CA2638866C - Peptide based inhibition of capcna protein-protein interactions in cancer - Google Patents
Peptide based inhibition of capcna protein-protein interactions in cancer Download PDFInfo
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- CA2638866C CA2638866C CA2638866A CA2638866A CA2638866C CA 2638866 C CA2638866 C CA 2638866C CA 2638866 A CA2638866 A CA 2638866A CA 2638866 A CA2638866 A CA 2638866A CA 2638866 C CA2638866 C CA 2638866C
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- capcna
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- pcna
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- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 description 1
- 108010062760 transportan Proteins 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 108010078580 tyrosylleucine Proteins 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74331306P | 2006-02-17 | 2006-02-17 | |
| US60/743,313 | 2006-02-17 | ||
| PCT/US2007/062335 WO2007098415A2 (en) | 2006-02-17 | 2007-02-16 | Peptide based inhibition of capcna protein-protein interactions in cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2638866A1 CA2638866A1 (en) | 2007-08-30 |
| CA2638866C true CA2638866C (en) | 2015-11-10 |
Family
ID=38235155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2638866A Active CA2638866C (en) | 2006-02-17 | 2007-02-16 | Peptide based inhibition of capcna protein-protein interactions in cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8653039B2 (enExample) |
| EP (1) | EP1989225A2 (enExample) |
| JP (1) | JP2009527498A (enExample) |
| CN (1) | CN101384618A (enExample) |
| AU (1) | AU2007217037A1 (enExample) |
| BR (1) | BRPI0707948A2 (enExample) |
| CA (1) | CA2638866C (enExample) |
| EA (1) | EA200801847A1 (enExample) |
| WO (1) | WO2007098415A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101384618A (zh) * | 2006-02-17 | 2009-03-11 | 印第安纳大学研究及科技有限公司 | 癌中capcna蛋白-蛋白相互作用的肽基抑制 |
| WO2008036929A2 (en) * | 2006-09-21 | 2008-03-27 | Alnylam Pharmaceuticals, Inc. | Complex for transferring an anionic substance into a cell |
| GB0803352D0 (en) * | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| AU2009273873A1 (en) * | 2008-07-24 | 2010-01-28 | Indiana University Research And Technology Corporation | Cancer peptide therapeutics |
| FR2942798B1 (fr) * | 2009-03-05 | 2011-04-08 | Centre Nat Rech Scient | Peptides utilisables pour le traitement de la leucemie lymphoide chronique |
| US20120195978A1 (en) * | 2009-10-07 | 2012-08-02 | Indiana University Research And Technology Corpora | Capcna peptide therapeutics for cancer |
| US20130059773A1 (en) * | 2010-02-24 | 2013-03-07 | Veronique Witko-Sarsat | Compounds for the treatment of inflammation and neutropenia |
| JP2013522613A (ja) * | 2010-03-18 | 2013-06-13 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 化学療法に対する応答性を予測するための方法 |
| WO2013127829A1 (en) | 2012-02-27 | 2013-09-06 | Universitat De Barcelona | Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs |
| GB201214007D0 (en) * | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
| US10420840B2 (en) * | 2015-04-10 | 2019-09-24 | Rll, Llc | Anticancer therapeutic agents |
| US10836818B2 (en) | 2016-12-15 | 2020-11-17 | The National Institute For Biotechnology I | Anti-PCNA monoclonal antibodies and use thereof |
| GB201815041D0 (en) | 2018-09-14 | 2018-10-31 | Scancell Ltd | Epitopes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935797A (en) | 1994-06-16 | 1999-08-10 | Stanford University | Interaction of MHC Class II proteins with members of the PCNA family of proteins |
| GB9509557D0 (en) | 1995-05-11 | 1995-07-05 | Univ Dundee | PCNA binding substance |
| WO1999065515A2 (en) * | 1998-06-15 | 1999-12-23 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| US7294471B2 (en) | 2002-02-27 | 2007-11-13 | Cskeys, Llc | Method for purifying cancer-specific proliferating cell nuclear antigen |
| EA200702361A1 (ru) | 2005-04-27 | 2008-04-28 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | АНТИТЕЛА ПРОТИВ csPCNA ИЗОФОРМЫ И ИХ ПРИМЕНЕНИЕ |
| CN101258161A (zh) | 2005-06-27 | 2008-09-03 | 印第安纳大学研究及科技有限公司 | csPCNA同种型修饰及其用途 |
| CN101384618A (zh) * | 2006-02-17 | 2009-03-11 | 印第安纳大学研究及科技有限公司 | 癌中capcna蛋白-蛋白相互作用的肽基抑制 |
-
2007
- 2007-02-16 CN CNA2007800052894A patent/CN101384618A/zh active Pending
- 2007-02-16 EP EP07757135A patent/EP1989225A2/en not_active Withdrawn
- 2007-02-16 AU AU2007217037A patent/AU2007217037A1/en not_active Abandoned
- 2007-02-16 WO PCT/US2007/062335 patent/WO2007098415A2/en not_active Ceased
- 2007-02-16 BR BRPI0707948-6A patent/BRPI0707948A2/pt not_active Application Discontinuation
- 2007-02-16 CA CA2638866A patent/CA2638866C/en active Active
- 2007-02-16 US US12/279,028 patent/US8653039B2/en active Active
- 2007-02-16 EA EA200801847A patent/EA200801847A1/ru unknown
- 2007-02-16 JP JP2008555524A patent/JP2009527498A/ja active Pending
-
2014
- 2014-02-18 US US14/182,550 patent/US9187526B2/en active Active
-
2015
- 2015-10-29 US US14/926,904 patent/US20160304559A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007098415A2 (en) | 2007-08-30 |
| EP1989225A2 (en) | 2008-11-12 |
| US20160304559A1 (en) | 2016-10-20 |
| US8653039B2 (en) | 2014-02-18 |
| CA2638866A1 (en) | 2007-08-30 |
| CN101384618A (zh) | 2009-03-11 |
| US9187526B2 (en) | 2015-11-17 |
| US20090232882A1 (en) | 2009-09-17 |
| BRPI0707948A2 (pt) | 2011-05-17 |
| AU2007217037A1 (en) | 2007-08-30 |
| WO2007098415A3 (en) | 2007-12-13 |
| EA200801847A1 (ru) | 2009-02-27 |
| US20140296156A1 (en) | 2014-10-02 |
| JP2009527498A (ja) | 2009-07-30 |
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| EEER | Examination request |