JP2009526795A5 - - Google Patents
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- Publication number
- JP2009526795A5 JP2009526795A5 JP2008554655A JP2008554655A JP2009526795A5 JP 2009526795 A5 JP2009526795 A5 JP 2009526795A5 JP 2008554655 A JP2008554655 A JP 2008554655A JP 2008554655 A JP2008554655 A JP 2008554655A JP 2009526795 A5 JP2009526795 A5 JP 2009526795A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- group
- independently
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 89
- 150000001875 compounds Chemical class 0.000 claims 52
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 46
- 229910052757 nitrogen Inorganic materials 0.000 claims 44
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 36
- 229910052760 oxygen Inorganic materials 0.000 claims 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 30
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 26
- 125000005842 heteroatom Chemical group 0.000 claims 24
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 19
- 239000001301 oxygen Substances 0.000 claims 19
- 239000011593 sulfur Substances 0.000 claims 19
- -1 N ( R31) Inorganic materials 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 238000004519 manufacturing process Methods 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000004122 cyclic group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- 150000001491 aromatic compounds Chemical class 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000004129 fatty acid metabolism Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000883 anti-obesity agent Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004980 cyclopropylene group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229920002866 paraformaldehyde Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003142 primary aromatic amines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006007048 | 2006-02-15 | ||
| PCT/EP2007/001214 WO2007093366A1 (en) | 2006-02-15 | 2007-02-13 | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526795A JP2009526795A (ja) | 2009-07-23 |
| JP2009526795A5 true JP2009526795A5 (enExample) | 2010-04-02 |
Family
ID=38169583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554655A Pending JP2009526795A (ja) | 2006-02-15 | 2007-02-13 | 新規なアミノアルコール置換アリールジヒドロイソキノリノン、それらの製造方法及び薬剤としてそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8501771B2 (enExample) |
| EP (1) | EP1987006B1 (enExample) |
| JP (1) | JP2009526795A (enExample) |
| KR (1) | KR20080094699A (enExample) |
| CN (1) | CN101384555A (enExample) |
| AR (1) | AR059522A1 (enExample) |
| AT (1) | ATE495157T1 (enExample) |
| AU (1) | AU2007214711A1 (enExample) |
| BR (1) | BRPI0707836A2 (enExample) |
| CA (1) | CA2636617A1 (enExample) |
| DE (1) | DE602007011897D1 (enExample) |
| IL (1) | IL193339A0 (enExample) |
| MY (1) | MY149854A (enExample) |
| TW (1) | TW200800907A (enExample) |
| UY (1) | UY30165A1 (enExample) |
| WO (1) | WO2007093366A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| MX2008014672A (es) * | 2006-05-19 | 2009-03-09 | Abbott Lab | Derivados de alcano azabiciclico sustituidos con bicicloheterociclo fusionado activos en el sistema nervioso central. |
| MX2008015662A (es) * | 2006-06-08 | 2009-01-12 | Lilly Co Eli | Nuevos receptores antagonistas de la hormona concentradora de melanina (mch). |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9078888B2 (en) | 2007-01-22 | 2015-07-14 | Gtx, Inc. | Nuclear receptor binding agents |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| US8344160B2 (en) | 2008-10-08 | 2013-01-01 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
| US20120316200A1 (en) * | 2010-04-12 | 2012-12-13 | Merck Sharp & Dohme Corp. | Pyridone derivatives |
| WO2011140190A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Tetrazolones as inhibitors of fatty acid synthase |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| TW201215387A (en) * | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| PL3186233T3 (pl) | 2014-08-29 | 2022-02-28 | Chdi Foundation, Inc. | Sondy do obrazowania białka huntingtyny |
| WO2021028935A1 (en) * | 2019-08-12 | 2021-02-18 | Dr Reddy's Institute Of Life Sciences | Heterocyclic compounds, and their use as allosteric modulators of 5-hydroxytryptamine 2c receptor (5-ht2cr) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10259176A (ja) * | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | 血管新生阻害作用を有する新規アミド誘導体及びその用途 |
| CA2386474A1 (en) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| EP1268432A1 (en) | 2000-03-24 | 2003-01-02 | Millenium Pharmaceuticals, Inc. | ISOQUINOLONE INHIBITORS OF FACTOR Xa |
| WO2002002744A2 (en) | 2000-07-05 | 2002-01-10 | Synaptic Pharmaceutical Corporation | Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof |
| AU783403B2 (en) | 2000-07-05 | 2005-10-20 | H. Lundbeck A/S | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
| MXPA03000923A (es) | 2000-07-31 | 2003-06-09 | Smithkline Beecham Plc | Compuestos de carboxamida y su uso como antagonistas de un receptor 11cby humano. |
| US20030022891A1 (en) | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
| EP1392298B1 (en) | 2001-05-04 | 2009-02-18 | Amgen Inc. | Fused heterocyclic compounds |
| GB0124627D0 (en) | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| SK2242004A3 (en) | 2001-10-25 | 2004-11-03 | Takeda Chemical Industries Ltd | Quinoline compound |
| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| AU2003222648A1 (en) | 2002-05-13 | 2003-12-02 | Eli Lilly And Company | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP2006522812A (ja) * | 2003-04-11 | 2006-10-05 | スミスクライン ビーチャム コーポレーション | 複素環ｍｃｈｒ１アンタゴニスト |
| US7390820B2 (en) | 2003-08-25 | 2008-06-24 | Amgen Inc. | Substituted quinolinone derivatives and methods of use |
| CA2543122A1 (en) * | 2003-10-23 | 2005-05-12 | Glaxo Group Limited | 3-(4-aminophenyl) thienopyrimid-4-one derivatives as mch r1 antagonists for the treatment of obesity, diabetes, depression and anxiety |
| US20050176738A1 (en) | 2003-11-07 | 2005-08-11 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
| KR20070026385A (ko) * | 2004-02-13 | 2007-03-08 | 반유 세이야꾸 가부시끼가이샤 | 축합환 4-옥소피리미딘 유도체 |
| US20050256124A1 (en) | 2004-04-15 | 2005-11-17 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
-
2007
- 2007-02-13 TW TW096105356A patent/TW200800907A/zh unknown
- 2007-02-13 KR KR1020087020097A patent/KR20080094699A/ko not_active Withdrawn
- 2007-02-13 CA CA002636617A patent/CA2636617A1/en not_active Abandoned
- 2007-02-13 AT AT07722802T patent/ATE495157T1/de not_active IP Right Cessation
- 2007-02-13 BR BRPI0707836-6A patent/BRPI0707836A2/pt not_active IP Right Cessation
- 2007-02-13 DE DE602007011897T patent/DE602007011897D1/de active Active
- 2007-02-13 WO PCT/EP2007/001214 patent/WO2007093366A1/en not_active Ceased
- 2007-02-13 EP EP07722802A patent/EP1987006B1/en not_active Not-in-force
- 2007-02-13 MY MYPI20083055A patent/MY149854A/en unknown
- 2007-02-13 JP JP2008554655A patent/JP2009526795A/ja active Pending
- 2007-02-13 AU AU2007214711A patent/AU2007214711A1/en not_active Abandoned
- 2007-02-13 CN CNA2007800057008A patent/CN101384555A/zh active Pending
- 2007-02-15 UY UY30165A patent/UY30165A1/es not_active Application Discontinuation
- 2007-02-15 AR ARP070100661A patent/AR059522A1/es not_active Application Discontinuation
-
2008
- 2008-08-10 IL IL193339A patent/IL193339A0/en unknown
- 2008-08-14 US US12/191,697 patent/US8501771B2/en not_active Expired - Fee Related
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