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101384618A (zh) * 2006-02-17 2009-03-11 印第安纳大学研究及科技有限公司 癌中capcna蛋白-蛋白相互作用的肽基抑制
WO2008036929A2 (en) * 2006-09-21 2008-03-27 Alnylam Pharmaceuticals, Inc. Complex for transferring an anionic substance into a cell
GB0803352D0 (en) * 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
AU2009273873A1 (en) * 2008-07-24 2010-01-28 Indiana University Research And Technology Corporation Cancer peptide therapeutics
FR2942798B1 (fr) * 2009-03-05 2011-04-08 Centre Nat Rech Scient Peptides utilisables pour le traitement de la leucemie lymphoide chronique
US20120195978A1 (en) * 2009-10-07 2012-08-02 Indiana University Research And Technology Corpora Capcna peptide therapeutics for cancer
US20130059773A1 (en) * 2010-02-24 2013-03-07 Veronique Witko-Sarsat Compounds for the treatment of inflammation and neutropenia
WO2013127829A1 (en) 2012-02-27 2013-09-06 Universitat De Barcelona Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
US10836818B2 (en) 2016-12-15 2020-11-17 The National Institute For Biotechnology I Anti-PCNA monoclonal antibodies and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504933A (ja) * 1995-05-11 1999-05-11 サイクレイセル リミテッド Pcna結合物質
JP2008539271A (ja) * 2005-04-27 2008-11-13 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション csPCNAイソ型抗体およびその使用
JP2008547034A (ja) * 2005-06-27 2008-12-25 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション csPCNA異性体修飾およびその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935797A (en) 1994-06-16 1999-08-10 Stanford University Interaction of MHC Class II proteins with members of the PCNA family of proteins
WO1999065515A2 (en) * 1998-06-15 1999-12-23 Arch Development Corporation Combination of radiotherapy and anti-angiogenic factors
US7294471B2 (en) 2002-02-27 2007-11-13 Cskeys, Llc Method for purifying cancer-specific proliferating cell nuclear antigen
CN101384618A (zh) * 2006-02-17 2009-03-11 印第安纳大学研究及科技有限公司 癌中capcna蛋白-蛋白相互作用的肽基抑制

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504933A (ja) * 1995-05-11 1999-05-11 サイクレイセル リミテッド Pcna結合物質
JP2008539271A (ja) * 2005-04-27 2008-11-13 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション csPCNAイソ型抗体およびその使用
JP2008547034A (ja) * 2005-06-27 2008-12-25 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション csPCNA異性体修飾およびその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012026584; HUFF,J.P. et al: The Journal of experimental medicine Vol.172, No.2, 1990, p.419-29 *
JPN6012026587; ROOS,G. et al: Experimental cell research Vol.226, No.1, 1996, p.208-13 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522613A (ja) * 2010-03-18 2013-06-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 化学療法に対する応答性を予測するための方法
KR20150040314A (ko) * 2012-08-07 2015-04-14 스캔셀 리미티드 개질된 자가 항원결정기에 대한 항종양 반응
JP2015525569A (ja) * 2012-08-07 2015-09-07 スキャンセル リミテッド 修飾型自己エピトープに対する抗腫瘍免疫応答
JP2018197236A (ja) * 2012-08-07 2018-12-13 スキャンセル リミテッド 修飾型自己エピトープに対する抗腫瘍免疫応答
KR102203096B1 (ko) * 2012-08-07 2021-01-14 스캔셀 리미티드 개질된 자가 항원결정기에 대한 항종양 반응
JP2018510917A (ja) * 2015-04-10 2018-04-19 アールエルエル・リミテッド・ライアビリティ・カンパニーRll, Llc 抗癌治療剤
US12458688B2 (en) 2018-09-14 2025-11-04 Scancell Limited Epitopes

Also Published As

Publication number Publication date
WO2007098415A2 (en) 2007-08-30
EP1989225A2 (en) 2008-11-12
US20160304559A1 (en) 2016-10-20
US8653039B2 (en) 2014-02-18
CA2638866A1 (en) 2007-08-30
CN101384618A (zh) 2009-03-11
US9187526B2 (en) 2015-11-17
US20090232882A1 (en) 2009-09-17
BRPI0707948A2 (pt) 2011-05-17
AU2007217037A1 (en) 2007-08-30
WO2007098415A3 (en) 2007-12-13
EA200801847A1 (ru) 2009-02-27
CA2638866C (en) 2015-11-10
US20140296156A1 (en) 2014-10-02

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